Patents Assigned to Smith Kline & French Laboratories Limited
  • 3-hydroxypyridines
    Patent number: 4764519
    Abstract: The disclosure relates to a class of 2-(pyridylalkylamino)-3-hydroxypyridines which are active as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: August 16, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, Peter D. Miles, Rodney C. Young
  • Pyridine derivatives and use as histamine H.sub.2 antagonists
    Patent number: 4758576
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylallyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: July 19, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Tricyclic pyridazinone compounds
    Patent number: 4755511
    Abstract: This invention relates to tricyclic pyridazinone compounds, pharmaceutical compositions containing the compounds, and a method of stimulating cardiac activity in a mammal by administering an effective amount of the compound. A compound of the invention is 7-carboxamido-4,4a-dihydro-4a-methyl-[5H]-indeno[1,2-c]-pyridazin-3[2H]-on e.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: July 5, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Brian H. Warrington
  • Process for preparing an aziridine derivative
    Patent number: 4739077
    Abstract: Process for preparing N-cyano-N'-methyl-1-aziridinoamidine by reacting aziridine with a N-cyano-N'-methyl-O-arylisourea.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: April 19, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George R. White
  • Substituted aminopyridones and aminoquinolones having histamine H.sub.2 -receptor blocking activity
    Patent number: 4738969
    Abstract: This invention relates to 2-substituted aminopyridone compounds which have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: April 19, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Thomas H. Brown
  • Intermediates for 3-amino-1,2,5-thiadiazole-1-oxides
    Patent number: 4732980
    Abstract: This invention relates to intermediates of Mannich-alkynyl aminothiadiazole oxides having histamine H.sub.2 -antagonist activity. A particular final product of this invention is 3-amino-4-[7-piperidinohept-5-ynylamino]-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: March 22, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Peter Blurton
  • Histamine antagonist triadiazole derivatives, compositions, and method of use therefor
    Patent number: 4728648
    Abstract: New 3,4-diamino-1,2,5-thiadiazole oxide derivatives which are histamine H.sub.1 -antagonists. A specific compound of this invention is 3-[3-[N-(4-fluorobenzyl)-N-pyrid-2-yl-amino]propylamino]-4-[pyrimidin-4-yl -methylamino]-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: February 4, 1986
    Date of Patent: March 1, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Andrew D. Gribble, Robert J. Ife
  • Chemical compounds
    Patent number: 4694008
    Abstract: This invention relates to 5-oxypyrimidinone compounds having H.sub.2 -antagonist activity. A particular compound of the invention is 2-[3-(3-piperidinomethyl)phenoxy)propyl]-5-benzyloxypyrimidin-4-one.
    Type: Grant
    Filed: August 15, 1985
    Date of Patent: September 15, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Graham J. Durant
  • 3-Pyridylaminoalkyleneamino-4-amino-1,2,5-thiadiazole-1-oxides, composition containing them, and use of them to block histamine h.sub.2 -receptors
    Patent number: 4692456
    Abstract: New 3,4-diamino-1,2,5-thiadiazole oxide derivatives which are histamine H.sub.1 -antagonists. A specific compound of this invention is 3-[3-(N-propyl-N-2-pyridylamino)-propylamino]-4-(4-pyridylmethyl)amino-1,2 ,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: September 8, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Histamine H.sub.2 -antagonist oxazole and thiazole derivatives and compositions therefor
    Patent number: 4681883
    Abstract: This invention relates to aminoalkylphenoxyalkyl substituted heterocycles. These compounds antagonize the action of histamine on histamine H.sub.2 -receptors in the brain. A compound of the invention is 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]benzthiazole.
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: July 21, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert C. Mitchell, Ian R. Smith, Rodney C. Young
  • Pharmaceutical compositions having .beta.-adrenoceptor antagonist activity employing pyridazinone derivatives
    Patent number: 4678786
    Abstract: This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: July 7, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Anthony M. Roe, William J. Coates, Robert A. Slater, Stephen P. Breukelman, George D. Meakins
  • Tricyclic derivatives and pharmaceutical use
    Patent number: 4668671
    Abstract: This invention describes tricyclic derivatives which are useful as histamine H.sub.1 -antagonists. A particular compound of this invention is 3-[3-(pyrido[3,2-b][1,4]-benzothiazin-10-yl)propylamino]-4-(pyrid-4-ylmeth ylamino)-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: April 23, 1986
    Date of Patent: May 26, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Andrew D. Gribble, Robert J. Ife
  • 2-(3-amino-5-halo-2-pyridylalkylamino)-pyrimidones useful as histamine H1-antagonists
    Patent number: 4665078
    Abstract: The invention describes 5-halo-3-amino-2-pyridyl derivatives which are useful as histamine H.sub.1 -antagonists. Particular compounds described are 2-[4-(5-bromo-3-aminopyrid-2-yl)butylamino]-5-(6-methylpyrid-3-ylmethyl)-4 -pyrimidone and 2-[4-(5-bromo-3-aminopyrid-2-yl)butylamino]-5-(N-oxopyrid-4-ylmethyl)-4-py rimidone.
    Type: Grant
    Filed: July 11, 1984
    Date of Patent: May 12, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 3-(2-pyridylaminoalkylamino)cyclobutenediones and pyridones useful as histamine H.sub.1 -antagonists
    Patent number: 4659725
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: April 21, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Pyridylaminoalkylamine intermediates
    Patent number: 4652650
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: August 5, 1985
    Date of Patent: March 24, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • 2-(furanyl alkylamino or thienyl alkylamino or phenylalkylamino)-3-carboxy (or hydroxy)-pyridines
    Patent number: 4652572
    Abstract: This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.
    Type: Grant
    Filed: July 12, 1985
    Date of Patent: March 24, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Martin Jones, Rodney C. Young
  • Pyrimidine compounds
    Patent number: 4649141
    Abstract: The compounds are substituted pyrimidine compounds which are histamine H.sub.2 -antagonists. A specific compound of the present invention is 2-[2-(5-dimethylaminomethyl)-2-furylmethylthio)ethylamino]-5-(3-pyridylmet hyl)-4-pyrimidone.
    Type: Grant
    Filed: June 21, 1985
    Date of Patent: March 10, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • Pharmaceutical dosage unit
    Patent number: 4647448
    Abstract: The invention describes a pharmaceutical dosage unit suitable for oral administration with at least one face having a recess, which recess extends from one edge across and into the face; the recess being so shaped as to accommodate at least the tip of the user's tongue.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: March 3, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • 3,5-Substituted-2-pyridylalkylaminothiadiazoles having histamine H.sub.1 -antagonist activity
    Patent number: 4640926
    Abstract: 3,5-Substituted-2-pyridylalkylaminothiadiazole compounds are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: February 3, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 2-substituted alkylaminopyrimidones useful as H.sub.2 -antagonists and antiinflamatory agents
    Patent number: 4639519
    Abstract: The compounds are isoureas and isothioureas which have an O- or S-alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents.A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: January 27, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen