Abstract: This invention relates to thiadiazinone derivatives which have inotropic and vasodilator activity. A specific compound of this invention is 7-acetamido-9,9a-dihydroindeno[1,2-e][1,3,4]thiadiazine-2(3H)-one.
Type:
Grant
Filed:
November 6, 1984
Date of Patent:
October 7, 1986
Assignee:
Smith Kline & French Laboratories Limited
Abstract: Compounds of the formula: ##STR1## where R.sup.1 is halogen or nitro; R.sup.2 is C.sub.1-4 alkyl; and R.sup.3 is a C.sub.1-3 alkylene group are intermediates to 2-(3,5-disubstituted pyridyl-alkyl amino)-5-pyridylmethyl-4-pyrimidone derivatives which are useful as histamine H.sub.1 -antagonists.
Type:
Grant
Filed:
September 17, 1984
Date of Patent:
April 22, 1986
Assignee:
Smith Kline & French Laboratories Limited
Abstract: 3-Nitro-2-substituted aminopyrroles are histamine H.sub.2 -receptor antagonists. The 2-position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5-positions of the pyrrole ring can also be substituted.
Type:
Grant
Filed:
August 6, 1984
Date of Patent:
April 22, 1986
Assignee:
Smith Kline & French Laboratories Limited