Patents Assigned to Smith Kline & French Laboratories Limited
  • Dust recovery apparatus
    Patent number: 4576619
    Abstract: Dust recovery apparatus is disclosed which recovers air-entrained dust in a high state of purity. The apparatus comprises a housing capable of sustaining at least slight positive pressure and suitable for accommodating powder processing machinery, an air supply system for passing air at a predetermined rate and at a slight positive pressure to the housing, a collector which collects dust entrained in air leaving the housing and an air-flow rate sensor which detects air-flow rate in the apparatus and activates valves for stopping air passing to the collector when the air-flow rate falls outside a predetermined range.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: March 18, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Graham P. Manning
  • Pyridine derivatives histamine H.sub.2 -antagonists
    Patent number: 4574126
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylalkyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: March 4, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Cytosine derivatives having histamine H.sub.2 -antagonist activity
    Patent number: 4571398
    Abstract: This invention relates to cytosine derivatives which have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 4-[3-(3-(piperidinomethyl)phenoxy)propylamino]-pyrimidin-2-thione.
    Type: Grant
    Filed: June 20, 1984
    Date of Patent: February 18, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Thomas H. Brown
  • Process for preparing substituted pyrimidinones
    Patent number: 4569996
    Abstract: This invention provides a process for the preparation of pyrimidinone compounds with a group R.sup.2 CH(OH)-- at the 5-position thereof, wherein R.sup.2 is an optionally substituted acid-stable 5- or 6-membered nitrogen-containing heteroaryl group. The pyrimidinone ring is further substituted by a side-chain of a H.sub.1 -antagonist or H.sub.2 -antagonist or a precursor thereof.The compounds are convertible to 5-heteroaryl methyl compounds which are either useful H.sub.1 - or H.sub.2 -antagonists or precursors thereof.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: February 11, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: John Kitteringham, Brian P. Slingsby
  • 4H-Imidazol-4-ones and their pharmaceutical use
    Patent number: 4567176
    Abstract: This invention relates to Mannich-furyl(thienyl, pyridyl or phenyl) alkylaminoimidazolinones which have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(5-dimethylaminomethylfuran-2-ylmethylthio)-ethylamino]-1-methyl-imid azolin-4-one.
    Type: Grant
    Filed: April 18, 1984
    Date of Patent: January 28, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Thomas H. Brown
  • 2-Substituted alkylaminopyrimidones
    Patent number: 4558128
    Abstract: The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: December 10, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Pyridyl-2-oxy-propyl-1H-1,2,4-triazole-3,5-diamines
    Patent number: 4551466
    Abstract: This invention relates to diaminotriazole derivatives in which one amino group is substituted by a 4-dialkylamino- or piperidinyl- or pyrolidinylmethyl pyrid-2-yloxypropyl group. The compounds have histamine H.sub.2 -antagonist activity. One specific compound is 1-methyl-N.sup.5 -3-(4-[1-piperidinomethyl]-pyridyl-2-oxy)-propyl-1H-1,2,4-triazole-3,5-dia mine.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: November 5, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Pyridylaminoalkylaminopyrimidones useful as histamine H.sub.1 -antagonists
    Patent number: 4548940
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: October 22, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • 2-Pyridylaminoakylamino-4-pyrimidones useful as histamine H.sub.1 -antagonists
    Patent number: 4547506
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: October 15, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • 2-(Imidazolyl alkylamino)-3-carboxy(or hydroxy)-pyridines
    Patent number: 4547512
    Abstract: This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.
    Type: Grant
    Filed: November 25, 1983
    Date of Patent: October 15, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Martin Jones, Rodney C. Young
  • N-Substituted pyridinones having histamine H.sub.2 -antagonist activity
    Patent number: 4540699
    Abstract: This invention relates to N-substituted pyridinone compounds which have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(1-methyl-2-oxopyridin -4-ylmethyl)pyrimidin-4-one.
    Type: Grant
    Filed: November 29, 1983
    Date of Patent: September 10, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Derek A. Rawlings
  • Pyrimidine compounds
    Patent number: 4539207
    Abstract: The compounds are substituted pyrimidine compounds which are histamine H.sub.2 -antagonists. A specific compound of the present invention is 2-[2-(5-dimethylaminomethyl)-2-furylmethylthio)ethylamino]-5-(3-pyridylmet hyl)-4-pyrimidone.
    Type: Grant
    Filed: June 4, 1980
    Date of Patent: September 3, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • Pharmacologically active compounds
    Patent number: 4537779
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: August 27, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • 2-(3,5-Substituted-2-pyridylalkylamino)-5-oxopyridylmethyl-4-pyrimidones useful as histamine H.sub.1 -antagonists
    Patent number: 4537890
    Abstract: Pyridone derivatives useful as histamine H.sub.1 -antagonists are disclosed.
    Type: Grant
    Filed: November 23, 1983
    Date of Patent: August 27, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 2-(3,5-Substituted-2-pyridylalkylamino)-5-benzyl-4-pyrimidones
    Patent number: 4537891
    Abstract: 3,5-Disubstituted-2-pyridylalkylamino-5-optionally substituted benzyl-4-pyrimidones having histamine H.sub.1 -antagonist activity are disclosed.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: August 27, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 2-Aminoalkyl-pyridine derivatives
    Patent number: 4535163
    Abstract: The invention provides 2-(3,5-disubstituted pyridylalkyl amino)-5-pyridylmethyl-4-pyrimidone derivatives which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: August 13, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 2-(2-Pyridylaminoalkylamino)-4-pyrimidones
    Patent number: 4532246
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: July 30, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • 3,5-Substituted-2-pyridylalkylamino compounds having histamine H.sub.1 -antagonist activity
    Patent number: 4532252
    Abstract: 3,5-Substituted-2-pyridylalkylamino derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 9, 1983
    Date of Patent: July 30, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone
    Patent number: 4528371
    Abstract: A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine.6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.
    Type: Grant
    Filed: June 14, 1983
    Date of Patent: July 9, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, Brian H. Warrington
  • Synthesis of 2-pyridylalkylamines
    Patent number: 4526974
    Abstract: The invention provides a process for preparing 2-pyridylalkylamines by reacting an alkali metal derivative of a 2-methylpyridine with a haloalkylamine. The compounds are useful as intermediates in the preparation of compounds having histamine H.sub.1 - and H.sub.2 -antagonist activity.
    Type: Grant
    Filed: March 22, 1983
    Date of Patent: July 2, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Brian M. Adger, Antonietta R. Mastrocola