Abstract: There are provided a subsurface imaging apparatus and method for modeling a subsurface structure by solving a wavefield equation by waveform inversion. A virtual source that generates an observed wavefield and is distributed over grid points of the subsurface is obtained by applying a least-square method to an equation including a Green's function of the subsurface medium. Then, a subsurface model generating the observed wavefield when applying the virtual source is obtained.
Abstract: The present invention relates to novel amino acid derivatives containing heterocyclic chelating residues thereof; radioactive or nonradioactive metal complexes thereof; methods for preparation thereof; and apyrogenic and sterile preparative kits of the composition for targeting cancer cells. The compounds of the present invention can easily be taken up to cancer cells as they contain amino acid residues thereof; radioactive or nonradioactive metals can be labeled easily as they contain heterocyclic chelating residues thereof; cancer lesion can be imaged easily by targeting using the present invention.
Type:
Application
Filed:
March 31, 2010
Publication date:
February 2, 2012
Applicant:
SNU R&DB FOUNDATION
Inventors:
Jae Min Jeong, Dinesh Shetty, Dong Soo Lee, June Key Chung, Myung Chul Lee
Abstract: The present invention provides a novel cationic lipid, a preparation method of the same and a delivery system comprising the same. The cationic lipid of the present invention is used for the preparation of delivery systems of nucleic acids or physiologically active anionic proteins. The cationic lipid of the present invention can be conveniently prepared and purified by a simple process and is therefore economically highly advantageous for industrial-scale production thereof. Further, a nucleic acid or protein delivery system comprising the cationic lipid of the present invention not only significantly improves the intracellular delivery efficiency of desired nucleic acid drugs (such as DNAs, RNAs, siRNAs, antisense oligonucleotides, and nucleic acid aptamers) or anionic proteins having physiological activity, but also is usefully used to augment therapeutic efficacy of nucleic acid or protein drugs due to attenuated cytotoxicity of the delivery system.
Type:
Application
Filed:
August 20, 2008
Publication date:
January 26, 2012
Applicants:
SNU R&DB FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventors:
Yu-Kyoung Oh, Min-Sung Suh, Hye-Jeong Shin, Ga Yong Shim
Abstract: The present invention relates to a method for isolating pluripotent/multipotent stem cells derived from umbilical cord blood, characterized by culturing monocytes isolated from umbilical cord blood in a culture vessel containing fibronectin and then harvesting stem cells from the culture, the umbilical cord blood-derived pluripotent/multipotent stem cells isolated thereby; and a cell therapeutic agent containing the pluripotent/multipotent stem cells derived from umbilical cord blood or cells differentiated therefrom. The present invention also relates to a novel culture media for stem cells, a culture method for stem cells which is characterized by culturing and proliferating stem cells in the culture media, and a method for increasing stemness of stem cells which is characterized by a sphere culture or a three-dimensional culture of stem cells.
Abstract: A thin film transistor, which has a first passivation layer and a second passivation layer to maintain high reliability while preventing hydrogen from being induced to a semiconductor layer, and a method for fabricating the thin film transistor are provided. The method includes providing a substrate including an insulation substrate, forming a gate electrode on the substrate, forming a gate insulation layer on the substrate and the gate electrode, forming a semiconductor layer on the gate insulation layer, forming source/drain electrodes on the semiconductor layer to expose a portion of a top portion of the semiconductor layer, forming a first passivation layer to cover exposed top portions of the gate insulation layer, the semiconductor layer and the source/drain electrodes, and forming a second passivation layer on the first passivation layer, wherein the forming of the second passivation layer comprises performing deposition at a higher temperature than the forming of the first passivation layer.
Abstract: The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.
Type:
Application
Filed:
August 5, 2011
Publication date:
January 19, 2012
Applicants:
SNU R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Sang Gyu Park, Kyong Soo Park, Sunghoon Kim
Abstract: Provided is a method for modifying the surface of a bioinert material, the method including preparing a base material composed of a bioinert material; and spraying a bioactive powder onto the bioinert base material through a spray nozzle using a high pressure carrier gas to form a bioactive layer on the base material. The surface modification method enables mass production, at low cost, of new biomaterials having the advantages of both a coating substance and a body to be coated, by applying a bioactive material to various bodies to be coated through a cold spray method.
Type:
Application
Filed:
January 22, 2010
Publication date:
January 12, 2012
Applicant:
SNU R&DB FOUNDATION
Inventors:
Jun Hong Noh, Dong Wook Kim, Jae Sul An, Hae Rin Chang, Dong Hoe Kim, Kug Sun Hong, Dong Kyu Chin
Abstract: A catalyst for diesel particle filter includes a platinum (Pt)-neodymium (Nd) alloy that is carried in silica, a preparation method thereof and a soot reduction device for diesel engine including the same, wherein the catalyst for diesel particle filter can maintain high catalyst activity and implement high nitrogen monoxide (NO) conversion efficiency even though it is used under the high temperature or vulcanization condition for a long time.
Type:
Application
Filed:
November 15, 2010
Publication date:
January 12, 2012
Applicants:
HYUNDAI MOTOR COMPANY, SNU R&DB FOUNDATION, KIA MOTORS CORPORATION
Inventors:
Ho-In LEE, Yeon-Su Kim, Yong-Kwon Chung, Jin Ha Lee, Jie Won Park
Abstract: Provided are a method for read-out of information in a magnetic recording element and a method for read-out of information in a magnetic random access memory. In the method, a magnetic recording element including a magnetic free layer where a magnetic vortex is formed is prepared, and “0” or “1” is assigned according to a core orientation of a magnetic vortex formed in the magnetic free layer. The magnetic vortex core formed in the magnetic free layer rotates on the magnetic free layer by applying a current or magnetic field, of which a direction varies with time, to the magnetic free layer with the magnetic vortex formed. “0” or “1” assigned according to the core orientation of the magnetic vortex formed in the magnetic free layer is read out by measuring a characteristic caused by a difference in a rotation radius of the magnetic vortex core.
Type:
Grant
Filed:
October 17, 2008
Date of Patent:
January 10, 2012
Assignee:
SNU R&DB Foundation
Inventors:
Sang-Koog Kim, Ki-Suk Lee, Young-Sang Yu
Abstract: Walking status estimation in a portable terminal includes a method for estimating walking status. The method includes setting an observation using an estimated temporary step length, an acceleration variance, and a step frequency. The method also includes generating an observed probability vector comprising probabilities per walking status according to the observation. The method further includes determining final probabilities per walking status by multiplying the observed probability vector by at least one of an initial probability matrix and one or more status transition probability vectors. The method still further includes determining a walking status having the greatest final probability as a final walking status.
Abstract: A method for dedifferentiating adipose tissue stromal cells (ATSC) is provided. When the ATSC is treated under hypoxia condition and with a 4-(3,4-Dihydroxy-phenyl)-derivative (DHP-derivative), expression of stemness genes, cellular growth-related genes and cellular mobility-related genes increase, and expression of histone and DNA methylation-related genes decrease so that cell proliferation increases and pluripotency for differentiating into adipocytes, osteocytes, myocytes, beta cells and cartilage cells is acquired. When the dedifferentiated ATSC is implanted into animal model with spinal cord injury and diabetic animal model, effects of nerve regeneration and increased blood surge level are confirmed. As a result, the method for dedifferentiating the ATSC can be effectively used in the stem cell research, tissue regeneration and development of cytotherapeutic medicines.
Abstract: Techniques, apparatus and systems are described for performing variable length decoding. In one aspect, a variable length decoding apparatus includes a first computation unit to determine whether a symbol corresponding to an input data is included in an upper group or a lower group of a variable length code tree. Responsive to the determination, when the symbol corresponding to the input data is included in the lower group, the first computation unit detects look-up table information corresponding to a subgroup that includes the symbol corresponding to the input data within the lower group that includes multiple subgroups. The variable length decoding apparatus includes a second computation unit to detect the symbol corresponding to the input data by searching a look-up table corresponding to the look-up table information when the look-up table information is received from the first computation unit.
Type:
Grant
Filed:
December 10, 2009
Date of Patent:
January 3, 2012
Assignees:
Core Logic, Inc., SNU R&DB Foundation
Inventors:
Ki Wook Yoon, Venkata Krishna Prasad Arava, Ki Young Choi, Man Hwee Jo, Hyouk Joong Lee
Abstract: Disclosed is a composition for treating dementia including shRNA to inhibit expression of S100a9. More particularly, the present disclosure describes a composition for prevention or treatment of dementia which includes shRNA having a nucleotide sequence defined by SEQ. ID No. 1 or 2 or a mixture thereof wherein the nucleotide sequence is complementarily bonded to mRNA of S100a9 in order to inhibit expression of S100a9, as well as a method for prevention or treatment of dementia, including administering the foregoing shRNA into a mammalian cell including a human cell or in vitro established mammalian cell-line, in order to inhibit expression of S100a9 protein.
Abstract: The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and hydrophobic face. The method of the present invention provides a screening method of an amphiphilic peptide which is specific to hairpin RNA. So, the peptide selected by the method of the present invention can be effectively used for the study of hairpin RNA functions and for the production of a novel drug using an artificial peptide binding to a hairpin RNA target.
Abstract: A method of processing frames obtained by multiple exposures may include categorizing, by at least one processor, a plurality of frames captured by multiple exposures into one of a reference frame and a target frame, compensating for global motion resulting from motion of a capturing apparatus capturing an object, and compensating for local motion resulting from motion of the object, based on a joint histogram between the reference frame and the target frame.
Abstract: Disclosed herein is a micro-electrode array package including a micro-electrode array comprising: a substrate section including a liquid crystal polymer; an electrode section collecting and transferring bio-signals; and a cover section insulating and protecting the electrode section and including a liquid crystal polymer, wherein the electrode section is disposed in contact with one surface of the substrate section, the cover section is adhered in contact with the surface of the substrate section on which the electrode section is disposed, and a space independent from the external environment is formed between the substrate section and the cover section adhered thereto.
Type:
Application
Filed:
August 14, 2009
Publication date:
December 22, 2011
Applicants:
NURO BIO-SYSTEMS CORP., SNU R&DB FOUNDATION
Inventors:
Sung June Kim, Seung Woo Lee, Choong Jae Lee, Soonkwan An
Abstract: The present invention relates to a composition for diagnosing a Parkinson's disease comprising mesenchymal stromal cells derived from adipose tissue, a method of providing information for diagnosing Parkinson's disease and/or the extent of the disease progression, a biomarker for diagnosing a Parkinson's disease, and a method of screening a drug candidate treating Parkinson's disease where the drug candidate is a target of the biomarker.
Type:
Application
Filed:
December 17, 2010
Publication date:
December 22, 2011
Applicant:
SNU R&DB Foundation
Inventors:
Sun Ha Paek, Hyo Eun Moon, Hyung Woo Park, Hye Young Shin
Abstract: The present invention relates to cubic or octahedral ferrite nanoparticles and a method for preparing the same. In particular, the present invention is directed to a ferrite nanocube which is superparamagnetic or ferromagnetic, and a method for preparing a ferrite nanocube, comprising heating a mixture of a metal precursor, a surfactant and a solvent.
Abstract: The present invention relates to a displayable wind turbine. The displayable wind turbine includes a central shaft arranged vertically to a flow direction of fluid. Radially extending upper spokes are coupled to an upper hub. Radially extending lower spokes are coupled to a lower hub. Blades have first ends connected to an end of the upper hub and second ends connected to an end of the lower hub. A pitch control unit adjusts a blade pitch angle. A detection unit includes a fluid direction detection unit, a fluid velocity detection unit, a central shaft speed detection unit, and a central shaft position detection unit. A light emitting unit includes a printed circuit board and light emitting devices. A control unit controls operations of the pitch control unit and the light emitting unit.
Abstract: Provided is an opportunistic concurrent transmission method for achieving efficient transmission with limited wireless resources in a WLAN environment. According to an exemplary embodiment of the present invention, when a packet to be transmitted is provided in an access point in a wireless network system, information on a link which is performing transmission from another access point is acquired by overhearing transmission from another access point, a signal to interference plus noise ratio (SINR) value of the link is verified by referring an interference map, and the packet is concurrently transmitted when the verified SINR value is equal to or more than a predetermined capture threshold.
Type:
Application
Filed:
November 4, 2010
Publication date:
December 15, 2011
Applicant:
SNU R&DB FOUNDATION
Inventors:
Chong Kwon Kim, Young Myoung Kang, Joon Soo Lee