Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.

Abstract: Xerogels and compositions comprising xerogels comprising a transition metal oxide and silicon oxide xerogel matrix. The xerogels and compositions can be made from mixtures of transition metal alkoxide(s) and tetraalkoxysilane(s) and, optionally, alkyltrialkoxysilane(s), aminoalkyl-, alkylaminoalkyl-, dialkylaminoalkyltrialkoxysilane(s), or a combination thereof. The xerogels and compositions can be used as antifouling coatings on, for example; boats.

Abstract: Water-in-salt electrolytes for zinc metal batteries are disclosed. The electrolyte includes a zinc halide. The electrolyte may be a hybrid water-in-salt electrolyte further including an additional metal halide or nonmetal halide. Batteries including the electrolytes are disclosed, as well as devices including the batteries and methods of making the batteries.

Abstract: An OpenCL-defined scalable runtime-flexible programmable accelerator architecture for accelerating convolutional neural network (CNN) inference in cloud/edge computing is provided, referred to herein as Systolic-CNN. Existing OpenCL-defined programmable accelerators (e.g., field-programmable gate array (FPGA)-based accelerators) for CNN inference are insufficient due to limited flexibility for supporting multiple CNN models at runtime and poor scalability resulting in underutilized accelerator resources and limited computational parallelism. Systolic-CNN adopts a highly pipelined and paralleled one-dimensional (1-D) systolic array architecture, which efficiently explores both spatial and temporal parallelism for accelerating CNN inference on programmable accelerators (e.g., FPGAs). Systolic-CNN is highly scalable and parameterized, and can be easily adapted by users to efficiently utilize the coarse-grained computation resources for a given programmable accelerator.

Abstract: This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1? deletion mutant fungal cells.

Abstract: Computer vision systems and methods for real-time localization of a needle in an ultrasound video are provided. The method includes a step of receiving at a processor a plurality of frames from the ultrasound video. The method also includes the step of identifying by the processor one of the plurality of frames as a background image and a frame adjacent to the background image as a current image. The method further includes the step of performing by the processor a bitwise complement operation on the background image to generate a complement image. Moreover, the method includes the step of performing by the processor a pointwise logical AND operation on the complement image and the current image to identify the location of the needle.

Abstract: A system and method for demodulation of a fiber optic interferometric sensor are provided. Another aspect pertains to a system and method employing a single laser to generate multiple quadratic wavelengths to demodulate fiber optic interferometric sensors with approximately sinusoidal fringes. Yet another aspect of the present system and method uses a single frequency laser which is split into multiple paths using a fiber optic coupler, with one path including an intensity modulator and another path including an acousto-optic modulator, whereafter the paths are recombined into a fiber which leads to an interferometric sensor, and the light reflected from the sensor is then directed to a photodetector. A further aspect employs a single frequency laser which is split into multiple paths, with the light in the paths being modulated at different frequencies, whereafter the paths are recombined into a fiber which leads to an interferometric sensor.

Abstract: A remote test apparatus is configured to simulate an environment of at least one remotely located room and configured to receive at least one air sample from the at least one remotely located room. The apparatus includes a sealed enclosure forming an interior cavity and including an inlet in connection with the at least one remotely located room and an outlet in connection with a sample collection unit. The sample collection unit is configured to communicate the at least one air sample from the remotely located room at a first flow rate. The apparatus further includes at least one sensor disposed in the interior cavity and at least one air transfer unit configured to transfer test air from the interior cavity of the sealed enclosure to the at least one sensor at a second flow rate.

Abstract: Anti-heparanase compounds for the treatment of cancer are described. The anti-heparanase compounds are high affinity, synthetic glycopolymers that result in minimal anticoagulant activity. Stereoselective fluorinated forms of these compounds are also provided.

Abstract: A membrane comprising a crystalline material deposited on a porous support. The crystalline material is made of tectosilicate with a portion of the Si atoms substituted with metal atoms. The membrane is useful in the separation of oil and water.

Abstract: Deep mutational scanning is a foundational tool for addressing functional consequences of large numbers of mutants, yet a more efficient and accessible method for construction of user-defined mutagenesis libraries is needed. Provided herein are nicking saturation mutagenesis, a single-day, single-pot saturation mutagenesis method using routinely prepped plasmid dsDNA as input substrate. Reproducibility and convenience of the method are demonstrated through validation by an external research laboratory.

Abstract: The present invention provides a longitudinally split immature tiller separated from a rhizome (LSITR), a duster of multiple in vitro shoots (CMIT), a cluster of stem segments containing shoot primordia (CSSSP) and an in vitro tiller of Miscanthus x giganteus (Giant miscanthus), and their uses in propagating Miscanthus x giganteus (Giant miscanthus).

Abstract: A method of forming a metal oxide material having a rod shape or polyhedral nanostructure includes preparing a first reverse micro-emulsion system comprising an aqueous precipitating agent dispersion and a second reverse micro-emulsion system containing an aqueous metal salt dispersion; combining the micro-emulsions together to initiate a reaction; allowing the reaction to continue to form a product mixture comprising a metal oxide gel and aqueous media; separating the metal oxide gel from the aqueous media; collecting the metal oxide gel; and calcining the metal oxide gel to form the metal oxide material. The metal oxide material corresponds to the chemical formula of La2MxNi1-xO4, Pr2-yAyNiO4, or La2-zDzNiO4, wherein M is copper, cobalt, iron, manganese, chromium, aluminum, or platinum; A is lanthanum or neodymium; D is calcium, barium or strontium; x ranges from 0 to 1; y ranges from 0 to 2; and z ranges from 0 to 0.25.

Abstract: The present disclosure is directed toward membrane biofilm reactors primarily comprising microorganisms that produce chemical fuel products or precursors thereof. Reactors of the present disclosure can primarily comprise acetogens, a methanotrophs, and/or Methanosarcina acetivorans.

Abstract: The present invention is directed to a polymerase activity assay that produces a strong optical signal when a primer-template complex is extended to full-length product. The assay uses Cy3 as the molecular beacon and Iowa Black® RQ as the quencher. The signal-to-noise-ratio (STNR) of this donor-quencher pairing is ˜200-fold over background, which is considerably better than other donor-quencher pairs (STNRs ˜10-20-fold). The STNR allows for solution-based monitoring of polymerase activity. Because the sensor functions via Watson-Crick base pairing, the polymerase activity assay may also be used to evolve polymerases to accept xeno nucleic acids as substrates.

Abstract: Fluorescent pH sensors are provided. The fluorescent pH sensor comprises a copolymer for sensing pH and a polymerized form of N-(2-hydroxypropyl)methacrylamide (HPMA) or 2-hydroxyethyl methacrylate (HEMA). The probe for sensing pH has formula (I): wherein R1 and R2 are as defined herein. The fluorescent pH sensors may be used in determining the pH of a sample and detecting extracellular pH in a sample. Methods for preparing the fluorescent pH sensors and the probe for sensing pH are also provided.

Abstract: A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The method can be used in a number of ways including: production of large quantities of properly folded, post-translationally modified proteins using mammalian cell machinery a in-cell fluorescence spectroscopy and imaging using small molecule fluorophores and a in-cell NMR spectroscopy using living mammalian cells. The method permits cell biology at atomic resolution that is physiologically and pathological relevant and permits protein therapy to treat human diseases. The method can also be used to deliver exogenous protein inside mammalian cells, wherein the exogenous proteins follow a similar secretion pathway as that of the endogenous protein.

Abstract: The present application relates generally to bio-adhesive components isolated from bio-oil prepared from animal waste, methods of preparation of the bio-adhesive components and uses thereof. Such uses include, but are not limited to, asphalt bio-binders, bio-adhesion promoters, asphalt bio-rejuvenators, asphalt bio-extenders, bio-asphalt as well as uses in roofing, soil stabilization, crack and joint sealing and flooring adhesives.

Abstract: The present invention generally provides methods to generate plants with high frequency of spontaneous haploid genome doubling for use in doubled haploid production. The invention relates to the BUBR1 nucleic acid and protein sequences identified, which are associated with spontaneous haploid genome doubling.

Abstract: Insect control compositions and methods of their use in control of Drosophila suzukii damage to commercial fruit and berry crops are provided.