Abstract: Disclosed are cathodes comprising a conductive support substrate having an electrocatalyst coating containing nickel phosphide nanoparticles. The conductive support substrate is capable of incorporating a material to be reduced, such as CO2 or CO. A co-catalyst, either incorporated into the electrolyte solution, or adsorbed to, deposited on, or incorporated into the bulk cathode material, provides increased selectivity and activity of the nickel phosphide electrocatalyst. Also disclosed are electrochemical methods for selectively generating hydrocarbon and/or carbohydrate products from CO2 or CO using water as a source of hydrogen.

Abstract: A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.

Abstract: An injectable formulation for a sustained-release of a local anesthetic is provided. The formulation comprises a pharmaceutically effective amount of a local anesthetic encapsulated into polymeric particles having a diameter from about 1 ?m to about 4 ?m. Such formulation prolongs analgesic effect, decreases toxicity, and allows loading larger doses, and at the same time is injectable directly at a patient's body site of the interest without generating a surgical wound. Methods of use and preparation are also provided.

Abstract: One or more techniques and/or systems are disclosed for a harvester vehicle that includes a crop processing system comprising at least an accumulator and a round module builder. The harvester vehicle has a feedback fusion system that operably provides crop processing data indicative of an estimated accumulator fill level to a crop feed rate control system. The feedback fusion system has a plurality of feedback devices that operably provide feedback signals including data indicative of two or more of: crop mass flow, module builder status, module size, and accumulator fill level. The feedback fusion system has a control module that operably receives the feedback signals and generates an accumulator fill level signal based at least upon two or more of the feedback signals. The accumulator fill level signal is indicative of the estimated fill level in the accumulator.

Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

Abstract: The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4?, O-6?, or O-4? and O-6? positions having reduced antimicrobial activity for targeting Connexin Hemichannels.

Abstract: Methods, computer program products, and systems can include, for example: receiving a plurality of signal instances of a signal emitted by a transmitter, wherein respective signal instances of the plurality of signal instances are collected at different positions. There is also set forth herein receiving by a movable receiver moving within a first location a plurality of signal instances of a signal emitted by a transmitter, wherein signal instances defining the plurality of signal instances are collected by the moveable receiver at different respective receiver positions within the first location. There is also set forth herein discovering a direction of arrival parameter value that specifies a direction of arrival of the signal emitted by the transmitter, wherein the discovering includes using a set of signal instances from the plurality of signal instances.

Abstract: Methods, systems, and storage media are described for motion estimation in video frame interpolation. Disclosed embodiments use feature pyramids as image representations for motion estimation and seamlessly integrates them into a deep neural network for frame interpolation. A feature pyramid is extracted for each of two input frames. These feature pyramids are wrapped together with the input frames to the target temporal position according to the inter-frame motion estimated via optical flow. A frame synthesis network is used to predict interpolation results from the pre-warped feature pyramids and input frames. The feature pyramid extractor and the frame synthesis network are jointly trained for the task of frame interpolation. An extensive quantitative and qualitative evaluation demonstrates that the described embodiments utilizing feature pyramids enables robust, high-quality video frame interpolation. Other embodiments may be described and/or claimed.

Abstract: An induction machine with localized voltage unbalance compensation is disclosed. The use of an induction machine with a voltage unbalance correction compensator (VUC) may be used to maintain proper working conditions of the machine during intervals of voltage unbalance.

Abstract: A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel.

Abstract: In various example embodiments, a system and method for tracking objects in a three-dimensional space is disclosed. One method includes receiving detections representing targets, increasing a classification of a track in response to a detection matching the track, decreasing a classification of a track in response to no detections matching the track, and processing detections according to a classification level of the track.

Abstract: A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.

Abstract: Two rhodamine reversible fluorescent sensor derivatives, L1 and L2, bearing 2-methoxy-1-naphthaldehyde and 5-bromo-3-methoxy salicylaldehyde units were synthesized using microwave-assisted organic synthesis and used for selective and sensitive reversible sequential fluorescence detection of aluminum ion (Al3+) and azide (N3?) in aqueous acetonitrile solution via the fluorescence spectral changes. Stoichiometry and binding mechanisms for both sensors are well characterized and established by the respective spectroscopic techniques. L1 and L2 sensors are useful for the analysis of Al3+ and N3? in environmental samples and biological studies.

Abstract: Methods for the production of carbon-based and other nanostructures are provided.

Abstract: A system and method for determining position of a steerable assembly within tissue of an animal body utilizes an elongated body structure with an implement arranged at a distal end thereof, and a premagnetized material proximate to the distal end. A signal indicative of a length of insertion of the elongated body structure into the tissue is used with a signal indicative of (i) force, strain, shape of a sensor associated with the elongated body structure and/or (ii) directionality of magnetic field applied to the premagnetized material, to determine a three-dimensional (3D) trajectory of the steerable assembly. The 3D trajectory is superimposed on a 3D model of the tissue to determine position of the steerable assembly within the tissue.

Abstract: A fault-tolerant computer system includes a plurality of redundant processor cores configured to simultaneously execute identical sets of processor-executable instructions, and a coprocessor component including a data storage component and a configurable logic region, where the plurality of processor cores are configured with processor-executable instructions to perform operations including configuring the configurable logic region of the coprocessor component with a first coprocessing module, and controlling the first coprocessing module to perform first processing operations on data located in the data storage component. In various embodiments, the redundant processor cores and the coprocessor component may be implemented on an FPGA, and the redundant processor cores may be configured to swap out different coprocessing modules using Partial Reconfiguration (PR) to perform data processing algorithms using hardware acceleration.

Abstract: Provided herein are methods of detecting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) and/or other plasmonic metal nanoparticles (MNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first and second epitopes of SARS-CoV-2 proteins, such as receptor-binding domain (RBDs) under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first and second epitopes of the SARS-CoV-2 proteins in the sample to produce bound SARS-CoV-2 proteins. The methods also include detecting the SARS-CoV-2 proteins when aggregations of the bound SARS-CoV-2 proteins form with one another. Related compositions, reaction mixtures, devices, kits, and systems are also provided.

Abstract: A walking rover system with a rover, a base station, and a tether extending between the rover and the base station. The rover has a rover body, a plurality of mobilizing legs, and a plurality of stabilizing legs. The stabilizing legs have one degree of freedom and the mobilizing legs have three degrees of freedom. The mobilizing legs and the stabilizing legs may alternate around the rover body such that each of the mobilizing legs is separated from adjacent mobilizing legs by a stabilizing leg and each of the stabilizing legs is separated from adjacent stabilizing legs by a mobilizing leg. The tether is configured to transmit electricity from the base station to the rover, transmit data gathered by the rover back to the base station, and support a weight of the rover and act as a mechanical rappel line between the base station and the rover.

Abstract: Systems and methods for utilizing laboratory equipment in a hybrid reality environment or augmented virtual reality environment, are contemplated herein and include: at least one piece of laboratory equipment having at least one feature, wherein the at least one piece of laboratory equipment is tracked; a tracking module for tracking a position and an orientation of the at least one piece of tracked laboratory equipment; a virtual model, stored in a memory, comprising at least one 3-D virtual representation of the at least one feature of the at least one piece of laboratory equipment; and an experimentation module.

Abstract: A pressure sensor apparatus is provided. In another aspect, a wireless intraocular pressure sensor includes a deformable or stretchable inductor having a three-dimensionally serpentine or wavy shape. A further aspect of an intraocular pressure sensing system includes a closed loop, deformable and variable inductor of an undulating shape in lateral and depth directions, within a ring-shaped and polymeric carrier layer, sized to contact an eye. A method of making a wireless intraocular pressure sensor, including a three-dimensionally deformable metal layer, is also provided.