Abstract: A device and method for early detection of eye disease including a corneal topography device including a camera, such as a rotating Scheimpflug camera, configured to measure the elevation of a patient's two anterior corneas sequentially or simultaneously; a computer processor; and non-transitory computer readable media including computer readable instructions, which, when executed by the computer processor, causes the device to measure and store elevation data at a plurality of points on the patient's anterior corneal surfaces; organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame, rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, subtract data on each corresponding corneal point, and generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography.

Abstract: Provided are methods for transferring graphene from graphene-on-metal foil onto a substrate. The method does not require chemical etching to remove the metal foil and provides more a uniform graphene with improved electronic properties. The present invention also provides compositions comprising graphene, a binder, and a substrate.

Abstract: Amide lipid conjugates of benzyl isothiocyanates are disclosed. The benzyl isothiocyanate is conjugated to a fatty acid, such as a C12-C26 fatty acid. The disclosed amide lipid conjugates have a structure according to Formula I, where one of R1A and R1B is alkoxy or hydroxy, and the other of R1A and R1B is —H; and R2 is C12-C26 aliphatic. Sunscreen formulations include a compound according to Formula I and one or more excipients. The sunscreen formulation may further include one or more additional sunscreen active agents.

Abstract: A time-based prediction model that models surface roughness of an additively manufactured (AM) component as a single equivalent notch with a crack at the notch root in which the notch reflects the stress concentration due to an entire spectrum of surface roughness of the AM component is disclosed herein.

Abstract: Examples of a simulation framework are provided to evaluate time varying systems using a piecewise linear time invariant simulation (PLIS) approach. The simulation framework can be configured for an artificial pancreas wireless network system that controls blood glucose in Type 1 Diabetes patients with time varying properties such as physiological changes associated with psychological stress and meal patterns.

Abstract: A microbial platform for rare earth element bioaccumulation comprises a bacterial culture, a medium comprising methanol, inorganic phosphate, and a swarf pulp, wherein the platform is selective for bioaccumulation of a rare earth element.

Abstract: A method of treating reperfusion injury in a tissue of a subject in need thereof. The method includes applying light, to the tissue, that inhibits electron transfer from cytochrome c to cytochrome c oxidase (CcO) to molecular oxygen to attenuate creation of reactive oxygen species. The light includes wavelengths in a first wavelength range of 730-770 nm and a second wavelength range of 930-970 nm.

Abstract: Seminaphthofluorophore-selenium probes are disclosed. The probes include a seminaphthofluorophore scaffold substituted with at least one diselenide moiety having a formula —Y—C(Q)O—(CH2)m—Se—Se—(CH2)n—ORf, where Rf is hydrogen or C1-C3 alkyl, Q is O or S, Y is O or N(Rg) where Rg is H or alkyl, and m and n independently are integers. The probes may be used to detect presence of a thioredoxin reductase.

Abstract: A coil configuration and method for transcranial magnetic stimulation enabling stimulation of deep regions of the brain without excessively stimulating the cortex is provided. The coil configuration utilizes at least one coil to produce an off-plane magnetic field to enhance the magnetic field from a top TMS coil. In one configuration at least a single variable position coil referred to as the Variable Halo Coil and positionable vertically and/or angularly is used.

Abstract: Aspects of the present disclosure generally relate to short-wave infrared (SWIR) materials, SWIR detectors, and methods of use. In an aspect, a SWIR detector is provided and includes a conductive layer disposed over a first portion of a substrate, the conductive layer having a trench therein, and a hole transport layer disposed over at least a second portion of the substrate and within the trench of the conductive layer. The SWIR detector further includes a light conversion layer disposed over at least a portion of the hole transport layer, the light conversion layer comprising a composition having the formula AaBbMcXd, wherein: A is an organic group or ion thereof; B is an organic group, an inorganic group, or ion thereof; M is a metal or ion thereof; X is a halogen or ion thereof; and a, b, c, and d are numbers expressing amounts of A, B, M, and X.

Abstract: The present invention relates to microbial cells, including but not limited to aerobic bacteria cells and anaerobic bacteria cells, as well as yeast cells, and methods for producing the cells, feed additives and compositions comprising the cells, and uses involving administration of the cells to animals.

Abstract: Various embodiments relate to forming particles using undercooled metal particles in response to focused low power laser light. Particle growth can be initiated by utilizing the metastable and liquid nature of the particles, allowing for surface instability promoted by the laser light to induce liquid flow to translate to a neighboring particle. This event can cascade radially leading to accumulation of the liquid metal at the epicenter. The grown solidified particle size can be varied by using different power, exposure time, or working distance. Once the liquid has accumulated into a single region, it eventually solidifies either through homogeneous or heterogeneous nucleation to give a solid particle of larger size than the original. Such a method can be used to print patterns on a surface in four dimensions, where the fourth dimension (4D) is attained through gradient in size of the particles made. Additional systems and methods are disclosed.

Abstract: Methods according to aspects of the disclosure, compositions and kits therefore, include at least one, two, or three sets of amplification primers and hydrolysis probes with at least two separate corresponding readouts per set. According to aspects of the present disclosure, the at least two hydrolysis probes and associated pair of primers of each set are directed to opposite strands of an amplification product of the set. According to aspects of the present disclosure, one of the two hydrolysis probes in each set is directed to a first strand of the amplification product and therefore has a sequence complementary to the first strand of the amplification product and the second of the two hydrolysis probes in the set is directed to the second strand of the amplification product and therefore has a sequence complementary to the second strand of the amplification product.

Abstract: An apparatus, including a scanning probe microscope base that includes a configured to be secured to an end of an insert in a cryostat; a top configured to be connected to a base of a scanning probe microscope head that is configured to be disposed inside the insert; and a damping system disposed between the frame and the top and comprising a bellows that seals the end of the insert. This sealing separates an ultra-high vacuum (UHV) environment in the insert from a high vacuum (HV) environment surrounding the end of the insert and also positions an upper surface of the top in the UHV environment.

Abstract: In some embodiments, the present disclosure pertains to methods and systems for optimizing a property of a plant. In some embodiments, the methods of the present disclosure include: (1) receiving one or more growth-related parameters of the plant; (2) receiving one or more phenotype-related parameters of the plant; (3) receiving one or more qualitative parameters of the plant; (4) utilizing a computing unit to evaluate said one or more growth-related parameters, phenotype-related parameters and qualitative parameters of the plant; and (5) utilizing the computing unit to adjust the one or more of the growth-related parameters of the plant based on the evaluation. In some embodiments, the aforementioned steps are repeated a plurality of times. In some embodiments, the parameters are stored in a database and utilized by a machine-learning algorithm to optimize the evaluation of the parameters and adjustment of the growth-related parameters.

Abstract: The disclosure provides methods of making gene-edited plants that are resistant to downy mildew, such as plants with reduced expression of homoserine kinase (HSK), 2-oxoglutarate-Fe(II) oxygenase (2OGO), or both. The disclosure further provides methods of making gene-edited modified plants that are cold tolerant, such as plants with reduced expression of MYB14. In some examples, CRISPR/Cas methods are used, wherein the plants include a mutated HSK, 2OGO, and/or MYB14 gene resulting in reduced expression and/or gene activity. Plants generated using the methods are provided. Such plants can include other desirable traits. HSK, 2OGO, and/or MYB14 nucleic acid and protein molecules are provided, as are gRNAs specific for HSK, 2OGO, or MYB14 and vectors containing such.

Abstract: The invention relates in part to a growth model for the growth of Group III-Group V (III-V) alloys by molecular beam epitaxy (MBE) based on the kinetics of adsorption, desorption, incorporation, anion exchange, anion-assisted removal, and surface droplet accumulation of the Group V elements. The invention also relates to methods to optimize MBE growth conditions used to produce a target III-V alloy composition. The invention is further related to methods of predicting III-V alloy compositions resulting from a set of MBE growth conditions.

Abstract: Semiconducting devices, and more specifically back end of line (BEOL) portions for semiconducting devices that may include dielectric materials incorporating deuterium are disclosed. The semiconducting devices may include a back end of line (BEOL) portion electrically coupled to a front end of line (FEOL) portion. The BEOL portion may include at least one BEOL level having a dielectric layer. The dielectric layer may include at least one section formed from a low-k material including deuterium (D). The BEOL level(s) may also include an etch stop layer disposed over the dielectric layer, and at least one conductive structure disposed within the dielectric layer. The at least one conductive structure may extend through the dielectric layer and the etch stop layer, respectively.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: The present invention provides a compound having the structure: and methods of using the compound in targeted PET and SPECT imaging.