Abstract: A biologically-inspired model for sequence representation, method of construction and application of such models, and systems incorporating same are provided. The model captures the statistical nature of sequences and uses that for sequence encoding, recognition, and recall. The model can be trained in real time, has few tunable parameters, and is highly parallelizable, which ensures that it can scale up to very large problems. Applications of the model to word and speech recognition, machine leaning, robotics, computational bioinformatics, genetics datasets, and other sequence processing pipelines are provided.

Abstract: An apparatus including a heating element and a sublimation vessel disposed adjacent the heating element such that the heating element heats a portion thereof. A collection vessel is removably disposed within the sublimation vessel and is open on an end thereof. A crucible is configured to sealingly position a solid mixture against the collection vessel.

Abstract: The wear status of a micro-endmill tool may be inferred by monitoring the chip production rate of the tool in operation. Chips may be extracted from a work area, captured on an adhesive surface, imaged, and counted to determine the chip production rate. When the rate of chip production falls, the feed rate of the micro-endmill may be modified to a level suitable for the current state of tool wear. In this manner, costly and inconvenient work stoppages to evaluate the wear status of a tool are eliminated.

Abstract: Multimodal data mining in a multimedia database is addressed as a structured prediction problem, wherein mapping from input to the structured and interdependent output variables is learned.

Abstract: A neural prosthetic device can selectively deliver light to different cortical layers, at different depths, in the brain. The device includes LEDs and corresponding waveguides that can extend into the brain. At least two of the waveguides have different lengths. The neural prosthetic device or other devices can be manufactured by changing the hydrophilicity or lyophilicity of a portion of a substrate layer, then depositing uncured polymer on the treated portion of the substrate layer. The uncured polymer flows under the influence of surface tension to form a volume. The volume is shaped as a dome that extends laterally to a boundary between the treated and untreated portions. The polymer is cured in discrete regions through the substrate layer. The discrete regions extend longitudinally from the substrate layer to a curved surface of the dome. The uncured portion of the polymer is removed. The cured regions form the waveguides.

Abstract: The present invention relates to compositions and methods for providing RNA interference (RNAi) vectors comprising trigalactosyldiacylglycerol (tgd) biosynthesis enzyme constructs for increasing oil content of plants. Further, the use of tgd RNAi silencing vectors in combination with co-expression of heterologous oil regulating transcription factors, such as WRINKLED1, are contemplated to overcome the reduced growth and variable levels of embryonic lethality in plants with reduced TGD protein. Additionally, plants having reduced APS1, a gene encoding a major catalytic isoform of the small subunit of AGPase (AGP(?) plants), co-expressing a heterologous oil modulating transcription factor are contemplated for use in combination with plants having reduced TGD. Oil harvested from vegetative tissues of plants comprising vectors and genes of the present invention is contemplated for use in biofuel and biodiesel products.

Abstract: Innovations in the construction and use of variable-input-length tweakable ciphers (“VILTCs”). In some cases, a VILTC uses an initialization vector that is protected from exposure outside an encryption/decryption system in order to provide enhanced security with efficient performance. For example, a system for encryption and/or decryption includes two fixed-input-length tweakable block ciphers (“FIL TBCs”) and a VILTC. The first FIL TBC is adapted to produce a fixed-length initialization vector. The VILTC is adapted to produce a variable-length output string using the fixed-length initialization vector as a tweak. The second FIL TBC is adapted to produce a fixed-length output string. In this way, the first FIL TBC and the second FIL TBC protect the fixed-length initialization vector from exposure outside the system. In other cases, a VILTC is used for a reliable and efficient implementation of authenticated encryption/decryption with associated data.

Abstract: The embodiments herein generally relates to compounds and methods for releasing H2S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H2S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H2S.

Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.

Abstract: A method includes obtaining information associated with a forming operation involving a manufacturing machine having a tool that contacts material and simulating deformation of the material based on the information. Simulating the deformation of the material includes evaluating combinations of shear planes within an initial structure of the material. Simulating the deformation of the material also includes predicting a mode of deformation comprising one or more of the shear planes along which the initial structure of the material will likely deform. Simulating the deformation of the material further includes calculating a deformed shape of the material after an increment of deformation along the predicted mode of deformation.

Abstract: A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hybridization probes, each singly labeled with the same fluorescent label and each containing a nucleic acid sequence that is complementary to a different probe binding region of said target sequence; washing said fixed cell to remove unbound probes; and detecting fluorescence from said probes.

Abstract: The present invention relates to systems, devices, collections, techniques, and methods for diagnosing autism spectrum disorder (ASD) in a subject in addition to methods of treatment. In particular, the present disclosure relates to systems, devices, collections, techniques, and methods that utilize direct sequencing of micro ribonucleic acid (miRNA) or the use of miRNA probes having ribonucleotide sequences that may undergo nucleic acid hybridization with complementary nucleic acids present in a biological sample from the subject. Hybridization of the miRNA probes may be detected in the sample to determine if the subject has an ASD. Upon detection of an ASD using the methods discussed herein, therapy guidance may be effectuated to the subject.

Abstract: The present disclosure provides co-cultures of a population of hepatocytes, at least one non-parenchymal cell population, and a population of hepatic stellate cells in vitro, methods of preparing the co-cultures, and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The hepatocytes co-culture system provides an in vitro model in which both cell viability and phenotype are maintained for extended periods relative to conventional monoculture.

Abstract: Systems and methods are provided for detecting instability in power hardware-in-the-loop simulations for protection of the equipment being tested. The technology includes computing the magnitude of the time-derivative of reference quantities supplied to a power amplifier and applying a moving average filter. The result from the filter is compared to a threshold for detection of an instability resulting in oscillations of the reference quantities. Once oscillations are detected mitigating steps are taken to protect the device under test.

Abstract: The present disclosure is directed to adeno-associated viral vector monoclonal antibody constructs and compositions thereof, methods of improving locomotor function after spinal cord injury, methods of treating neurodegenerative diseases.

Abstract: Herein provided are a model and method for a transgenic a bovidae having an TGF-?1 gene inserted into the bovidae genome and capable of expressing higher than normal levels of TGF-?1 in cardiac muscle.

Abstract: The present invention relates to a method of detecting inorganic gunshot residue (GSR) particles. The method includes providing a sample comprising gunshot residue, subjecting the sample to spectroscopic analysis to produce a spectroscopic signature for the sample, and identifying inorganic gunshot residue particles based on the spectroscopic signature for the sample. Also disclosed is a method of detecting gunshot residue particles. The method includes providing a sample comprising gunshot residue, subjecting the sample to spectroscopic analysis to produce a spectroscopic signature for the sample, where the spectroscopic signature spans a range of wavenumbers, creating one or more spectroscopic maps from the spectroscopic signature for the sample, where each different spectroscopic map is for a different wavenumber, and identifying gunshot residue particles based on the one or more spectroscopic maps for the sample.

Abstract: Provided is an apparatus and method for operation of the apparatus that includes an onboard fuel reformer comprising a catalytic material, a shell containing the catalytic material enclosing an air/fuel mixture in a leak-free environment, an inlet to the shell for feeding the air and fuel, and an outlet to the shell for discharge of the reformate mixture at the completion of an air-fuel reaction, wherein a reactivity separation is provided for RCCI combustion between the reformate and the parent fuel, thereby enabling single-fuel RCCI.

Abstract: In an example, a method to form a low work function insert includes preparing a mixture that includes a first powder that contains barium, a second powder that contains calcium, a third powder that contains at least one of aluminum, samarium, or magnesium, and a fourth powder that contains a refractory metal. The method may also include heating the mixture, contained in a crucible, in a furnace. Oxygen concentration in the furnace may be maintained at a low partial pressure during heating of the mixture in the furnace. The low work function of the insert allows electrons to be readily extracted from its surface.

Abstract: Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.