Abstract: A metal matrix has a biocompatible solid lubricant in at least a portion of its surface and the solid lubricant functions to protect the interior of the metal matrix and minimize the friction coefficient and related wear induced damage at the articulating surface of the metal device. The lubricated biocompatible metal device is made of materials compatible for in vivo and ex vivo applications in order to minimize wear induced degradation as well as metal ion release. The lubricated biocompatible metal device is suited for use as medical implants.
Abstract: A multi-hop ad hoc communications network may allow optical communications between underwater nodes. Each node may be fitted with environmental sensors. Each node may collect data from the sensors and transmit the data to other nodes in the network according to a time division multiple access (TDMA) scheme. The data may propagate through a series of child and parent nodes to reach a master node. The master node may have a wired connection for power and data transfer.
Type:
Grant
Filed:
June 13, 2014
Date of Patent:
June 5, 2018
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Cody Youngbull, David Ganger, Andres Mora, Andrea Richa, Jin Zhang, Chenyang Zhou, Xinhui Hu
Abstract: The present invention includes a method of controlling a fluid flow using momentum and/or vorticity injections. Actively controlling an actuator allows for direct, precise, and independent control of the momentum and swirl entering into the fluid system. The perturbations are added to the flow field in a systematic mater providing tunable control input, thereby modifying behavior thereof in a predictable manner to improve the flow characteristics.
Type:
Grant
Filed:
August 29, 2016
Date of Patent:
June 5, 2018
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: A method for preparing a device having a film on a substrate is disclosed. In the method, a film is deposited on a polymeric substrate. The film includes at least one metal. A metal in the film is converted to a metal oxide using microwave radiation. One example device prepared by the method includes a polyethylene napthalate substrate and a film on the substrate, wherein the film includes a semiconducting copper oxide and silver as a dopant.
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
June 5, 2018
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Abstract: This invention relates to bio-renewable fertilizer compositions and methods of making and using the bio-renewable fertilizer compositions. In particular, the fertilizer compositions include biodegradable nutrient carriers, which have naturally derived, bio-renewable nitrogen content. The fertilizer compositions also contain biodegradable stabilizer.
Type:
Grant
Filed:
October 12, 2015
Date of Patent:
June 5, 2018
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
James Schrader, William Graves, Jr., David Grewell
Abstract: Methods for attenuating or treating, or reducing the mortality of sepsis or septic shock using an ectonucleotidase such as CD39 or CD73 are provided.
Type:
Grant
Filed:
August 9, 2013
Date of Patent:
June 5, 2018
Assignee:
Rutgers, The State University of New Jersey
Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.
Type:
Grant
Filed:
July 23, 2014
Date of Patent:
June 5, 2018
Assignee:
Board of Supervisor of Louisiana State University and Agricultural and Mechanical College
Abstract: Embodiments of the disclosure pertain to compositions containing (i) one or more non-antifreeze proteins or cell components or cells and (ii) one or more antifreeze proteins (AFPs), mimetics thereof, and/or analogs thereof, and a method of stabilizing a biologic (e.g., a protein, microbe, cell component or cell) against temperature stress and aggregation. The AFP may be selected from known antifreeze polypeptides and antifreeze peptides, analogs and mimetics of antifreeze proteins, active fragments of such antifreeze proteins, polypeptide and peptide mimetics, antifreeze peptoids and polymers, and combinations thereof. The non-antifreeze protein, cell component or cell comprises a known protein, cell component or cell used in the pharmaceutical, medical, agricultural, veterinary and/or food industry(ies). The AFP protects the function of the non-antifreeze protein, microbe(s), cell component(s) or cell(s) under temperature stress (e.g., a temperature of ?20-60° C.).
Type:
Application
Filed:
November 22, 2017
Publication date:
May 31, 2018
Applicant:
The Board of Trustees of the California State University
Abstract: A biologically-inspired model for sequence representation, method of construction and application of such models, and systems incorporating same are provided. The model captures the statistical nature of sequences and uses that for sequence encoding, recognition, and recall. The model can be trained in real time, has few tunable parameters, and is highly parallelizable, which ensures that it can scale up to very large problems. Applications of the model to word and speech recognition, machine leaning, robotics, computational bioinformatics, genetics datasets, and other sequence processing pipelines are provided.
Type:
Application
Filed:
January 9, 2015
Publication date:
May 31, 2018
Applicant:
Iowa State University Research Foundation, Inc.
Abstract: The present disclosure is directed to carbon nanomaterials and methods for delivering a drug to a mammal's cell including administering the carbon nanomaterial to the mammal. The present disclosure is also directed to carbon nanomaterials and methods for delivering a nucleic acid to a mammal's cell including administering the carbon nanomaterial to the mammal.
Type:
Application
Filed:
May 26, 2016
Publication date:
May 31, 2018
Applicant:
The Research Foundation for The State University of New York
Abstract: The present disclosure covers apparatuses and associated methods for embedding a wireless power transfer coil in concrete. In embodiments, a wireless power inductor pad embedded in concrete includes a wireless power inductor pad comprising a first and second layer of continuously strung stranded wire, each layer arranged in a circular pattern. The first layer is positioned above the second layer such that the stranded wire of the first layer is offset vertically from the stranded wire of the second layer by a vertical wire-to-wire distance. Additionally, the first layer is offset horizontally from the second layer such that the stranded wire of the first layer is offset horizontally from the stranded wire of the second layer by a horizontal wire-to-wire distance; the horizontal wire-to-wire distance being zero inches. Finally, concrete permeates between the first and second layers and between the stranded wires of each layer.
Type:
Application
Filed:
September 27, 2017
Publication date:
May 31, 2018
Applicant:
Utah State University
Inventors:
Ryan J. Bohm, Trevor G. Gardner, Marvin Halling, Baljit S. Riar, Regan Zane
Abstract: The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
Type:
Application
Filed:
January 19, 2018
Publication date:
May 31, 2018
Applicants:
Virginia Tech Intellectual Properties, Inc., Iowa State University Research Foundation, Inc.
Inventors:
Xiang-Jin Meng, Martijn Fenaux, Patrick G. Halbur
Abstract: Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments of the present disclosure may be incorporated into or operatively-linked with affinity molecules for attachment to silicon oxide surfaces to, for example, measure interactions between an affinity molecule and its targeting biomolecules.
Type:
Grant
Filed:
October 28, 2014
Date of Patent:
May 29, 2018
Assignee:
Arizona Board of Regents On Behalf of Arizona State University
Inventors:
Peiming Zhang, Subhadip Senapati, Saikat Manna
Abstract: Relational clustering has attracted more and more attention due to its phenomenal impact in various important applications which involve multi-type interrelated data objects, such as Web mining, search marketing, bioinformatics, citation analysis, and epidemiology. A probabilistic model is presented for relational clustering, which also provides a principal framework to unify various important clustering tasks including traditional attributes-based clustering, semi-supervised clustering, co-clustering and graph clustering. The model seeks to identify cluster structures for each type of data objects and interaction patterns between different types of objects. Under this model, parametric hard and soft relational clustering algorithms are provided under a large number of exponential family distributions.
Type:
Grant
Filed:
June 17, 2016
Date of Patent:
May 29, 2018
Assignee:
The Research Foundation for the State University of New York
Abstract: A concentric ring gas atomization nozzle with isolated gas supply manifolds is provided for manipulating the close-coupled atomization gas structure to improve the yield of atomized powders.
Type:
Grant
Filed:
September 24, 2014
Date of Patent:
May 29, 2018
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Joel R. Rieken, Andrew J. Heidloff, Iver E. Anderson
Abstract: Methods and compositions for treating or preventing inflammatory disorders are provided. The compositions of the invention comprise a recombinant bacterium genetically modified to decrease the display of lipoteichoic acid on the cell surface. Methods of the invention comprise administering to a subject a recombinant bacterium modified to decrease the display of lipoteichoic acid on the cell surface. Administration of the recombinant bacterium promotes a desired therapeutic response. The recombinant bacterium may be administered in a single dose or series of doses. Methods of the invention find use in treating or preventing a variety of inflammatory disorders including, for example, treating or preventing inflammatory bowel disease, colitis, or Crohn's disease.
Type:
Grant
Filed:
April 13, 2016
Date of Patent:
May 29, 2018
Assignees:
Northwestern University, North Carolina State University
Inventors:
Todd R. Klaenhammer, Erika Pfeiler, Mansour Mohamadzadeh
Abstract: A system and method for producing a near-infrared sensitive luminescent materials beyond 1000 nm is disclosed. The method includes reacting K2[PtCl4] and cyanoxime ligands in an aqueous solution to achieve dark-green one-dimensional coordination-polymeric materials having a molecular formula of PtL2, wherein L are the cyanoxime ligands having a molecular formula of NC—C(?NOH)—R with R being an electron withdrawing group such as: N?N-diethylacetamide, N-piperidine, N-morpholyl, 2-pyridine, benzoyl, or N-pyrrolidine.
Abstract: Disclosed are methods, systems, and apparatuses for rapidly detecting a cellular interaction, such as ligand:receptor interactions. For example, the disclosed methods and systems can be used to detect a cellular interaction within 15 minutes to 75 minutes. This allows cells to be used as biosensors to detect cell activating agents in a sample.
Type:
Grant
Filed:
December 4, 2014
Date of Patent:
May 29, 2018
Assignee:
Georgia State University Research Foundation, Inc.
Inventors:
Jitto Titus, Chadi Filfili, A. G. Unil Perera, Julia K. Hilliard