Abstract: The present disclosure provides synthetic repressor constructs and the proteins encoded therein, as well as synthetic repressible promoter constructs for use in combination with the synthetic repressor constructs/synthetic repressors disclosed herein. Various combinations of synthetic repressor constructs and synthetic repressible promoter constructs are also provided in synthetic genetic circuits for modifying expression of a protein of interest in a plant cell.
Type:
Application
Filed:
October 18, 2017
Publication date:
April 19, 2018
Applicant:
Colorado State University Research Foundation
Inventors:
June I. Medford, Mauricio S. Antunes, Tessema K. Kassaw
Abstract: The high thermal conduction resistances of a lithium-ion battery (LIB) severely limit the effectiveness of a conventional external thermal management system (TMS). A method for a new thermal management system for lithium-ion batteries that utilizes a multi-functional electrolyte (MFE) to remove heat locally inside the cell by evaporating a volatile component of the MFE is disclosed. These new electrolyte mixtures comprise a high vapor pressure co-solvent. The characteristics of a previously unstudied high vapor pressure co-solvent HFE-7000 (65 kPa at 25° C.) in an MFE (1 M LiTFSI in 1:1 HFE-7000/EMC), and other possible MFE compositions that can be utilized in a custom electrolyte boiling facility, are disclosed.
Type:
Grant
Filed:
August 3, 2017
Date of Patent:
April 17, 2018
Assignee:
Colorado State University Research Foundation
Abstract: A system and method is provided for simultaneous ion current sensing and gas analysis. The system acquires an ion current signal and analyzes the composition of a corresponding gas sample.
Type:
Grant
Filed:
July 15, 2011
Date of Patent:
April 17, 2018
Assignee:
Wayne State University
Inventors:
Tamer H. Badawy, Fadi Estefanous, Naeim A. Henein
Abstract: Systems and methods for making ice utilize self-demolding ice molds. Responsive to freezing of water in the mold into ice, an ejection apparatus is compressed. Via a force arising from the compression, the ejection apparatus ejects the ice from the mold. Ice machines may utilize multiple molds, and water filling a first mold may be utilized to at least partially melt ice in a second mold to facilitate ejection of the ice from the second mold.
Type:
Grant
Filed:
August 4, 2015
Date of Patent:
April 17, 2018
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The invention relates to plants that contain higher proportions of mannans. Such plants express transcription factors that increase the expression of CSLA9, a mannan synthase.
Type:
Grant
Filed:
November 13, 2014
Date of Patent:
April 17, 2018
Assignee:
Board of Trustees of Michigan State University
Inventors:
Kyung-Hwan Han, Won-Chan Kim, Ida-Barbara Reca, Kenneth Keegstra
Abstract: Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting.
Type:
Grant
Filed:
June 9, 2014
Date of Patent:
April 17, 2018
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Joseph Blattman, Hao Yan, Louis Schoettle, Xixi Wei
Abstract: The present invention provides compositions and methods of altering/improving Durum wheat phenotypes. Furthermore, methods of breeding Durum wheat and/or other closely related species to produce plants having altered or improved phenotypes are provided.
Abstract: The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.
Abstract: Loss tangents in microwave dielectric materials may be modified (increased and/or reduced), particularly at cryogenic temperatures, via application of external magnetic fields. Exemplary electrical devices, such as resonators, filters, amplifiers, mixers, and photonic detectors, configured with dielectric components having applied magnetic fields may achieve improvements in quality factor and/or modifications in loss tangent exceeding two orders of magnitude.
Type:
Grant
Filed:
August 20, 2014
Date of Patent:
April 17, 2018
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.
Type:
Grant
Filed:
December 16, 2013
Date of Patent:
April 17, 2018
Assignee:
The Research Foundation of State University of New York
Abstract: An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
April 17, 2018
Assignee:
The Research Foundation for The State University of New York
Inventors:
Thomas E. Amidon, Raymond Francis, Gary M. Scott, Jeremy Bartholomew, Bandaru V. Ramarao, Christopher D. Wood
Abstract: A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
Type:
Grant
Filed:
January 28, 2015
Date of Patent:
April 17, 2018
Assignee:
Rutgers, The State University of New Jersey
Abstract: Construction and expression of synthetic pathways to produce (5) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.
Type:
Grant
Filed:
September 8, 2014
Date of Patent:
April 17, 2018
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Bo Wang, Weiwen Zhang, Deirdre Meldrum, David Nielsen
Abstract: Some embodiments include a method. The method can include: providing a carrier substrate; providing a bond promoting layer over the carrier substrate; and depositing a first device substrate over the carrier substrate and the bond promoting layer. The first device substrate can be configured to bond to the carrier substrate with a first device substrate-carrier substrate adhesion strength. Meanwhile, depositing the first device substrate can include: bonding the first device substrate to the bond promoting layer, the first device substrate bonding to the bond promoting layer with a first device substrate-bond promoting layer adhesion strength greater than the first device substrate-carrier substrate adhesion strength; and coupling the first device substrate to the carrier substrate. Other embodiments of related methods and devices are also disclosed.
Type:
Application
Filed:
December 4, 2017
Publication date:
April 12, 2018
Applicant:
Arizona Board of Regents, Acting for and on Behalf of Arizona State University
Inventors:
Emmett Howard, Nick Munizza, Paul Yee, Zachary Hartke
Abstract: For measuring an area of interest based on a sensor task, a method generates a sensor task comprising a sensor type and an area of interest. The method further routes the sensor task to a sensor of the sensor type and with a sensor motion track that includes the area of interest. The method measures the area of interest with the sensor based on the sensor task.
Type:
Application
Filed:
October 11, 2016
Publication date:
April 12, 2018
Applicants:
Utah State University, The Government of the United States of America, as represented by the Secretary of the Navy
Inventors:
Scott Allen Anderson, Troy R. Johnson, Jonathan Haws, Brad D. Petersen, Thomas J. Walls
Abstract: A sequential state element (SSE) is disclosed. In one embodiment, an SSE includes a differential sense flip flop (DSFF) and a completion detection circuit (CDC) operably associated with the DSFF. The DSFF is configured to generate a differential logical output. During a normal operational mode, the DSFF is synchronized by a clock signal to provide a differential logical output in a differential output state in accordance with a data input or in a precharge state based on the clock signal. The differential logical output is provided in a differential output state in accordance with a test input during a scan mode. The CDC is configured to generate a test enable input during the scan mode that indicates the scan mode once the differential logical output is in the differential output state. Accordingly, another SSE can be asynchronously triggered to operate in the scan mode without a separate scan clock.
Type:
Application
Filed:
May 23, 2016
Publication date:
April 12, 2018
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The present invention relates to a novel composition of HIV-1 Env proteins that contain structurally and immunologically distinct VI/V2 domains. Methods of isolating such proteins, and methods of using such proteins as immunogens, therapeutic agents, vaccines, and test compounds for use in identifying a HIV antiviral are also provided.
Type:
Grant
Filed:
September 6, 2013
Date of Patent:
April 10, 2018
Assignee:
Rutgers, The State University of New York
Abstract: Provided is a detector that includes a scintillator, a common electrode, a pixel electrode, and a plurality of insulating layers, with a plurality of nano-pillars formed in the plurality of insulating layers, a nano-scale well structure between adjacent nano-pillars, with a-Se separating the adjacent nano-pillars, and a method for operation thereof.
Type:
Grant
Filed:
May 23, 2017
Date of Patent:
April 10, 2018
Assignee:
The Research Foundation for The State University of New York
Inventors:
Amirhossein Goldan, Wei Zhao, John A. Rowlands
Abstract: A method performed by one or more processing devices includes conducting a plurality of tests of a manufacturing process. Each test is conducted at a different combination of at least a first process variable and a second process variable, and each test comprises locally heating a region of a structure, where the local heating results in formation of a thermal field in the structure, and assessing a temperature derivative of the thermal field. Based on results of the plurality of tests, a process map of the temperature derivative of the thermal field is generated, with the temperature derivative based on a function of the first process variable and the second process variable.
Type:
Grant
Filed:
August 16, 2013
Date of Patent:
April 10, 2018
Assignees:
Carnegie Mellon University, Wright State University
Inventors:
Jack Lee Beuth, Jr., Nathan W. Klingbeil, Joy Davis Gockel