Patents Assigned to State University
  • Patent number: 8975356
    Abstract: A polymer and a method of forming a polymer are provided. The polymer has the general structure (I): wherein M is a main group element, a transition metal element, or an organic moiety; X is a main group element selected from S, P, As, Se, Te, and Sb; R1 is a direct bond between M and the ethylene group depicted between M and X or a hydrocarbyl linking moiety having between 1 and about 9 carbon atoms; R2 is a hydrocarbyl moiety; R3 is an organic linking group; Y has a value of 0, 1, 2, 3, or 4; Z has a value of 0, 1, 2, 3, or 4; YY has a value of 0, 1 or 2; and Y, YY, and Z are such that the total number of moieties bonded to M is 3, 4, 5, or 6.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: March 10, 2015
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Albert Stiegman
  • Publication number: 20150065561
    Abstract: The present invention is based, in part, on our studies of molecular pathways that include the deubiquitinase CYLD. Accordingly, the present invention features, inter alia, nucleic acid constructs that express CYLD or a biologically active variant thereof (e.g., a variant including the catalytic domain), nucleic acids that inhibit the expression of a negative regulator of CYLD (e.g., PDE4B or LNK2), nucleic acids that modulate the expression of downstream CYLD targets (e.g., Akt, by inhibiting or promoting the expression of the downstream target), compositions including one or more of these types of constructs (e.g., pharmaceutical compositions), kits including one or more of the compositions described herein and instructions for use, screening methods to identify therapeutic agents {e.g., anti-inflammatory agents) that upregulate CYLD, downregulate a negative regulatory of CYLD, or modulate (e.g., inhibit) a downstream CYLD target (e.g.
    Type: Application
    Filed: April 9, 2013
    Publication date: March 5, 2015
    Applicant: Georgia State University Research Foundation, Inc.
    Inventor: Jian-Dong Li
  • Publication number: 20150065868
    Abstract: A computer-based method for diagnosing a region of interest within an anatomical structure having the steps of receiving a 3D volumetric representation of the anatomical structure, and identifying at least one volume of interest and volume of normal of the anatomical structure. A first feature set can be generated based on a density, a gradient and a curvature of the volume of interest, and the first feature set can be compared to a second feature set to diagnose the region of interest to at least one a plurality of pathology types.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 5, 2015
    Applicant: The Research Foundation for the State University New York
    Inventors: Jerome Zheng Liang, Hongbing Lu, Guopeng Zhang
  • Patent number: 8971572
    Abstract: Hand pointing has been an intuitive gesture for human interaction with computers. A hand pointing estimation system is provided, based on two regular cameras, which includes hand region detection, hand finger estimation, two views' feature detection, and 3D pointing direction estimation. The technique may employ a polar coordinate system to represent the hand region, and tests show a good result in terms of the robustness to hand orientation variation. To estimate the pointing direction, Active Appearance Models are employed to detect and track, e.g., 14 feature points along the hand contour from a top view and a side view. Combining two views of the hand features, the 3D pointing direction is estimated.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 3, 2015
    Assignee: The Research Foundation for The State University of New York
    Inventors: Lijun Yin, Shaun Canavan, Kaoning Hu
  • Patent number: 8969027
    Abstract: The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: March 3, 2015
    Assignee: Kansas State University Research Foundation
    Inventors: Stefan H. Bossmann, Deryl L. Troyer, Matthew T. Basel
  • Patent number: 8968515
    Abstract: A method of alkaline pretreatment of biomass, in particular, pretreating biomass with gaseous ammonia.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 3, 2015
    Assignee: Board of Trustees of Michigan State University
    Inventors: Venkatesh Balan, Bruce E. Dale, Shishir Chundawat, Leonardo Sousa
  • Patent number: 8968540
    Abstract: A device for reading the sequence of a polymer, consisting of a first electrode and a second electrode, each electrode being functionalized with a reader molecule strongly bonded to the electrodes, but forming weak bonds with a molecule to be sequenced. In particular, the reader molecule is designed to form bonds with at least two points on the target molecule such that the target molecule is trapped between a first reader molecule on one electrode and a second reader molecule on the second electrode, with the overall size of the molecular complex being small enough to permit significant electric current to flow.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: March 3, 2015
    Assignee: Arizona Board of Regents, a Body Corporate of the State of Arizona Acting for and on Behalf of Arizona State University
    Inventors: Kevin Reinhart, Stuart Lindsay, Peiming Zhang
  • Patent number: 8972254
    Abstract: Environmental recognition systems may improve recognition accuracy by leveraging local and nonlocal features in a recognition target. A local decoder may be used to analyze local features, and a nonlocal decoder may be used to analyze nonlocal features. Local and nonlocal estimates may then be exchanged to improve the accuracy of the local and nonlocal decoders. Additional iterations of analysis and exchange may be performed until a predetermined threshold is reached. In some embodiments, the system may comprise extrinsic information extractors to prevent positive feedback loops from causing the system to adhere to erroneous previous decisions.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: March 3, 2015
    Assignee: Utah State University
    Inventors: Jacob Gunther, Todd Moon
  • Patent number: 8973161
    Abstract: A control-based approach is provided for achieving accurate indentation quantification in broadband and in-liquid nanomechanical property measurements using atomic force microscope (AFM). Accurate indentation measurement is desirable for probe-based material property characterization because the force applied and the indentation generated are the fundamental physical variables that are measured in the characterization process. Large measurement errors, however, occur when the measurement frequency range becomes large (i.e., broadband), or the indentation is measured in liquid on soft materials. Such large measurement errors are generated due to the inability of the conventional method to account for the convolution of the instrument dynamics with the viscoelastic response of the soft sample when the measurement frequency becomes large, and the random-like thermal drift and the distributive hydrodynamic force effects when measuring the indentation in liquid.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: March 3, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Qingze Zou, Juan Ren
  • Patent number: 8966991
    Abstract: An apparatus for sensing strain or stress includes a body including magnetic shape-memory alloy (MSMA) material, having a first axis. A first drive coil and first sensor coil are wound around the body about the first axis. The drive coil is coupled to a power source and configured to generate an alternating magnetic field on the body. The first sensor coil is configured to detect changes in inductance of the body due to changes in magnetic permeability of the body with deformation thereof.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: March 3, 2015
    Assignee: Boise State University
    Inventors: Kari Ullakko, Kotaro Sasaki, Peter Müllner
  • Patent number: 8968003
    Abstract: A surgical simulator is disclosed herein. The surgical simulator includes an artificial organ and an enclosure substantially enclosing the artificial organ. The artificial organ is substantially formed of platinum cured room temperature vulcanization silicone rubber (“PCRTVS”).
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: March 3, 2015
    Assignee: Colorado State University Research Foundation
    Inventors: Dean A. Hendrickson, Fausto Bellezzo
  • Patent number: 8969200
    Abstract: An apparatus and method are provided for integrating TSVs into devices prior to device contacts processing. The apparatus includes a semiconducting layer; one or more CMOS devices mounted on a top surface of the semiconducting layer; one or more TSVs integrated into the semiconducting layer of the device wafer; at least one metal layer applied over the TSVs; and one or more bond pads mounted onto a top layer of the at least one metal layer, wherein the at least one metal layer is arranged to enable placement of the one or more bond pads at a specified location for bonding to a second device wafer. The method includes obtaining a wafer of semiconducting material, performing front end of line processing on the wafer; providing one or more TSVs in the wafer; performing middle of line processing on the wafer; and performing back end of line processing on the wafer.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: March 3, 2015
    Assignee: The Research Foundation of State University of New York
    Inventors: Jeremiah Hebding, Megha Rao, Colin McDonough, Matthew Smalley, Douglas Duane Coolbaugh, Joseph Piccirillo, Jr., Stephen G. Bennett, Michael Liehr, Daniel Pascual
  • Publication number: 20150057513
    Abstract: Methods and devices to continuously measure electrochemical activity of one or more biochemical or molecular markers (FIG. 9). A substrate having electronics for measuring electrochemical activity and a plurality of electrodes such that the electrodes are in contact with the subcutaneous layer are attached to subject's skin or intravenously. The devices measure a biochemical process associated with one or more biochemical or molecular markers in vivo by detecting an electrochemical signal in subcutaneous layer (or intravenously) using the plurality of electrodes.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 26, 2015
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Jeffrey LaBelle, Katherine Ruh, Brittney Haselwood
  • Publication number: 20150056232
    Abstract: The present invention provides a recombinant bacterium and methods of using the recombinant bacterium to induce a cellular immune response.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 26, 2015
    Applicant: The Arizona Board of Regents for and on behalf of Arizona State University
    Inventor: Roy Curtiss, III
  • Patent number: 8962812
    Abstract: A method is provided for extraction of chemical compounds from an organism having a cell wall that includes adding nanomaterials, which may be metallic nanofibers such as silver nanofibers, to the organism.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: February 24, 2015
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Maria Teresa Gutierrez-Wing, Kelly Ann Rusch
  • Patent number: 8962557
    Abstract: Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: February 24, 2015
    Assignee: Florida State University Research Foundation
    Inventors: Michael Blaber, Jihun Lee
  • Patent number: 8964161
    Abstract: The present invention provides an electro-optical device comprising a cell of polymer-stabilized blue phase (PSBP) liquid crystal under an electrical field and a method of controlling the reflection and transmission of an incident electromagnetic radiation such as visible light, by way of controlling the electrical field. The invention exhibits merits such as cost-effectiveness; simpler manufacturability due to the removal of requirements of polarizer and color filter; and fast switching, among others.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: February 24, 2015
    Assignee: Kent State University
    Inventors: Liang-Chy Chien, Shin-Ying Lu
  • Patent number: 8961948
    Abstract: Methods for constructing tyrosine-derived biotinylated polymers. Biotinylated polymers and polymer scaffolds constructed with the biotinylated polymers are also disclosed.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: February 24, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Jared S. Bushman, Jenny E. Raynor, Joachim B. Kohn
  • Patent number: RE45396
    Abstract: A wave rotor apparatus is provided. In another aspect of the present invention, a radial wave rotor includes fluid passageways oriented in a direction offset from its rotational axis. A further aspect of the present invention employs stacked layers of generally radial channels in a wave rotor. Moreover, turbomachinery is located internal to a wave rotor in yet another aspect of the present invention. In yet another aspect of the present invention, a radial wave rotor has an igniter and fuel injector. Correctional passages are employed in still another aspect of the present invention wave rotor.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: March 3, 2015
    Assignee: Board of Trustees of Michigan State University
    Inventors: Norbert Müller, Pejman Akbari, Janusz Piechna, Florin Iancu
  • Patent number: D723818
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: March 10, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Amanda Cleveland, Marlo Ransdell