Abstract: The invention is embodied in methods for finding gene expression signatures of circulating melanoma cells, ovarian, breast, colorectal cancer cells, and circulating endothelial progenitor cells, which signatures are effective in distinguishing the circulating cancer cell from normal circulating cells and can also distinguish between different types of circulating cancer cells.

Abstract: A highly dislocation free compound semiconductor, e.g. AlxInyGa1-x-yN (0?x, y?1), is formed on a lattice mismatched substrate, e.g. Si, by first depositing a polycrystalline buffer layer on the substrate. A defective layer is then created at or near the interface of the substrate and the polycrystalline buffer layer, e.g. through ion implantation. A monocrystalline template layer of the compound semiconductor is then created on the buffer layer, and an epilayer of the compound semiconductor is grown on the template layer. A compound semiconductor based device structure may be formed in the epilayer.

Abstract: The disclosure describes use of flagellin polypeptides to induce tolerance to gram negative bacteria, such as Pseudomonas aeruginosa, in order to alleviate the effects of the inflammatory response to bacterial infection in a patient. Also described are methods and compositions for treating and preventing keratitis, cystic fibrosis, asthma, and other diseases and conditions in which inflammation contributes to the pathology and symptoms.

Abstract: The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary proteins thereof, as compared to normal control or benign tissue is indicative of breast cancer.

Abstract: The present invention provides methods of improving growth performance, improving the efficiency of feed utilization, increasing feed digestibility, and decreasing mortality of immature and developing animals receiving animal feed. Methods of producing a crude keratinise enzyme extract and animal feed supplements for achieving the same are also provided.

Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.

Abstract: Disclosed are encapsulated zinc compounds, together with methods for preparing and use the same. Also disclosed are methods for mixing the encapsulated zinc mixtures with a cement, and the resulting concrete compositions.

Abstract: A nuclear reactor module includes a reactor vessel containing coolant, a reactor core submerged in the coolant, and a heat exchanger configured to remove heat from the coolant. The nuclear reactor module further includes one or more heaters configured to add heat to the coolant during a startup operation and prior to the reactor core going critical.

Abstract: The present invention encompasses a recombinant bacterium comprising a regulated rfaH nucleic acid, as well as a vaccine comprising said recombinant bacterium. Other embodiments of the present invention encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and a regulated rfc nucleic acid, while additional embodiments encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and at least one nucleic acid encoding at least one exogenous antigen.

Abstract: This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.

Abstract: An simpler, cheaper method for enhancing the percentage of eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) from source oils has been discovered. This method hydrolyzes the oil using the lipase enzyme but does not inactivate the lipase enzyme with either added chemicals or increased temperature. The method relies on centrifugation to separate the enzyme from the desired oil and separate the oil from aqueous impurities. The hydrolyzed oil is enhanced with EPA and DHA, and can be further purified by using activated surface adsorbents, e.g., activated alumina, to remove more free fatty acids and impurities.

Abstract: A new method is disclosed for recycling waste asphalt shingles in hot mix asphalt, i.e. asphalt pavement construction. Ground asphalt shingles are treated as a binder component instead of as an aggregate component. The recycled asphalt shingles that are blended with virgin binder in a wet process act both as a partial binder replacement and as a binder extender due to the presence of fillers, rubber, and fibers in the processed material.

Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.

Abstract: Disclosed are probes, systems, and devices that can be used to assay the presence of a biomarker in the sinus of a patient. The probes, systems, and devices can be used to contact the sinus fluid inside the sinus of a patient with an immunoassay for the presence of a biomarker that is characteristic of sinusitis. The probes can therefore be used to determine the underlying cause of sinusitis in a patient. Also provided are methods of treating sinusitis by administering to a patient a therapeutic regimen selected in view of a biomarker detected in the sinus of the patient. As the biomarker is associated with one or more causative agents of sinusitis, a therapy effective to treat the underlying causative agent can be selected.

Abstract: A novel method and apparatus is introduced to provide a new and robust alternative design for linear magnetorheological (MR) brakes, i.e. MR-brakes. The novel embodiments herein combines a serpentine flux path concept to eliminate conventional piston-cylinder arrangements and as a beneficial result when coupled with the linear brake embodiment disclosed herein, significantly reduce off-state friction and facilitates such devices to provide longer stroke length (i.e., infinite stroke lengths) beyond that as provided in conventional systems. The present linear brake embodiments disclosed herein thus provides, for example, for a ratio of the off-state friction force to the maximum force output at about 3% compared to 10% up to about 27% for similar conventional/commercial brake mechanisms. At the same time, the compactness is beneficially improved be being about half the size of a commercially available product.http://en.wikipedia.org/wiki/File:Paul_Patent_2939952_Fig5.

Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.

Abstract: A method of producing pristine graphene particles through a one-step, gas-phase, catalyst-free detonation of a mixture of one or more carbon-containing compounds hydrocarbon compounds and one or more oxidizing agents is provided. The detonation reaction occurs very quickly and at relatively high temperature, greater than 3000 K, to generate graphene nanosheets that can be recovered from the reaction vessel, such as in the form of an aerosol. The graphene nanosheets may be stacked in single, double, or triple layers, for example, and may have an average particle size of between about 35 to about 250 nm.

Abstract: Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.

Abstract: Automated, standardized and accurate extraction of relationships within text. Automatic extraction of such relationships/information allows the information to be stored in structured form so that it can be easily and accurately retrieved when needed. Such information can be used to build online search engines for highly specific and accurate information retrieval. The current invention discloses a novel approach to extract such information from raw text based on natural language processing (NLP) and graph theoretic algorithm. The novel method can be applied, for example, to extract protein-protein relationships in biomedical literature. The method can be easily extended to extract other biological relationships between biological terms such as proteins, genes, pathways, diseases and drugs. The method can also be applied to other information domains to extract other relationships.

Abstract: One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R.