Patents Assigned to State University
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Publication number: 20150010947Abstract: Methods and systems for creating a genetic construct, a protein, and a polymer comprising a domain swapping module. A domain swapping module is a fusion protein in which a lever protein, which has a long amino (N) to carboxy (C) terminal distance, is inserted into a surface loop of an assembler protein, thereby stretching the assembler protein and splitting it into two fragments held apart by the lever so that they cannot rejoin. If the assembler protein is split at the proper location, the fragments will recombine with their respective counterparts from either one or more different—but similarly-split—assembler proteins.Type: ApplicationFiled: December 27, 2012Publication date: January 8, 2015Applicant: The Research Foundation For The State University Of New YorkInventors: Stewart Loh, Jeung-hio Ha, Diana Mitrea
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Publication number: 20150010938Abstract: Probes for selectively detecting compounds comprising a thiol group and an amino group (“thiols”) are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an ?,?-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7 and R8 together form a cycloalkyl or aryl ring; X1 is CH2, S, NH, O, Se, Si(CH3)2, Ge(CH3)2, Sn(CH3)2, or C(CH3)2; and X2 is CH, CH2, N, NH, or CR9 where R9 is aryl.Type: ApplicationFiled: February 22, 2013Publication date: January 8, 2015Applicant: Oregon State Board of Higher Education on Behalf of Portland State UniversityInventors: Robert M. Strongin, Yixing Guo, Lovemore Hakuna, Mark Allen Lowry, Jorge Omar Escobedo Córdova
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Publication number: 20150010945Abstract: A method for expression of engineered constructs containing sequences coding for functional genes of interest in E. coli strains. Here tceA and tceB are fused to an inducible, active promoter to optimize transcription of the open reading frames, and an introduced consensus Shine-Dalgarno sequence allowing for optimal ribosome binding and translation of the open reading frames, and codons optimized for expression in E. coil. This over-expressed protein is then used to design appropriate mass spectro metric methods for environmental detection.Type: ApplicationFiled: June 19, 2012Publication date: January 8, 2015Applicant: Arizona State Board of Regents For and on Behalf of Arizona State UniversityInventors: Rosa Krajmalnik-Brown, Rolf U. Halden, James W. Wilson
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Patent number: 8927682Abstract: Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.Type: GrantFiled: August 25, 2008Date of Patent: January 6, 2015Assignee: Board of Trustees of Michigan State UniversityInventors: Gregory L. Baker, Milton R. Smith, III, Xuwei Jiang, Erin B. Vogel
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Patent number: 8927029Abstract: Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.Type: GrantFiled: November 25, 2013Date of Patent: January 6, 2015Assignee: North Carolina State UniversityInventors: Christian Melander, John Cavanagh, David Ritchie, Robert W. Huigens, III, T. Eric Ballard, Justin J. Richards, Thomas W. Lindsey, Jonathan S. Lindsey
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Patent number: 8930304Abstract: In a corpus of scientific articles such as a digital library, documents are connected by citations and one document plays two different roles in the corpus: document itself and a citation of other documents. A Bernoulli Process Topic (BPT) model is provided which models the corpus at two levels: document level and citation level. In the BPT model, each document has two different representations in the latent topic space associated with its roles. Moreover, the multi-level hierarchical structure of the citation network is captured by a generative process involving a Bernoulli process. The distribution parameters of the BPT model are estimated by a variational approximation approach.Type: GrantFiled: January 14, 2014Date of Patent: January 6, 2015Assignee: The Research Foundation for The State University of New YorkInventors: Zhen Guo, Mark Zhang
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Patent number: 8927207Abstract: MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3? untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.Type: GrantFiled: June 5, 2009Date of Patent: January 6, 2015Assignee: Research Foundation of State University of New YorkInventors: Jingfang Ju, Bo Song, Yuan Wang
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Patent number: 8930705Abstract: With the widespread use of the distributed systems comes the need to secure such systems against a wide variety of threats. Recent security mechanisms are grossly inadequate in authenticating the program executions at the clients or servers, as the clients, servers and the executing programs themselves can be compromised after the clients and servers pass the authentication phase. A generic framework is provided for authenticating remote executions on a potentially untrusted remote server—essentially validating that what is executed at the server on behalf of the client is actually the intended program. Details of a prototype Linux implementation are also described, along with some optimization techniques for reducing the run-time overhead of the present scheme. The performance overhead of this technique varies generally from 7% to 24% for most benchmarks, as seen from the actual remote execution of SPEC benchmarks.Type: GrantFiled: September 27, 2012Date of Patent: January 6, 2015Assignee: The Research Foundation for the State University of New YorkInventors: Kanad Ghose, Erdem Aktas
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Patent number: 8927024Abstract: The invention provides compositions and methods to treat microbial infections in animals, to inhibit the replication of microbes in infected cells, and to kill pathogens in infected cells. The methods can include administering to an animal in need of such treatment an effective antimicrobial amount of a composition comprising polyanhydride microparticles or nanoparticles that encapsulate a plurality of antimicrobial agents. The polyanhydride microparticles or nanoparticles can be, for example, copolymers of sebacic anhydride (SA) and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, copolymers of 1,8-bis(carboxyphenoxy)-3,6-dioxaoctane (CPTEG) anhydrides and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, or various combinations thereof.Type: GrantFiled: April 19, 2013Date of Patent: January 6, 2015Assignee: Iowa State University Research Foundation, Inc.Inventors: Bryan Bellaire, Balaji Narasimhan
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Patent number: 8928521Abstract: Embodiments of the invention can predict the ground location and intensity of storm cells for a future time using radar reflectivity data. In some embodiments, a Sinc approximation of the general flow equation can be solved to predict the ground location and intensity of a storm cell. In some embodiments, to solve the Sinc approximation the velocity of a storm cell can be estimated using various techniques including solving the flow equation in the frequency domain. The results can provide efficient prediction of storm cell position in nowcasting applications.Type: GrantFiled: June 25, 2009Date of Patent: January 6, 2015Assignee: Colorado State University Research FoundationInventors: Chandrasekaran Venkatachalam, Yanting Wang
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Patent number: 8926822Abstract: An integrated sensing device is capable of detecting analytes using electrochemical (EC) and electrical (E) signals. The device introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.Type: GrantFiled: May 13, 2013Date of Patent: January 6, 2015Assignee: Arizona Board of Regents for and on behalf of Arizona State UniversityInventors: Nongjian Tao, Erica Forzani
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Patent number: 8926990Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.Type: GrantFiled: April 13, 2012Date of Patent: January 6, 2015Assignee: Rutgers, The State University of New JerseyInventor: Scott C. Kachlany
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Patent number: 8929644Abstract: A method for three-dimensional (3D) shape measurement includes generating fringe patterns using a dithering technique, projecting the fringe patterns onto an object using a projector, capturing the fringe patterns distorted by surface geometry of the object using an imaging device, and performing a fringe analysis to reconstruct a 3D shape of the object using the fringe patterns and the fringe patterns distorted by the surface geometry of the object. The step of generating the fringe patterns using the dithering technique may include binarizing sinuisoidal fringe patterns with the dithering technique. The step of generating the fringe patterns using the dithering technique may include applying an optimization algorithm.Type: GrantFiled: January 2, 2013Date of Patent: January 6, 2015Assignee: Iowa State University Research FoundationInventors: Song Zhang, Yajun Wang, William F. Lohry
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Patent number: 8927728Abstract: Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.Type: GrantFiled: May 7, 2012Date of Patent: January 6, 2015Assignee: The Florida State University Research Foundation, Inc.Inventors: Igor Alabugin, Wang-Yong Yang, Saumya Roy, Kemal Kaya, Qing-Xiang Sang
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Patent number: 8927834Abstract: The present invention provides methods for producing glyphosate-tolerant wheat genotypes by mutagenesis, glyphosate wheat plants produced by such methods, and related compositions and methods.Type: GrantFiled: December 19, 2013Date of Patent: January 6, 2015Assignees: Washington State University, The United States of America, as represented by the Secretary of AgricultureInventors: Kimberlee Kae Kidwell, Camille Marie Steber, Victor Louis Demacon, Gary Bruce Shelton, Adrienne Bryan Burke
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Patent number: 8927727Abstract: Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens.Type: GrantFiled: June 29, 2012Date of Patent: January 6, 2015Assignee: The State of Oregon Acting by and through the State Board of Higher Education on behalf of Portland State UniversityInventors: Robert Michael Strongin, Martha Sibrian-Vazquez
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Patent number: 8927509Abstract: This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.Type: GrantFiled: May 20, 2009Date of Patent: January 6, 2015Assignee: The Research Foundation of State University of New YorkInventors: Hua Shi, Albert J. T. Millis, Kimi Nishikawa, Prabhat Kumar Mallik
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Patent number: 8927778Abstract: A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.Type: GrantFiled: October 24, 2012Date of Patent: January 6, 2015Assignee: The Florida State University Research Foundation, Inc.Inventors: Igor Alabugin, Philip M. Byers
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Publication number: 20150004257Abstract: A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.Type: ApplicationFiled: February 23, 2012Publication date: January 1, 2015Applicant: Colorado State University Research FoundationInventors: Melissa M. Reynolds, Vinod B. Damodaran
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Patent number: 8921110Abstract: Provided are methods for generating iris plants having flowers expressing red, red/orange, or orange/red color, previously non-existing in this plant genus, thereby expanding the color palette of, and generating new and exciting varieties of, ornamental plants. These methods employ capsanthin-capsorubin synthase-encoding nucleotide sequences, and are also applicable to other genera, species, cultivars, and varieties of ornamental plants in which red, red/orange, or orange/red flowers have been desired. The nucleotide sequences and methods disclosed herein can be applied to genera, species, cultivars, and varieties of ornamental plants that produce yellow pigments, or yellow/orange flowers, but no red flowers, to produce novel red-, red/orange, or orange/red-flowering plants.Type: GrantFiled: September 11, 2013Date of Patent: December 30, 2014Assignee: Oregon State UniversityInventors: Zoran Jeknic, Tony H. H. Chen