Patents Assigned to State University
  • Publication number: 20150010947
    Abstract: Methods and systems for creating a genetic construct, a protein, and a polymer comprising a domain swapping module. A domain swapping module is a fusion protein in which a lever protein, which has a long amino (N) to carboxy (C) terminal distance, is inserted into a surface loop of an assembler protein, thereby stretching the assembler protein and splitting it into two fragments held apart by the lever so that they cannot rejoin. If the assembler protein is split at the proper location, the fragments will recombine with their respective counterparts from either one or more different—but similarly-split—assembler proteins.
    Type: Application
    Filed: December 27, 2012
    Publication date: January 8, 2015
    Applicant: The Research Foundation For The State University Of New York
    Inventors: Stewart Loh, Jeung-hio Ha, Diana Mitrea
  • Publication number: 20150010938
    Abstract: Probes for selectively detecting compounds comprising a thiol group and an amino group (“thiols”) are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an ?,?-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7 and R8 together form a cycloalkyl or aryl ring; X1 is CH2, S, NH, O, Se, Si(CH3)2, Ge(CH3)2, Sn(CH3)2, or C(CH3)2; and X2 is CH, CH2, N, NH, or CR9 where R9 is aryl.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 8, 2015
    Applicant: Oregon State Board of Higher Education on Behalf of Portland State University
    Inventors: Robert M. Strongin, Yixing Guo, Lovemore Hakuna, Mark Allen Lowry, Jorge Omar Escobedo Córdova
  • Publication number: 20150010945
    Abstract: A method for expression of engineered constructs containing sequences coding for functional genes of interest in E. coli strains. Here tceA and tceB are fused to an inducible, active promoter to optimize transcription of the open reading frames, and an introduced consensus Shine-Dalgarno sequence allowing for optimal ribosome binding and translation of the open reading frames, and codons optimized for expression in E. coil. This over-expressed protein is then used to design appropriate mass spectro metric methods for environmental detection.
    Type: Application
    Filed: June 19, 2012
    Publication date: January 8, 2015
    Applicant: Arizona State Board of Regents For and on Behalf of Arizona State University
    Inventors: Rosa Krajmalnik-Brown, Rolf U. Halden, James W. Wilson
  • Patent number: 8927682
    Abstract: Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: January 6, 2015
    Assignee: Board of Trustees of Michigan State University
    Inventors: Gregory L. Baker, Milton R. Smith, III, Xuwei Jiang, Erin B. Vogel
  • Patent number: 8927029
    Abstract: Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: January 6, 2015
    Assignee: North Carolina State University
    Inventors: Christian Melander, John Cavanagh, David Ritchie, Robert W. Huigens, III, T. Eric Ballard, Justin J. Richards, Thomas W. Lindsey, Jonathan S. Lindsey
  • Patent number: 8930304
    Abstract: In a corpus of scientific articles such as a digital library, documents are connected by citations and one document plays two different roles in the corpus: document itself and a citation of other documents. A Bernoulli Process Topic (BPT) model is provided which models the corpus at two levels: document level and citation level. In the BPT model, each document has two different representations in the latent topic space associated with its roles. Moreover, the multi-level hierarchical structure of the citation network is captured by a generative process involving a Bernoulli process. The distribution parameters of the BPT model are estimated by a variational approximation approach.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: January 6, 2015
    Assignee: The Research Foundation for The State University of New York
    Inventors: Zhen Guo, Mark Zhang
  • Patent number: 8927207
    Abstract: MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3? untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: January 6, 2015
    Assignee: Research Foundation of State University of New York
    Inventors: Jingfang Ju, Bo Song, Yuan Wang
  • Patent number: 8930705
    Abstract: With the widespread use of the distributed systems comes the need to secure such systems against a wide variety of threats. Recent security mechanisms are grossly inadequate in authenticating the program executions at the clients or servers, as the clients, servers and the executing programs themselves can be compromised after the clients and servers pass the authentication phase. A generic framework is provided for authenticating remote executions on a potentially untrusted remote server—essentially validating that what is executed at the server on behalf of the client is actually the intended program. Details of a prototype Linux implementation are also described, along with some optimization techniques for reducing the run-time overhead of the present scheme. The performance overhead of this technique varies generally from 7% to 24% for most benchmarks, as seen from the actual remote execution of SPEC benchmarks.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: January 6, 2015
    Assignee: The Research Foundation for the State University of New York
    Inventors: Kanad Ghose, Erdem Aktas
  • Patent number: 8927024
    Abstract: The invention provides compositions and methods to treat microbial infections in animals, to inhibit the replication of microbes in infected cells, and to kill pathogens in infected cells. The methods can include administering to an animal in need of such treatment an effective antimicrobial amount of a composition comprising polyanhydride microparticles or nanoparticles that encapsulate a plurality of antimicrobial agents. The polyanhydride microparticles or nanoparticles can be, for example, copolymers of sebacic anhydride (SA) and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, copolymers of 1,8-bis(carboxyphenoxy)-3,6-dioxaoctane (CPTEG) anhydrides and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, or various combinations thereof.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: January 6, 2015
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Bryan Bellaire, Balaji Narasimhan
  • Patent number: 8928521
    Abstract: Embodiments of the invention can predict the ground location and intensity of storm cells for a future time using radar reflectivity data. In some embodiments, a Sinc approximation of the general flow equation can be solved to predict the ground location and intensity of a storm cell. In some embodiments, to solve the Sinc approximation the velocity of a storm cell can be estimated using various techniques including solving the flow equation in the frequency domain. The results can provide efficient prediction of storm cell position in nowcasting applications.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: January 6, 2015
    Assignee: Colorado State University Research Foundation
    Inventors: Chandrasekaran Venkatachalam, Yanting Wang
  • Patent number: 8926822
    Abstract: An integrated sensing device is capable of detecting analytes using electrochemical (EC) and electrical (E) signals. The device introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: January 6, 2015
    Assignee: Arizona Board of Regents for and on behalf of Arizona State University
    Inventors: Nongjian Tao, Erica Forzani
  • Patent number: 8926990
    Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: January 6, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Scott C. Kachlany
  • Patent number: 8929644
    Abstract: A method for three-dimensional (3D) shape measurement includes generating fringe patterns using a dithering technique, projecting the fringe patterns onto an object using a projector, capturing the fringe patterns distorted by surface geometry of the object using an imaging device, and performing a fringe analysis to reconstruct a 3D shape of the object using the fringe patterns and the fringe patterns distorted by the surface geometry of the object. The step of generating the fringe patterns using the dithering technique may include binarizing sinuisoidal fringe patterns with the dithering technique. The step of generating the fringe patterns using the dithering technique may include applying an optimization algorithm.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: January 6, 2015
    Assignee: Iowa State University Research Foundation
    Inventors: Song Zhang, Yajun Wang, William F. Lohry
  • Patent number: 8927728
    Abstract: Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: January 6, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Wang-Yong Yang, Saumya Roy, Kemal Kaya, Qing-Xiang Sang
  • Patent number: 8927834
    Abstract: The present invention provides methods for producing glyphosate-tolerant wheat genotypes by mutagenesis, glyphosate wheat plants produced by such methods, and related compositions and methods.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: January 6, 2015
    Assignees: Washington State University, The United States of America, as represented by the Secretary of Agriculture
    Inventors: Kimberlee Kae Kidwell, Camille Marie Steber, Victor Louis Demacon, Gary Bruce Shelton, Adrienne Bryan Burke
  • Patent number: 8927727
    Abstract: Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 6, 2015
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on behalf of Portland State University
    Inventors: Robert Michael Strongin, Martha Sibrian-Vazquez
  • Patent number: 8927509
    Abstract: This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: January 6, 2015
    Assignee: The Research Foundation of State University of New York
    Inventors: Hua Shi, Albert J. T. Millis, Kimi Nishikawa, Prabhat Kumar Mallik
  • Patent number: 8927778
    Abstract: A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 6, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Philip M. Byers
  • Publication number: 20150004257
    Abstract: A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.
    Type: Application
    Filed: February 23, 2012
    Publication date: January 1, 2015
    Applicant: Colorado State University Research Foundation
    Inventors: Melissa M. Reynolds, Vinod B. Damodaran
  • Patent number: 8921110
    Abstract: Provided are methods for generating iris plants having flowers expressing red, red/orange, or orange/red color, previously non-existing in this plant genus, thereby expanding the color palette of, and generating new and exciting varieties of, ornamental plants. These methods employ capsanthin-capsorubin synthase-encoding nucleotide sequences, and are also applicable to other genera, species, cultivars, and varieties of ornamental plants in which red, red/orange, or orange/red flowers have been desired. The nucleotide sequences and methods disclosed herein can be applied to genera, species, cultivars, and varieties of ornamental plants that produce yellow pigments, or yellow/orange flowers, but no red flowers, to produce novel red-, red/orange, or orange/red-flowering plants.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: December 30, 2014
    Assignee: Oregon State University
    Inventors: Zoran Jeknic, Tony H. H. Chen