Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
Type:
Grant
Filed:
April 28, 2008
Date of Patent:
December 30, 2014
Assignees:
Board of Regents of the University of Texas System, The Ohio State University Research Foundation
Abstract: Multimodal data mining in a multimedia database is addressed as a structured prediction problem, wherein mapping from input to the structured and interdependent output variables is learned.
Type:
Grant
Filed:
May 28, 2013
Date of Patent:
December 30, 2014
Assignee:
The Research Foundation for the State University of New York
Abstract: A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase) that is then followed by an activation of VGSCs, for example, by electrical or pharmacological stimulation. Activation of VGSCs conducts sodium into the cancer cells in much greater amounts than non-cancer cells. Water follows this sodium gradient into the cancer cells, causing swelling and lysis. Because non-cancerous cells do not over-express VGSCs, less sodium and less water will enter the cells, and the non-cancerous cells will not lyse. This method is applicable to all cells that over-express VGSCs, including, but not limited to, highly invasive breast cancer, prostate cancer, small cell lung cancer, non-small cell lung carcinoma, lymphoma, mesothelioma, neuroblastoma, and cervical cancer.
Type:
Grant
Filed:
July 19, 2012
Date of Patent:
December 30, 2014
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Several different pyrrolysine analogs are disclosed in this application. Those analogs have distinct chemical and biophysical properties. Some analogs are useful in chemical ligation applications. Methods of making and using are also disclosed.
Type:
Grant
Filed:
October 6, 2010
Date of Patent:
December 30, 2014
Assignee:
The Ohio State University
Inventors:
Michael K. Chan, Tomasz Fekner, Xin Li, Marianne Lee, Manoj Nair, Jennifer Jo Ottensen
Abstract: The invention provides a yeast-enhanced red fluorescent protein. In an embodiment of the invention, the yeast-enhanced red fluorescent protein is monomeric and is expressible in Candida albicans. The invention also provides a novel visible color marker for plasmid expression in yeast, particularly Saccharomyces cerevisiae and Candida albicans.
Type:
Grant
Filed:
February 26, 2009
Date of Patent:
December 30, 2014
Assignee:
The Research Foundation for The State University of New York
Abstract: A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5? non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.
Type:
Grant
Filed:
October 7, 2011
Date of Patent:
December 30, 2014
Assignee:
The Research Foundation of The State University of New York
Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
Type:
Grant
Filed:
May 8, 2012
Date of Patent:
December 30, 2014
Assignees:
Trustees of Dartmouth College, Rutgers, The State University of New Jersey, The United States of America, as represented by the Secretary Department of Health and Human Services
Inventors:
Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Nanjoo Suh, Damian Medici, Pamela Gehron Robey
Abstract: A system and method to enable electronically controlled internal combustion engines to self-adjust parameters and operate properly on different fuels that have wide ranges of physical and chemical properties. Input from a sensor is utilized that gives a signal indicative of the combustion process. The ECU processes the signal and readjusts the engine operating parameters to achieve its operating goals.
Abstract: The present invention provides novel mammalian alpha-kinase proteins: melanoma alpha-kinase (MK), heart alpha-kinase (HK), kidney alpha-kinase (KK), skeletal muscle alpha-kinase (SK), and lymphocyte alpha-kinase (LK). In particular, a novel kinase type is herein provided, characterized by the presence of an alpha-kinase catalytic domain and an ion channel domain. Isolated nucleic acids of the alpha-kinases MK, HK, KK, SK and LK are provided. Methods for making the novel alpha-kinases, cells that express the alpha-kinases and methods for treating an animal in need of either increased or decreased activity of the alpha-kinases are provided.
Type:
Grant
Filed:
June 17, 2010
Date of Patent:
December 23, 2014
Assignee:
Rutgers, The State University of New Jersey
Abstract: Mesoporous calcium silicate compositions for controlled release of bioactive agents and methods for producing such compositions are disclosed herein. In one embodiment, mesoporous calcium silicate is synthesized by acid modification of wollastonite particles using hydrochloric acid. A hydrated silica gel layer having abundant Si—OH functional groups can be formed on the surface of wollastonite after acid modification. Bruhauer-Emmett-Teller (BET) surface area increased significantly due to acid modification and, in one arrangement, reached over 350 m2/g. Acid modified mesoporous calcium silicate compositions show a higher ability to adsorb protein compared to unmodified particles and demonstrate controlled release kinetics of these proteins.
Type:
Grant
Filed:
September 15, 2008
Date of Patent:
December 23, 2014
Assignee:
Washington State University
Inventors:
Susmita Bose, Amit Bandyopadhyay, Weichang Xue
Abstract: An artificial body wall is disclosed herein. The artificial body wall may include a first layer and a second layer. The first layer is substantially formed of a silicone rubber and includes at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer. The second layer extends along and below the first layer and is substantially formed of a silicone rubber. The second layer includes at least one of an artificial fascia layer or an artificial muscle layer. At least one of the first layer or second layer may be vascularized.
Type:
Grant
Filed:
November 19, 2013
Date of Patent:
December 23, 2014
Assignee:
Colorado State University Research Foundation
Abstract: The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presence of one or more target nucleic acid sequences is immobilized on the silicon. A nucleic acid, such as an oligonucleotide probe, having a sequence substantially complementary to the target nucleic acid sequence can be used to detect the immobilized nucleic acid on the silicon. If the nucleic acid used for detection hybridizes with a target nucleic acid sequence, the hybridized sequences can be detected directly or indirectly. In an exemplified embodiment, the oligonucleotide probe can be labeled with a detectable label, for example, a fluorescent molecule. The subject invention also concerns methods for detecting a target nucleic acid using a silicon-based biochip of the invention.
Type:
Grant
Filed:
January 24, 2011
Date of Patent:
December 23, 2014
Assignees:
University of South Florida, Alabama State University
Inventors:
Arun Kumar, Ashok Kumar, Shree R. Singh, Souheil Zekri
Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
Abstract: Provided herein are pharmaceutical compositions and methods for treating disorders characterized by reduced expression of anti-oxidative stress enzymes in a subject. In one aspect, the present invention provides a method for inducing expression of anti-oxidative stress enzymes in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a demethylating agent. The demethylating agent includes a phytochemical that induces expression of Nrf2 and Nrf2-mediated genes expressing anti-oxidative stress. Such phytochemicals include indoles, such as 3,3?-diindolylmethane (DIM) and indole-3-carbinol (I3C), and isothiocyanates, such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).
Type:
Grant
Filed:
May 31, 2012
Date of Patent:
December 23, 2014
Assignee:
Rutgers, The State University of New Jersey
Abstract: Nanocomposite materials and methods of making composite materials reinforced with carbon nanotubes are disclosed. The composite material includes an array of functionalized and aligned carbon nanotubes having a degree of functionalization of about 1% to about 10%; and a polymeric matrix material bonded to the array of functionalized and aligned carbon nanotubes.
Type:
Grant
Filed:
April 20, 2011
Date of Patent:
December 23, 2014
Assignee:
Florida State University Research Foundation, Inc.
Inventors:
Qunfeng Cheng, Richard Liang, Ben Wang, Chuck Zhang
Abstract: The present invention provides a novel system and method for identifying individuals and for face recognition utilizing facial features for face identification. The system and method of the invention comprise creating facial features or face patterns called face pattern words and face pattern bytes for face identification. The invention also provides for pattern recognitions for identification other than face recognition. The invention further provides a means for identifying individuals based on visible and/or thermal images of those individuals by utilizing computer software implemented by instructions on a computer or computer system and a computer readable medium containing instructions on a computer system for face recognition and identification.
Abstract: The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
Type:
Grant
Filed:
August 22, 2008
Date of Patent:
December 23, 2014
Assignees:
Colorado School of Mines, Colorado State University Research Foundation
Inventors:
Stephen G. Boyes, Misty D. Rowe, Douglas H. Thamm, Susan L. Kraft
Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
Type:
Grant
Filed:
June 24, 2014
Date of Patent:
December 23, 2014
Assignees:
Rutgers, The State University of New Jersey, Board of Regents, The University of Texas System
Inventors:
Gaetano T. Montelione, Kalyan Das, Edward Arnold, Li-Chung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
Abstract: Reconfigurable 3D interconnect is provided that can be used for digital and RF signals. The reconfigurable 3D interconnect can include an array of vertical interconnect vias (or TSVs) providing a signal path between a first core element of a 3D IC and a second core element of the 3D IC stacked above the first core element. A routing circuit can be used to route a signal from the first core element to the second core element through selected TSVs of the array of TSVs providing the signal path between the first core element and the second core element. The routing circuit allows re-routing of the signal through different selected TSVs during operation, which can provide real time adjustments and capacity optimization of the TSVs passing the particular signal between the elements.
Type:
Grant
Filed:
December 13, 2010
Date of Patent:
December 23, 2014
Assignee:
Research Foundation of State University of New York
Abstract: A portable optical sensor for measuring surface strain in an object, such as pre-stressed concrete articles, is provided. The sensor is a modular device comprising at least first and second modules, each of which includes a laser and image sensor. When placed adjacent to the object, the laser of each module illuminates respective, spaced-apart areas of the object's surface and each module's image sensor captures at least a portion of the light reflected from the illuminated area and generates a speckle image of the area. Speckle images of the areas taken at various times and/or under various object stress conditions are compared to arrive at a surface strain measurement for the object.
Type:
Grant
Filed:
March 21, 2013
Date of Patent:
December 23, 2014
Assignee:
Kansas State University Research Foundation
Inventors:
Weixin Zhao, Burdette Terry Beck, Robert Peterman, Chih-Hang Wu