Patents Assigned to State University
  • Electrobiocatalytic reactors having reversible bioelectronic interfaces and methods and devices related thereto
    Patent number: 9406959
    Abstract: An inexpensive, easily renewable bioelectronic device useful for bioreactors, biosensors, and biofuel cells includes an electrically conductive carbon electrode and a bioelectronic interface bonded to a surface of the electrically conductive carbon electrode, wherein the bioelectronic interface includes catalytically active material that is electrostatically bound directly or indirectly to the electrically conductive carbon electrode to facilitate easy removal upon a change in pH, thereby allowing easy regeneration of the bioelectronic interface.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: August 2, 2016
    Assignee: Board of Trustees of Michigan State University
    Inventors: Robert Mark Worden, Brian L Hassler, Lawrence T. Drzal, Ilsoon Lee
  • Real-time assessment of absolute muscle effort during open and closed chain activities
    Patent number: 9402579
    Abstract: Methods and apparatus based on vibromyography technology are provided that overcome the substantial limitations of current VMG muscle assessment approaches. Specifically, embodiments of the invention provide a means by which clinicians and trainers can perform real-time muscle assessment during typical functional activities (activities involving substantial human movements). In some embodiments, the invention allows the artisan to simultaneously measure muscle forces being generated by complementary, supplementary, and/or antagonistic muscle pairs such that real-time muscle effort ratios can be calculated. In some embodiments, the measurements provide a means by which clinicians and trainers can diagnose musculo-skeletal injuries and pains associated with muscle imbalances.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: August 2, 2016
    Assignee: The Research Foundation for the State University of New York
    Inventors: Kenneth J. McLeod, Jason P. Cole
  • System and method for enhancing the binaural representation for hearing-impaired subjects
    Patent number: 9407999
    Abstract: A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated interaural time differences using the first signal and the second signal, converting each of the number of estimated interaural time differences to a corresponding interaural level difference, using one or more of the corresponding interaural level differences to generate an adjusted first signal, and using the adjusted first signal to generate a number of signals delivered to the subject for enhancing the hearing of the subject.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: August 2, 2016
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Arizona Board of Regents Acting for and on Behalf of Arizona State University
    Inventor: Christopher A. Brown
  • Methods and devices for modulating cellular activity using ultrasound
    Patent number: 9403038
    Abstract: The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: August 2, 2016
    Assignee: Arizona Board of Regents for and on Behalf of Arizona State University
    Inventor: William James P. Tyler
  • HIGH PERFORMANCE PHASE FREQUENCY DETECTORS
    Publication number: 20160218724
    Abstract: A phase frequency detector with two stages of operation; each stage containing two D flip-flops. Each D flip-flop is interconnected to eliminate detection dead zone while avoiding glitches and incorrect output conditions for fast phase locked loop convergence and wide-band applications.
    Type: Application
    Filed: January 4, 2016
    Publication date: July 28, 2016
    Applicant: Wright State University
    Inventors: Joseph Strzelecki, Saiyu Ren
  • IDENTIFICATION OF NATURAL PLANT EXTRACTS HARBORING ANTI-HEPATITIS C VIRUS NS5B POLYMERASE ACTIVITY
    Publication number: 20160213730
    Abstract: The present invention relates to a novel use of naturally occurring plants, mushroom, extracts thereof that exhibit properties as HCV NS5B polymerase inhibitors.
    Type: Application
    Filed: April 1, 2016
    Publication date: July 28, 2016
    Applicant: Rutgers, The State University
    Inventors: James E. Simon, Qingli Wu, Neerja Kaushik-Basu
  • METHOD IMPROVING PRODUCER GAS FERMENTATION
    Publication number: 20160215303
    Abstract: Providing a microbial catalyst in a reaction broth, providing an adsorptive solid into the reaction broth, providing a producer gas into the reaction broth, and obtaining a fermentation product from the reaction broth resulting from activity of the microbial catalyst in the presence of the adsorptive solid.
    Type: Application
    Filed: August 4, 2014
    Publication date: July 28, 2016
    Applicants: BRIGHAM YOUNG UNIVERSITY, THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
    Inventors: Hasan K. Atiyeh, Randy S. Lewis, John Randall Phillips, Raymond L. Huhnke
  • POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES
    Publication number: 20160213638
    Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 24, 2015
    Publication date: July 28, 2016
    Applicants: The Research Foundation for The State University of New York, Chem-Master International, Inc.
    Inventors: Lorne M. GOLUB, Francis JOHNSON, Galina I. BOTCHKINA, Iwao OJIMA
  • Methods for Diagnosing Prostate Cancer Using MicroRNAs
    Publication number: 20160215352
    Abstract: Described herein are methods for treating prostate cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided.
    Type: Application
    Filed: April 11, 2016
    Publication date: July 28, 2016
    Applicant: The Ohio State University
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Carbon Monoxide Releasing Molecules and Associated Methods
    Publication number: 20160214955
    Abstract: The present disclosure relates to carbon monoxide releasing molecules (“CORMs”), and methods of synthesizing and applying the molecules. More specifically, this disclosure relates to structurally tunable CORMS, compounds containing CORMS (and salts thereof).
    Type: Application
    Filed: January 26, 2016
    Publication date: July 28, 2016
    Applicant: Utah State University
    Inventors: Lisa M. Berreau, Stacey N. Anderson
  • PEPTIDOMIMETIC INHIBITORS OF PSMA
    Publication number: 20160215006
    Abstract: Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent; (3) methods for inhibiting or treating prostrate cancer; and (4) methods for blocking or destabilizing neovasculature of a tumor.
    Type: Application
    Filed: April 1, 2016
    Publication date: July 28, 2016
    Applicants: WASHINGTON STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Clifford E. BERKMAN, Henry F. VANBROCKLIN
  • Method for conformal visualization
    Patent number: 9401044
    Abstract: Provided is a method for obtaining a conformal mapping of first image data corresponding to a source mesh to a target mesh, by generating a template of the source mesh and a template of the target mesh, processing the generated source mesh template and the generated target mesh template to obtain a conformal mapping from the source mesh to the target mesh, mapping the first image data corresponding to the source mesh to second image data corresponding to the target mesh according to the obtained conformal mapping, and outputting a mapped texture corresponding to the mapped second image data to the display corresponding to the target mesh.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: July 26, 2016
    Assignee: The Research Foundation for The State University of New York
    Inventor: Arie E. Kaufman
  • Textured micrometer scale templates as light managing fabrication platform for organic solar cells
    Patent number: 9401442
    Abstract: A three-dimensional, microscale-textured, grating-shaped organic solar cell geometry. The solar cells are fabricated on gratings to give them a three-dimensional texture that provides enhanced light absorption. Introduction of microscale texturing has a positive effect on the overall power conversion efficiency of the devices. This grating-based solar cell having a grating of pre-determined pitch and height has shown improved power-conversion efficiency over a conventional flat solar cell. The improvement in efficiency is accomplished by homogeneous coverage of the grating with uniform thickness of the active layer, which is attributed to a sufficiently high pitch and low height of the underlying gratings. Also the microscale texturing leads to suppressed reflection of incident light due to the efficient coupling of the incident light into modes that are guided in the active layer.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 26, 2016
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Sumit Chaudhary, Kai-Ming Ho, Joong-Mok Park, Kanwar Singh Nalwa, Wai Y. Leung
  • Methods and compositions for high efficiency transfection of siRNA
    Patent number: 9399771
    Abstract: Described herein are methods and compositions for high efficiency transfection of siRNA into a cell population. Such methods and compositions utilize a low voltage pre-conditioning pulse to modulate the efficiency of siRNA transfection. In some embodiments, the methods and compositions permit spatial and temporal control of siRNA transfection efficiency within a population of cells. The disclosed methods and compositions, in some embodiments, are amenable to high throughput applications such as siRNA library-based phenotypic screening.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: July 26, 2016
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Arati Sridharan, Jitendran Muthuswamy
  • Materials and methods for using an acyl-acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
    Patent number: 9399768
    Abstract: A method of increasing production of fatty acids comprising introducing into a host and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE) from Bryantella formatexigens or a mutant thereof; a method of making a mutant B. formatexigens acyl-ACP TE; a method of making a chimeric Cuphea viscosissima acyl-ACP TE; a nucleic acid molecule comprising a nucleotide sequence encoding a mutant acyl-ACP TE or a chimeric Cuphea viscosissima acyl-ACP TE; a host comprising the nucleic acid molecule; a mutant acyl-ACP TE or chimeric Cuphea viscosissima acyl-ACP TE; a method of altering the specificity of a plant acyl-ACP TE for at least one of its substrates comprising introducing into the plant acyl-ACP TE a substrate specificity-altering mutation; and a method of altering the level of activity of a plant acyl-ACP TE.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: July 26, 2016
    Assignee: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Basil J. Nikolau, Marna Yandeau-Nelson, Fuyuan Jing
  • Detection of biopolymer interactions, cancer cells, and pathogens using split-supercharged GFP
    Patent number: 9400249
    Abstract: Systems and methods for detecting protein-protein interactions and/or detecting a targeted cell using a split supercharged protein reporter system are described.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: July 26, 2016
    Assignee: Colorado State University Research Foundation
    Inventors: Brian R. McNaughton, Alex M. Chapman, Brett Blakeley
  • Methods, systems, and computer readable media for testing cutting blade integrity
    Patent number: 9400239
    Abstract: A system for evaluating integrity of a cutting blade includes at least one stress wave generator for generating at least one stress wave in a cutting blade under test. A sensor detects a signal generated by the at least one stress wave. An integrity analyzer coupled to the sensor determines an indication of integrity of the cutting blade based on at least one characteristic of the signal.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: July 26, 2016
    Assignee: North Carolina State University
    Inventor: Richard Len Lemaster
  • Metallic layer-by-layer photonic crystals for linearly-polarized thermal emission and thermophotovoltaic device including same
    Patent number: 9400219
    Abstract: Metallic thermal emitters consisting of two layers of differently structured nickel gratings on a homogeneous nickel layer are fabricated by soft lithography and studied for polarized thermal radiation. A thermal emitter in combination with a sub-wavelength grating shows a high extinction ratio, with a maximum value close to 5, in a wide mid-infrared range from 3.2 to 7.8 ?m, as well as high emissivity up to 0.65 at a wavelength of 3.7 ?m. All measurements show good agreement with theoretical predictions. Numerical simulations reveal that a high electric field exists within the localized air space surrounded by the gratings and the intensified electric-field is only observed for the polarizations perpendicular to the top sub-wavelength grating. This result suggests how the emissivity of a metal can be selectively enhanced at a certain range of wavelengths for a given polarization.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 26, 2016
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Jae-Hwang Lee, Kai-Ming Ho, Kristen P. Constant
  • Attachment of conducting graphene electrode layer to an organic polymer
    Patent number: 9401489
    Abstract: A method of attaching reduced graphene oxide and/or graphene oxide to a polymer layer that includes: forming a polymer layer having a hydrophobic, exterior surface; subjecting the hydrophobic, exterior surface of the polymer layer to ultraviolet/ozone (UV/O3) exposure to change the hydrophobic, exterior surface to a hydrophilic, exterior surface; and applying reduced graphene oxide and/or graphene oxide to the hydrophilic surface of the polymer layer. The UV/O3 exposure reduces the contact angle of droplets on the exterior surface of the polymer layer so that greater amounts of reduced graphene oxide and/or graphene oxide can be applied to the surface.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 26, 2016
    Assignee: The Research Foundation for the State University of New York
    Inventors: Miriam Rafailovich, Rebecca Isseroff, Andrew Chen, Sneha Chittabathini, Alexandra Tse
  • Nanosecond liquid crystalline optical modulator
    Patent number: 9400412
    Abstract: An optical modulator includes a liquid crystal cell containing liquid crystal material having liquid crystal molecules oriented along a quiescent director direction in the unbiased state, and a voltage source configured to apply an electric field to the liquid crystal material wherein the direction of the applied electric field does not cause the quiescent director direction to change. An optical source is arranged to transmit light through or reflect light off the liquid crystal cell with the light passing through the liquid crystal material at an angle effective to undergo phase retardation in response to the voltage source applying the electric field. The liquid crystal material may have negative dielectric anisotropy, and the voltage source configured to apply an electric field to the liquid crystal material whose electric field vector is transverse to the quiescent director direction.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: July 26, 2016
    Assignee: KENT STATE UNIVERSITY
    Inventors: Volodymyr Borshch, Sergij V. Shiyanovskii, Oleg D. Lavrentovich