Abstract: Described herein is the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed herein.
Abstract: The present invention provides a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. The device has a pair of spaced apart sensing electrodes that border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction.
Type:
Grant
Filed:
April 7, 2008
Date of Patent:
July 19, 2016
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The uses of antifreeze proteins (AFPs), including polypeptides, peptides, fragments of AFPs, and mimicries of AFPs, as highly efficient additives for crystal growth control are provided. AFPs are demonstrated to efficiently inhibit the nucleation of commercially and pharmaceutically important compounds (e.g., nucleosides, sugars, salts), increase the supersaturation of their solutions, modify their crystal habits, and result in novel morphologies.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
July 19, 2016
Assignee:
The Trustees of California State University
Abstract: A system and method for transferring agricultural material from a transferring vehicle to a storage portion of a receiving vehicle, and detecting and filling void areas of the agricultural material is disclosed. A transferring vehicle having a spout transfers agricultural material to a storage portion of a receiving vehicle. An imaging device associated with the transferring vehicle and facing towards the storage portion of the receiving vehicle collects imaging data. An image processing module is operable to, based on the imaging data, estimate fill levels of agricultural material within the storage portion; identify an area of the storage portion as targeted to fill; and identify a first void within the targeted area. A controller in communication with the image processing module is configured to command the spout to a position to direct agricultural material to the first void.
Type:
Grant
Filed:
September 30, 2013
Date of Patent:
July 19, 2016
Assignees:
DEERE & COMPANY, IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Matthew J. Darr, Robert McNaull, John Kruckeberg, Zachary T. Bonefas
Abstract: An isotope production target may include an outer diameter wall and an inner diameter wall. An isotope source may be located between the inner diameter wall and the outer diameter wall, and the isotope source may comprise fissile material interspersed with one or more voided regions. A central region may be located within the inner diameter wall, and the central region may be configured to house a neutron thermalization volume.
Type:
Grant
Filed:
July 27, 2011
Date of Patent:
July 19, 2016
Assignee:
OREGON STATE UNIVERSITY
Inventors:
Steven Richard Reese, Todd Stephen Palmer, Stephen Todd Keller, Madicken Munk
Abstract: For global routing using a graphics processing unit (GPU), a method routes a net of node interconnections for a semiconductor design. In addition, the method decomposes the net into subnets. Each subnet has no shared paths. The method further identifies a congested region of the routed net that exceeds routing capacities. In addition, the method correlates the congested region with a plurality of first subnets with workloads within the congested region. The method routes the subnets in parallel using the GPU.
Type:
Grant
Filed:
October 2, 2014
Date of Patent:
July 19, 2016
Assignee:
Utah State University
Inventors:
Yiding Han, Koushik Chakraborty, Sanghamitra Roy
Abstract: Provided are compositions for attracting and/or stimulating oviposition. The compositions comprise a suitable carrier and a bacterium capable of producing nonanoic acid, tetradecanoic acid, or methyl tetradecanoate; Bacillus thuringiensis; Lactococcus lactis; Klebsiella oxytoca; Shigella dysenteriae; Brevundimonas vesicularis; a supernatant of a culture of any of the these bacteria; nonanoic acid; tetradecanoic acid; or methyl tetradecanoate, or any combination thereof, at a concentration effective to attract the mosquito to a target. The compositions may be comprised within a kit or trap. Also provided are methods of attracting mosquitoes to a target.
Type:
Grant
Filed:
November 6, 2009
Date of Patent:
July 19, 2016
Assignee:
North Carolina State University
Inventors:
Loganathan Ponnusamy, Ning Xu, Coby Schal, Charles S. Apperson, Dawn Wesson
Abstract: Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
Type:
Application
Filed:
March 28, 2016
Publication date:
July 14, 2016
Applicant:
The Ohio State University Research Foundation
Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments for identifying material. An embodiment includes ionizing, in gas phase, a target substance; creating, in gas phase, a pulse of ionized material from the ionized target substance; injecting the pulse of ionized material into a condensed phase drift medium; and identifying, by at least one processor, the target substance using the pulse of ionized material in the condensed phase drift medium.
Type:
Application
Filed:
June 11, 2014
Publication date:
July 14, 2016
Applicants:
The MITRE Corporation, Washington State University
Abstract: Systems for providing a chronically ill patient with medical alerts, pharmacological alerts and information are disclosed that includes: a mobile device comprising a GPS receiver, a display, a microprocessor and a wireless communication transceiver, the mobile device programmed to process encrypted medical data, medical tags and medical information through an application; a server comprising a central processing unit, a memory, a clock and a server communication transceiver that receives input from the wireless communication transceiver of the mobile device, the memory having encrypted medical data, medical tags and medical information stored therein for a plurality of chronically ill patients, the central processing unit programmed to: receive encrypted medical data, medical tags and medical information from the mobile device; analyze the encrypted medical data, medical tags and medical information from the mobile device; generate a new set of unique and revised encrypted medical data, medical tags and medic
Type:
Application
Filed:
October 20, 2015
Publication date:
July 14, 2016
Applicant:
The Trustees of the California State University AKA California State University San Marcos
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Type:
Application
Filed:
February 10, 2016
Publication date:
July 14, 2016
Applicant:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
Abstract: A new and distinct Corylus plant named ‘McDonald’ characterized by moderate vigor and upright-spreading plant habit, yellowish-green developing and fully expanded leaves during the spring and summer, resistance to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller, presence of random amplified polymorphic DNA markers 152-800 and 268-580 in DNA, expression of incompatibility alleles S2 and S15 in the styles, and DNA fingerprints at 14 of 21 microsatellite marker loci differ from both parents, ‘Tonda Pacifica’ and ‘Santiam’, and from one parent at an additional 5 marker loci.
Type:
Application
Filed:
January 13, 2015
Publication date:
July 14, 2016
Applicant:
Oregon State University
Inventors:
Shawn A. Mehlenbacher, David C. Smith, Rebecca L. McCluskey
Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.
Type:
Application
Filed:
December 17, 2015
Publication date:
July 14, 2016
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
Abstract: Methods are provided for modulating the activity of multimeric ubiquitin-protein E3 ligases including, but not limited to, E6AP ligase activities. The methods reduce the level of oligomer formation such as homotrimeric E6AP ligase to reduce the enzyme activity. Alternatively, agents are provided that can promote the association of the ligase monomers, thereby increasing the ligase activity. Accordingly, novel therapeutic strategies are provided that are useful for the treatment of pathologies resulting from mutations in the genes encoding the ligases and which adversely increase or decrease a ubiquitination reaction.
Type:
Application
Filed:
March 31, 2016
Publication date:
July 14, 2016
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Methods and kits for detection of bacteria, especially Salmonella spp. and Listeria spp., are provided using a unique combination of selective ingredients and two-phase culture (solid-phase culture gel and liquid-phase culture/enrichment broth) allows for high sensitivity and specificity of the kits for growth of Salmonella and Listeria in the detection methods and kits. The invention, through the detection mechanism accomplished by the novel formulation of selective ingredients and the two-phase culture, allows for real-time detection of a single cell of Salmonella and Listeria within 24±2 hours of introducing a target sample to the Salmonella and Listeria detection kits. The detection methods and kits for Salmonella may optionally further comprise a confirmation step that can increase sensitivity and accuracy for this pathogenic bacteria.
Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
Type:
Application
Filed:
June 26, 2013
Publication date:
July 14, 2016
Applicant:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Inventors:
Yuri Bushkin, Maria L. Gennaro, Sanjay Tyagi, Richard Pine
Abstract: The present invention provides a system to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a microturbine.
Type:
Grant
Filed:
December 8, 2015
Date of Patent:
July 12, 2016
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Passinam Tatcho, Mischa Steurer, Hui Li
Abstract: The present invention provides a system to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a wind turbine.
Type:
Grant
Filed:
December 8, 2015
Date of Patent:
July 12, 2016
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Passinam Tatcho, Mischa Steurer, Hui Li
Abstract: The present invention provides a system to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject a direct current (DC) signal from the controllable voltage source converter of at least one DC voltage distributed resource into the distribution system and modulating an alternating current (AC) signal on top of the direct current (DC) signal.
Type:
Grant
Filed:
December 8, 2015
Date of Patent:
July 12, 2016
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Passinam Tatcho, Mischa Steurer, Hui Li
Abstract: For multi-node encryption, a method generates an upstream node nonce from communication data exchanged with an upstream node. In addition, the method generates a first upstream message transformation as a function of the upstream node nonce. The method further generates a tunnel transformation as a function of previous upstream message transformations and the first upstream message transformation.