Abstract: Type 1 diabetes (T1D) patients make antibodies to self-proteins that are potential biomarkers for early detection and risk prediction. We have identified seventeen antigens as biomarkers for early diagnosis and risk prediction of T1D, including the antigens MLH1, MTIF3, PPIL2, NUP50, TOX4, FIGN, C9orf142, ZNF280D, HES1, QRFPR, CTRC, SNX6, SYTL4, ELA2A, IGRP, PAX6, and HMGN3.

Abstract: Devices, methods, and systems for providing a solid grain fuel for a hybrid rocket. In one embodiment, the solid grain fuel includes a housing having a length extending between a first side and a second side. The housing defines a central axis and a bore extending from the first side to the second side. The bore of the housing extends with a helical configuration along the length of the housing. Further, the housing includes multiple segments configured to interlock together to form the bore along the length of the housing.

Abstract: A pressure sensitive adhesive construct comprising: (a) a backing substrate; and (b) a pressure sensitive adhesive composition disposed on the backing substrate, wherein the pressure sensitive adhesive includes a product made from at least one epoxidized vegetable oil and at least one dibasic acid or anhydride, or a combination of a dibasic acid or anhydride and a monobasic acid or anhydride.

Abstract: Platinum compounds of Formulas I and II useful in a variety of devices, such as, for example organic-light emitting diodes (OLEDs).

Abstract: Provided is a fluidic device including a main channel, wherein a first inlet fluidly connects to an upstream end of the main channel and introduces magnetic beads into a first side of the main channel. A second inlet is fluidly connected to the upstream end of the main channel and introduces a sample stream into a second side of the main channel. A magnet disposed adjacent to the second side of the main channel pulls the magnetic beads towards a sidewall of the second side, and thus into the sample stream. The beads continue through an extended incubation channel before entering a return channel. The return channel includes a detection region. Also provided is a multi-layer micro-fluidic assay device. An assay method that utilizes a microfluidic assay device is provided as well.

Abstract: Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.

Abstract: Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structural importance. The polymers are capable of high-yield production for a variety of applications.

Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.

Abstract: Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.

Abstract: The described invention provides a packaged electrochemical device comprising an electrochemical battery, further comprising at least one electrochemical cell stack and a barrier packaging material. The present invention further provides a method of fabricating the packaged electrochemical device. The present invention further provides a flexible multifunctional liquid-based thermogalvanic cell that converts and stores electricity derived from low grade temperature differentials that exist in ubiquitous scenarios.

Abstract: The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.

Abstract: The present invention provides a compound having the structure: wherein X is an imaging agent containing at least one amine nitrogen; Y is a chemical linker, wherein Y is present or absent, and when present Y is a chemical linker containing at least one amine nitrogen or Y is a para-aminobenzyl alcohol linker; Z is CH3 or CF3; R1 is —H, —NR2R3, —NH—C(?O)—R4, —NH—C(?O)—OR4, —CH2—C(?O)—NR5R6, —OR7, —CO2R7, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, or heteroaryl, wherein R2, R3, R4, R5, R6 and R7 are each, independently, —H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, an amino acid or an oligopeptide; wherein an amine of the amino acid or oligopeptide is substituted or unsubstituted; and n is an integer from 0 to 6; or a diastereomer, enantiomer or pharmaceutically acceptable salt of the compound.

Abstract: Described herein are methods and compositions for the diagnosis and treatment of lung cancers. Methods of identifying inhibitors of tumorigenesis are also provided.

Abstract: An encapsulated polymer stabilized cholesteric texture (EPSCT) light shutter is formed from a cholesteric liquid crystal and monomer that is encapsulated into micron sized, polymer-coated droplets by either an emulsification or phase separation process. The polymer-coated droplets are disposed between transparent electrodes, where they are irradiated by ultra-violet (UV) light to polymerize the monomer.

Abstract: A medium access control (MAC) protocol may be used to facilitate communication between nodes in a network. A protocol for allocating network resources between a set of nodes with demands may be an adaptive topology- and load-aware (TLA) allocation protocol. The allocation protocol may be executed by a bidder algorithm and an auctioneer algorithm on each node of the network. Claims and offers may be generated at each node and transmitted to other nodes on the network. The claims and offers may be updated as load and topology of the network change.

Abstract: The invention is directed to methods and metric suitable for use in determining the solubility, expression and usability of a polypeptide encoded by a nucleic acid sequence. In certain aspects, the invention also relates to methods for introducing modifications in a polypeptide, for example through substitution of one or more codons in the nucleic acid sequence encoding the polypeptide, to increase or decrease the solubility, expression or usability of the polypeptide.

Abstract: A surface polymer-assisted vertically aligned (SPA-VA) liquid crystal (LC) cell has a surface alignment layer of surface localized polymer nano spikes capable of controlling the pretilt angle of liquid crystal molecules and ensuring fast switching characteristics. The deposition of the polymer nanospikes as a part of the alignment layer is achieved by polymerizing a small amount of a reactive monomer in vertically aligned liquid crystal with or without an applied voltage. Due to the alignment of liquid crystal molecules by the surface alignment layers, the polymerized polymer acts as an internal surface to modify and control the field-induced reorientation of the liquid crystal molecules. The SPA-VA LC cell realizes a stable alignment and the considerable advantage of the formation of polymer spikes via UV irradiation on both substrates of the cell. Furthermore, the switch-off of a SPA-VA is fast due to the enhanced surface anchoring strength by the surface-localized polymer nano spikes.

Abstract: A high throughput bioluminescence mutant screening procedure is disclosed. This procedure utilizes robotics, and bacterial luciferase to allow real-time monitoring of mutant viability. The procedure was used to decelop a live attenuated vaccine for a catfish against E. ictaluri, which is further claimed herein. Additionally, genes from other bacterial species are disclosed which may also be used to create vaccines.

Abstract: The present invention provides a method of producing a crystalline rare earth phosphate nanostructure. The method comprising: providing a rare earth metal precursor solution and providing a phosphate precursor solution; placing a porous membrane between the metal precursor solution and the phosphate precursor solution, wherein metal cations of the metal precursor solution and phosphate ions of the phosphate precursor solution react, thereby producing a crystalline rare earth metal phosphate nanostructure.

Abstract: ‘Pinnacle’ is a new and distinct variety of blueberry plant that has the following unique combination of desirable features outstanding in a new variety. ‘Pinnacle’ provides season ripening when prices remain high and consistently good yields of large size fruit. In addition, ‘Pinnacle’ provides high percentages of fruit in very large diameter categories, which are tailored for premium market outlets, very good fruit color and quality, excellent fruit firmness and fruit with very good post-harvest shelf-life.