Abstract: The present disclosure provides for an expression system for the production of blue pigment indigoidine. The system comprises a heterologous host cell, a DNA sequence encoding a Sc-IndB protein, and a DNA sequence encoding a Sc-IndC protein. The system may be configured for the co-expression of the Sc-IndB and Sc-IndC. DNA sequences encoding the Sc-IndB and Sc-IndC may be provided on at least one vector. Alternatively, the DNA sequences encoding the Sc-IndB and Sc-IndC may optionally be integrated into the genome of the heterologous host genome. The expression system may further comprise a sfp gene or a PPTase.
Abstract: Methods and materials for producing meso-biliverdin are provided where the methods include reacting phycocyanobilin with an amphoteric compound in a solvent to yield meso-biliverdin.
Type:
Grant
Filed:
October 12, 2012
Date of Patent:
January 26, 2016
Assignee:
Utah State University
Inventors:
Jon Y. Takemoto, Dong Chen, Cheng-Wei T. Chang
Abstract: Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications.
Abstract: A composition, reactor apparatus, method, and control system for growing epitaxial layers of group III-nitride alloys. Super-atmospheric pressure is used as a process parameter to control the epitaxial layer growth where the identity of alloy layers differ within a heterostructure stack of two or more layers.
Type:
Grant
Filed:
August 12, 2010
Date of Patent:
January 26, 2016
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: The present invention relates to methods for rapid crystallization of amino acids, drug molecules, proteins and DNA/peptides. One method for rapid crystallization of functional group-containing molecules selected from the group consisting of amino acids, drug molecules, proteins and DNA/peptides includes (A) providing at least one metal or metal oxide in particulate or thin film form to provide (a) selective nucleation sites for crystallization of the functional group-containing molecules due to interactions of their functional groups and metal surfaces or engineered metal surfaces and (b) a microwave-transparent medium to create a thermal gradient between the metal surfaces or engineered metal surfaces and a warmer solution containing functional group-containing molecules to be crystallized, and (B) conducting microwave heating to cause the functional group-containing molecules to be crystallized.
Abstract: Devices and techniques for using four wave mixing in optical sensing of various materials, including isotopes, chemical and biological substances.
Abstract: A method for determining a replication timing footprint comprises the following steps: (a) selecting a set of chosen regions of the replication timing profile of a chromosome of an individual, (b) choosing a set of selected regions from the set of chosen regions to form a set of selected regions and a set of unused regions, (c) conducting a iterative algorithm on the set of selected regions until a domain number for the set of selected regions has decreased to a predetermined minimum, (d) determining a replication timing footprint based the set of selected regions after step (c) has been conducted, and (e) displaying the replication timing footprint to a user.
Type:
Grant
Filed:
August 27, 2012
Date of Patent:
January 26, 2016
Assignee:
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
David M. Gilbert, Tyrone Ryba, Jinfeng Zhang
Abstract: A method and apparatus for LCL resonant converter control utilizing Asymmetric Voltage Cancellation is described. The methods to determine the optimal trajectory of the control variables are discussed. Practical implementations of sensing load parameters are included. Simple PI, PID and fuzzy logic controllers are included with AVC for achieving good transient response characteristics with output current regulation.
Abstract: The present invention is directed to natural blue anthocyanin-containing colorants comprising fractions of anthocyanin molecules separated from anthocyanin-containing vegetable and fruit juices and extracts. Anthocyanin fractions are separated at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts. The invention is directed to the anthocyanin fractions providing color characteristics similar to those provided by the synthetic blue colorant, FD&C Blue No. 1. The present invention is also directed to natural green colorants comprising the natural blue anthocyanin-containing colorant and a natural yellow colorant. The present invention is further directed to edible products comprising the natural blue anthocyanin-containing colorants.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 21, 2016
Applicants:
THE OHIO STATE UNIVERSITY, MARS, INCORPORATED
Inventors:
Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
Abstract: A multicaloric alloy material combines two isostructural compounds, the first compound being MnNiSi and the second compound being either MnFeGe or CoFeGe, each such compound having extremely different magnetic and thermo-structural properties. The resulting alloy material (MnNiSi)1-x(MnFeGe)x or (MnNiSi)1-x(CoFeGe)x possesses extraordinary magnetocaloric and/or barocaloric properties with an acute sensitivity to applied pressure and no appreciable magnetic hysteresis losses.
Type:
Application
Filed:
July 17, 2015
Publication date:
January 21, 2016
Applicants:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
Inventors:
Tapas Samanta, Shane Stadler, Naushad Ali
Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with said first and second volumes of fluid, and means for applying an electric potential difference between said first and second volumes of fluid. In some such embodiments, a conjugate product is provided which comprises charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving a product in the first volume of fluid, the product is directed into the orifice.
Type:
Application
Filed:
March 5, 2014
Publication date:
January 21, 2016
Applicant:
ARIZONA BOARD OF REGENTS ACTING FOR AND On behalf of ARIZONA STATE UNIVERSITY
Abstract: The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 21, 2016
Applicants:
THE OHIO STATE UNIVERSITY, MARS, INCORPORATED
Inventors:
Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 21, 2016
Applicant:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Inventors:
Neal WOODBURY, Stephen JOHNSTON, Phillip STAFFORD
Abstract: An optical modulator includes a liquid crystal cell containing liquid crystal material having liquid crystal molecules oriented along a quiescent director direction in the unbiased state, and a voltage source configured to apply an electric field to the liquid crystal material wherein the direction of the applied electric field does not cause the quiescent director direction to change. An optical source is arranged to transmit light through or reflect light off the liquid crystal cell with the light passing through the liquid crystal material at an angle effective to undergo phase retardation in response to the voltage source applying the electric field. The liquid crystal material may have negative dielectric anisotropy, and the voltage source configured to apply an electric field to the liquid crystal material whose electric field vector is transverse to the quiescent director direction.
Type:
Application
Filed:
July 16, 2014
Publication date:
January 21, 2016
Applicant:
KENT STATE UNIVERSITY
Inventors:
Sergij V. Shiyanovskii, Volodymyr Borshch, Oleg D. Lavrentovich
Abstract: A bistable liquid crystal spatial light modulating (SLM) device (SLM) device utilizes the homeotropic and bubble domain texture change of a cholesteric liquid crystal that is responsive to external stimuli, such as electric voltage, light and pressure. The SLM device is configured to be switched between the two stable textures of the bubble domain texture or the fingerprint texture. In addition, the SLM device may be switched between transparent and light-scattering states by the application of an electric field, light irradiation or physical/mechanical pressure. The light transmission state and the light-scattering states of the present invention are also stable in time at zero voltage, and are reversible upon the application of an external field at a different voltage, frequency or wavelength of light.
Abstract: A coplanar waveguide transmission line for use in detecting biomolecules and bioparticles is provided that includes a signal conductor disposed on a top surface of the dielectric substrate, a ground conductor disposed on the top surface of the dielectric substrate on each side of the signal conductor, a continuous gap defined between the signal conductor and each of the ground conductors, micro-channels disposed below a top surface of the dielectric substrate, and reservoirs disposed below the top surface of the substrate.
Type:
Application
Filed:
July 17, 2015
Publication date:
January 21, 2016
Applicant:
WRIGHT STATE UNIVERSITY
Inventors:
Elliott R. Brown, Leamon Viveros, Edgar A. Mendoza
Abstract: A method for preventing colorectal cancer in a patient possessing human tropomyocin isoform TC22 is disclosed. The method comprises: (a) detecting a serum protein concentration of TC22 in a patient and (b) administering to said patient prior to detecting colorectal cancer in said patient a therapeutically effective amount of a chemotherapeutic composition comprising a chemotherapeutic compound that reduces the level of TC22, wherein the chemotherapeutic compound is selected from the group consisting of sulfasalazine, 5-amino-2-hydroxybenzoic acid, osalazine, and balsalazide.
Type:
Grant
Filed:
May 17, 2006
Date of Patent:
January 19, 2016
Assignees:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, UNIVERSITY OF IOWA RESEARCH FOUNDATION
Abstract: Platinum and palladium complexes are disclosed that can be useful as narrow band phosphorescent emitters. Also disclosed are methods for preparing and using the platinum and palladium complexes.
Type:
Grant
Filed:
May 24, 2012
Date of Patent:
January 19, 2016
Assignee:
ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: A system and method of management of communication in a potentially unreliable wide-area network that contains one or more nodes connected to said network, each potentially having access to one or more inputs and/or outputs and capable of evaluating said inputs and directing said outputs, a global address space (GAS) accessible by said nodes, and a communication system using said GAS that provides communications between said nodes.
Type:
Grant
Filed:
July 10, 2013
Date of Patent:
January 19, 2016
Assignee:
Board of Supervisors of Louisiana State University and Agriculture and Mechanical College
Inventors:
Supratik Mukhopadhyay, S. Sitharama Iyengar
Abstract: A method for using a location-based service while preserving anonymity includes receiving a location associated with a mobile node, receiving an anonymity level associated with the mobile node, computing a region containing the location of the mobile node and a number of footprints based on the anonymity level, wherein each of the footprints from a different user, and providing the region to a location-based service to thereby preserve anonymity of the mobile node. A method also allow a mobile device or its user to specify the anonymity level by selecting a public region consistent with a user's feelings towards desired privacy.
Type:
Grant
Filed:
August 29, 2014
Date of Patent:
January 19, 2016
Assignee:
Iowa State University Research Foundation, Inc.