Abstract: An isolated antibody having a specific binding affinity for a polypeptide comprising the amino acid sequence HTEGKP (SEQ ID NO: 2) phosphorylated at threonine is described. The antibody may be used as biomarker for mitotic cells. A method for using the antibody includes contacting a cell with the antibody and detecting antibody bound to the cell as an indicator of the cell being in the mitotic state. A reagent kit comprising the antibody is also described.

Abstract: The present invention provides for monophosphorylated lipid A derivatives and carbohydrate derivatives that are useful as agents in the treatment of diseases and conditions, including cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I-IV. In addition, methods for the treatment of cancers are provided.

Abstract: An electrical capacitance tomography sensor comprised of a sensor having a plurality of electrodes, where each electrode is further comprised of a plurality of capacitance segments. Each of the capacitance segments of each electrode can be individually addressed to focus the electric field intensity or sensitivity to desired regions of the electrodes and the sensor.

Abstract: Disclosed are RNA targeting compounds, methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed.

Abstract: A phase retarder comprises first and second ?-cells or other tunable birefringent devices arranged optically in series. The phase retardation value of the phase retarder is a difference between the phase retardation values of the first and second ?-cells. Driving circuitry drives the phase retarder to generate a target phase retardation value by: (1) prior to a relaxation period, biasing the ?-cells to produce the target phase retardation value; (2) during the relaxation period, biasing the first ?-cell at a constant bias value; and (3) during the relaxation period, lowering the bias value of the second ?-cell continuously or stepwise to maintain the target phase retardation value for the phase retarder throughout the relaxation period. In some embodiments the operation (2) comprises applying zero bias to the first ?-cell throughout the relaxation period. In some embodiments the operation (1) comprises applying a maximum operational bias to the second ?-cell.

Abstract: The present invention relates to the use of natural isotopes 44Ca/42Ca 87Sr/86Sr as biomarkers to measure changes in bone mineral balance and loss.

Abstract: A hermetically-sealed, ohmic heating packet for storing, heating and sterilizing food and beverage items. The packet is formed of a multilayer laminate material having interior and exterior polymer layers and an intermediate metallic foil layer. Conductive tags on the exterior of the packet are electrically connected to electrodes on the interior of the packet through reverse-patched regions of the packet's sidewalls. The configuration of the electrical connection prevents current from leaking into the metallic foil layer of the packet during heating, thereby mitigating the risk of a short circuit condition in the packet. The rectangular prism geometry of the packet and the parallel configuration of the electrodes within the packet facilitate uniform heating of the packet's contents.

Abstract: Systems and apparatuses for a secure mobile cloud framework (referred to as MobiCloud) for mobile computing and communication are disclosed. Embodiments of MobiCloud transfer each mobile node from a traditional strictly layer-structured communication node into a service node (SN). Each SN may be used as a service provider or a service broker according its capability. Each SN may be incorporated as a virtualized component of the MobiCloud. In some embodiments, MobiCloud mirrors an SN to one or multiple virtual images in the Cloud for addressing communication and computation deficiencies of mobile devices. Virtual images can create a visualized MANET routing and communication layer that can maximally assist the mobile nodes to enable pervasive computing services for each mobile device owner. A secure data processing framework is disclosed for the MobiCloud.

Abstract: This disclosure includes systems and methods for extracting hydrocarbons from a geologic structure. Some systems use or include a well-bore that extends at least partially through the geologic structure, a first electrode disposed within the wellbore, an ionically conductive medium in fluid communication with the first electrode, a second electrode in electrical communication with the first electrode, and a power source configured to establish an electrical current between the first and second electrodes to cause an electrochemical reaction. Some systems are configured to facilitate extraction of hydrocarbons from a geologic structure.

Abstract: The presently-disclosed subject matter includes methods for producing liquid hydrocarbons from syngas. In some embodiments the syngas is obtained from biomass and/or comprises a relatively high amount of nitrogen and/or carbon dioxide. In some embodiments the present methods can convert syngas into liquid hydrocarbons through a one-stage process. Also provided are catalysts for producing liquid hydrocarbons from syngas, wherein the catalysts include a base material, a transition metal, and a promoter. In some embodiments the base material includes a zeolite-iron material or a cobalt-molybdenum carbide material. In still further embodiments the promoter can include an alkali metal.

Abstract: Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome M. tuberculosis bacterial resistance to an existing antibiotic.

Abstract: Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species.

Abstract: The subject invention provides a method of reducing the presence of toxic intermediates of amyloidosis from islet amyloid polypeptide (IAPP) in a patient, comprising administering a compound to the patient a compound having the structure: (Formula 1) wherein R1 and R2 are each independently hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, or R1 and R2 are linked so as to form a cyclopropyl cyclobutyl, cyclopentyl, or cyclohexyl ring; wherein R3, R4, R5, R6 are each independently hydrogen, fluorine or chlorine; and wherein R7 is hydrogen, phenyl, fluorine, chlorine, bromine, hydroxyl, amine, carboxylic acid, C1-C6 alkyl carboxylate, amide, methyl, ethyl, butyl, pentyl, hexyl, or a pharmaceutically acceptable salt or ester thereof, so as to thereby reduce the presence of toxic intermediates of amyloidosis from islet amyloid polypeptide (IAPP) in the patient.

Abstract: Methods for sample collection for assessment of air quality include generating an atmospheric condensate from air to be sampled, and collecting the atmospheric condensate in a collection vessel for subsequent use and analysis. Atmospheric condensate may be generated through a heat exchange module, such as a cold trap or the cooling coils of an HVAC system. The collection vessel may be an ultraclean glass jar or a cold trap. Air may be sampled actively or passively for both chemical and biological agents.

Abstract: The analysis tool employs a computer-implemented algorithm that uses homotopy-based approaches to map the solution from the exit point to the controlling unstable equilibrium point (UEP). The computational time is reduced significantly by using an approximate exit point rather than computing an accurate exit point as it is required in finding the controlling UEPs using traditional transient stability direct methods. In addition, this method eliminates the necessity of computing the minimum gradient point (MGP) which is a key element in using Newton methods. These properties provide an advantage to homotopy-based approaches over traditional iterative methods in terms of both speed of computation and reliability of finding solutions.

Abstract: This invention relates generally to a field of rational drug design. In particular, the present invention relates to a 19 F NMR assay for screening inhibitors of specific protein-target interactions, preferably those that inhibit influenza A NS 1 protein and can be useful in treating influenza A viral infections. The invention also relates to agents, compositions, and methods for treating influenza A viral infections.

Abstract: The present invention relates to (i) novel fluoroionic compounds capable of dispersing particulate filler compositions into a fluoropolymer; (ii) novel particulate compositions in which particulates are surface-functionalized with a fluoroionic compound; (iii) fluoropolymer composite materials containing the surface-functionalized particulates of (ii) incorporated into a fluoropolymer; (iv) crosslinked versions of (iii); v) methods for producing the crosslinked material of (iv); and (vi) articles of manufacture containing the compositions (iii) and (iv).

Abstract: A low phase noise dual mode resonator and a method of making and using said resonator is disclosed. The dual mode resonator is capable of sustaining two frequency vibration modes simultaneously. The two frequency vibration modes are capable of exhibit non-linear coupling when one is driven at a higher voltage than the other. The dual mode resonator is configured such that the ratio of the two vibration frequency modes is a value that maximizes the non-linear coupling effect. As a result of the non-linear effect, the phase noise on the mode that is not overdriven is reduced.

Abstract: Methods for aligning nanoscale fibers are provided. One method comprises providing a network of nanoscale fibers and mechanically stretching the network of nanoscale fibers in a first direction. The network of nanoscale fibers is substantially devoid of a liquid. A network of aligned nanoscale fibers and a composite comprising a network of aligned nanoscale fibers are also provided.

Abstract: The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.