Abstract: Mechanoluminescent devices and articles, such as wearable articles, that include mechanoluminescent devices. The mechanoluminescent devices may have a lateral type architecture or a vertical type architecture. The mechanoluminescent devices may be sensors, including pressure sensors.

Abstract: Provided is a particle detection device and method of fabrication thereof. The particle detection device includes a scintillator array that includes a plurality of scintillator crystals; a plurality of detectors provided on a bottom end of the scintillator array; and a plurality of prismatoids provided on a top end of the scintillator array. Prismatoids of the plurality of prismatoids are configured to redirect particles between top ends of crystals of the scintillator array. Bottom ends of a first group of crystals of the scintillator array are configured to direct particles to a first detector of the plurality of detectors and bottom ends of a second group of crystals of the scintillator array are configured to direct particles to a second detector substantially adjacent to the first detector.

Abstract: Disclosed herein are low density particles comprising polymerized fibrin that are micrometer or nanometer sized in diameter. The particles can further include at least one therapeutic agent. The particles may be used to treat wounds, by administration directly or systemically to the site of the wound. Exemplary wounds that may be treated with the fibrin particles include a trauma wound, a surgical wound, a burn wound, or an ulcer wound. Also disclosed herein are methods for preparing the particles using a shearing process.

Abstract: Devices, systems, and methods for drying a bulk waste product, such as animal waste, having a moisture content of 95% or more water can include a trough configured to receive the bulk waste product and to dispense it in a form suitable for convective drying, one or more conveyors having an air-permeable conveyor belt, each conveyor receiving the waste product from the trough and transporting the waste product along a transport path; and one or more air moving devices (AMDs) that pass air through the air-permeable conveyor belt and across the waste product as it is transported along the transport path to transform the bulk waste product into a dried waste product having a moisture content of about 5% to about 20%, inclusive.

Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.

Abstract: A method of light messaging, in which a hidden message is transmitted via coded image emitted from a display device and retrieved using a camera, comprises training a camera-display transfer model that receives images with hidden messages from an embedding model and generates modified coded images based on training data that accounts for properties of displays and cameras, the modified coded images delivered to a recovery model that decodes the hidden messages and outputs hidden message determinations, training both the embedding and recovery models using the CDTF model and training data to minimize differences between the input hidden messages and the hidden message determinations. After training the CDTF model and other models, embedding a hidden message in a carrier image using the embedding model, displaying the coded image using the display device, receiving the coded image at the camera, and retrieving the hidden message using the recovery model.

Abstract: Precast construction elements are described suitable for use in high seismic areas. The precast construction elements can be precast, pre-topped double tees. The precast construction elements incorporate a passive energy dissipation device in a flange. The energy dissipation device provides a ductile connection having a deformation capacity of larger than 0.6?. Adjacent elements are connected to one another at joints that include the passive energy dissipation device. Passive energy dissipation devices can be passive hysteretic dampeners, such as U-shaped flexural plates. Passive energy dissipation devices can be bar dissipaters (e.g., grooved dissipaters). Also described are passive hysteretic dampers that include U-shaped flexural plates held in conjunction with a reinforcement element that defines a circle around which the flexural plate can bend.

Abstract: Disclosed herein are microneedle devices, kits comprising the microneedle devices, and methods of using the microneedle devices. Specifically, disclosed is a device for transport of a material across a biological barrier of a subject comprising: a plurality of microneedles each having a base end and a tip, with at least one pathway disposed at or between the base end and the tip; a substrate to which the base ends of the microneedles are attached or integrated; and at least one reservoir which is in connection with the base ends of the microneedles array, wherein the reservoir comprises an agent delivery system, wherein the agent delivery system comprises an agent to be transported across the biological barrier, or a means for producing an agent to be transported across the biological barrier, and a means for detecting a physiological signal from the recipient.

Abstract: The present invention provides for polycrystalline superconducting permanent magnets which are synthesized of doped superconducting (AE) Fe2As2 compounds, where AE denotes an alkaline earth metal, such as Ba, Sr, Mg or Ca. The superconducting permanent magnets of the present invention can be magnetized in their superconducting state by induced currents, resulting in trapped magnetization that scales with the size of the bulk material. The magnitude of the trapped field has been demonstrated to be over 1 T and is predicted to be over 10 T if the technology is scaled, which is much higher than the capabilities of permanent magnets and other superconducting polycrystalline bulks currently known in the art.

Abstract: A system and method for generating a predictive model include accessing data from a dynamic dataset and a static dataset, generating a unique individual profile for each of a plurality of subjects within a population, assigning a class attribute to each subject, and based on the unique individual profile and the class attribute for each subject, developing a classification model based on the unique individual profile and the class attribute for each of the plurality of subject, and generating an individual score for each of the plurality of subjects using the classification model. The unique individual profile is generated from the data in the dynamic and the static datasets.

Abstract: A magnetic shape memory (MSM) microfluidic device may include a flexible membrane positioned between a channel and an MSM element. The MSM element may engage the flexible membrane to deform the channel at portions of the flexible membrane that are adjacent to non-contracted portions of the MSM element. The flexible membrane may prevent contact between a fluid within the channel and the MSM element. Magnetic field components may be applied to the MSM element and moved along the MSM element enable fluidic flow within the channel while. The device may include an upper portion including the flexible membrane and a lower portion including the MSM element. The upper portion may be interchangeable with additional upper portions.

Abstract: Provided herein are imaging probes and systems and methods employing such imaging probes for real-time, label-free, multiplexed imaging of RNAs in living cells. More particularly, aptamer-based sensors (“aptasensors”) and molecular fuses comprising multiple aptasensors are genetically encoded imaging probes comprising RNA-target binding sequence and an intramolecular reconfiguration sequence. The probe is configured such that binding of a RNA target by the RNA-target binding sequence triggers the intramolecular reconfiguration sequence to reconfigure such that an optically detectable output is generated by the probe.

Abstract: Microphones, microphone systems, and methods for capturing and processing sound are described. The microphones and microphone systems may adaptively change the direction from which sound is captured. The microphones and microphone systems avoid the need to provide arrays of microphones, while providing adaptive beamforming without a time delay between each channel of information, and multi-directional sound capture. A dependency between the frequency response and system size is also avoided.

Abstract: A unique pipeline is employed for biomarker discovery that entailed domain antibody phage display, next generation sequencing analysis, and nanotechnology strategies to generate antibody mimetics are disclosed. Also disclosed are the temporal biomarkers of traumatic brain injury and their methods of use. In some embodiments, the temporal biomarkers are synthetic peptides comprising the HCDR3 sequences identified using the disclosed pipeline. In some aspects, the synthetic peptides have less than 30 amino acid residues and comprise a biotin scaffold that is linked to the HCDR3 sequences.

Abstract: Disclosed herein are metal-organic frameworks and methods of making and use thereof.

Abstract: The invention provides compounds formula (I) and salts thereof: wherein R1-R2 have any of the values defined in the specification. The compounds are useful for treating conditions including Alzheimer? s disease, Parkinson’s disease, diabetes, cancer, inflammation, hyperresponsiveness, allergic conditions, asthma, and psychotic disorders such as schizophrenia. The compounds are also useful to lower IL-4, IL-5, or IL-15 levels in an animal.

Abstract: Engineered CRISPR proteins may be generated for localized anchoring to targeted cellular locations. Engineered CRISPR proteins may be generated by a lipidation motif with a CRISPR protein. The lipidation motif may be post-translationally modified to anchor the lipidation motifs and the fused CRISPR protein to a targeted cellular location, such as membranes of organelles associated with viral infections or other ailments. To account for possible additional amino acids that might affect the efficiency of post-translational modifications, linkers derived from C-terminal ends OAS1 (p46 isoform) and ZAP-L proteins may be used. Different fusion designs and/or different lipidation motifs may be used to target CRISPR proteins to specific and respective cellular locations. Targeted cellular localization of engineered CRISPR proteins may enable targeted therapies involving the engineered CRISPR proteins.

Abstract: A high-performance computing (HPC) framework for accelerating sparse Cholesky factorization on field-programmable gate arrays (FPGAs) is provided. The proposed framework includes an FPGA kernel implementing a throughput-optimized hardware architecture for accelerating a supernodal multifrontal algorithm for sparse Cholesky factorization. The proposed framework further includes a host program implementing a novel scheduling algorithm for finding the optimal execution order of supernode computations for an elimination tree on the FPGA to eliminate the need for off-chip memory access for storing intermediate results. Moreover, the proposed scheduling algorithm minimizes on-chip memory requirements for buffering intermediate results by resolving the dependency of parent nodes in an elimination tree through temporal parallelism.

Abstract: The invention provides American chestnut leaf compositions comprising oxalate oxidase. The compositions reduce oxalate levels in dietary sources of oxalate and are useful in reducing oxalate levels and reducing stone disease in patients. The invention provides methods of extracting and purifying oxalate oxidase from American chestnut leaf. The invention provides methods of extracting oxalate from biological samples.

Abstract: Described herein is a technique (e.g., apparatus and method) to improve consistency of lumbar lordosis (LL) and disc height index (DHI) measurements. In at least one embodiment, one or more processors are to measure lumber spine based, at least in part, on cross-sectional area and optical center of mass of segmented intervertebral discs (IVDs).