Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).

Abstract: An assay device includes an electrochemical testing assembly having a test channel including a capture reagent selected to capture a target analyte and an electrode having a surface in communication with the test channel. The assay device further includes a microfluidic network in communication with the test channel, a buffer fluid inlet in communication with the microfluidic network, and a detection reagent disposed within the microfluidic network. When a buffer fluid is provided to the buffer fluid inlet, the buffer fluid transports the detection reagent to the test channel by capillary-driven flow, and wherein the electrode is configured to measure an electrical response indicating capture of the target analyte by the capture reagent after transportation of the detection reagent to the test channel.

Abstract: This disclosure provides an improved assay capable of identifying and distinguishing viral variants, such as SARS-CoV-2 variants and subvariants, including Alpha, Beta, Gamma, Delta, and Omicron, with high specificity and sensitivity. The disclosed assay can be used for real-time monitoring of viral variants (e.g., SARS-CoV-2 variants) spread without the need for whole-genome sequencing on all samples.

Abstract: Compositions and methods for rapid and efficient Toehold mediated strand displacement (TMSD) reactions are disclosed.

Abstract: Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of virions connected to the first surface via one or more linker moieties, wherein viral envelopes of the virions display one or more proteins that bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the virions to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the virions over a duration. Related virion oscillator array devices, systems and computer readable media are also provided.

Abstract: A method of calculating a boundary value of a set of numerical values in a volatile memory comprises storing a set of numerical values in a volatile memory, initializing a comparison vector, initializing a matching vector, transpose-copying a first bit of each of the set of numerical values into a buffer, calculating a result vector, updating the matching vector, repeating the previous steps for each of the bits in the set of numerical values, and returning the matching vector, where the position of each 1 remaining in the matching vector corresponds to an index of the boundary value in the set of numerical values, wherein the computation and the memory storage take place on the same integrated circuit. A system for calculating a boundary value of a set of numerical values is also disclosed.

Abstract: A communications network system is disclosed. The system may include a central processing unit (CPU) in data communication with a first access point (AP) configured to enable a data communication between the CPU and a first user equipment (UE). The CPU may include a processor configured to select a first group of APs including the first AP, establish a first data communications link over a first frequency band between the CPU- and the first AP, cause the first AP to establish a second data communications link over a second frequency band between the first AP and the first UE, and transmit a portion of data to the first AP over the first data communications link. The first data communications link may be a wireless data communications link. The first frequency band may include higher frequency levels than those of the second frequency band.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: Disclosed herein are embodiments of aluminum-based alloys having improved intergranular corrosion resistance. Methods of making and using the disclosed alloy embodiments also are disclosed herein.

Abstract: Provided herein are techniques for making low-carbon steels with high surface hardness. A technique includes heating a low-carbon steel precursor material in a furnace to form molten steel material, increasing the free oxygen content of the molten steel material to a predetermined level, and then solidifying the molten steel material having the predetermined oxygen level to produce a steel structure by cooling the molten steel material at a predetermined cooling rate. The predetermined oxygen level and the predetermined cooling rate are effective to produce the low-carbon steel with a high surface hardness. The low-carbon steel may have inclusions smaller than about 1 ?m.

Abstract: A data-driven nonuniform subsampling approach for computation-free on-sensor data dimensionality is provided, referred to herein as selective sensing. Designing an on-sensor data dimensionality reduction scheme for efficient signal sensing has long been a challenging task. Compressive sensing is a generic solution for sensing signals in a compressed format. Although compressive sensing can be directly implemented in the analog domain for specific types of signals, many application scenarios require implementation of data compression in the digital domain. However, the computational complexity involved in digital-domain compressive sensing limits its practical application, especially in resource-constrained sensor devices or high-data-rate sensor devices. Embodiments described herein provide a selective sensing framework that adopts a novel concept of data-driven nonuniform subsampling to reduce the dimensionality of acquired signals while retaining the information of interest in a computation-free fashion.

Abstract: A system estimates spectral radius and leverages local updates from neighboring nodes in a wireless network to iteratively update state values of each node in the network and estimate a spectral radius of the network with guaranteed convergence. A method associated with the system method is a distributed method that efficiently converges to an invertible function of the spectral radius based only on local communications of the network for digital communication models in the presence and/or absence of packet loss, as opposed to conventional centralized methods.

Abstract: Fabricating a layer including lithium lanthanum zirconate (Li7La3Zr2O12) layer includes forming a slurry including lanthanum zirconate (La2Zr2O7) nanocrystals, a lithium precursor, and a lanthanum precursor in stoichiometric amounts to yield a dispersion including lithium, lanthanum, and zirconium. In some cases, the dispersion includes lithium, lanthanum, and zirconium in a molar ratio of 7:3:2. In certain cases, the slurry includes excess lithium. The slurry is dispensed onto a substrate and dried. The dried slurry is calcined to yield the layer including lithium lanthanum zirconate.

Abstract: The present invention provides a compound having the structure: a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.

Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.

Abstract: Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with a competitive inhibitor of a glucose transporter, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo.

Abstract: Described herein are means for learning semantics-enriched representations via self-discovery, self-classification, and self-restoration in the context of medical imaging. Embodiments include the training of deep models to learn semantically enriched visual representation by self-discovery, self-classification, and self-restoration of the anatomy underneath medical images, resulting in a collection of semantics-enriched pre-trained models, called Semantic Genesis. Other related embodiments are disclosed.

Abstract: A reactor for water splitting or water treatment includes a first electrode, a second electrode electrically coupled to the first electrode, and a proton exchange membrane separating the first electrode and the second electrode. The first electrode includes a first optical fiber coated with a photocatalytic material.

Abstract: Systems, methods, and apparatuses for implementing a geo-demographic zoning optimization engine are disclosed.

Abstract: A method, system and apparatus are provided for estimating characteristics of a wireless communication channel between at least two passive radio frequency (RF) nodes. Backscatter channel state information (BCSI) is measured during communication between the at least two passive RF nodes using the wireless communication channel. An RF node aggregates the measured BCSI and the aggregated BSCI is analyzed to detect at least one activity of a plurality of activities.