Patents Assigned to Surmodics, Inc.
  • Patent number: 10098846
    Abstract: The disclosure provides bioactive agent-containing particulates that include bioactive agent, biocompatible polymer, negatively charged groups, and a cationic agent. The particulates can be associated with a medical device, such as a balloon catheter, which can be used to move the particulates to a treatment site. Transfer of the particulates from the device to tissue is facilitated by the arrangement of the cationic and bioactive agent-containing particulates.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: October 16, 2018
    Assignee: SURMODICS, INC.
    Inventor: Joram Slager
  • Patent number: 10099041
    Abstract: Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: October 16, 2018
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 10080688
    Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: September 25, 2018
    Assignee: SURMODICS, INC.
    Inventors: Shawn Fuller, Bryan A. Claseman, Joram Slager, Jeffrey J. Missling, Gary Maharaj, Gary W. Opperman, Nathan A. Lockwood, Robert W. Hergenrother, Charles Olson
  • Patent number: 10058634
    Abstract: Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: August 28, 2018
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach
  • Patent number: 9999675
    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 19, 2018
    Assignee: Surmodics, Inc.
    Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
  • Patent number: 9993441
    Abstract: A biocompatible polymeric controlled release matrix barrier structure for delivery of one or more bioactive agents from an implantable medical device is described. In an embodiment, a biocompatible polymeric controlled release matrix barrier structure is included. The biocompatible polymeric controlled release matrix can include a body structure formed of a compliant material comprising one or more compliant biocompatible polymers and one or more bioactive agents. The body structure can define a central aperture through which a subcutaneous element of an implantable medical device passes. Other embodiments are included herein.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: June 12, 2018
    Assignee: Surmodics, Inc.
    Inventors: Joseph Schmidt McGonigle, Aleksey V. Kurdyumov, Jeffrey J. Missling, Nathan A. Lockwood, Kevin W. Burton, Beth A. Petersen
  • Patent number: 9994721
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: June 12, 2018
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: 9949957
    Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 ?m to 10 ?m, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 24, 2018
    Assignee: SURMODICS, INC.
    Inventor: Joram Slager
  • Patent number: 9895516
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: February 20, 2018
    Assignee: SURMODICS, INC.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 9861727
    Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: January 9, 2018
    Assignee: Surmodics, Inc.
    Inventors: Joram Slager, Toni M. Heyer, David E. Babcock
  • Publication number: 20170367824
    Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.
    Type: Application
    Filed: January 14, 2016
    Publication date: December 28, 2017
    Applicant: SURMODICS, INC.
    Inventors: Bruce M. Jelle, Joram Slager, Joseph S. McGonigle, Rick Murphy, Andrew G. Bach, Teryl L. Woodwick Sides, Ambereen Angamuthu, Sean Lundquist, Gary Opperman, Nathan A. Lockwood
  • Patent number: 9827401
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: November 28, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 9795720
    Abstract: Aspects herein relate to coatings with crystallized active agent(s) and related methods. A method for coating a medical device herein includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: October 24, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Kimberly K. M. Lindsoe
  • Patent number: 9770537
    Abstract: The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20?m or less, or 10?m or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 26, 2017
    Assignee: SURMODICS, INC.
    Inventors: Joram Slager, Aleksey V. Kurdyumov, Toni M. Heyer
  • Patent number: 9757497
    Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: September 12, 2017
    Assignee: Surmodics, Inc.
    Inventor: Joram Slager
  • Patent number: 9737639
    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: August 22, 2017
    Assignee: Surmodics, Inc.
    Inventor: David E. Babcock
  • Publication number: 20170224876
    Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological mo lecule.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 10, 2017
    Applicant: SURMODICS, INC.
    Inventors: David E. Babcock, Sean Lundquist, Gary Opperman, Adriyn Torguson, Tim Jentz
  • Patent number: 9669192
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: June 6, 2017
    Assignee: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 9649413
    Abstract: Embodiments herein include coatings with crystallized active agent(s) and related methods. In an embodiment, a method is included for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, an elution control coating disposed on a medical device is included, the elution control coating including an active agent that is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, a method is included for enhancing the formation of active agent crystals within a coating layer including adjusting the concentration of an active agent in a coating solution to reach some percentage of the active agent saturation point.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 16, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Kimberly K. M. Lindsoe
  • Patent number: D817894
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 15, 2018
    Assignee: Surmodics, Inc.
    Inventor: Karl Ganske