Patents Assigned to Surmodics, Inc.
  • Patent number: 9949957
    Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 ?m to 10 ?m, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 24, 2018
    Assignee: SURMODICS, INC.
    Inventor: Joram Slager
  • Patent number: 9895516
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: February 20, 2018
    Assignee: SURMODICS, INC.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 9861727
    Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: January 9, 2018
    Assignee: Surmodics, Inc.
    Inventors: Joram Slager, Toni M. Heyer, David E. Babcock
  • Publication number: 20170367824
    Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.
    Type: Application
    Filed: January 14, 2016
    Publication date: December 28, 2017
    Applicant: SURMODICS, INC.
    Inventors: Bruce M. Jelle, Joram Slager, Joseph S. McGonigle, Rick Murphy, Andrew G. Bach, Teryl L. Woodwick Sides, Ambereen Angamuthu, Sean Lundquist, Gary Opperman, Nathan A. Lockwood
  • Patent number: 9827401
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: November 28, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 9795720
    Abstract: Aspects herein relate to coatings with crystallized active agent(s) and related methods. A method for coating a medical device herein includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: October 24, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Kimberly K. M. Lindsoe
  • Patent number: 9770537
    Abstract: The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20?m or less, or 10?m or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 26, 2017
    Assignee: SURMODICS, INC.
    Inventors: Joram Slager, Aleksey V. Kurdyumov, Toni M. Heyer
  • Patent number: 9757497
    Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: September 12, 2017
    Assignee: Surmodics, Inc.
    Inventor: Joram Slager
  • Patent number: 9737639
    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: August 22, 2017
    Assignee: Surmodics, Inc.
    Inventor: David E. Babcock
  • Publication number: 20170224876
    Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological mo lecule.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 10, 2017
    Applicant: SURMODICS, INC.
    Inventors: David E. Babcock, Sean Lundquist, Gary Opperman, Adriyn Torguson, Tim Jentz
  • Patent number: 9669192
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: June 6, 2017
    Assignee: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 9649413
    Abstract: Embodiments herein include coatings with crystallized active agent(s) and related methods. In an embodiment, a method is included for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, an elution control coating disposed on a medical device is included, the elution control coating including an active agent that is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, a method is included for enhancing the formation of active agent crystals within a coating layer including adjusting the concentration of an active agent in a coating solution to reach some percentage of the active agent saturation point.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 16, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Kimberly K. M. Lindsoe
  • Patent number: 9629945
    Abstract: The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: April 25, 2017
    Assignee: SURMODICS, INC.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan, Nathan A. Lockwood, Bruce M. Jelle
  • Patent number: 9631190
    Abstract: Cell attachment coatings for articles such as implantable medical devices and cell culture vessels are disclosed. The coatings include an intermediate coater layer which includes a phosphorous-containing component that is bonded in the coating by reacted photoreactive functional groups. The coating also include a second coated layer including an immobilized ECM protein or peptide that includes an active portion of an ECM protein that is able to serve as an outer layer to contact cells during use. The coatings promoted enhanced cell binding and growth.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: April 25, 2017
    Assignee: SURMODICS, INC.
    Inventor: Joseph S. McGonigle
  • Patent number: 9623215
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: April 18, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 9598532
    Abstract: Disclosed herein are terpolymers that can function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymers adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive terpolymer adhered to a surface thereof. The pressure-sensitive adhesive terpolymer can promote adhesion of the implant device to a location in a subject.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: March 21, 2017
    Assignee: Surmodics, Inc.
    Inventors: Howard Bowman, Bruce W. Hudson
  • Patent number: 9579491
    Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 28, 2017
    Assignee: SURMODICS, INC.
    Inventors: Ralph A. Chappa, Mark F. Carlson
  • Patent number: 9555119
    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 31, 2017
    Assignee: Surmodics, Inc.
    Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
  • Patent number: 9487663
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: November 8, 2016
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: RE46251
    Abstract: A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: December 27, 2016
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Mark F. Carlson