Patents Assigned to Surmodics, Inc.
  • Patent number: 9629945
    Abstract: The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: April 25, 2017
    Assignee: SURMODICS, INC.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan, Nathan A. Lockwood, Bruce M. Jelle
  • Patent number: 9631190
    Abstract: Cell attachment coatings for articles such as implantable medical devices and cell culture vessels are disclosed. The coatings include an intermediate coater layer which includes a phosphorous-containing component that is bonded in the coating by reacted photoreactive functional groups. The coating also include a second coated layer including an immobilized ECM protein or peptide that includes an active portion of an ECM protein that is able to serve as an outer layer to contact cells during use. The coatings promoted enhanced cell binding and growth.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: April 25, 2017
    Assignee: SURMODICS, INC.
    Inventor: Joseph S. McGonigle
  • Patent number: 9623215
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: April 18, 2017
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 9598532
    Abstract: Disclosed herein are terpolymers that can function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymers adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive terpolymer adhered to a surface thereof. The pressure-sensitive adhesive terpolymer can promote adhesion of the implant device to a location in a subject.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: March 21, 2017
    Assignee: Surmodics, Inc.
    Inventors: Howard Bowman, Bruce W. Hudson
  • Patent number: 9579491
    Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 28, 2017
    Assignee: SURMODICS, INC.
    Inventors: Ralph A. Chappa, Mark F. Carlson
  • Patent number: 9555119
    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 31, 2017
    Assignee: Surmodics, Inc.
    Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
  • Patent number: 9487663
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: November 8, 2016
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: 9439892
    Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 ?m to 10 ?m, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: September 13, 2016
    Assignee: Surmodics, Inc.
    Inventor: Joram Slager
  • Patent number: 9427501
    Abstract: Coatings with crystallized active agent(s) and related methods are disclosed. One method includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. Also disclosed is an elution control coating which includes an active agent that is at least about 80% crystallized within one week of being disposed on a medical device. One method enhances the formation of active agent crystals within a coating layer by adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. Another method includes increasing the rate of active agent nucleation within the coating.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: August 30, 2016
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Kimberly K. M. Lindsoe
  • Patent number: 9416221
    Abstract: Disclosed herein are terpolymers and blends prepared from polyester terpolymers that can function as pressure-sensitive adhesives. The disclosed articles can comprise the terpolymer and terpolymer blends coated to a conformable backing member. The terpolymer and terpolymer blends can further comprise a bioactive agent.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: August 16, 2016
    Assignee: SurModics, Inc.
    Inventors: Howard Bowman, Don Lucast, Philip Morris
  • Patent number: 9415197
    Abstract: Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: August 16, 2016
    Assignee: SurModics, Inc.
    Inventor: Thomas R. Tice
  • Patent number: 9410044
    Abstract: Embodiments of the invention include linking agents including borate, borazine, or boronate groups and coatings and devices that incorporate such linking agents, along with related methods. Other embodiments are also included herein.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: August 9, 2016
    Assignee: SurModics, Inc.
    Inventor: Aleksey V. Kurdyumov
  • Patent number: 9375519
    Abstract: Bioerodable poly(etheresteramides) and matrices formed therefrom, such as medical device coatings, are described. The matrices show desirable erosion properties desirable for therapeutic use. The matrices can include a bioactive agent which can be used to treat medical conditions.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: June 28, 2016
    Assignee: SurModics, Inc.
    Inventors: Kyle Eastenson, Aleksey V. Kurdyumov, Darin DuMez, Klaus Wormuth, Nathan A. Lockwood
  • Patent number: 9364349
    Abstract: The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: June 14, 2016
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, James H. Arps
  • Patent number: 9295820
    Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: March 29, 2016
    Assignee: SURMODICS, INC.
    Inventors: Ralph A. Chappa, Mark F. Carlson
  • Patent number: 9283350
    Abstract: Embodiments of the invention include coating apparatuses and related methods. In an embodiment, the invention includes a coating apparatus. The coating apparatus can include a motor, a rotating contact member, a fluid applicator, a fluid pump, and a base member. The fluid applicator can include an orifice. The rotating contact member can be configured to rotate around a device to be coated that does not rotate. The rotating contact member can be configured to move along the lengthwise axis of a device to be coated. In an embodiment, the invention includes a method of coating a medical device.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 15, 2016
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Timothy M. Kloke
  • Patent number: 9155671
    Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: October 13, 2015
    Assignee: SurModics, Inc.
    Inventors: Shawn Fuller, Bryan A. Claseman, Joram Slager, Jeffrey J. Missling, Gary Maharaj, Gary W. Opperman, Nathan Lockwood, Robert W. Hergenrother, Charles Olson
  • Patent number: 9090737
    Abstract: Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: July 28, 2015
    Assignee: SurModics, Inc.
    Inventors: Peter Markland, Howard Bowman
  • Publication number: 20150165094
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 18, 2015
    Applicant: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: RE46251
    Abstract: A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: December 27, 2016
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Mark F. Carlson