Patents Assigned to Surmodics, Inc.
  • Patent number: 8790701
    Abstract: The present invention provides biocompatible, biodegradable matrices formed from poly-?(1?4)glucopyranose and reactive hydrazide groups. The matrices can be used for various applications in the body, including drug delivery and cell therapy.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: July 29, 2014
    Assignee: SurModics, Inc.
    Inventors: Emily R. Rolfes, Jeff J. Ross, Joseph S. McGonigle, Gary W. Opperman, Pamela J. Reed
  • Publication number: 20140200411
    Abstract: Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers polymers are described and electrically conductive coatings that include activatable conductive polymers.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 17, 2014
    Applicant: SurModics, Inc.
    Inventors: Bruce M. Jelle, Aleksey V. Kurdyumov, Joseph Schmidt McGonigle, Robert W. Hergenrother, Nathan A. Lockwood, Joseph Ventura, Sean M. Stucke
  • Publication number: 20140162083
    Abstract: The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 12, 2014
    Applicant: SurModics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan, Nathan A. Lockwood, Bruce M. Jelle
  • Publication number: 20140161964
    Abstract: Embodiments of the invention include coating apparatuses and related methods. In an embodiment, the invention includes a coating apparatus. The coating apparatus can include a motor, a rotating contact member, a fluid applicator, a fluid pump, and a base member. The fluid applicator can include an orifice. The rotating contact member can be configured to rotate around a device to be coated that does not rotate. The rotating contact member can be configured to move along the lengthwise axis of a device to be coated. In an embodiment, the invention includes a method of coating a medical device.
    Type: Application
    Filed: October 25, 2013
    Publication date: June 12, 2014
    Applicant: SurModics, Inc.
    Inventors: Ralph A. Chappa, Timothy M. Kloke
  • Publication number: 20140142166
    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 22, 2014
    Applicant: SurModics, Inc.
    Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
  • Patent number: 8722076
    Abstract: The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: May 13, 2014
    Assignee: SurModics, Inc.
    Inventors: Emily R. Rolfes Meyering, Aron B. Anderson
  • Publication number: 20140121597
    Abstract: Embodiments of the invention include apparatus and methods for coating medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit including a fluid applicator; a first rotation mechanism and a second rotation mechanism; and a controller, wherein the controller causes the first rotation mechanism and the second rotation mechanism to rotate a medical device at substantially the same speed, wherein the speed is greater than 500 rotations per minute. In an embodiment, the invention includes a method of coating a medical device including rotating a medical device with a rotation mechanism at a speed of greater than 500 rotations per minute; contacting the medical device with a fluid applicator; and applying a coating solution to the device. In an embodiment, the invention includes a medical device. In some embodiments a surface of a shaft of the device comprises high points and low points.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 1, 2014
    Applicant: SurModics, Inc.
    Inventors: Ralph A. Chappa, Mark F. Carlson
  • Patent number: 8709489
    Abstract: The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: April 29, 2014
    Assignee: SurModics, Inc.
    Inventors: Joram Slager, Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: 8709827
    Abstract: The invention provides polypeptide microparticles and methods for the preparation thereof using a nucleating agent.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: April 29, 2014
    Assignee: SurModics, Inc.
    Inventors: Joram Slager, John V. Wall
  • Patent number: 8697105
    Abstract: The invention provides an injectable formulation that includes an active agent; a biocompatible solvent system, crosslinkable polymers such as polysaccharides; and crosslinking agents; wherein the formulation is substantially free of water. The invention also provides a drug delivery depot formed from the injectable formulation wherein the polymers crosslink in the presence of water in the body of a patient, or in the air, prior to implantation in the patient. Also provided are methods of treatment using such formulations and drug delivery systems.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: April 15, 2014
    Assignee: SurModics, Inc.
    Inventor: Joram Slager
  • Patent number: 8697106
    Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: April 15, 2014
    Assignee: SurModics, Inc.
    Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa
  • Patent number: 8685421
    Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: April 1, 2014
    Assignee: SurModics, Inc.
    Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa
  • Patent number: 8679454
    Abstract: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: March 25, 2014
    Assignee: Surmodics, Inc.
    Inventors: Patrick E. Guire, Kristin S. Taton, John V. Wall
  • Patent number: 8668667
    Abstract: The present invention relates to a catheter assembly that can deliver a therapeutic composition. The catheter assembly can include an outer balloon with openings for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: March 11, 2014
    Assignee: Surmodics, Inc.
    Inventor: Ralph A. Chappa
  • Patent number: 8663673
    Abstract: The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: March 4, 2014
    Assignee: Surmodics, Inc.
    Inventors: Timothy M. Kloke, Robert W. Hergenrother, Laurie R. Lawin
  • Patent number: 8663674
    Abstract: Polymeric matrices including microparticles that provide sustained release of a hydrophilic bioactive agent are described. The matrices can be in the form of a coating on the surface of an implantable medical article or an in situ formed matrix. The microparticles of the matrix include a first polymer and a second polymer that modulates release of the hydrophilic bioactive agent from the matrix.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: March 4, 2014
    Assignee: Surmodics, Inc.
    Inventors: Jie Wen, Aron B. Anderson
  • Patent number: 8632877
    Abstract: The invention provides methods for forming ultra-thin hydrophilic polymeric coatings on articles, as well as articles formed therefrom. The coatings are formed by irradiating a composition including a polymer having pendent photoreactive groups while the composition is in contact with a surface of the article.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: January 21, 2014
    Assignee: Surmodics, Inc.
    Inventor: Gary Opperman
  • Patent number: 8586731
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 19, 2013
    Assignee: Surmodics, Inc.
    Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Pamela J. Reed
  • Patent number: 8568760
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 29, 2013
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • Publication number: 20130261566
    Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.
    Type: Application
    Filed: April 2, 2013
    Publication date: October 3, 2013
    Applicant: SurModics, Inc.
    Inventors: Nathan A. Lockwood, Bruce M. Jelle, Aleksey V. Kurdyumov