Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.
Type:
Application
Filed:
December 10, 2010
Publication date:
June 16, 2011
Applicant:
SurModics, Inc.
Inventors:
Dale G. Swan, Emily Rose Rolfes Meyering, Aleksey V. Kurdyumov, Peter H. Duquette, Robert W. Hergenrother, Toni M. Heyer
Abstract: The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.
Abstract: This invention provides a coating apparatus and methods for coating a device, such as an industrially or medically applicable device. The apparatus is suitable for providing a coating using a photoactivatable compound and a polymerizable compound. In another aspect, the apparatus and methods are useful for coating a device wherein the surface of the device has small pores or apertures. The apparatus includes of containers suitable for holding the object to be coated and the coating solution, a gas supply source for supplying gas to solution, an irradiation station for providing light used in the coating process, and a conveyor mechanism to direct the containers to and from the irradiation station.
Type:
Application
Filed:
December 29, 2010
Publication date:
May 5, 2011
Applicant:
SurModics, Inc.
Inventors:
Mark F. Carlson, Steven J. Porter, Sean M. Stucke, Ralph A. Chappa
Abstract: Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implants can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.
Type:
Grant
Filed:
March 15, 2007
Date of Patent:
April 5, 2011
Assignee:
SurModics, Inc.
Inventors:
Stephen J. Chudzik, Signe R. Erickson, Jeffrey J. Missling
Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
Type:
Application
Filed:
November 8, 2010
Publication date:
March 3, 2011
Applicant:
SurModics, Inc.
Inventors:
Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
Abstract: A method for coating a device, such as an industrially or medically applicable device, with a polymer layer is provided. The method includes contacting the device with a grafting initiator comprising at least one photoinitiator group, exposing the device to radiation, contacting the device with a polymerizable monomer, and again exposing the device to radiation.
Type:
Grant
Filed:
March 14, 2006
Date of Patent:
February 8, 2011
Assignee:
Surmodics, Inc.
Inventors:
Mark F. Carlson, Steven J. Porter, Sean M. Stucke, Ralph A. Chappa
Abstract: An electrically conductive coating composition that includes a polymeric mixture, an electrically conductive material dispersed within the polymeric mixture and, optionally, one or more bioactive agents is described.
Type:
Application
Filed:
July 7, 2010
Publication date:
January 27, 2011
Applicant:
SurModics, Inc.
Inventors:
James H. Arps, Peter J. Barnett, Jeffrey J. Missling
Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.
Type:
Application
Filed:
September 9, 2010
Publication date:
January 13, 2011
Applicant:
SurModics, Inc.
Inventors:
Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
Abstract: Described herein is a medical device that has a collapsed configuration and an expanded configuration wherein one or more polymeric network layers are applied to the substrate and microparticles embedded in the polymeric network. The polymeric network layer or layers is/are configured to retain the microparticles when the device is in a collapsed configuration and to release the microparticles when the device is in an expanded configuration. Methods for delivering a therapeutic agent using the device and making the device are also disclosed.
Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
Type:
Grant
Filed:
August 19, 2005
Date of Patent:
November 16, 2010
Assignee:
Surmodics, Inc.
Inventors:
Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.
Type:
Grant
Filed:
September 14, 2007
Date of Patent:
November 9, 2010
Assignee:
SurModics, Inc.
Inventors:
Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
Abstract: The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
Type:
Grant
Filed:
August 15, 2005
Date of Patent:
November 2, 2010
Assignee:
Surmodics, Inc.
Inventors:
Aron B. Anderson, Laurie R. Lawin, Byron C. Shen, Eugene de Juan, Signe E. Varner, Ralph A. Chappa
Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic ? cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.
Abstract: A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity and anti-microbial activity.
Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.
Type:
Application
Filed:
May 20, 2010
Publication date:
September 23, 2010
Applicant:
SurModics, Inc.
Inventors:
Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.
Type:
Grant
Filed:
March 23, 2006
Date of Patent:
September 14, 2010
Assignee:
SurModics, Inc.
Inventors:
Stephen J. Chudzik, Terrence P. Everson, Richard A. Amos
Abstract: A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.
Abstract: The invention provides a durable, lubricious coating for a medical article that can be prepared from a first polymer that is synthetic, soluble in a polar liquid, and having first reactive groups, and a second polymer that is synthetic, hydrophilic, and that includes second reactive groups. The first reactive groups and a portion of the second reactive groups react to bond the first polymer to the second polymer. A portion of the second reactive groups remains unbonded which, upon neutralization, provide lubricious properties to the coating. In some aspects the coating is formed using a crosslinking agent having latent reactive groups. The coatings provide particularly long dry out times and are very useful for catheterization processes. In addition, the coatings can be subject to sterilization with ethylene oxide and retain very good durable and lubricious properties.
Abstract: The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.
Abstract: A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
Type:
Application
Filed:
March 3, 2010
Publication date:
June 24, 2010
Applicant:
SurModics, Inc.
Inventors:
Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran