Patents Assigned to Surmodics, Inc.
  • Coating composition
    Patent number: 8697106
    Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: April 15, 2014
    Assignee: SurModics, Inc.
    Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa
  • Beaded wound spacer device
    Patent number: 8685421
    Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: April 1, 2014
    Assignee: SurModics, Inc.
    Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa
  • Particle immobilized coatings and uses thereof
    Patent number: 8679454
    Abstract: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: March 25, 2014
    Assignee: Surmodics, Inc.
    Inventors: Patrick E. Guire, Kristin S. Taton, John V. Wall
  • Double wall catheter for delivering therapeutic agent
    Patent number: 8668667
    Abstract: The present invention relates to a catheter assembly that can deliver a therapeutic composition. The catheter assembly can include an outer balloon with openings for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: March 11, 2014
    Assignee: Surmodics, Inc.
    Inventor: Ralph A. Chappa
  • Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
    Patent number: 8663673
    Abstract: The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: March 4, 2014
    Assignee: Surmodics, Inc.
    Inventors: Timothy M. Kloke, Robert W. Hergenrother, Laurie R. Lawin
  • Microparticle containing matrices for drug delivery
    Patent number: 8663674
    Abstract: Polymeric matrices including microparticles that provide sustained release of a hydrophilic bioactive agent are described. The matrices can be in the form of a coating on the surface of an implantable medical article or an in situ formed matrix. The microparticles of the matrix include a first polymer and a second polymer that modulates release of the hydrophilic bioactive agent from the matrix.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: March 4, 2014
    Assignee: Surmodics, Inc.
    Inventors: Jie Wen, Aron B. Anderson
  • Ultra-thin photo-polymer coatings and uses thereof
    Patent number: 8632877
    Abstract: The invention provides methods for forming ultra-thin hydrophilic polymeric coatings on articles, as well as articles formed therefrom. The coatings are formed by irradiating a composition including a polymer having pendent photoreactive groups while the composition is in contact with a surface of the article.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: January 21, 2014
    Assignee: Surmodics, Inc.
    Inventor: Gary Opperman
  • Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation
    Patent number: 8586731
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 19, 2013
    Assignee: Surmodics, Inc.
    Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Pamela J. Reed
  • Hydrophobic polysaccharides with pendent groups having terminal reactive functionalities and medical uses thereof
    Patent number: 8568760
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 29, 2013
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • HYDROPHILIC POLYMERIC COATINGS FOR MEDICAL ARTICLES WITH VISUALIZATION MOIETY
    Publication number: 20130261566
    Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.
    Type: Application
    Filed: April 2, 2013
    Publication date: October 3, 2013
    Applicant: SurModics, Inc.
    Inventors: Nathan A. Lockwood, Bruce M. Jelle, Aleksey V. Kurdyumov
  • Pro-fibrotic coatings
    Patent number: 8535700
    Abstract: Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: September 17, 2013
    Assignee: Surmodics, Inc.
    Inventors: Joseph A. Chinn, Stephen J. Chudzik, Sean M. Stucke
  • Coatings including natural biodegradable polysaccharides and uses thereof
    Patent number: 8512736
    Abstract: Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
    Type: Grant
    Filed: November 11, 2005
    Date of Patent: August 20, 2013
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
  • LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES
    Publication number: 20130197433
    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
    Type: Application
    Filed: January 18, 2013
    Publication date: August 1, 2013
    Applicant: SurModics, Inc.
    Inventor: David E. Babcock
  • Coating systems for the controlled delivery of hydrophilic bioactive agents
    Patent number: 8496954
    Abstract: Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: July 30, 2013
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Robert W. Hergenrother, Shannon A. Wadman, Klaus R. Wormuth
  • DELIVERY OF COATED HYDROPHOBIC ACTIVE AGENT PARTICLES
    Publication number: 20130190689
    Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 25, 2013
    Applicant: SURMODICS, INC.
    Inventor: SURMODICS, INC.
  • Silyl ether-modified hydrophilic polymers and uses for medical articles
    Patent number: 8475843
    Abstract: Silane-functionalized hydrophilic polymers and polymeric matrices are described. Hydrophilic matrices can be formed from the polymers, and can be used in association with the preparation of implantable and injectable medical devices. Exemplary devices include those having a durable lubricious coating formed from the hydrophilic polymers.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: July 2, 2013
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Robert Hergenrother, Bruce M. Jelle
  • Systems and methods for filling medical device lumen
    Patent number: 8459310
    Abstract: The invention relates to systems and methods for filling a medical device with an active agent composition. In an embodiment, the invention includes a method for filling a medical device with an active agent composition. The method can include applying the active agent composition to the outside surface of the medical device, the medical device comprising a housing defining a lumen and a plurality of apertures. The method can also include contacting a surface of a press member against the outside surface of the medical device thereby pushing the active agent composition through the apertures and into the lumen of the medical device. Other embodiments are also included herein.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: June 11, 2013
    Assignee: SurModics, Inc.
    Inventor: Ralph A. Chappa
  • PHOTO-VINYL LINKING AGENTS
    Publication number: 20130143056
    Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R1—X—R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R1—X—R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Other embodiments are also included herein.
    Type: Application
    Filed: June 7, 2012
    Publication date: June 6, 2013
    Applicant: SURMODICS, INC.
    Inventors: Dale G. Swan, Aleksey V. Kurdyumov, Bruce M. Jelle
  • Methods and devices for the treatment of ocular conditions
    Patent number: 8454582
    Abstract: Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: June 4, 2013
    Assignee: Surmodics, Inc.
    Inventors: Eugene deJuan, Signe E. Varner, Laurie R. Lawin
  • ULTRA-THIN PHOTO-POLYMER COATINGS AND USES THEREOF
    Publication number: 20130052456
    Abstract: The invention provides methods for forming ultra-thin hydrophilic polymeric coatings on articles, as well as articles formed therefrom. The coatings are formed by irradiating a composition including a polymer having pendent photoreactive groups while the composition is in contact with a surface of the article.
    Type: Application
    Filed: October 1, 2012
    Publication date: February 28, 2013
    Applicant: SURMODICS, INC.
    Inventor: SURMODICS, INC.