Patents Assigned to Surmodics, Inc.
  • Patent number: 8586731
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 19, 2013
    Assignee: Surmodics, Inc.
    Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Pamela J. Reed
  • Patent number: 8568760
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 29, 2013
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • Publication number: 20130261566
    Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.
    Type: Application
    Filed: April 2, 2013
    Publication date: October 3, 2013
    Applicant: SurModics, Inc.
    Inventors: Nathan A. Lockwood, Bruce M. Jelle, Aleksey V. Kurdyumov
  • Patent number: 8535700
    Abstract: Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: September 17, 2013
    Assignee: Surmodics, Inc.
    Inventors: Joseph A. Chinn, Stephen J. Chudzik, Sean M. Stucke
  • Patent number: 8512736
    Abstract: Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
    Type: Grant
    Filed: November 11, 2005
    Date of Patent: August 20, 2013
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
  • Publication number: 20130197433
    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
    Type: Application
    Filed: January 18, 2013
    Publication date: August 1, 2013
    Applicant: SurModics, Inc.
    Inventor: David E. Babcock
  • Patent number: 8496954
    Abstract: Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: July 30, 2013
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Robert W. Hergenrother, Shannon A. Wadman, Klaus R. Wormuth
  • Patent number: 8475843
    Abstract: Silane-functionalized hydrophilic polymers and polymeric matrices are described. Hydrophilic matrices can be formed from the polymers, and can be used in association with the preparation of implantable and injectable medical devices. Exemplary devices include those having a durable lubricious coating formed from the hydrophilic polymers.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: July 2, 2013
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Robert Hergenrother, Bruce M. Jelle
  • Patent number: 8459310
    Abstract: The invention relates to systems and methods for filling a medical device with an active agent composition. In an embodiment, the invention includes a method for filling a medical device with an active agent composition. The method can include applying the active agent composition to the outside surface of the medical device, the medical device comprising a housing defining a lumen and a plurality of apertures. The method can also include contacting a surface of a press member against the outside surface of the medical device thereby pushing the active agent composition through the apertures and into the lumen of the medical device. Other embodiments are also included herein.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: June 11, 2013
    Assignee: SurModics, Inc.
    Inventor: Ralph A. Chappa
  • Patent number: 8454582
    Abstract: Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: June 4, 2013
    Assignee: Surmodics, Inc.
    Inventors: Eugene deJuan, Signe E. Varner, Laurie R. Lawin
  • Patent number: 8377461
    Abstract: The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: February 19, 2013
    Assignee: Surmodics, Inc.
    Inventors: Joseph A. Chinn, Sean M. Stucke, Stephen J. Chudzik
  • Patent number: 8318263
    Abstract: Described herein is a method for coating an object with a polymer layer. The method includes contacting the object with a first solution comprising a non-polymeric grafting initiator comprising at least one photoinitiator group capable of generating a free radical active species upon absorption of electromagnetic energy, wherein the photoinitiator group is selected from the group consisting of an initiator that is insoluble in polar solvent; and a negatively charged initiator; irradiating the first solution and the object, resulting in the grafting initiator binding to the object; removing the first solution; contacting the object with a second solution comprising a polymerizable monomer having at least one free-radical polymerizable group; and irradiating the second solution and the object, wherein the non-polymeric grafting initiator acts as a photoinitiator for a free-radical polymerization reaction.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: November 27, 2012
    Assignee: SurModics, Inc.
    Inventors: Mark F. Carlson, Steven J. Porter, Sean M. Stucke, Ralph A. Chappa
  • Patent number: 8277928
    Abstract: The invention provides methods for forming ultra-thin hydrophilic polymeric coatings on articles, as well as articles formed therefrom. The coatings are formed by irradiating a composition including a polymer having pendent photoreactive groups while the composition is in contact with a surface of the article.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: October 2, 2012
    Assignee: Surmodics, Inc.
    Inventor: Gary Opperman
  • Patent number: 8246576
    Abstract: Described herein is a medical device that has a collapsed configuration and an expanded configuration wherein one or more polymeric network layers are applied to the substrate and microparticles embedded in the polymeric network. The polymeric network layer or layers is/are configured to retain the microparticles when the device is in a collapsed configuration and to release the microparticles when the device is in an expanded configuration. Methods for delivering a therapeutic agent using the device and making the device are also disclosed.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: August 21, 2012
    Assignee: SurModics, Inc.
    Inventor: Joram Slager
  • Patent number: 8246974
    Abstract: Embodiments of the invention include coated medical devices that can elute one or more bioactive agents within the body, and methods for producing the same. In an embodiment, the invention includes a method of forming a coated medical device including depositing a coated composition onto a medical device having a roughened segment and a smooth segment. In an embodiment, the invention includes a method of forming a coated implantable medical device including depositing a coated composition onto a medical device having a body segment and a piercing segment. In an embodiment, the invention includes a medical device, a coated composition provided on the substrate surface, the composition including a bioactive agent and a polymer. The medical device includes an uncoated component wherein the edge of the coated composition is within 0.5 mm of the uncoated component.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: August 21, 2012
    Assignee: SurModics, Inc.
    Inventor: Ralph A. Chappa
  • Patent number: 8242179
    Abstract: The invention provides a system and method for treating an orthopedic condition using a hydrogel-forming composition, which forms a hydrogel in situ at a target location and at least bio-mechanically treats the condition. The invention also provides a hydrogel forming composition designed to form a hydrogel with desirable biocompatible and biomechanical properties. In some aspects the hydrogel is formed in a water-permeable casing, which is delivered to an orthopedic joint in a minimally invasive manner. In particular, the system and method can be used for intervertebral disc replacement or repair.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc.
    Inventor: Stephen J. Chudzik
  • Patent number: 8241656
    Abstract: Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.
    Type: Grant
    Filed: November 11, 2005
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc
    Inventors: Stephen J. Chudzik, Dale G. Swan, Michael J. Burkstrand
  • Patent number: 8241921
    Abstract: The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc.
    Inventors: Joram Slager, Aron B. Anderson
  • Patent number: 8241655
    Abstract: Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
  • Publication number: 20120165760
    Abstract: Described herein is an implantable medical device that has one or more surfaces that include one or more shallow recesses configured to receive a drug delivery composition comprising a polymeric matrix and one or more biologically active agents. In one embodiment, one or more surfaces comprise a frictional surface. In a more particular embodiment, the implantable medical device comprises a stem configured for insertion into a bone of a patient, wherein the stem comprises one or more surfaces that include one or more shallow recesses configured to receive a drug delivery composition comprising a matrix and one or more biologically active agents. The drug delivery composition can be a durable drug delivery matrix, a biodegradable drug delivery matrix, or a combination thereof. Methods of making such an implant are also provided.
    Type: Application
    Filed: December 28, 2011
    Publication date: June 28, 2012
    Applicant: SurModics, Inc.
    Inventors: Jeffrey J. Missling, Bryan A. Claseman