Abstract: A process for the preparation of 13-cis-retinoic acid (I) from 3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl)-triphenylphosphonium chloride (IIa) and 5-hydroxy-4-methyl-2(5H)-furanone (III) is herein disclosed. Compounds (IIa) and (III) are reacted in ethanol as the solvent and KOH as the base at a temperature ranging from ?5 to 0° C. to give a mixture of retinoic acids which is isomerized to (I) by treatment with a palladium complex.

Abstract: The invention relates to a method for generating electrical sounds and to an interactive music player. According to the invention, an audio signal in digital format, which lasts for a predeterminable length of time, is used as the starting material. The reproduction position and/or the reproduction direction and/or the reproduction speed of said signal is/are modulated automatically with respect to the rhythm using control information in different predeterminable ways, based on information concerning the musical tempo.

Abstract: A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.

Abstract: A method is provided for correcting lightness of an image using a multiscale retinex. Lightness of a subject pixel of an original image is corrected using a convolution operation of a surround function and surround pixels with respect to the subject pixel of the original image, and the convolution operation is performed over a plurality of scales. The surround function has a simplified model such that a value of the surround function is changed in a stepwise way along two axes orthogonal to each other.

Abstract: A lateral-shear interferometer utilizes two relatively thick glass plates bonded together in a single block with a tilted air gap between opposing inner surfaces. The thickness of the glass plates is selected to be sufficiently large to separate the output beams from the light reflected from the top and bottom surfaces of the block, thereby eliminating the need for antireflection coatings. The shear interferometer is combined with an external mirror mounted on a tilt stage actuated by a computer-controlled tilt actuator to perform phase-shifting interferometric analysis in conventional manner.

Abstract: The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.

Abstract: A process for purifying pravastatin sodium comprising the steps of: a. clarifying a fermentation broth containing pravastatin sodium to obtain a clear solution; and adjusting the clear solution to be basic having pH value ranging from pH 10˜13; b. adsorbing the pravastatin sodium with non-ionic resin; eluting the pravastatin sodium by water-soluble organic solvent; and forming a concentrate of pravastatin sodium; c. treating the concentrate with water-soluble anti-solvent or inorganic salt to form a precipitate of pravastatin sodium; and d. recrystallizing the precipitate for making pravastatin sodium crystal with high purity and high yield.

Abstract: A method for correcting lightness of an image includes the steps of: calculating a first scale and a second scale based on an image scale of an original image from image information of the original image; multiscale retinex processing the original image with respect to the first scale and the second scale; and synthesizing a result of the multiscale retinex processing with the image information of the original image.

Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Abstract: A method of matching the tempo and phase in pieces of music which allows the conjunction of the pieces of music to form a continuous stream of music. The interactive music player which digitally executes the method of matching the tempo and phase in pieces of music is also disclosed.

Abstract: A differential signal reception device and method for supporting variable threshold levels. The device flexibly makes an input to the decision circuit appear to an outside driving circuit as if the decision circuit were a purpose-built input network supporting a fixed impedance input into either a floating or fixed DC termination voltage. The device further allows the internal decision process to support a variable threshold level when deciding logical 1/0 values and to attenuate the users input signal range for the purpose of making sure the range of the user's signals do not exceed the operating range of readily available decision circuit (limiting amplifier) integrated circuits.

Abstract: A catalyst in the form of extruded bodies is disclosed, which consists of an inert binding agent and a catalytically active phase of a silica/alumina gel. The catalyst is particularly active in acid-catalysed reactions.

Abstract: Disclosed herein is a method for determining the location of at least one error in a digital data stream and identifying the data surrounding the error which comprises selecting a user data stream to be analyzed for errors, selecting a seed bit segment out of the user data stream and converting that to a reference data stream, synchronizing the reference data stream with the user data stream, determining if an error exists, if an error has occurred calculating where on the data stream the error occurred, comparing the data stream segment containing the error with the reference data stream, analyzing the data surrounding the error, and computing actual data values from phase, data type and error location.

Abstract: Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following combinatorial synthesis using molecular mass measurements of individual compounds, thereby eliminating the necessity of encoding synthetic steps. The analysis of mass spectrometric data for sets of related compounds reveals compounds that are missing in a group of related compounds and identifies compounds that do not belong to a group of related compounds due to unexpected chemical, physical, or biological transformations. The methods may be applied to any group of compounds originating from chemical reactions where one reactant is common to the synthetic transformation. One particular application of these methods is in the analysis of the products of combinatorial synthesis. Systems, computer programs products, and kits are additionally provided.

Abstract: A method for preparing hydrophilic pressure sensitive adhesive (PSA) compositions is provided, wherein the method enables preparation of adhesives having a particular, optimized degree of adhesion. That is, the hydrophilic PSA is comprised of a hydrophilic polymer and a complementary short-chain plasticizing agent, wherein the hydrophilic polymer and plasticizing agent are capable of hydrogen bonding or electrostatic bonding to each other and are present in a ratio that optimizes key characteristics of the adhesive composition, such as adhesive strength, cohesive strength and hydrophilicity. The adhesive is useful in a wide variety of contexts, e.g., as a biomedical adhesive for application to the skin or other body surface, and as such finds utility in the areas of drug delivery systems (e.g., topical, transdermal, transmucosal, iontophoretic), medical skin coverings and wound healing products and biomedical electrodes.

Abstract: The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.

Abstract: A method of preparing amorphous copolymers of ethylene and at least one norbornene (NB)-type comonomer is disclosed. These polymers may be random or alternating depending on the choice of catalyst and/or the relative ratio of the monomers used. This method comprises polymerizing said monomers in a diluent or in bulk in the presence of a neutral nickel catalyst which may be represented by the formula wherein Y may be a saturated or unsaturated hydrocarbyl chain, X may be oxygen or sulfur, E may be phosphorus, arsenic, antimony, oxygen or nitrogen, R and R′ independently each is hydrogen or a hydrocarbyl group, L is a ligand containing a heteroatom P, N or O or L and R together with L may form part of a chelating structure in which case L is an ethylenic double bond.

Abstract: A method for removing hydrocarbon products from water surfaces, which entails contacting the hydrocarbon products with a crystalline polypropylene, which when observed under a microscope of 2500 magnetization, exhibits a spongy surface having relatively homogeneous intercommunicating pores, with dimensions of between about 3 &mgr;m and 20 &mgr;m in diameter.

Abstract: A catalytic composition is described for the alkylation or transalkylation of aromatic compounds consisting of zeolite Beta, as such or modified by the isomorphic substitution of aluminium with boron, iron or gallium or by the introduction of alkaline/earth-alkaline metals following ion exchange processes, and of an inorganic ligand, wherein the extrazeolite porosity, i.e. the porosity obtained by adding the mesoporosity and macroporosity fractions present in the catalytic composition itself, is such as to be composed for a fraction of at least 25% of pores with a radius higher than 100 .ANG..

Abstract: A cross-linked development and deployment system that links system design, simulation, real-time emulation, integration, and in-system verification to system implementation in the field, creating final products that are field programmable systems on printed circuit boards or field programmable systems on silicon. In a preferred embodiment, hardware and software models are created and verified in an integrated co-development environment. These models can be synchronized with each other and can also be used for in-circuit emulation and in-system verification of the system under development. Once the system has gone through verification and completed system integration, the system design database that has been generated from that testing is used to program either a field programmable printed circuit board or a field programmable system on silicon.