Patents Assigned to Syracuse University
  • SINGLE-MOLECULE PORE-BASED SENSOR FOR PROTEINS AND TRANSIENT PROTEIN-PROTEIN INTERACTIONS
    Publication number: 20190128867
    Abstract: A bioinspired protein pore-based nanostructure that can provide selective, real-time sampling of protein-protein interactions at single-molecule resolution. This modular nanostructure relied on a single polypeptide chain that encompassed a heavily truncated outer membrane protein, a highly flexible connector, a protein receptor element, as well as a polypeptide adapter. The presence of a protein ligand analyte in solution produced reversible binding and release events, in the form of discrete and stochastic current transitions between open substates of the transmembrane pore, the nature of which depend on both the amount of protein ligand analyte and the strength of the transient PPIs in aqueous phase.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Liviu Movileanu, Avinash Kumar Thakur
  • DIAGNOSTIC METHOD AND DEVICE FOR ASSESSING HUMAN JOINT FLUID REACTIVITY TO CoCrMo ALLOY
    Publication number: 20190120780
    Abstract: A chamber for testing the reactivity of patient fluids to a metallic implant alloy, such as CoCrMo, and a method of determining the reactivity of the patent to the alloy. A sealed mini-electrochemical cell incorporates the alloy surface as well as reference and counter electrodes coupled to a potentiostat for performing electrochemical measurements of the alloy surface while it is in direct contact with freshly harvested human fluids. Freshly obtained body fluids are thus assessed in terms of their bioelectrochemical reactivity with the alloy surface as a measure of the likely reactivity of the patient to the alloy if it were to be implanted into the patient.
    Type: Application
    Filed: December 17, 2018
    Publication date: April 25, 2019
    Applicant: Syracuse University
    Inventor: Jeremy Gilbert
  • Heat-curling polymeric needle for safe disposal
    Patent number: 10252009
    Abstract: A needle having shaft that forms a tip and a portion proximate to the tip that is formed from a shape memory polymer. The shaft of the needle may be programmed to curl from a straight configuration to a curved configuration upon triggering by heat, thereby moving the sharp tip and providing a non-stick needle for safe and easy disposal.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 9, 2019
    Assignee: SYRACUSE UNIVERSITY
    Inventors: Patrick T. Mather, Pine Yang
  • HIERARCHICAL OPTIMIZED DETECTION OF RELATIVES
    Publication number: 20190102517
    Abstract: A system for evaluating a DNA sample and determining whether the sample contains related individuals and/or unrelated individuals with high levels of alleles sharing. Trained and pre-validated machine learning algorithms are to rapidly and probabilistically assess the presence of relatives in a DNA mixture. To make a probabilistic determination, the system evaluates aspect of the sample that have not be considered before, such as peak heights, peak height ratios, maximum peak heights, minimum peak heights, ratios of allele heights to one another, number of contributors using maximum allele count method, and quantitative measures of the amount of DNA contributed by the male and female organisms. The system identifies whether a DNA sample has contributors that are not readily identifiable based on the data and can thus improve downstream analysis.
    Type: Application
    Filed: October 1, 2018
    Publication date: April 4, 2019
    Applicant: Syracuse University
    Inventors: Michael Marciano, Jonathan D. Adelman
  • Diversity combining of non-coherently modulated LDPC codes in wireless communications
    Patent number: 10243696
    Abstract: A method of decoding a plurality of diverse signals for low-density parity-check (LDPC) decoders that takes advantage of signal diversity. The method allows for the combining of soft-decision LDPC encoded non-coherently modulated signals, which is in contrast to existing approaches where hard decision combining is used for non-coherently modulated signals. The method includes the steps of inputting each diversity signal into a unique demodulator, and calculating the LLR of each demodulated signal. When the diverse demodulated signals are combined into a single combined signal, each bit of the combined signal is selected according to the value of either the highest LLR value of each bit across the demodulated signals or according to the sum of the LLR of each bit across the demodulated signals.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: March 26, 2019
    Assignee: Syracuse University
    Inventors: Kapil Borle, Biao Chen, Fangfang Zhu, Yu Zhao
  • SUPERCONDUCTIVE POLYACETYLENE FORMED VIA IRRADIATION OF A UREA INCLUSION COMPOUND WITH A REACTIVE DIIODOPOLYENE GUEST
    Publication number: 20190071525
    Abstract: A conductive polymer formed by the photochemical condensation polymerization of polyacetylene. E,E,1,4-diiodobuta-1,4-diene ICH=CH?CH+CHI (DIBD) in a crystalline urea inclusion compound is illuminated with low power broad spectrum pulsed UV visible radiation to form an irradiated DIBD urea inclusion compound that exhibits superconductivity and can be configured into an energy storage device that is rechargeable via magnetic induction. Altnernatively, (E,E,E)-1,6-diiodohexa-1,3-5-triene may be used as the guest monomer that is polymerized in the crystalline urea inclusion compound and the resulting polyacetylene urea composite crystal may be formed into a circuit for use as a superconductor.
    Type: Application
    Filed: August 13, 2018
    Publication date: March 7, 2019
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Bruce Hudson, Steluta Dinca
  • Self-replenishing boundary lubrication in hydrogels using zwitterionic polymers
    Patent number: 10220118
    Abstract: A self-replenishing biocompatible hydrogel having a zwitterionic polymer embedded throughout the matrix system to act as a lubricant and a surface modified with the same zwitterionic polymer. When surface material loss occurs in the hydrogel, such as a surface crack or a scratch, the damage propagates through the matrix rupturing the pockets of lubricant. The zwitterionic polymer is then drawn into the site due to the change in entropy at the surface and the positive and negative charge groups of the side chains fuse across the damage cite due to strong electrostatic attraction causing inter-chain association.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: March 5, 2019
    Assignee: SYRACUSE UNIVERSITY
    Inventors: Michelle M. Blum, Patrick T. Mather, Allen Osaheni
  • FLAME-ASSISTED FUEL CELL INTEGRATED RICH BURN, QUICK MIX, LEAN BURN COMBUSTION FOR REDUCED NOx
    Publication number: 20190063283
    Abstract: A micro-tubular flame assisted fuel cell (mT FFC) integrated with a rich-burn, quick-mix, lean-burn (RQL) combustor for reduced NOx. Fuel and oxidant pass into a first-stage, fuel-rich combustion chamber. The exhaust products pass to the fuel cell for electrochemical conversion. Any remaining fuel is quickly mixed in a jet of oxidant to reduce temperature gradients and NOx formation in a second stage, fuel-lean combustion chamber. Preheating of the fuel, and different oxidant streams, is possible via heat exchangers in the fuel-rich and fuel-lean combustion chambers.
    Type: Application
    Filed: August 30, 2018
    Publication date: February 28, 2019
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Jeongmin Ahn, Ryan Milcarek
  • WIRELESS ELECTROSTIMULATION TO ERADICATE IMPLANTED DEVICE ASSOCIATED BIOFILMS
    Publication number: 20190046670
    Abstract: A medical device having DC treatment electrodes that can be wirelessly induced to produce the appropriate electrical current across the implant to eradicate any biofilm that has formed on the implant shell, such as that of a cochlear implant. The implant may also be configured to sample any changes in the redox properties of electrodes to detect the formation of biofilm on the implant and provide a notification that DC treatment is needed.
    Type: Application
    Filed: August 10, 2018
    Publication date: February 14, 2019
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Dacheng Ren, Hao Wang
  • PEPTIDES FOR PREVENTION OF HIV INFECTION
    Publication number: 20190038702
    Abstract: Two peptides that can selectively bind to SEVI and block the enhanced infectivity that results from the interaction of SEVI with HIV. The two peptides comprise the amino acid sequences FEEIVQEIEDFLENLV (SEQ. ID NO: 1) and GIGAVLEVLTTGLPALISWIEEEEQQ (SEQ. ID. NO: 2). The peptides may be administered topically, either alone or in combination with other prophylactics, agents, etc.
    Type: Application
    Filed: July 27, 2018
    Publication date: February 7, 2019
    Applicant: SYRACUSE UNIVERSITY
    Inventor: Ivan V. Korendovych
  • USE OF LIPIDS FOR PREVENTING FRETTING CORROSION IN THE MODULAR TAPERS OF ORTHOPEDIC IMPLANTS
    Publication number: 20190009002
    Abstract: The use of lipids in the taper junction or other metal on metal interface of a modular orthopedic implant to prevent fretting corrosion and increase the pull off load. The incorporation of lipids or a lipid-like substrate within the taper junction increases the onset load and decreases the amount of corrosion. The incorporation of lipids also increases the pull-off load necessary to separate the head from the neck. As a result, the use of lipids in the taper junction of an orthopedic implant should reduce the need for revisions of implants, such as such as knee and hip replacements, which are often needed because of fretting corrosion.
    Type: Application
    Filed: June 27, 2018
    Publication date: January 10, 2019
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Jeremy L. Gilbert, David Pierre
  • Furnace with an integrated flame assisted fuel cell for combined heating and power
    Patent number: 10170780
    Abstract: The present invention relates to a flame-assisted fuel cell (FFC) and, more particularly, to the integration of a FFC in a fuel fired furnace or boiler to enable the generation of both electricity and heat from the fuel's chemical energy, transforming the furnace/boiler into a Combined Heating and Power (CHP) system.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: January 1, 2019
    Assignee: SYRACUSE UNIVERSITY
    Inventors: Jeongmin Ahn, H. Ezzat Khalifa
  • MODE CONVERTER AND QUADRANT PHOTODIODE FOR SENSING OPTICAL CAVITY MODE MISMATCH
    Publication number: 20180374967
    Abstract: A new technique for sensing optical cavity mode mismatch using a mode converter formed from a cylindrical lens mode converting telescope, radio frequency quadrant photodiodes (RFQPDs), and a heterodyne detection scheme. The telescope allows the conversion of the Laguerre-Gauss basis to the Hermite-Gauss (HG) basis, which can be measured with quadrant photodiodes. Conversion to the HG basis is performed optically, measurement of mode mismatched signals is performed with the RFQPDs, and a feedback error signal is obtained with heterodyne detection.
    Type: Application
    Filed: June 27, 2018
    Publication date: December 27, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Fabian Magaña-Sandoval, Stefan Ballmer, Thomas Vo, Daniel Vander-Hyde, Jax Sanders
  • METHODS AND SYSTEMS FOR DETERMINATION OF THE NUMBER OF CONTRIBUTORS TO A DNA MIXTURE
    Publication number: 20180355347
    Abstract: A system configured to characterize a number of contributors to a DNA mixture within a sample, the system comprising: a sample preparation module configured to generate initial data about the DNA mixture within the sample; a processor comprising a number of contributors determination module comprising a machine-learning algorithm configured to: (i) receive the generated initial data; (ii) analyze the generated initial data to determine the number of contributors to the DNA mixture within the sample; and an output device configured to receive the determined number of contributors from the processor, and further configured output information about the received determined number of contributors.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Applicant: Syracuse University
    Inventors: Michael Marciano, Jonathan D. Adelman
  • PRODUCTION OF MALEIC ACID, FUMARIC ACID, OR MALEIC ANHYDRIDE FROM LEVULINIC ACID ANALOGS
    Publication number: 20180354883
    Abstract: A system and method for the conversion of a levulinate ester to maleic anhydride using a reducible oxide catalyst. Levulinic acid oxidation delivers maleic anhydride in good yields without viscosity and stability issues that make continuous production problematic. Due to the fact that levulinate esters are more amenable to processing, the conversion of levulinate esters to maleic anhydride represents an appropriate for the commercial production of maleic anhydride from renewable resources.
    Type: Application
    Filed: June 8, 2018
    Publication date: December 13, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Jesse Quentin Bond, Anargyros Chatzidimitriou
  • TIME RESOLVED NEAR INFRARED REMISSION SPECTROSCOPY FOR NONINVASIVE IN VIVO BLOOD AND TISSUE ANALYSIS
    Publication number: 20180353080
    Abstract: A system and method for obtaining the intravascular plasma volume, red blood cell volume, oxygen saturation SpO2 and Hgb hemoglobin concentration from a sample of in vivo tissue. A sample is irradiated with pulses of single incident wavelength light on a sample of tissue. The prompt emission (PE) and the delayed (DE) light emitted from the tissue are measured simultaneously. A relative volume of light emitted from two phases contained within the tissue is then determined, wherein the two phases comprise a first Rayleigh and Mie scattering and fluorescent phase associated with red blood cells, and a second, non-scattering phase associated with plasma. The plasma volume, Hct, Hgb and SpO2 is calculated from the relative volume of light emitted by the first phase and the relative volume of light emitted from the second phase differentiated by state of oxygenation.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 13, 2018
    Applicant: Syracuse University
    Inventors: Joseph Chaiken, Jerry Goodisman
  • DRIED ATTRACTIVE LURE AND KILL STATIONS FOR THE CONTROL OF AEDES AEGYPTI
    Publication number: 20180340053
    Abstract: An effective dried attractive toxic bait station that acts as a lure and kill device for Ae. aegypti and other mosquitoes. The bait station is a simulated refuge at least part of which is coated with a dried mixture of poison and sugar forming a dried toxic sugar-containing bait. The simulated refuge attracts Ae. aegypti and other mosquitoes to bait station and encourages them to land on the coated portion. Once a mosquito has landed, it detects the sugar in the dried mixture of sugar and poison and ingests some of it. Once ingested, the dried mixture of poison and sugar will eventually kill the mosquito.
    Type: Application
    Filed: May 29, 2018
    Publication date: November 29, 2018
    Applicant: Syracuse University
    Inventors: David Larsen, Anna Stewart, Marco Neira
  • COMPOSITIONS OF NANOPARTICLES WITH RADIAL GRADIENTS AND METHODS OF USE THEREOF
    Publication number: 20180326479
    Abstract: A nanoparticle with tunable radial gradients of compositions extending from the center of the nanoparticles. The nature of the gradient preserves the metallic state of the nanoparticles, the diffusion of the constituents, and the oxidation of the interface. The gradients can be purposely varied to allow for specific applications in fields ranging from corrosion, magnetics, information technology, imaging, electromagnetic absorption, coating technologies, and immuno-precipitation. The nanoparticles can be easily used to advance many areas of industry, technology, and life sciences.
    Type: Application
    Filed: November 18, 2016
    Publication date: November 15, 2018
    Applicant: Syracuse University
    Inventor: Mathew Maye
  • Triple shape memory composite foams
    Patent number: 10125233
    Abstract: A triple shape memory polymeric foam that is open cell in nature and features a two phase, crosslinked SMP with a glass transition temperature of one phase at a temperature lower than a melting transition of the second phase. The resulting soft material features high fidelity, repeatable triple shape behavior, and is useful for complex deployment using a combination of foam compression and bending.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: November 13, 2018
    Assignee: SYRACUSE UNIVERSITY
    Inventor: Patrick T. Mather
  • Coagonists of glucagon-like peptide 1 receptor and neuropeptide Y2 receptor
    Patent number: 10111932
    Abstract: Peptide sequences that can serve as agonists of both the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2). The peptide sequences include regions that correspond to certain aspect of natural substrates and known agonists of the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2) in a single sequence.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: October 30, 2018
    Assignee: Syracuse University
    Inventors: Robert Doyle, Ron Bonaccorso