Patents Assigned to Syracuse University
  • Coagonists of glucagon-like peptide 1 receptor and neuropeptide Y2 receptor
    Patent number: 10111932
    Abstract: Peptide sequences that can serve as agonists of both the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2). The peptide sequences include regions that correspond to certain aspect of natural substrates and known agonists of the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2) in a single sequence.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: October 30, 2018
    Assignee: Syracuse University
    Inventors: Robert Doyle, Ron Bonaccorso
  • EFFICIENT CHANNEL ESTIMATION AND SYMBOL DETECTION FOR MASSIVE MIMO-OFDM
    Publication number: 20180287825
    Abstract: A communication system that minimizes the transmission of pilot symbols while ensuring real-time channel tracking and symbol detection. The system employs a multiple-input multiple-output (MTMO) transmitter-receiver pair where there are many more receive antennas than transmit antennas. Communication occurs over a wide band RF channel via orthogonal frequency division multiplexing (OFDM) that employs a large number of sub-carriers.
    Type: Application
    Filed: October 12, 2016
    Publication date: October 4, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Biao Chen, Michael Gans, John Matyjas
  • SYSTEM AND METHOD FOR VISUALIZING CHEMICAL REACTIONS IN REAL TIME
    Publication number: 20180284086
    Abstract: A nanoparticle based assay for monitoring chemical reactions in real-time, ion concentrations in solution, and oxidation potential of ions in solution is describe. The assay is based on use of photoluminescent perovskite nanoparticles with the composition XYZ3. The XYZ3 nanoparticles are added to a reaction or a solution to be analyzed, and the optoelectronic response of the nanoparticle is proportional to the chemical kinetics of the reaction or concentration of target. The resulting color changes can be qualitatively monitored by eye or quantitatively by spectroscopy. The assays may serve as a compliment or replacement for routine chemical analysis performed over the course of a reaction.
    Type: Application
    Filed: August 30, 2016
    Publication date: October 4, 2018
    Applicant: Syracuse University
    Inventors: Mathew Maye, Tennyson Doane
  • COAGONISTS OF GLUCAGON-LIKE PEPTIDE 1 RECEPTOR AND NEUROPEPTIDE Y2 RECEPTOR
    Publication number: 20180271947
    Abstract: Peptide sequences that can serve as agonists of both the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2). The peptide sequences include regions that correspond to certain aspect of natural substrates and known agonists of the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2) in a single sequence.
    Type: Application
    Filed: August 26, 2016
    Publication date: September 27, 2018
    Applicant: Syracuse University
    Inventors: Robert Doyle, Ron Bonaccorso
  • Conformable reversible adhesives with shape memory assisted delamination
    Patent number: 10081746
    Abstract: A shape memory elastomeric composite that has temperature-controlled, shape memory, and reversible adhesive properties, and is soft enough to confirm to an irregular surface. The composite is formed from a synthesized polyhedral oligomeric silsesquioxane-containing thermoplastic polyurethane elastomer and poly(?-caprolactone) by electrospinning the two components separately and simultaneously and then hot compacting the electrospun composition to form a dense film.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 25, 2018
    Assignee: SYRACUSE UNIVERSITY
    Inventors: Patrick T. Mather, Jaimee Marie Robertson
  • Reversible shape memory polymers exhibiting ambient actuation triggering
    Patent number: 10040909
    Abstract: Shape memory polymers featuring reversible actuation capability under ambient stimulus for integration with apparel. One approach is to use a multiblock polymer consisting of two (or potentially more) blocks in which the one block is the crystalline switching block with relatively low melting transitions, the other block has a higher thermal transition, and the two blocks are linked together by a linker molecule. Another approach is to use a graft copolymer having high and low melting transitions where the graft copolymer has a first polymer serving as the backbone and a second polymer being grafted to or from the backbone at certain graft locations. A further approach is to use latent crosslinking of a semicrystalline polymer with reactive groups placed on the backbone.
    Type: Grant
    Filed: November 2, 2013
    Date of Patent: August 7, 2018
    Assignee: Syracuse University
    Inventor: Patrick T. Mather
  • Polysialic acid-polycaprolactone micelles for drug delivery
    Patent number: 10022324
    Abstract: PSA-PCL micelles were developed as carrier systems for pharmaceutical drugs. As an example, cyclosporine A (CyA) was encapsulated in the micelles and physical characterization, including size and zeta potential, demonstrated that the micelles possess favorable properties for drug delivery. In vitro studies verified that rheumatoid arthritis synovial fibroblasts are able to internalize the CyA-loaded micelles. CyA was released from the PSA-PCL micelle upon uptake and subsequently, partitioned into the phospholipid membrane. The PSA-PCL micelles also demonstrated improved therapeutic efficacy in drug delivery when used to deliver statins and disease modifying anti-rheumatic drugs (DMARDs).
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: July 17, 2018
    Assignee: Syracuse University
    Inventor: Rebecca Bader
  • CONFORMABLE REVERSIBLE ADHESIVES WITH SHAPE MEMORY ASSISTED DELAMINATION
    Publication number: 20180179425
    Abstract: A shape memory elastomeric composite that has temperature-controlled, shape memory, and reversible adhesive properties, and is soft enough to confirm to an irregular surface. The composite is formed from a synthesized polyhedral oligomeric silsesquioxane-containing thermoplastic polyurethane elastomer and poly(?-caprolactone) by electrospinning the two components separately and simultaneously and then hot compacting the electrospun composition to form a dense film.
    Type: Application
    Filed: December 22, 2016
    Publication date: June 28, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Patrick T. Mather, Jaimee Marie Robertson
  • ROBUST AND STABLE AUTONOMOUS VISION-INERTIAL NAVIGATION SYSTEM FOR UNMANNED VEHICLES
    Publication number: 20180164124
    Abstract: An onboard robust and stable vision-inertial navigation system that makes an unmanned vehicle autonomous in its navigation capabilities in the absence of external navigation aids like a global positioning system (GPS). The system is robust to the sensor noise properties of the onboard vision and inertial sensors, as well as errors in initial estimates of the position and orientation of the vehicle. The system enables any unmanned vehicle to autonomously navigate an unfamiliar or unknown environment. The system is also stable and robust to uncertainties in the measurement noise and dynamics of the unmanned vehicle, and does not exhibit any instability when sensors are changed or when sensor noise properties change over time.
    Type: Application
    Filed: September 15, 2017
    Publication date: June 14, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Sasi Prabhakaran Viswanathan, Amit K. Sanyal
  • Glycemic Control Using Intrinsic Factor Bound to A Vitamin B12 Conjugate of a Glucagon-Like Peptide-1 Receptor Agonist
    Publication number: 20180154007
    Abstract: The present invention provides compositions and methods for lowering blood glucose. More specifically, the present invention provides compositions comprising a complex comprising IF and B12 conjugated to a peptide comprising a GLP-1 agonist. Advantageously, the composition may be delivered subcutaneously.
    Type: Application
    Filed: May 20, 2016
    Publication date: June 7, 2018
    Applicant: Syracuse University
    Inventors: Robert Doyle, Jonathan D. Bortz, David S. Hermelin
  • Nanoparticle apparatus and method
    Patent number: 9985148
    Abstract: There is set forth herein a method for forming a suspension having nanoparticles. There is also set forth herein a method for making an interface including nanoparticles. A morphology of conductive nanoparticle interface is set forth herein.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: May 29, 2018
    Assignee: Syracuse University
    Inventors: Radhakrishna Sureshkumar, Miriam Israelowitz
  • Waterborne shape memory polymer coatings
    Patent number: 9982163
    Abstract: The present invention relates to shape memory polymers and waterborne coating materials and, more particularly, to waterborne shape memory polymer coatings.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: May 29, 2018
    Assignee: Syracuse University
    Inventors: Patrick Mather, Kazuki Ishida, Pamela Wilson
  • COMPOSITIONS AND METHODS FOR ENHANCING PEPTIDE STABILITY AGAINST PROTEASE DIGESTION
    Publication number: 20180140669
    Abstract: The present invention relates to the digestion of peptides by pancreatic proteases and, more specifically, to compositions and methods for protecting against protease digestion.
    Type: Application
    Filed: May 20, 2016
    Publication date: May 24, 2018
    Applicant: Syracuse University
    Inventors: Robert Doyle, Jonathan D. Bortz, David S. Hermelin
  • ASSAY FOR THE DIAGNOSIS OF MACULAR DEGENERATION
    Publication number: 20180113140
    Abstract: An assay and kit for detecting N-retinylidene-N-retinylethanolamine (A2E) in a sample that uses a lipid binding protein, such as Saposin B, to capture A2E in the sample and assist in the extraction and measurement of A2E via mass spectroscopy. A2E thus serves as a marker for macular degeneration so that the assay and kit of the invention can be used to detect the presence or severity of macular degeneration.
    Type: Application
    Filed: October 25, 2017
    Publication date: April 26, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventor: Robert P. Doyle
  • WEBSITE AUTHENTICATION USING AN INTERNET-CONNECTED DEVICE
    Publication number: 20180083959
    Abstract: The invention is an authentication framework that enables a user to log in to a website using an Internet-connected device, such as smartphone, smart watch, smart glasses, or tablet, while browsing on a computer. The framework makes it easier for people with certain disabilities to log in to a website, such as by removing the mandatory step of entering usernames and passwords while giving users multiple options through which they are establish their identity using Internet-connected devices. For example, gyroscope, camera, microphone, or the accelerometer can be used to provide credentials. This approach of the framework greatly reduces the number of barriers that a user with disability encounters when trying to use password-based authentication on the Internet.
    Type: Application
    Filed: April 2, 2016
    Publication date: March 22, 2018
    Applicant: Syracuse University
    Inventors: Nata Miccael Barbosa, Yang Wang
  • PIEZOELECTRIC SENSORS AND QUARTZ CRYSTAL MONITORS
    Publication number: 20180074024
    Abstract: Surface modifications and improvements to piezoelectric-based sensors, such as QCMs and other piezoelectric devices, that significantly increase the sensitivity and the specificity (selectivity). These modifications can comprise mechanical and chemical changes to the surfaces of the sensors, either individually or together. For example, nanosize structures may be provided on the surface to improve sensitivity. Additionally, chemical coatings may be tethered to the surfaces, walls, or crystal to provide targeted sensitivity. Additionally, porous, layered and multiple senor arrays may be formed to enhance sensitivity and selectivity.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Fritz H. Schlereth, James Spencer
  • SYSTEM AND METHOD FOR DNA EXTRACTION
    Publication number: 20180051273
    Abstract: A portable device for extracting DNA from a sample comprising a tissue with a plurality of cells. The device includes an opening configured to receive the sample, a first region in fluid communication with the opening and comprising a plurality of tissue processing elements; a second region having a first dehydrated buffer configured to change a first characteristic of the sample and cause lysis of at least some of the plurality of cells in the sample; a third region having a second dehydrated buffer configured to prevent at least some of a plurality of proteins in the sample from progressing from said third region to the fourth region; a fourth region having a third dehydrated buffer configured to purify the DNA from said sample; and an exit designed to allow for the purified DNA to exit the device.
    Type: Application
    Filed: August 17, 2017
    Publication date: February 22, 2018
    Applicant: Syracuse University
    Inventors: Molly M. Cadle-Davidson, Dannielle Loranger
  • Multi-shape product
    Patent number: 9878487
    Abstract: Multi-shape products of the present disclosure comprise two components: a matrix component and a fiber component that is embedded or otherwise disposed in the matrix component. The matrix component exhibits certain shape memory properties. The fiber component interpenetrates the matrix component to facilitate fixing of the multi-shape product in various temporary shapes.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: January 30, 2018
    Assignee: SYRACUSE UNIVERSITY
    Inventors: Patrick Mather, Xiaofan Luo
  • NONINVASIVE, CONTINUOUS IN VITRO SIMULTANEOUS MEASUREMENT OF TURBIDITY AND CONCENTRATION
    Publication number: 20180011017
    Abstract: The invention provides a method of determining turbidity and concentration simultaneously a sample by irradiating the sample with a single incident wavelength and simultaneously measuring wavelength shifted (IE) and unshifted (EE) light emitted. A relative volume of light emitted from two phases may be determined, wherein the two phases comprise a first Rayleigh and Mie scattering and fluorescent phase associated with suspended particles, and a second, non-scattering but fluorescent phase associated with suspending solution. Volumes of the phases and/or concentrations of specific fluorophores or Raman active species are calculated from the volume of light emitted by the first phase relative to the total volume of light emitted from the first and second phases.
    Type: Application
    Filed: September 5, 2017
    Publication date: January 11, 2018
    Applicant: Syracuse University
    Inventors: Joseph Chaiken, Jerry Goodisman
  • High-resolution melt curve classification using neural networks
    Patent number: 9864834
    Abstract: The present invention relates to a method and system for classifying high-resolution melt (“HRM”) curves, and, more specifically, to a method and system for classifying HRM curves by genotype where the curves are represented by a mathematical function with varying coefficient values.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 9, 2018
    Assignee: Syracuse University
    Inventors: Jonathan David Adelman, William Ryon McKay, Jacquelyn Lillis, Katherine Lawson