Abstract: Chimeric and other variant ?-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.

Abstract: A container such as a barrel or drum is provided for processing of solid material or parts with a liquid. The container is designed with grooves leading to holes or slots in the side that draw liquid into the container due to the rotation of the container when it is immersed in a tank of liquid. The holes or slots have a small dimension in the direction of rotation to minimize the probability of solid material coming out of the container. The fluid flow caused by the rotation serves to increase the rate of solution replacement inside the container as well as to keep the solid material from falling out through the holes or slots. The container disclosed is useful in processes in the plating, etching, leaching, and surface finishing industries.

Abstract: Compensating a speech signal for the presence of a speaker mask includes receiving a speech signal, dividing the speech signal into subframes, generating speech parameters for a subframe, and determining whether the subframe is suitable for use in detecting a mask. If the subframe is suitable for use in detecting a mask, the speech parameters for the subframe are used in determining whether a mask is present. If a mask is present, the speech parameters for the subframe are modified to produce modified speech parameters that compensate for the presence of the mask.

Abstract: Systems, methods, and apparatuses for providing dynamic, prioritized spectrum utilization management. The system includes at least one monitoring sensor, at least one data analysis engine, at least one application, a semantic engine, a programmable rules and policy editor, a tip and cue server, and/or a control panel. The tip and cue server is operable utilize the environmental awareness from the data processed by the at least one data analysis engine in combination with additional information to create actionable data.

Abstract: A system for performing continuous transaction log backups with minimal resource usage of the client computing devices that are processing the transactions is disclosed. The system detects at least one input/output (I/O) activity at a client computing device. The I/O activity can be associated with at least one database operation performed via the client computing device. The system then executes one or more native commands to backup transactions log data associated with the detected I/O activity to a virtualized location. Backing-up the transactions log data comprises dynamically identifying a mount path location corresponding to the virtualized location, and transferring the transactions log data to the dynamically identified mount path using the one or more native commands. The system can then perform data processing operations (for example, data chunking and deduplicating) on the transactions log data after it is received at the dynamically identified mount path location.

Abstract: Systems, methods, and apparatuses for providing dynamic, prioritized spectrum utilization management. The system includes at least one monitoring sensor, at least one data analysis engine, at least one application, a semantic engine, a programmable rules and policy editor, a tip and cue server, and/or a control panel. The tip and cue server is operable utilize the environmental awareness from the data processed by the at least one data analysis engine in combination with additional information to create actionable data.

Abstract: A distributed cloud computing system is disclosed that includes a controller configured to deploy a first gateway in a first cloud computing network and a second gateway in a second cloud computing network, and logic. The logic, upon execution by one or more processors, causes performance of operations including receiving, from the controller, metadata pertaining to a plurality of constructs corresponding to a plurality of time instances, receiving, from each of the first and second gateways, network data corresponding to the plurality of time instances, wherein the metadata and the network data identify each of the plurality of constructs, communication paths between each construct, and in which cloud computing network each construct is deployed, generating a visualization illustrating differences between the plurality of constructs and communication paths at the first time instance and at the second time instance, and causing rendering of the visualization on a display screen.

Abstract: A highly versatile process control or factory automation field device is configured with an interface and communication connection structure that enables the field device to operate as a data server that communicates with and supports multiple different applications or clients, either directly or indirectly, while simultaneously performing standard process and factory automation control functions. Moreover, various different process control and factory automation network architectures and, in particular, communication architectures, support the versatile field device to enable the versatile field device to simultaneously communicate with multiple different client devices or applications (each associated with a different system) via a common communication network infrastructure, using the same or different communication protocols.

Abstract: A method of treating patients by using a pharmaceutical composition for intra-intestinal administration comprises (i) a dopamine replacement agents, (ii) a dopamine decarboxylase inhibitor (DDI), and (iii) a COMT inhibitor where the composition is continuously administered.

Abstract: Provided herein is a method for fabricating a heat source for a radioisotope thermoelectric generator (RTG). The method may include reducing a particle size in a strontium compound by powdering and sieving the strontium compound and/or dissolving the strontium compound into an aqueous solution; mixing the strontium compound with graphite to obtain a strontium-graphite mixture; performing a press to the strontium-graphite mixture; and encapsulating the pressed strontium-graphite mixture into an x-ray shielding to obtain the heat source.

Abstract: A system for georeferencing three-dimensional (3D) geometric data associated with a global positioning system (GPS)-denied environment. The system includes an apparatus couplable to a mobile platform and a computing system communicably couplable with the apparatus. The apparatus includes a processing circuit and a range sensor and/or a camera. The computing system includes a 3D generator module configured to generate a digital 3D model of the GPS-denied environment based on data acquired by the range sensor and/or the camera, a 3D survey control generator module configured to identify a survey control point within the GPS-denied environment and generate a 3D digital anchor within the 3D model of the GPS-denied environment, a georeferencing module configured to apply one or more non-rigid transformations to the 3D model of the GPS-denied environment, and a second processing circuit communicably couplable with the 3D generator module, the 3D survey control generator module and the georeferencing module.

Abstract: Automated systems to make target compounds from slide stainer waste streams inactive utilizing advanced oxidation processes are described herein. Advanced oxidation processes are promoted by UV irradiation and further accelerated by use of radical initiators, such as hydrogen peroxide. The automated systems further include mechanisms for segregating components of the waste streams.

Abstract: A resuscitation system including a device or kit adapted for connection to a gas outlet of a resuscitation bag with a first gas inlet thereto and upstream of a face mask, the device or kit providing gas flow in a path from the bag to the mask. A check valve is operably connected to the gas outlet of the resuscitation bag and substantially blocking gas flow upstream thereof and allowing gas flow downstream thereof. A first safety release valve operably located downstream of the resuscitation bag and operable to release gas from the gas flow path at a predetermined pressure differential between the path and ambient. The first safety release valve is located downstream of the check valve.

Abstract: Systems, methods, and apparatuses for providing dynamic, prioritized spectrum utilization management. The system includes at least one monitoring sensor, at least one data analysis engine, at least one application, a semantic engine, a programmable rules and policy editor, a tip and cue server, and/or a control panel. The tip and cue server is operable utilize the environmental awareness from the data processed by the at least one data analysis engine in combination with additional information to create actionable data.

Abstract: Microbolometer systems and methods are provided herein. For example, an infrared imaging device includes a substrate having contacts and a surface. The surface defines a plane. The infrared imaging device further includes a microbolometer array coupled to the substrate. Each microbolometer of the microbolometer array includes a cross-section having a first section, a second section substantially parallel to the first section, and a third section joining the first section and the second section.

Abstract: A device comprising: a sample stage configured to be coupled to a microplate receiver; a microplate receiver configured to be coupled to a microplate; at least one heating element thermally coupled to the microplate receiver; a fluidics dispenser configured to dispense one or more reagents into the microplate; and an imaging system configured to detect one or more features in the microplate; and a structure physically coupled to the sample stage, the heating element, the fluidics dispenser, and the imaging system.

Abstract: A heuristic solver is wrapped in a meta algorithm that will perform multiple sub-runs within the desired time limit, and expand or reduce the effort based on the time it has taken so far and the time left. The goal is to use the largest effort possible as this typically increases the probability of success. In another implementation, the meta algorithm iterates the time-like parameter from a small value, and determine the next test-value so as to minimize time to target collecting data at large effort only as necessary. The meta algorithm evaluates the energy of the solutions obtained to determine whether to increase or decrease the value of the time-like parameter. The heuristic algorithm may be Simulated Annealing, the heuristic algorithm may run on a quantum processor, including a quantum annealing processor or a gate-model quantum processor.

Abstract: A microprocessor includes execution units that execute macro-operations (MOPs), a decode unit that decodes architectural instructions into MOPs, an instruction fetch unit (IFU) having an instruction cache that caches architectural instructions and a macro-operation cache (MOC) that caches MOPs into which the architectural instructions are decoded. A prediction unit (PRU) predicts a series of fetch blocks (FBs) in a program instruction stream to be fetched by the IFU from the MOC if hit or from the instruction cache otherwise. A branch target buffer (BTB) caches information about previously fetched and decoded FBs. A counter of each BTB entry is incremented when the entry predicts the associated FB is present again. For each FB in the series, the PRU indicates whether the counter has exceeded a threshold for use deciding whether to allocate the MOPs into the MOC in response to an instance of decoding the instructions into the MOPs.

Abstract: Systems, methods, and apparatus for automatic signal detection in a radio-frequency (RF) environment are disclosed. At least one node device is in a fixed nodal network. The at least one node device is operable to measure and learn the RF environment in a predetermined period based on statistical learning techniques, thereby creating learning data. The at least one node device is operable to create a spectrum map based on the learning data. The at least one node device is operable to calculate a power distribution by frequency of the RF environment in real time or near real time, including a first derivative and a second derivative of fast Fourier transform (FFT) data of the RF environment. The at least one node device is operable to identify at least one signal based on the first derivative and the second derivative of FFT data.

Abstract: A method for merging buffers and associated operations includes receiving a compute graph for a reconfigurable dataflow computing system and conducting a buffer allocation and merging process responsive to determining that a first operation specified by a first operation node is a memory indexing operation and that the first operation node is a producer for exactly one consuming node that specifies a second operation. The buffer allocation and merging process may include replacing the first operation node and the consuming node with a merged buffer node within the graph responsive to determining that the first operation and the second operation can be merged into a merged indexing operation and that the resource cost of the merged node is less than the sum of the resource costs of separate buffer nodes. A corresponding system and computer readable medium are also disclosed herein.