Patents Assigned to Taipei Medical University
-
Publication number: 20100143271Abstract: A method for preparing amorphous calcium phosphate (ACP) and oral care composition containing ACP prepared by the same are disclosed, wherein the method comprises the following steps: (a) cleaning and pulverizing the oyster shells; (b) sintering the oyster shells to obtain a calcium-containing powder; (c) dissolving the calcium-containing powder in water to obtain a calcium-containing solution; and (d) mixing the calcium-containing solution with a other phosphate-containing solution, to produce amorphous calcium phosphate. The method of the present invention not only can simplify the process and reduce the cost, but also can solve the problem of environment pollution resulting from wasted oyster shells. In addition, the ACP prepared in accordance with the method of the present invention further comprises some trace elements, such as strontium (Sr) and fluoride (F), which can improve dental health.Type: ApplicationFiled: August 28, 2009Publication date: June 10, 2010Applicant: Taipei Medical UniversityInventors: Jen-Chang Yang, Dian-Yu Ji, Chien-Chung Chen, Haw-Ming Huang, Sheng-Yang Lee
-
Publication number: 20100129432Abstract: The invention is directed to a microorganism-killing combination comprising a photosensitizer in an amount effective to kill microorganisms in a photodynamic process and a chitosan in an amount effective to enhance the microorganism-killing effect of the photosensitizer in the photodynamic process. The invention also provides the methods of administering the synergistic bacteria-killing combination to kill bacteria or treat infection.Type: ApplicationFiled: November 25, 2008Publication date: May 27, 2010Applicant: TAIPEI MEDICAL UNIVERSITYInventors: Chin-Tin Chen, Tsuimin Tsai, Hsiung-Fei Chien, Tse-Hsien Wang
-
Publication number: 20100111956Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.Type: ApplicationFiled: October 30, 2008Publication date: May 6, 2010Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTEInventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
-
Patent number: 7700066Abstract: The invention provides a process for preparing ?-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain ?-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: ?0.4x5+7.33x4?52.83x3+187.17x2?328.27x+316<y<1.2x5?22x4+158.5x3?561.5x2+984.8x?588 (2<X<5).Type: GrantFiled: October 3, 2008Date of Patent: April 20, 2010Assignee: Taipei Medical UniversityInventors: Jen-Chang Yang, Hong-Da Wu, Nai-Chia Teng, Sheng-Yang Lee
-
Publication number: 20100086474Abstract: The invention provides a process for preparing ?-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain ?-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: ?0.4x5+7.33x4?52.83x3+187.17x2?328.27x+316<y<1.2x5?22x4+158.5x3?561.5x2+984.8x?588(2<X<5).Type: ApplicationFiled: October 3, 2008Publication date: April 8, 2010Applicant: TAIPEI MEDICAL UNIVERSITYInventors: Jen-Chang Yang, Hong-Da Wu, Nai-Chia Teng, Sheng-Yang Lee
-
Publication number: 20100087373Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.Type: ApplicationFiled: September 29, 2009Publication date: April 8, 2010Applicant: TAIPEI MEDICAL UNIVERSITYInventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
-
Publication number: 20100070254Abstract: A method is provided for generating real-time haptic response information for a haptic simulating device during a surgery simulation performed on an object volume by a virtual tool that is associated with the haptic simulating device. The object volume includes tissue voxels, null voxels, and object boundary points located between corresponding adjacent pairs of the tissue and null voxels.Type: ApplicationFiled: September 15, 2009Publication date: March 18, 2010Applicants: Chung Yuan Christian University, Taipei Medical UniversityInventors: Ming-Dar Tsai, Ming-Shium Hsieh
-
Publication number: 20100047310Abstract: Disclosed is a bio-electrospinning technique for preparing a cell-containing, oriented, continuous tubular scaffold, made of biodegradable polymer, designed for use as a nerve guide conduit (NGC) in nerve regeneration. With a coaxial spinneret, the PC-12 cell medium solution was co-electrospun into a core of tubular fibers, with PLA on the outer shell. The resulted fibers' morphology was characterized via SEM and optical microscopy, and following structural characteristics were found: 1. the larger, hollow fibers had diameters in tenth of microns and wall thicknesses around few microns, 2. an orientation in a preferred direction with the aid of a high-rotating collection device. The fluorescent PC12 cells embedded within the scaffold were cultured and nerve growth factor was added. We observed cells could not only survive the process, but also sustain their viability by undergoing differentiation process, extending neurite along the micro tubular scaffold in the desired direction.Type: ApplicationFiled: July 15, 2009Publication date: February 25, 2010Applicant: Taipei Medical UniversityInventors: Chien-Chung CHEN, Jeng-Chang YANG, Suhan LI, En-Sheng KE, Yung-Sheng LIN
-
Publication number: 20100022753Abstract: A method for modifying a thiol group is provided. The method includes: providing a first material containing at least one sulfhydryl group; providing a second material containing at least one thiourea group; and reacting the first material with the second material in the presence of copper (II) ions to quickly form a disulfide bond between the sulfhydryl group and the thiourea group, wherein the disulfide bond can be easily reduced.Type: ApplicationFiled: July 25, 2008Publication date: January 28, 2010Applicant: TAIPEI MEDICAL UNIVERSITYInventors: Yu-Wei Wu, Yu-Hui Tsai
-
Publication number: 20100003519Abstract: A novel solvent system for dissolving rigid-rod like polymers, such as polybenzoxazole (PBO), is disclosed, wherein said solvent system includes: a methanesulfonic acid (MSA) and a trifluoroacetic acid (TFA). Therefore, the rigid-rod like polybenzoxazole (PBO) can be easily dissolved in said solvent system without extra heat treatment. Besides, the polybenzoxazole (PBO) solution of said solvent system is firstly able to apply into electrospinning at room temperature to produce PBO nano-fiber, which has metallic luster and high thermal stability. Evident supported by the WAXD suggested these fibers have their molecular chains well aligned along the fiber spinning direction and has the advantages of heat resistance, flame retardance, and chemical environmental resistance, thus can be applied to a wide usage.Type: ApplicationFiled: March 25, 2009Publication date: January 7, 2010Applicant: Taipei Medical UniversityInventors: Chien-Chung Chen, Jeng-Chang Yang, Dien-Yu Ji, Yi Lu
-
Patent number: 7608247Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.Type: GrantFiled: March 11, 2008Date of Patent: October 27, 2009Assignee: Taipei Medical UniversityInventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, I-Jen Huang, Neng-Yao Shih, Ko-Jiunn Liu, Mei-Ru Chen, Wen-Shyang Hsieh, Chi-Hsin Lee
-
Publication number: 20090233853Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.Type: ApplicationFiled: March 11, 2008Publication date: September 17, 2009Applicant: TAIPEI MEDICAL UNIVERSITYInventors: Yi-Yuan YANG, Hsueh-Hsia WU, Sy-Jye LEU, I-Jen HUANG, Neng-Yao SHIH, Ko-Jiunn LIU, Mei-Ru CHEN, Wen-Shyang HSIEH, Chi-Hsin LEE
-
Publication number: 20090232852Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.Type: ApplicationFiled: January 23, 2009Publication date: September 17, 2009Applicant: Taipei Medical UniversityInventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yueh-Lun Lee, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
-
Patent number: 7560491Abstract: A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is independently hydrogen, halogen, C1-C10 alkyl, or C1-C10 alkoxyl. Furthermore, A is hydrogen, hydroxyl, or amino group. The compounds of the present invention have both aqueous solubility and anti-tumor activity. The Z-stilbenes derivatives of the present invention can further include a pharmaceutical carrier to form pharmaceutical compositions as potent anti-mitotic agents and anti-cancer agents.Type: GrantFiled: January 19, 2007Date of Patent: July 14, 2009Assignees: Taipei Medical University, National Health Research InstitutesInventors: Jing-Ping Liou, Jang-Yang Chang
-
Publication number: 20090110752Abstract: A composition for controlling a blood glucose and a method thereof are provided. The composition comprises a far-infrared ray releasing substance, wherein the composition reduces the blood glucose of a subject via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of providing a far-infrared ray releasing substance having an oxide mineral as a main component, and disposing the far-infrared ray releasing substance in a place close to a subject in an appropriate distance, wherein the subject has an insulin resistance and the appropriate distance is within an irradiation range of the far infrared ray.Type: ApplicationFiled: February 8, 2008Publication date: April 30, 2009Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL APPLIED RESEARCH LABORATORIESInventors: Huey-Fang Shang, Ting-Kai Leung, Yung-Sheng Lin, Chung-Huei Hsu
-
Publication number: 20090098307Abstract: A manufacturing method for a far-infrared irradiating substrate is provided. The manufacturing method comprises steps of providing a substrate, providing a far-infrared irradiating material and evaporating the far-infrared irradiating material to form a thin film onto the substrate. The far-infrared irradiating substrate provided by the present invention not only has a high emission coefficient of far-infrared ray, but also do not cause a potential exposure of an ionizing radiation.Type: ApplicationFiled: February 22, 2008Publication date: April 16, 2009Applicants: NATIONAL APPLIED RESEARCH LABORATORIES, TAIPEI MEDICAL UNIVERSITYInventors: Po-Kai CHIU, Wen-Hao CHO, Han-Chang PAN, Yung-Sheng LIN, Ting-Kai LEUNG
-
Publication number: 20090053287Abstract: A porous dressing is provided. The porous dressing includes a polymeric layer, a pharmaceutically active ingredient and a metal oxide. The polymeric layer has a porosity and a bio-compatibility, and the pharmaceutically active ingredient and the metal oxide distribute in one selected from a group consisting of in the polymeric layer, on a surface of the polymeric layer and a combination thereof.Type: ApplicationFiled: October 29, 2007Publication date: February 26, 2009Applicants: Medical And Pharmaceutical Industry Technology And Development Center, National Applied Research Laboratories, Taipei Medical UniversityInventors: Ching-Cheng HUANG, Quang-Wei CHANG, Yung-Sheng LIN, Ting-Kai LEUNG
-
Publication number: 20090036518Abstract: A pharmaceutical composition is provided, where the pharmaceutical composition contains formula (I), (II), or (III) flavonoids which possess (PDE4), as a main ingredient. Especially, this composition has a binding affinity of high affinity rolipram binding sites (HARBS) of a PDE4 lower than a binding affinity of low affinity rolipram binding sites (LARBS) of the PDE4 is used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), or chronic inflammation, and has bronchodilatory effects. In addition, whether the above-mentioned flavonoids have side effects, such as nausea, vomiting, gastric hypersecretion, etc., in accordance with their binding affinity to HARBS of particulates of brain cells are disclosed.Type: ApplicationFiled: September 30, 2008Publication date: February 5, 2009Applicant: TAIPEI MEDICAL UNIVERSITYInventor: Wun-Chang Ko
-
Publication number: 20090037334Abstract: An electronic medical record system is disclosed. The disclosed electronic medical record system comprises a data input module for receiving medical record data; a certificate module for receiving the medical record data from the data input module and processing the medical record data; a medical record data module for receiving the medical record data from the certificate module and storing the medical record data therein; and a data output module for receiving the medical record data from the certificate module and outputting the medical record data. A method for storing the medical record data into the electronic medical record system and a portable electronic device loading the electronic medical record system are also disclosed.Type: ApplicationFiled: April 7, 2008Publication date: February 5, 2009Applicant: Taipei Medical UniversityInventors: Chien-Yeh Hsu, Wen-Shan Jian, Hsiao-Hsien Rau, Te-Hui Hao
-
Publication number: 20080308408Abstract: A method for increasing an amount of effective constituents from a plant in a solvent is provided. The method comprises steps of treating the solvent with a far-infrared radiating (FIR) material and extracting the effective constituents from the plant by the treated solvent for increasing the amount of the effective constituents dissolved in the solvent.Type: ApplicationFiled: September 18, 2007Publication date: December 18, 2008Applicants: NATIONAL APPLIED RESEARCH LABORATORIES, TAIPEI MEDICAL UNIVERSITYInventors: Kai-Hsuan CHANG, Ming-Yu LIN, Yung-Sheng LIN, Ting-Kai LEUNG