Patents Assigned to Taipei Medical University
  • Publication number: 20100143271
    Abstract: A method for preparing amorphous calcium phosphate (ACP) and oral care composition containing ACP prepared by the same are disclosed, wherein the method comprises the following steps: (a) cleaning and pulverizing the oyster shells; (b) sintering the oyster shells to obtain a calcium-containing powder; (c) dissolving the calcium-containing powder in water to obtain a calcium-containing solution; and (d) mixing the calcium-containing solution with a other phosphate-containing solution, to produce amorphous calcium phosphate. The method of the present invention not only can simplify the process and reduce the cost, but also can solve the problem of environment pollution resulting from wasted oyster shells. In addition, the ACP prepared in accordance with the method of the present invention further comprises some trace elements, such as strontium (Sr) and fluoride (F), which can improve dental health.
    Type: Application
    Filed: August 28, 2009
    Publication date: June 10, 2010
    Applicant: Taipei Medical University
    Inventors: Jen-Chang Yang, Dian-Yu Ji, Chien-Chung Chen, Haw-Ming Huang, Sheng-Yang Lee
  • Publication number: 20100129432
    Abstract: The invention is directed to a microorganism-killing combination comprising a photosensitizer in an amount effective to kill microorganisms in a photodynamic process and a chitosan in an amount effective to enhance the microorganism-killing effect of the photosensitizer in the photodynamic process. The invention also provides the methods of administering the synergistic bacteria-killing combination to kill bacteria or treat infection.
    Type: Application
    Filed: November 25, 2008
    Publication date: May 27, 2010
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Chin-Tin Chen, Tsuimin Tsai, Hsiung-Fei Chien, Tse-Hsien Wang
  • Publication number: 20100111956
    Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
    Type: Application
    Filed: October 30, 2008
    Publication date: May 6, 2010
    Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTE
    Inventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
  • Patent number: 7700066
    Abstract: The invention provides a process for preparing ?-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain ?-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: ?0.4x5+7.33x4?52.83x3+187.17x2?328.27x+316<y<1.2x5?22x4+158.5x3?561.5x2+984.8x?588 (2<X<5).
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: April 20, 2010
    Assignee: Taipei Medical University
    Inventors: Jen-Chang Yang, Hong-Da Wu, Nai-Chia Teng, Sheng-Yang Lee
  • Publication number: 20100086474
    Abstract: The invention provides a process for preparing ?-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain ?-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: ?0.4x5+7.33x4?52.83x3+187.17x2?328.27x+316<y<1.2x5?22x4+158.5x3?561.5x2+984.8x?588(2<X<5).
    Type: Application
    Filed: October 3, 2008
    Publication date: April 8, 2010
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Jen-Chang Yang, Hong-Da Wu, Nai-Chia Teng, Sheng-Yang Lee
  • Publication number: 20100087373
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 8, 2010
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Publication number: 20100070254
    Abstract: A method is provided for generating real-time haptic response information for a haptic simulating device during a surgery simulation performed on an object volume by a virtual tool that is associated with the haptic simulating device. The object volume includes tissue voxels, null voxels, and object boundary points located between corresponding adjacent pairs of the tissue and null voxels.
    Type: Application
    Filed: September 15, 2009
    Publication date: March 18, 2010
    Applicants: Chung Yuan Christian University, Taipei Medical University
    Inventors: Ming-Dar Tsai, Ming-Shium Hsieh
  • Publication number: 20100047310
    Abstract: Disclosed is a bio-electrospinning technique for preparing a cell-containing, oriented, continuous tubular scaffold, made of biodegradable polymer, designed for use as a nerve guide conduit (NGC) in nerve regeneration. With a coaxial spinneret, the PC-12 cell medium solution was co-electrospun into a core of tubular fibers, with PLA on the outer shell. The resulted fibers' morphology was characterized via SEM and optical microscopy, and following structural characteristics were found: 1. the larger, hollow fibers had diameters in tenth of microns and wall thicknesses around few microns, 2. an orientation in a preferred direction with the aid of a high-rotating collection device. The fluorescent PC12 cells embedded within the scaffold were cultured and nerve growth factor was added. We observed cells could not only survive the process, but also sustain their viability by undergoing differentiation process, extending neurite along the micro tubular scaffold in the desired direction.
    Type: Application
    Filed: July 15, 2009
    Publication date: February 25, 2010
    Applicant: Taipei Medical University
    Inventors: Chien-Chung CHEN, Jeng-Chang YANG, Suhan LI, En-Sheng KE, Yung-Sheng LIN
  • Publication number: 20100022753
    Abstract: A method for modifying a thiol group is provided. The method includes: providing a first material containing at least one sulfhydryl group; providing a second material containing at least one thiourea group; and reacting the first material with the second material in the presence of copper (II) ions to quickly form a disulfide bond between the sulfhydryl group and the thiourea group, wherein the disulfide bond can be easily reduced.
    Type: Application
    Filed: July 25, 2008
    Publication date: January 28, 2010
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yu-Wei Wu, Yu-Hui Tsai
  • Publication number: 20100003519
    Abstract: A novel solvent system for dissolving rigid-rod like polymers, such as polybenzoxazole (PBO), is disclosed, wherein said solvent system includes: a methanesulfonic acid (MSA) and a trifluoroacetic acid (TFA). Therefore, the rigid-rod like polybenzoxazole (PBO) can be easily dissolved in said solvent system without extra heat treatment. Besides, the polybenzoxazole (PBO) solution of said solvent system is firstly able to apply into electrospinning at room temperature to produce PBO nano-fiber, which has metallic luster and high thermal stability. Evident supported by the WAXD suggested these fibers have their molecular chains well aligned along the fiber spinning direction and has the advantages of heat resistance, flame retardance, and chemical environmental resistance, thus can be applied to a wide usage.
    Type: Application
    Filed: March 25, 2009
    Publication date: January 7, 2010
    Applicant: Taipei Medical University
    Inventors: Chien-Chung Chen, Jeng-Chang Yang, Dien-Yu Ji, Yi Lu
  • Patent number: 7608247
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: October 27, 2009
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, I-Jen Huang, Neng-Yao Shih, Ko-Jiunn Liu, Mei-Ru Chen, Wen-Shyang Hsieh, Chi-Hsin Lee
  • Publication number: 20090233853
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 17, 2009
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yi-Yuan YANG, Hsueh-Hsia WU, Sy-Jye LEU, I-Jen HUANG, Neng-Yao SHIH, Ko-Jiunn LIU, Mei-Ru CHEN, Wen-Shyang HSIEH, Chi-Hsin LEE
  • Publication number: 20090232852
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
    Type: Application
    Filed: January 23, 2009
    Publication date: September 17, 2009
    Applicant: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yueh-Lun Lee, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Patent number: 7560491
    Abstract: A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is independently hydrogen, halogen, C1-C10 alkyl, or C1-C10 alkoxyl. Furthermore, A is hydrogen, hydroxyl, or amino group. The compounds of the present invention have both aqueous solubility and anti-tumor activity. The Z-stilbenes derivatives of the present invention can further include a pharmaceutical carrier to form pharmaceutical compositions as potent anti-mitotic agents and anti-cancer agents.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: July 14, 2009
    Assignees: Taipei Medical University, National Health Research Institutes
    Inventors: Jing-Ping Liou, Jang-Yang Chang
  • Publication number: 20090110752
    Abstract: A composition for controlling a blood glucose and a method thereof are provided. The composition comprises a far-infrared ray releasing substance, wherein the composition reduces the blood glucose of a subject via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of providing a far-infrared ray releasing substance having an oxide mineral as a main component, and disposing the far-infrared ray releasing substance in a place close to a subject in an appropriate distance, wherein the subject has an insulin resistance and the appropriate distance is within an irradiation range of the far infrared ray.
    Type: Application
    Filed: February 8, 2008
    Publication date: April 30, 2009
    Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL APPLIED RESEARCH LABORATORIES
    Inventors: Huey-Fang Shang, Ting-Kai Leung, Yung-Sheng Lin, Chung-Huei Hsu
  • Publication number: 20090098307
    Abstract: A manufacturing method for a far-infrared irradiating substrate is provided. The manufacturing method comprises steps of providing a substrate, providing a far-infrared irradiating material and evaporating the far-infrared irradiating material to form a thin film onto the substrate. The far-infrared irradiating substrate provided by the present invention not only has a high emission coefficient of far-infrared ray, but also do not cause a potential exposure of an ionizing radiation.
    Type: Application
    Filed: February 22, 2008
    Publication date: April 16, 2009
    Applicants: NATIONAL APPLIED RESEARCH LABORATORIES, TAIPEI MEDICAL UNIVERSITY
    Inventors: Po-Kai CHIU, Wen-Hao CHO, Han-Chang PAN, Yung-Sheng LIN, Ting-Kai LEUNG
  • Publication number: 20090053287
    Abstract: A porous dressing is provided. The porous dressing includes a polymeric layer, a pharmaceutically active ingredient and a metal oxide. The polymeric layer has a porosity and a bio-compatibility, and the pharmaceutically active ingredient and the metal oxide distribute in one selected from a group consisting of in the polymeric layer, on a surface of the polymeric layer and a combination thereof.
    Type: Application
    Filed: October 29, 2007
    Publication date: February 26, 2009
    Applicants: Medical And Pharmaceutical Industry Technology And Development Center, National Applied Research Laboratories, Taipei Medical University
    Inventors: Ching-Cheng HUANG, Quang-Wei CHANG, Yung-Sheng LIN, Ting-Kai LEUNG
  • Publication number: 20090036518
    Abstract: A pharmaceutical composition is provided, where the pharmaceutical composition contains formula (I), (II), or (III) flavonoids which possess (PDE4), as a main ingredient. Especially, this composition has a binding affinity of high affinity rolipram binding sites (HARBS) of a PDE4 lower than a binding affinity of low affinity rolipram binding sites (LARBS) of the PDE4 is used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), or chronic inflammation, and has bronchodilatory effects. In addition, whether the above-mentioned flavonoids have side effects, such as nausea, vomiting, gastric hypersecretion, etc., in accordance with their binding affinity to HARBS of particulates of brain cells are disclosed.
    Type: Application
    Filed: September 30, 2008
    Publication date: February 5, 2009
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventor: Wun-Chang Ko
  • Publication number: 20090037334
    Abstract: An electronic medical record system is disclosed. The disclosed electronic medical record system comprises a data input module for receiving medical record data; a certificate module for receiving the medical record data from the data input module and processing the medical record data; a medical record data module for receiving the medical record data from the certificate module and storing the medical record data therein; and a data output module for receiving the medical record data from the certificate module and outputting the medical record data. A method for storing the medical record data into the electronic medical record system and a portable electronic device loading the electronic medical record system are also disclosed.
    Type: Application
    Filed: April 7, 2008
    Publication date: February 5, 2009
    Applicant: Taipei Medical University
    Inventors: Chien-Yeh Hsu, Wen-Shan Jian, Hsiao-Hsien Rau, Te-Hui Hao
  • Publication number: 20080308408
    Abstract: A method for increasing an amount of effective constituents from a plant in a solvent is provided. The method comprises steps of treating the solvent with a far-infrared radiating (FIR) material and extracting the effective constituents from the plant by the treated solvent for increasing the amount of the effective constituents dissolved in the solvent.
    Type: Application
    Filed: September 18, 2007
    Publication date: December 18, 2008
    Applicants: NATIONAL APPLIED RESEARCH LABORATORIES, TAIPEI MEDICAL UNIVERSITY
    Inventors: Kai-Hsuan CHANG, Ming-Yu LIN, Yung-Sheng LIN, Ting-Kai LEUNG