Patents Assigned to Taipei Medical University
  • Calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same
    Patent number: 8263048
    Abstract: The invention is directed to a calcium phosphate complex and the composition containing the same for oral care applications, in which the calcium phosphate complex is formed by chelating the ?-polyglutamic acid (?-PGA) with amorphous calcium phosphate (ACP). This complex can prevent crystallization of ACP and maintain its high solubility. The calcium phosphate complex has superior mucoadhesion properties, allowing it to remain in the mouth longer and offering effective buffering, by which dental caries can be alleviated and prevented.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: September 11, 2012
    Assignee: Taipei Medical University
    Inventors: Jen-Chang Yang, Sheng-Yang Lee, Der-Zen Liu, Nai-Chia Teng, En-Sheng Ke, Chien Chung Chen, Dian-Yu Ji, Chen-Feng Ma, Hong-Da Wu
  • SMALL INTERFERING RNAS AND METHODS FOR PREVENTION, INHIBITION AND/OR TREATMENT OF MALIGNANT PROGRESSION OF BREAST CANCER
    Publication number: 20120207817
    Abstract: The invention found that overexpression and activation of ?9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of ?9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of ?9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.
    Type: Application
    Filed: February 14, 2011
    Publication date: August 16, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Chia-Hwa Lee, Ching-Shui Huang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Yu-Jia Chang, Ka-Wai Tam, Po-Li Wei, Tzu-Chun Cheng, Jan-Show Chu, Li-Ching Chen, Chih-Hsiung Wu, Yuan-Soon Ho
  • TEA POLYPHENOLS PRODUCTS FOR CEASING SMOKING AND TREATING AND/OR PREVENTING NICOTINE OR NICOTINE-DERIVED COMPOUNDS OR ESTROGEN INDUCED BREAST CANCER
    Publication number: 20120208873
    Abstract: This invention relates to methods of aiding smoking cessation and/or treating and/or preventing smoking addition or methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in aiding smoking cessation and/or treating and/or preventing smoking addition or treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
    Type: Application
    Filed: May 31, 2011
    Publication date: August 16, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Shih-Hsin Tu, Chung-Yu Ku, Ching-Shyang Chen, Ching-Shui Huang, Chia-Hwa Lee, Li-Ching Chen, Min-Hsiung Pan, Hui-Wen Chang, Chien-Hsi Chang, Yu-Jia Chang, Po-Li Wei, Chih-Hsiung Wu, Yuan-Soon Ho
  • USE OF TEA POLYPHENOLS FOR TREATING AND/OR PREVENTING NICOTINE OR NICOTINE-DERIVED COMPOUNDS OR ESTROGEN INDUCED BREAST CANCER
    Publication number: 20120208872
    Abstract: This invention relates to methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 16, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Shih-Hsin Tu, Chung-Yu Ku, Ching-Shyang Chen, Ching-Shui Huang, Chia-Hwa Lee, Li-Ching Chen, Min-Hsiung Pan, Hui-Wen Chang, Chien-Hsi Chang, Yu-Jia Chang, Po-Li Wei, Chih-Hsiung Wu, Yuan-Soon Ho
  • Histone deacetylase inhibitors
    Patent number: 8242282
    Abstract: This invention relates to compounds of the following general formula: The variables are defined herein. Also disclosed is a method for treating mucositis or cancer using these compounds.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: August 14, 2012
    Assignee: Taipei Medical University
    Inventors: Hui-po Wang, On Lee, Yu-Wen Cheng, Chun-li Wang, Feng-Shuo Chang, Hsiao Che-Chih
  • COMPOSITE OF AMORPHOUS CALCIUM PHOSPHATE/CALCIUM SULFATE HEMIHYDRATE (CSH/ACP) FOR BONE IMPLANTATION AND PROCESS FOR PRODUCING THE SAME
    Publication number: 20120189683
    Abstract: The invention provides a composite of ?-calcium sulfate (CS) hemihydrate/amorphous calcium phosphate (?-CSH/ACP), comprising ?-CSH and ACP at a weight ratio of about 10:90 to about 90:10. Particularly, the composite of the invention has a resorption period of 3-6 months. The invention also provides a one-pot process for producing ?-CSH/ACP composite of the invention. The one-pot process of the invention can produce ?-CSH and ACP in a single process and easily obtain ?-CSH/ACP composite.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 26, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: JEN-CHANG YANG, SHENG-YANG LEE, DUEN-CHENG WANG, HAW-MING HUANG, WEI-JEN CHANG, MALOSI POMA, HONG-DA WU, DIAN-YU JI
  • HIGH PERFORMANCE AND INTEGRATED NOSOCOMIAL INFECTION SURVEILLANCE AND EARLY DETECTION SYSTEM AND METHOD THEREOF
    Publication number: 20120179491
    Abstract: A high performance and integrated nosocomial infection control surveillance and detection system includes a patient database having a patient information, a clinical database having a patient clinical information, a nosocomial infection surveillance model with capability to detect suspected cases, an infection monitoring dashboard presenting an integrated view of a patient information and infection conditions in the clinical database for each patient. The patient database, clinical database, nosocomial infection surveillance model and the infection monitoring dashboard are built in different network servers or a network server to meet the optimum efficiency for a user to conduct infection control and early detection of infected cases through his/her account.
    Type: Application
    Filed: January 6, 2012
    Publication date: July 12, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: CHIEN-TSAI LIU, YU-SHENG LO
  • Isolated transgenic mammalian neural cell for detection of a sample containing a chemical substance damage to neurological system or selection of drugs for treating neurodegenerative disorders
    Patent number: 8211695
    Abstract: The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: July 3, 2012
    Assignee: Taipei Medical University
    Inventors: Yi-Hsuan Lee, Cheng-Yu Wang, Shu-Hui Juan, Wen-Liang Chen, Kuo-Sheng Hung, Chun-Hua Lin
  • Hypoglycemic activity of osthole
    Patent number: 8198320
    Abstract: The present invention relates to a method for controlling blood glucose level and a method for the prophylaxis or treatment of diabetes mellitus and/or its complications. The present invention further relates to an anti-diabetic formulation for controlling blood glucose level and/or for the prophylaxis or treatment of diabetes mellitus and/or its complications.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: June 12, 2012
    Assignee: Taipei Medical University
    Inventors: Yu-Chih Liang, Der-Zen Liu, Ling-Fang Hung, Pei-Jung Lin, Nai-Qi Chen, Yu-Chien Chen
  • POLYLACTIC ACID/CALCIUM SULFATE SCAFFOLD
    Publication number: 20120136441
    Abstract: The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the composite is a calcium sulfate-polylactic acid composite or porous composite and the composite can be especially used as an in situ pore forming scaffold.
    Type: Application
    Filed: November 30, 2010
    Publication date: May 31, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: WEI-CHUNG YANG, JEN-CHANG YANG, DUEN-JENG WANG, SHENG-YANG LEE, YAN-CHIH CHEN
  • NOVEL TYPE OF ANION-CONTAINING CALCIUM PHOSPHATE COMPOUND FOR DENTAL REMINERALIZATION
    Publication number: 20120129135
    Abstract: The invention provides an anion-containing calcium phosphate compound, composition and dental patch comprising the same and their use in remineralizing teeth. The anion-containing calcium phosphate compound has the following formula: (Ca+2)x(anion?a)y(PO4?3)z wherein 2x=(a*y+3z); a is an integer of 1 to 3; and each of x, y and z is not 0.
    Type: Application
    Filed: November 22, 2010
    Publication date: May 24, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: JEN-CHANG Yang, Nai-Chia Teng, Chien-Chung Chen, Sheng-Yang Lee, Chen-Feng Ma, Dian-Yu Ji
  • Use of sp. for treating tic disorders or psychiatric disorders with sensorimotor gating deficits
    Patent number: 8182844
    Abstract: The present invention relates to the use of a composition made from Clerodendrum for treating tic disorder or sensorimotor gating deficits, wherein the composition is particularly made from the leaves of the plant.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: May 22, 2012
    Assignees: National Taiwan University, Taipei Medical University, Fu Jen Catholic University
    Inventors: Lih-Chu Chiou, Pi-Chuan Fan, Wei-Jan Huang, Su-Jane Wang
  • Extracts of hulls and use thereof in the treatment of cancer
    Patent number: 8168238
    Abstract: The invention discloses an ethyl acetate layer of methanol extract of Aquilaria hulls for killing cancer cells and treating/preventing cancers and its uses. The extracts of Aquilaria hulls has an significant amount of cucurbitacins and these cucurbitacins are effective in killing cancer cells and treating/preventing cancers.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: May 1, 2012
    Assignee: Taipei Medical University
    Inventors: Ching-Chiung Wang, Lih-Geeng Chen, Ting-Lin Chang, Chi-Ting Hsieh
  • COMPOSITION FOR INHIBITING CANCER METASTASIS
    Publication number: 20120101163
    Abstract: The invention provides a composition for inhibiting cancer metastasis, including: an effective amount of an amino acid hydroxamic acid derivative having a formula as shown as formula (I), formula (II) or formula (III): and a pharmaceutically acceptable carrier or salt, wherein the amino acid hydroxamic acid derivative has an effect for inhibiting cancer metastasis.
    Type: Application
    Filed: August 9, 2011
    Publication date: April 26, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Wen-Chi Hou, Yin-Shiou Lin, Wen-Chung Wu
  • Method to induce fatty liver in animal
    Patent number: 8138166
    Abstract: The present invention discloses a method to induce fatty liver in an animal. The steps of the method comprise: feeding an animal with a high calorie diet, and injecting a mitochondrial inhibitor into the animal to inhibit the mitochondrial activity of the animal, then resulting in fat accumulation and inflammation in the liver of the animal.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: March 20, 2012
    Assignee: Taipei Medical University
    Inventors: Rong-Hong Hsieh, Sheng-Mei Lin
  • Methods for detecting biomolecules in a sample
    Patent number: 8133683
    Abstract: The invention develops a high-throughput screening method based on charcoal-sorbent peptide binding assay (CPBA) which does not need a solid phase and can simultaneously detect plural target biomolecules in a sample. The method of the invention can achieve high-throughput screening of biomolecules (such as antibodies and antigens) with a molecular weight of more than 10 KD.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: March 13, 2012
    Assignee: Taipei Medical University
    Inventors: Yu-Wei Wu, Yu-Hui Tsai
  • Aryl substituted sulfonamide compounds and their use as anticancer agents
    Patent number: 8119683
    Abstract: Aryl substituted sulfonamide compounds of formula (I): wherein bond, X, Y, R1, R2, R3, m, and n are defined herein. Also disclosed is a method for treating cancer with these compounds.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: February 21, 2012
    Assignees: Taipei Medical University, DCB-USA LLC, National Health Research Institutes
    Inventors: Jing-Ping Liou, Jang-Yang Chang
  • USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS
    Publication number: 20120029066
    Abstract: Novel Use of flavones having 2-phenylchromen-4-one skeleton is disclosed herein. The flavones are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient diagnosed with a psychiatric disorder with sensorimotor gating deficits.
    Type: Application
    Filed: August 1, 2011
    Publication date: February 2, 2012
    Applicants: Taipei Medical University, National Taiwan University
    Inventors: Lih-Chu CHIOU, Wei-Jan HUANG
  • Compounds and Method for Inhibiting the Activity of Gelatinase and Collagenase
    Publication number: 20120022008
    Abstract: Compounds extracted from Rhodiola rosea have ability to inhibit gelatinases and collagenases activity. The compounds have the chemical structure as shown below.
    Type: Application
    Filed: June 23, 2011
    Publication date: January 26, 2012
    Applicants: CHINA MEDICAL UNIVERSITY, TAIPEI MEDICAL UNIVERSITY (TMU)
    Inventors: Ching-Kuo Lee, Chieh-Chih Hsu, George Hsiao, Shin-Hun Juang
  • Composition for Accelerating Nerve Repair
    Publication number: 20110318299
    Abstract: The present invention discloses a composition for accelerating nerve repair. The composition comprises platelet-rich fibrin, a growth factor and a cytokine. The composition may further comprise a tissue with a stem cell or a neural tube to be a scaffold for promoting nerve generation. The platelet-rich fibrin is obtained from the blood of the mammal to be operated on with a nerve repair.
    Type: Application
    Filed: August 31, 2010
    Publication date: December 29, 2011
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventor: Wing-Pong Chan