Patents Assigned to Taipei Medical University
  • WIRELESS DETECTION SYSTEM OF PHYSIOLOGICAL SIGNALS AND METHOD THEREOF
    Publication number: 20130317381
    Abstract: A wireless detection system of physiological signals is provided for wirelessly transmitting variation values of physiological signals, and includes a wireless detecting notification device and a wireless transceiver display device. The wireless detecting notification device comprises at least one transplantable sensor, a connecting line, a printed circuit board, a wireless communication micro-processor chip, an antenna and a power integration module. The power integration module includes a power management chip, a wireless charging coil and a chargeable battery, for integrating a power supply of the wireless detecting notification device. Further, a wireless detection method of physiological signals is further provided to detect variation values of physiological signals in organs of an organism.
    Type: Application
    Filed: May 23, 2013
    Publication date: November 28, 2013
    Applicant: Taipei Medical University
    Inventors: Chung-che Wu, Yung-hsiao Chiang, Jung-tang Huang
  • Equipment for electrospinning
    Patent number: 8540504
    Abstract: An electrospinning equipment is provided. The electrospinning equipment includes a power supply, a collector and a material supply electrically connected to the power supply facing the collector and having a spinneret and a guide unit coupled to the spinneret and bent toward the collector, and the spinneret is configured at a central portion of the guide unit.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: September 24, 2013
    Assignees: National Applied Research Laboratories, Taipei Medical University
    Inventors: Kuen-Wey Shieh, Chien-Chung Chen, Yung-Sheng Lin
  • METHOD FOR DETECTING AND EXAMINING TRAUMATIC BRAIN INJURY IN VITRO
    Publication number: 20130217021
    Abstract: The present invention discloses a method for detecting and examining traumatic brain injury (TBI) in vitro. The method is according to the principle of expression of Etk/Bmx protein which is correspondingly increased when TBI occurs, so that the Etk/Bmx protein is defined as a quantification reference indicator specific for neurological injury degree of TBI. Thus, the method can be used to detect the expression of the Etk/Bmx protein for examining and evaluating the neurological injury degree of TBI occurred due to an external impact.
    Type: Application
    Filed: July 8, 2012
    Publication date: August 22, 2013
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Kai-yun CHEN, Chung-che WU, Yung-hsiao CHIANG
  • Compounds and method for inhibiting the activity of gelatinase and collagenase
    Patent number: 8486898
    Abstract: Compounds extracted from Rhodiola rosea have ability to inhibit gelatinases and collagenases activity. The compounds have the chemical structure as shown below.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: July 16, 2013
    Assignees: Taipei Medical University (TMU), China Medical University
    Inventors: Ching-Kuo Lee, Chieh-Chih Hsu, George Hsiao, Shin-Hun Juang
  • Process for producing inorganic interconnected 3D open cell bone substitutes
    Patent number: 8465582
    Abstract: The present invention relates to a process of using a heat responsive mixture to produce inorganic interconnected 3D open-cell bone substitutes which can be applied in the orthopedic or dental field for treatment of bone damage. The invention provides a simple and easily-controlled process of preparing porous inorganic bone substitute materials.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: June 18, 2013
    Assignee: Taipei Medical University
    Inventors: Jen-Chang Yang, Sheng-Yang Lee, Tsuimin Tsai, Hong-Da Wu, Hsin-Tai Hu, Yan-Cheng Yang, Chen-Feng Ma
  • Method of accelerating osteogenic differentiation and composition thereof
    Patent number: 8455254
    Abstract: The invention discloses a method of accelerating osteogenic differentiation and a composition thereof. The method comprises a step of adding type II collagen into stem/progenitor cells or osteoblasts to accelerate the osteogenic differentiation of the added cells, and the composition comprises type II collagen, and stem/progenitor cells or osteoblasts. Type II collagen can accelerate osteogenesis of mesenchymal stem cells (MSCs) much faster than does type I collagen. The said composition is effective to facilitate bone repair upon introduction of the composition into various osseous defects.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: June 4, 2013
    Assignee: Taipei Medical University
    Inventors: Yu-Hui Tsai, Li-Hsuan Chiu
  • ELECTROSURGICAL UNIT WITH MICRO/NANO STRUCTURE AND THE MANUFACTURING METHOD THEREOF
    Publication number: 20130138103
    Abstract: An electrosurgical unit having micro/nano structure formed thereon and the manufacturing method thereof are disclosed, in which the electrosurgical unit is formed by the irradiation of a laser beam upon a blade so as to have a hybrid of micro/nano elements formed on the surface of the blade. The application of the hybrid of micro/nano elements on the surface of the blade has proven to be a valuable asset not only in providing a non-stick surface and a good heat dissipation ability to the blade, but also in providing a electrosurgical blade that will not release any toxic material under high temperature.
    Type: Application
    Filed: December 27, 2011
    Publication date: May 30, 2013
    Applicants: Taipei Medical University, INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chung-Wei CHENG, Cen-Ying LIN, Weng-Peng TSENG, Keng-Liang OU, Pei-Wen PENG
  • Anti-?-enolase I antibodies for diagnosis and treatment of ?-enolase I-associated diseases
    Patent number: 8449881
    Abstract: The invention relates to antibodies against ?-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-?-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-?-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: May 28, 2013
    Assignee: Taipei Medical University
    Inventors: Sy-Jye Leu, Yi-Yuan Yang, Neng-Yao Shih, I-Jen Huang, Ko-Jiunn Liu, Yu-Ching Lee, Yung-Leun Shih, Yu-Jia Chang, Bor-Yu Tsai, Yuan-Soon Ho
  • Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro
    Patent number: 8431399
    Abstract: The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: April 30, 2013
    Assignee: Taipei Medical University
    Inventors: Yu-Hui Tsai, Li-Hsuan Chiu, Chin-Chean Wong, Wen-Fu Lai, Shih-Ching Chen
  • Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer
    Patent number: 8361984
    Abstract: The invention found that overexpression and activation of ?9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of ?9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of ?9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: January 29, 2013
    Assignee: Taipei Medical University
    Inventors: Chia-Hwa Lee, Ching-Shui Huang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Yu-Jia Chang, Ka-Wai Tam, Po-Li Wei, Tzu-Chun Cheng, Jan-Show Chu, Li-Ching Chen, Chih-Hsiung Wu, Yuan-Soon Ho
  • Detection and therapy of bacterial infection caused by
    Patent number: 8361441
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: January 29, 2013
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • METHOD FOR REPAIR OF ARTICULAR CARTILAGE DEFECT AND A DEVICE USED THEREIN
    Publication number: 20130011442
    Abstract: The invention provides a single surgical procedure by using autologous platelet-rich fibrin (PRF) and cartilage fragments to solve problems of contamination during incubation of chondrocytes and transplant rejection in vivo, which has the benefit of a more efficient and shorter recovery time. The invention also provides a device for easily and rapidly cutting cartilage to cartilage fragments so as to reduce contamination of the implant and infection.
    Type: Application
    Filed: May 29, 2012
    Publication date: January 10, 2013
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventor: Wing-Pong Chan
  • SUPPORTS FOR CELL CULTURE AND CELL SHEET DETACHMENT AND METHODS FOR CELL SHEET DETACHMENT
    Publication number: 20120309089
    Abstract: The invention creates a support for cell culture and cell sheet detachment which has a substrate, whose surface is coated with a conjugate having a disulfide bond-containing amino acid as a spacer and a biopolymer enhancing cell attachment, migration or differentation. Unexpectedly, after being seeded on the support, the cells grow to form one or more layers of cell sheets and the cell sheets can be easily detached from the support by adding a reductant to cleave the disulfide bond. Accordingly, the invention provides a simple and non-toxic method for detachment of cell sheets.
    Type: Application
    Filed: May 31, 2011
    Publication date: December 6, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: HOW TSENG, JENG-KUEN TSAI, KENG-LIANG OU, PO-NIEN CHEN
  • POLYELECTROLYTE COMPLEX GELS AND SOFT TISSUE AUGMENTATION IMPLANTS COMPRISING THE SAME
    Publication number: 20120301436
    Abstract: The invention provides a polyelectrolyte complex gel comprising a chitosan and a ?-polyglutamic acid (?-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof, wherein the chitosan and the ?-PGA are swollen with an aqueous solution. Also provided is a soft tissue augmentation implant, comprising a polyelectrolyte complex gel of the invention as a carrier or a filler and an optional additive. The polyelectrolyte complex gel and the soft tissue augmentation implant containing the same has long degradation time and better supportability so as to provide good maintenance for soft tissue.
    Type: Application
    Filed: May 27, 2011
    Publication date: November 29, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: JEN-CHANG YANG, SHENG-YANG LEE, HAW-MING HUANG, DIAN-YU JI, HONG-DA WU, CHEN-FENG MA
  • CELL POPULATION COMPRISING ORBITAL FAT-DERIVED STEM CELLS (OFSCS) AND THEIR ISOLATION AND APPLICATIONS
    Publication number: 20120288480
    Abstract: The invention relates to a cell population comprising minimal volume of orbital fat-derived stem cells (OFSCs) and its isolation, purification, characterization and application. The OFSCs of the invention are capable of multilineage development and express at least CD90 and CD 105 but not hematopoietic and epithelial markers. The OFSCs have colony formation ability and multi-lineage differentiation ability. They possess at least osteogenic, chondrogenic and adipogenic differentiation capacity; besides mesodermal tri-linage differentiation, the OFSCs have corneal epithelial differentiation potential. Taking together, orbital fat tissues are a novel source for multi-potent stem cells which possess multiple therapeutic potential. Therefore, the OFSCs can be used in cell therapy and tissue engineering.
    Type: Application
    Filed: February 22, 2011
    Publication date: November 15, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventor: Jennifer Hui-Chun Ho
  • High yield dialysis-free process for producing organosoluble regenerated silk fibroin
    Patent number: 8309689
    Abstract: The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing the solvent power of the fibroin solution. The process of the invention simplifies the process of producing silk fibroin and greatly shortens the process time to 1 to 2 hours, whereas the conventional dialysis process is complex and needs around 2 to 3 days. In addition to reducing the time needed, the process of the invention can increase productivity of silk fibroin by at least 8%.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: November 13, 2012
    Assignee: Taipei Medical University
    Inventors: Jen-Chang Yang, Sheng-Yang Lee, Chien Chung Chen, Yun-Ting Hsu, Hong-Da Wu, Dian-Yu Ji
  • Amorphous metal salt for facilitating the handling property of portland cements and dental applications thereof
    Patent number: 8298328
    Abstract: A novel amorphous divalent metal ion salt for enhancing the manageability of a Portland cement and its application in dental field are disclosed. Typical formula (I), (II), or (III) of this amorphous metal ion salt are shown as following: M 2 + ? A x - ? B 2 - x - ( I ) M 2 + ? A y 2 - ? C ( 4 - y ) 4 2 - ( II ) M 2 + ? A z 3 - ? D ( 6 - z ) 9 3 - ( III ) wherein, M2+, A?, B?, C?2, D?3, x, y, and z are defined the same as the specification. A novel tooth filling material comprises: a Portland cement, a bone substitute substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). In addition, a novel root canal filling material comprises: a Portland cement, a radiopaque substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III).
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: October 30, 2012
    Assignee: Taipei Medical University
    Inventors: Jeng-Chang Yang, Pei-Ying Lee, Dian-Yu Ji, Nai-Chia Teng, Sung-Chih Hsieh, Sheng-Yang Lee
  • METHOD OF IDENTIFYING A CANDIDATE COMPOUND WHICH MAY INHIBIT a9-nAchR OVEREXPRESSION OR ESTROGEN RECEPTOR-DEPENDENT TRANSCRIPTION IN NICOTINE-DERIVED-COMPOUND-INDUCED BREAST CANCER CELLS
    Publication number: 20120270799
    Abstract: The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or ?9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that ?9-nAChR has an activating protein 1 (AP1)-binding site, that the ?9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the ?9-nAChR promoter at the AP1-binding site, indicating that ER-induced ?9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.
    Type: Application
    Filed: April 21, 2011
    Publication date: October 25, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Chia-Hwa Lee, Ya-Chieh Chang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Li-Ching Chen, Yu-Jia Chang, Po-Li Wei, Hui-Wen Chang, Chien-Hsi Chang, Ching-Shui Huang, Chih-Hsiung Wu, Yuan-Soon Ho
  • PIPERAZINEDIONE COMPOUNDS
    Publication number: 20120232088
    Abstract: This invention relates to piperazinedione compounds shown in the specification. These compounds are tyrosine kinase inhibitors and can be used to treat cancer.
    Type: Application
    Filed: February 24, 2012
    Publication date: September 13, 2012
    Applicants: National Taiwan University, Taipei Medical University
    Inventors: Hui-Po Wang, Che-Ming Teng, Chun-Li Wang, Jih-hwa Guh, Shiow-Lin Pan, Yuan-Yi Wang, Jang-Feng Lian
  • Pharmaceutical Composition for Inhibiting Histone H4 and Manufacturing Method Thereof
    Publication number: 20120231016
    Abstract: The present invention discloses a pharmaceutical composition for inhibiting histone H4 and a manufacturing method thereof. The pharmaceutical composition comprises an anti-histone H4 antibody and a pharmaceutically acceptable excipient. The hair loss resulted from medications, including cancer drugs, can be reduced by using the pharmaceutical composition of the present invention, thereby resolving mental depression and promoting prognosis effects for patients.
    Type: Application
    Filed: February 27, 2012
    Publication date: September 13, 2012
    Applicants: NATIONAL CHUNG CHENG UNIVERSITY, TAIPEI MEDICAL UNIVERSITY
    Inventors: Min-Jen Tseng, Ching-Wu Hsia, Ko-Ta Cheng, Chun-Mao Lin