Patents Assigned to Technion Research & Development
  • SYSTEMS AND METHODS FOR GENERATING VOLUMETRIC MODELS
    Publication number: 20190130642
    Abstract: There is provided a method of design and analysis of a geometric object comprising: receiving an initial definition of the geometric object in a coordinate system; generating a volumetric model according to the initial definition, the volumetric model comprises: volumetric cells each represented by one or more multivariate of three variables or more functions, and intra object general border surfaces in general orientation each defines topological adjacency between at least two of said plurality of volumetric cells.
    Type: Application
    Filed: May 24, 2017
    Publication date: May 2, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Gershon ELBER, Fady MASSARWI
  • SMART GROUND SYSTEM FOR MONITORING OF NANO-SATELLITES
    Publication number: 20190118980
    Abstract: A ground-based satellite control station to control an array of nanosatellites in low earth orbit to produce an illumination event visible at a predetermined ground location. The nanosatellites in the array may have an illumination element, and array of nanosatellites in low earth orbit (LEO) may controllably apply their illumination to be visible on the ground. The nanosatellites may be coordinated by the control station to provide illumination events visible on the ground at particular locations and particular times.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 25, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Oded SHMUELI, Ehud BEHAR
  • CONTROL SYSTEM FOR NANO-SATELLITES
    Publication number: 20190118979
    Abstract: A nanosatellite with an illumination element, and an arrangement of nanosatellites in low earth orbit (LEO) arranged to controllably apply their illumination to be visible on the ground. The nanosatellites may be coordinated to provide illumination events visible on the ground at particular locations and particular times.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 25, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Oded SHMUELI, Ehud BEHAR
  • HEPARANASE-NEUTRALIZING MONOCLONAL ANTIBODIES
    Publication number: 20190112391
    Abstract: The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, diabetes and related complications. The present invention further provides combined therapies comprising the heparanase-neutralizing m Ab and an anti-cancer treatment such as chemotherapy or radiation, for treating a proliferative disease in a subject.
    Type: Application
    Filed: October 13, 2016
    Publication date: April 18, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Israel VLODAVSKY, Marina WEISSMANN, Neta ILAN, Gil ARVATZ
  • Field effect transistor device
    Patent number: 10263068
    Abstract: A transistor device is described, the transistor comprising: a channel region in contact with the gate insulator and source and drain electrodes in contact with the channel region and arranged in a spaced-apart relationship. The channel region is configured with discontinuity in a material path of the channel, located between the source and drain electrodes. The channel being formed by a plurality of discrete semiconductor particles, distributed irregularly within the channel region, and a plurality of electrically conducting particles. The electrically conducting particles connect at least some of said semiconducting particles to one another to provide continuous path for electric coupling between said at least some semiconductor particles, forming an electrical path between the source and drain electrodes.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 16, 2019
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yoav Eichen, Nir Tessler, Pramod Kumar, Yulia Gerchikov
  • LIPOSOMAL FORMULATIONS AND METHODS OF USING SAME IN AGRICULTURE
    Publication number: 20190098895
    Abstract: Provided is a formulation including an agriculturally acceptable carrier and liposomes including a lipid membrane and an intraliposomal aqueous core. The liposome has a diameter in the range of between 100 nm to 300 nm and the lipid membrane includes at least one liposome forming phospholipid. The lipid membrane may include two or more phospholipids. At least one of the two or more phospholipids may be a liposome forming lipid. Further, at least one of the two or more phospholipids may be characterized by one or more of the following features: (a) it has an unsaturated lipid tail; (b) it includes a polar head group; (c) it includes an acidic head group. Further provided are methods of using the formulation for agricultural treatment and kits for preparing and using such formulations.
    Type: Application
    Filed: March 8, 2017
    Publication date: April 4, 2019
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Avi SCHROEDER, Avishai KARNY
  • Oblivious parallel random access machine system and methods
    Patent number: 10248324
    Abstract: A secure parallel processing technique for converting any parallel random access machine (PRAM) into an oblivious parallel random access machine (OPRAM), whose distribution of memory accesses is statistically independent of the data (with negligible error), while only inducing a polylogarithmic slowdown to both the total and parallel complexities of the program.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: April 2, 2019
    Assignees: Cornell University, Technion Research & Development Limited, Academia Sinica
    Inventors: Rafael Pass, Elette Boyle, Kai-Min Chung
  • Process for preparation of micron-sized single curved crystals of metals
    Patent number: 10246768
    Abstract: The present invention relates to metal micron-sized single crystals having a controlled curvature, which can be either fully or partially nanoporous; and to a process for growing of such single crystals from the confined volume of droplets of a eutectic composition melt comprising said metal as one of the two eutectic components, with no need of any fabrication steps.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: April 2, 2019
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDA
    Inventors: Boaz Pokroy, Maria Koifman Khristosov
  • MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR
    Publication number: 20190093078
    Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
    Type: Application
    Filed: September 3, 2018
    Publication date: March 28, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
  • INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES
    Publication number: 20190094223
    Abstract: Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
    Type: Application
    Filed: April 6, 2017
    Publication date: March 28, 2019
    Applicants: Technion Research & Development Foundation Limited, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shai S. SHEN-ORR, Elina STAROVETSKY, Naama MAIMON, Purvesh KHATRI, Renaud GAUJOUX, Francesco VALLANIA
  • Composition and method for treating androgen-dependent disorders
    Patent number: 10240132
    Abstract: Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3?-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: March 26, 2019
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Roee Amit, Alexey Tomsov, Orna Atar, Liron Abrahami, Yael Annis, Roni Cohen, Alexandra Ereskovsky, Noa Katz, Lior Levy, Maayan Lufton, Tal Ofek, Sagi Sheinkman, Nitzan Shmuel, Inbal Vaknin, Ruth Veksler, Adi Yannai
  • DISINFECTION AND REMOVAL OF NITROGEN SPECIES FROM SALINE AQUACULTURE SYSTEMS
    Publication number: 20190082661
    Abstract: Provided are physico-chemical processes for continuous and simultaneous water disinfection, oxidation of off flavor agents, minimization of trihalomethane (THM) production, reduction of nitrate and nitrite production and oxidation of ammonia so as to remove nitrogen species, in saline (for example, seawater) based aquaculture systems. The aquaculture system may be any handling/storage/transport system, for example, recirculated aquaculture systems (RAS), for fish or other aquaculture species.
    Type: Application
    Filed: March 8, 2017
    Publication date: March 21, 2019
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Ori LAHAV, Raz BEN-ASHER, Youri GENDEL, Liat BIRNHACK
  • CREATING A SYNTHETIC MODEL WITH ORGANIC VERACITY
    Publication number: 20190080510
    Abstract: A method of creating a real time synthetic model tracking a dynamic physical entity, comprising: a) Receiving multiple points extracted from a sequence of 3D information depicting a dynamic physical entity, each point is associated with position and photometric information. b) Identifying, within the multiply of points, a cloud point which includes multiple entity representative points which portray a surface of the dynamic physical entity. c) Generating a points-surface for a synthetic model by creating spatial presentation of the entity representative points through calculation of principal curvatures for each entity representative point according to the respective position information. d) Generating a continuous surface for the synthetic model by texturing ellipsoidal shapes created for each entity representative point according to the respective photometric information.
    Type: Application
    Filed: November 12, 2018
    Publication date: March 14, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Miriam Reiner, Tatiana Gelfeld
  • Structured light generation and processing on a mobile device
    Patent number: 10225533
    Abstract: A system comprising: a handheld mobile device comprising: a projector unit configured to project an image; a camera; and a prism configured to reflect the image projected by the projector such that the camera can capture the projected image.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: March 5, 2019
    Assignee: Technion Research and Development Foundation Limited
    Inventors: Aaron Wetzler, Ron Kimmel
  • NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
    Publication number: 20190060340
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Application
    Filed: November 14, 2018
    Publication date: February 28, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • Methods for expanding and maintaining human pluripotent stem cells (PSCs) in an undifferentiated state in a single cell suspension culture
    Patent number: 10214722
    Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliay Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: February 26, 2019
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • System and method for pad printing
    Patent number: 10201966
    Abstract: An apparatus for pad printing includes a printing pad (12). A textured transfer member (13) is configured to be pressed alternately by the printing pad (12) against an ink carrier (17) and against a substrate (24) so as to transfer an ink pattern to the substrate.
    Type: Grant
    Filed: August 24, 2014
    Date of Patent: February 12, 2019
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Yacov Shneider, Orna Ternyak, Svetlana Yofis
  • USE OF DECELLULARIZED EXTRACELLULAR MATRIX FOR ENCAPSULATING CELLS
    Publication number: 20190022017
    Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM) and, optionally, an outer layer. Also provided are methods of encapsulating cells in the microparticle, pharmaceutical compositions comprising the microparticle, and methods of treating disease in animals employing the microparticles of the invention, for example, treating Diabetes.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 24, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Marcelle MACHLUF, Deborah CHAIMOV
  • Delivery system comprising a proteolytic enzyme or effector thereof for use in a method for oral treatment and uses thereof
    Patent number: 10183064
    Abstract: The present disclosure provides a delivery system comprising (i) a physiologically acceptable carrier and (ii) a proteolytic enzyme or effector thereof for use in a method for relaxing fibers within a subject's oral cavity. In some embodiments, the relaxation is for use in tooth manipulation (particularly repositioning). In some embodiments, the method involves the use of the proteolytic enzyme or effector thereof at a concentration effective to cause relaxation of fibers between the tooth's alveolar bone and gingiva while maintaining integrity of the fibers surrounding the tooth. Also disclosed herein are methods for fiber relaxation and/or repositioning of tooth making use of the proteolytic enzyme or effector thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: January 22, 2019
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Avraham D. Schroeder, Assaf Yosef Zinger, Avishay Herman
  • AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING MICROBIAL INFECTIONS
    Publication number: 20190016745
    Abstract: Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, are disclosed. Also disclosed are pharmaceutical compositions containing the same, and uses thereof in the treatment of medical conditions associated with a pathogenic microorganism.
    Type: Application
    Filed: September 2, 2016
    Publication date: January 17, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventor: Timor BAASOV