Patents Assigned to Technion Research & Development
  • Publication number: 20220184554
    Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Alexander KRAYTSBERG, Yair EIN-ELI
  • Patent number: 11361503
    Abstract: There is provided a method of design and analysis of a geometric object comprising: receiving an initial definition of the geometric object in a coordinate system; generating a volumetric model according to the initial definition, the volumetric model comprises: volumetric cells each represented by one or more multivariate of three variables or more functions, and intra object general border surfaces in general orientation each defines topological adjacency between at least two of said plurality of volumetric cells.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: June 14, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Gershon Elber, Fady Massarwi
  • Publication number: 20220182229
    Abstract: One of the main obstacles of securing industrial control systems is the lack of an appropriate security model that is both implementable by vendors and addresses the inherent security and usability issues needed by organizations. Current solutions such as device passwords and IPSec lack scalable key management infrastructure and fine granularity access control mechanisms. A security model for industrial control systems that supports organizational level authorizations and authentication requirements, while hiding the low-level details (e.g., keys and passwords) from the users is disclosed. It also enables easy addition and removal of PLCs, engineering station, HMI devices and users, and assigning permission to them. A major advantage is its support for hybrid ICS systems, characterized by co-existence of legacy devices and new devices, while using the same protocol. Devices may communicate therein either natively, or by a connected converter.
    Type: Application
    Filed: December 7, 2021
    Publication date: June 9, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Eli BIHAM, Sara BITAN-ERLICH, Alon DANKNER
  • Publication number: 20220161275
    Abstract: A method of electroporation of a biological object, comprises: introducing a carrier particle into a medium containing the biological object; applying a first electric field to the medium to induce trapping of the biological object by the carrier particle; and varying at least one parameter of the first electric field so as to induce electroporation of the biological object.
    Type: Application
    Filed: March 17, 2020
    Publication date: May 26, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Gilad YOSSIFON, Yue WUE, Sinwook PARK
  • Publication number: 20220155243
    Abstract: A microwave device comprises: a cavity containing a crystal having paramagnetic defects, and being responsive to light; a magnetic field source for applying magnetic field to the cavity and the crystal; and a light source for generating a pump light beam directed to the crystal and having a frequency selected to induce inversion of spin energy levels of the crystal.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 19, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Aharon BLANK, Alexander SHERMAN
  • Patent number: 11318418
    Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: May 3, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Alexander Kraytsberg, Yair Ein-Eli
  • Patent number: 11301397
    Abstract: A computing device, comprising at least one peripheral computing component, electrically connected to each of a plurality of hardware processors; wherein at least one of the plurality of hardware processors is adapted to executing a code for: configuring the at least one peripheral computing component to access at least one first memory location in a first memory component electrically coupled with a first hardware processor of the plurality of hardware processors via a first electrical connection between the peripheral computing component and the first hardware processor; and configuring the at least one peripheral computing component to access at least one second memory location in a second memory component electrically coupled with a second hardware processor of the plurality of hardware processors via a second electrical connection between the peripheral computing component and the second hardware processor; and wherein the first hardware processor is not the second hardware processor.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: April 12, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Dan Tsafrir, Igor Smolyar
  • Patent number: 11291705
    Abstract: Provided are methods of selecting a treatment for a cancer in a subject in need thereof, by analyzing activity of Yes associated protein 1 (YAP) in cancer cells of the subject, and methods of treating cancer using a therapeutically effective amount of an caspase-3 inhibitor. Also provided are methods of improving wound healing by administering a wound healing effective amount of a caspase-3 activator.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 5, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yaron Fuchs, Yahav Yosefzon, Despina Soteriou
  • Patent number: 11292986
    Abstract: This invention is directed to intramolecular crosslinked polymer chains, commonly known also as single-chain polymer nanoparticles (SCPNs), with high resistance to mechanochemical bond scission and to uses thereof in solution.
    Type: Grant
    Filed: January 29, 2017
    Date of Patent: April 5, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Charles Eliezer Diesendruck
  • Patent number: 11291515
    Abstract: A compact robotic device for driving movement of two or more elongate surgical tools configured for a telescopic arrangement when said two or more elongate surgical tools are at least partially received within said device, the device comprising: a housing comprising walls which define an inner volume including at least two inner pathways for accommodating the two or more elongate surgical tools; the housing encasing: a plurality of motors, and two or more tool actuation assemblies configured at a position of each of the two or more inner pathways; the actuation assemblies driven by the plurality of motors and configured to operably contact an elongate surgical tool at least partially received in the inner pathway to at least one of advance, retract and/or roll said elongate surgical tool.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: April 5, 2022
    Assignees: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon Sharon, Idan Boader, Evgeny Kofman, Moshe Shoham, Eran Cohen, Eyal Morag
  • Publication number: 20220096161
    Abstract: A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate. This cannulated needle is robotically controlled to provide motion into and out of the subject's skull. A flexible needle is disposed coaxially within the cannulated needle, and it is controlled to move into and out of a non-axial aperture in the distal part of the cannulated needle. Coordinated control of the insertion motion of the cannulated and flexible needles, and rotation of the combined cannulated/flexible needle assembly enables access to be obtained to a volume of a region of the brain having lateral dimensions substantially larger than the width of the cannulated needle.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: David ZARROUK, Moshe SHOHAM, Menashe ZAAROOR, Hadas ZISO
  • Publication number: 20220073865
    Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 10, 2022
    Applicants: Technion Research & Development Foundation Limited, RISE Innventia AB
    Inventors: Noam ATTIAS, Jacob GROBMAN, Tiffany ABITBOL
  • Publication number: 20220071723
    Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 10, 2022
    Applicants: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon SHARON, Idan BOADER, Moshe SHOHAM, Eran COHEN, Eyal MORAG
  • Patent number: 11262358
    Abstract: Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: March 1, 2022
    Assignees: Technion Research & Development Foundation Limited, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shai S. Shen-Orr, Elina Starovetsky, Naama Maimon, Purvesh Khatri, Renaud Gaujoux, Francesco Vallania
  • Publication number: 20220056406
    Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliary Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.
    Type: Application
    Filed: November 10, 2021
    Publication date: February 24, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
  • Publication number: 20220040670
    Abstract: Provided herein is a porous ?-cyclodextrin-containing monolith having a microstructure templated by the external phase of a HIPE, as well as processes of manufacturing the same and uses thereof.
    Type: Application
    Filed: August 2, 2021
    Publication date: February 10, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Rajashekharayya A. SANGURAMATH, Inna BEREZOVSKA, Michael S. SILVERSTEIN
  • Patent number: 11245550
    Abstract: A system for authenticating messages transmitted on a bus based on physical location of transmitting units, comprising a reflector adapted to inject a plurality of reflection signals at a first point of a line topology bus, each in response to each of a plurality of messages transmitted by a plurality of bus connected units and a probe adapted to intercept the messages and the reflection signals at a second point of the bus. The probe calculates propagation timing between a reception time of the message and a reception time of an associated reflection signal transmitted in response to the message and determines validity of the message according to a match between the calculated propagation timing and a predefined propagation timings associated with the bus connected units. Wherein the bus connected units are statically connected to the bus between the first point and the second point.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: February 8, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Eli Biham, Eli Gavril, Sara Bitan-Erlich
  • Patent number: 11241291
    Abstract: A modular robotic surgical system includes one or more tool-receiver units arranged as separate units, each tool-receiver unit operable to move a first elongate surgical tool received therein. The device also includes a base comprising one or more motors, the base operable to move a second elongate surgical tool attached to the base or received therein, the base serving as a mounting for the one or more tool-receiver units, each of the tool-receiver units is independently and interchangeably attachable to the base via a mechanical coupling interface which transfers one or more of: driving force for driving movement of the first elongate surgical tool received within the unit; electrical power supply to one or more components of the unit which drive movement of the first elongate surgical tool received within the unit; and data for controlling movement of the first elongate surgical tool received within the unit.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: February 8, 2022
    Assignees: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon Sharon, Idan Boader, Evgeny Kofman, Moshe Shoham, Eran Cohen, Eyal Morag, Harel Gadot
  • Patent number: 11213362
    Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: January 4, 2022
    Assignees: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon Sharon, Idan Boader, Moshe Shoham, Eran Cohen, Eyal Morag
  • Patent number: 11208729
    Abstract: A system and method for generating hydrogen gas from an aqueous solution are disclosed herein. The system comprises a compartment with a working electrode for reducing water in response to an applied voltage to generate hydrogen and a redox-active electrode capable of reversibly undergoing oxidation and reduction. The system may further comprise a second compartment with a working electrode for generating oxygen and redox-active electrode electrically connectable to the redox-active electrode in the first compartment. The method comprises applying a voltage between a working electrode and a redox-active electrode of a system described herein and/or between comprising a working electrode of one compartment and a working electrode of a second compartment of a system described herein.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: December 28, 2021
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Avner Rothschild, Gideon Grader, Gennady Shter, Avigail Landman, Hen Dotan