Abstract: The present invention relates to the field of molecular imaging, i.e. nuclear and fluorescent imaging using metal ion radionuclides in combination with chelates highly functionalized with peptidic, nonpeptidic or protein ligands or additional signalling moieties.

Abstract: The present invention relates to a process for preparing substituted 2-aminobiphenyls and to a process for preparing (Het)arylamides of such 2-aminobiphenyls.

Abstract: The present invention relates to a mutein of human tear lipocalin, wherein the mutein comprises at least one mutated amino acid residue at any two or more of the sequence positions 24-36, 53-66, 79-84, and 102-110 (or 103-110) of the linear polypeptide sequence of the mature human tear lipocalin, and wherein the mutein binds to the extracellular region of the T-cell coreceptor CD4 with detectable affinity. The invention also relates to a method of generating such a mutein as well as to various pharmaceutical uses of such a mutein.

Abstract: The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

Abstract: A method for producing a component from a fibre composite. A number of layers of a dry fibrous material are stacked to form a pile, the pile is covered by a thermoplastic film in a gas-tight manner, the inner space occupied by the pile within the film is pumped dry and the layers are fixed to form a preform that is stable during transport, the preform is reshaped, a liquid thermosetting material is inserted into the inner space by infiltration of the fibrous material, and the preform is hardened with the infiltrated fibrous material to form the finished component, the film binding permanently as the surface. The invention also relates to a component produced in such a way, and to a corresponding preform. The production method provides a process-integrated surface finishing of the fibre composite. The surface properties are created by the bound thermoplastic film.

Abstract: The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a detectable label; or ii) a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins and combinations thereof, with the proviso that -L-Ar-D does not comprise a 18F-benzoyl residue.

Abstract: A method is proposed for the simultaneous optimization of an arbitrary number of electromagnetic pulses, which act in a cooperative way, or mutually compensate each other's errors. The method generally relates to pulses which can have improved properties when cooperating with each other compared to single pulses. In experiments with several scans, undesired signal contributions can be suppressed by COOP pulses, which complements and generalizes the concept of phase cycling. COOP pulses can also be used in individual scans. COOP pulses can be optimized efficiently with the aid of an extended version of the optimal-control-theory-based gradient ascent pulse engineering (GRAPE) algorithm. The advantage of the COOP pulse method is demonstrated theoretically and experimentally for broadband and band-selective excitation and saturation pulses.

Abstract: An aerodynamic element attachable to a primary wing to extend in a longitudinal direction at an angle to a spanwise direction of the primary wing. The aerodynamic element includes a downstream end having at least two flow flaps arranged next to each other and oriented in the longitudinal direction of the aerodynamic element.

Abstract: A shaft power plant (1) for generating electricity by energy conversion of a discharge between a headwater (2) and a tailwater (6), comprising a vertical shaft (7), the top (10) of which forms an inflow plane (11) which is parallel to the bed and extends below the water level (3) of the headwater, wherein the shaft (7) is open toward the top and is closed by a base (9) at its bottom end, a unit (15) composed of a turbine (16) and an electrical machine (17), wherein the unit (15) is arranged entirely under water in the shaft (7) and wherein the turbine (16) is arranged for water to pass through vertically, and an outflow (24), which is connected to the turbine (16), represents a closed flow channel and leads through a through-passage (28) in the shaft (7) to the tailwater (6), wherein, in a horizontal plane of a turbine runner (19) of the turbine (16), a first cross-sectional area of the shaft (7) is much larger than a second cross-sectional area taken up by the turbine runner (19).

Abstract: A force microscope for the detection of forces in the sub-micronewton range has a measurement head which is used to carry out a relative movement with respect to a sample holder and to which a carrier molecule is attached on which probe molecules are placed.

Abstract: A method for processing a set of navigation signals of a global navigation satellite system with at least three carrier signals is disclosed in which the processing of the navigation signals is based on a linear combination of the carrier signals to a combined signal. The weighting coefficients are selected such that the combined phase signal is free from geometry and free from frequency-independent disturbance variables.

Abstract: A device for imaging the local distribution of at least one thermodynamic variable includes a radiation emitter capable of emitting electromagnetic radiation and a filter for filtering electromagnetic radiation. The emitter and the filter form an arrangement adapted for modifying the electromagnetic radiation emitted by the emitter in dependency of the local distribution of at least one thermodynamic variable at the location of the arrangement. The emitter further includes at least one electroluminescent layer and the filter is provided with at least one filter layer. The electroluminescent layer and the filter layer are integrated within a cohesive sequence of layers. The device is particularly suitable for infrared camera systems.

Abstract: Disclosed herein are embodiments of a sampling system for fluid samples having sample receiving vessel for receiving the sample, which is sealed by a septum and holder for the sample receiving vessel for receiving and holding the sample receiving vessel and also a sample probe for dipping into a fluid volume and for taking a fluid sample from the fluid volume, the sample probe being configured as a hollow volume which, at one end, has a first opening for introducing the holder and the sample receiving vessel and, at another end, is sealed by a first valve which is provided with a hollow needle which projects into the interior of the sample probe said valve being able to be opened by contact with at least one of the group comprising the holder and the sample receiving vessel and then connecting the exterior of the sample probe to the inner volume of the hollow needle.

Abstract: A method for on-the-fly segmentations for image deformations, includes: selecting an object in an image that is displayed on a computer screen; immediately after selecting the object, automatically segmenting the object to find a boundary of the object and marking an area inside the boundary undeformable and an area outside the boundary deformable; and dragging the object to a desired location in the image while the area inside the boundary remains stiff and the area outside the boundary deforms.

Abstract: A method for deforming an image using a physical model includes inputting the image, discrediting the image into a grid, applying forces to the grid upon receiving an input command for dragging the grid, updating a mesh deformation of the grid according to the forces, and wrapping the image according to a deformed mesh to produce a deformed image, wherein a wrapped image is displayed on an display device.

Abstract: The present invention relates to novel methods and kits for predicting, prognosing, and/or monitoring therapeutic efficacy of cancer therapy on a subject having malignant tumor or cell proliferative disorder.

Abstract: In a method for transmitting satellite data of a global navigation satellite system each satellite transmit position data of neighboring satellites to a navigation device on the earth. The subset of neighboring satellites with respect to a specific satellite is determined by averaging over a period of the inter-satellite distance. The subsets are further restricted to the condition that all visible satellites are referenced by the position data of at least one other satellite. This requirement can be met by choosing appropriate permutations among the satellites with shortest distance.

Abstract: The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.

Abstract: The present invention relates to a sampling system for fluid samples having sample receiving vessel for receiving the sample, which is sealed by a septum and holder for the sample receiving vessel for receiving and holding the sample receiving vessel and also a sample probe for dipping into a fluid volume and for taking a fluid sample from the fluid volume, the sample probe being configured as a hollow volume which, at one end, has a first opening for introducing the holder and the sample receiving vessel and, at another end, is sealed by a first valve which is provided with a hollow needle which projects into the interior of the sample probe said valve being able to be opened by contact with the holder and/or with the sample receiving vessel and then connecting the exterior of the sample probe to the inner volume of the hollow needle.

Abstract: A new and distinct cultivar of Prunus plant named ‘Weiroot 720’, characterized by its upright plant habit; weak vegetative growth and low vigor; good soil adaptation; and as a rootstock, weak vegetative growth imparts uniformity, higher yield and larger fruit size to the scion plant.