Abstract: A core-shell nanowire laser structure comprises a substrate (12), an elongated support element (14) extending from the substrate, the support element having a first diameter, and an elongated body element (16) extending on and/or around the support element, the body element having a second diameter at least two times larger than the first diameter, wherein the body element is spaced apart from the substrate.

Abstract: A method and a device for discharging fertilizer for agricultural cultivated plants are disclosed. According to the invention, the required quantity of fertilizer is determined depending on the current nutrient uptake (nutrient status), optimum nutrient uptake (nutrient requirement) by the fertilizing deadline, and optimum nutrient uptake (nutrient requirement by the next fertilizing deadline, wherein other influencing factors are taken into consideration via a correction factor DIMA.

Abstract: A static Fourier transform spectrometer is disclosed that includes a beam splitter, a mirror device, and a collection optic. The beam splitter divides an input light beam into a first arm and a second arm, wherein the first arm is reflected by the beam splitter and the second arm passes through the beam splitter, wherein the first arm extends to the converging optical unit without deflection after reflection at the mirror device, wherein the second arm extends to the converging optical unit without deflection after passing through the beam splitter, and wherein the collection optic merges the first arm and the second arm for interference.

Abstract: The present invention relates to a method for providing a neopeptide-specific T cell, wherein the neopeptide-specific T cell forms a complex having a half-life (T½) of at least 50 s with a neopeptide-MHC monomer. The present invention further relates to a T cell obtainable by the method as well as a pharmaceutical composition comprising such T cells.

Abstract: A method is provided for demodulation of an analog receive signal carrying information, wherein a number of more than two analog signals is formed from the receive signal in separate channels such that the receive signal is multiplied in each case by a period function, the phase thereof respectively differing in the channels, and wherein the multiple signals are each low-pass filtered.

Abstract: The present disclosure relates to a collection of novel muteins derived from human ?1m (or a1m) polypeptide or a functional homologue thereof. The disclosure further refers to a ?1m mutein capable of specifically binding to one or more targets other than a target to which wild-type ?1m binds. The disclosure also relates to a method for producing such collection of muteins and a method for isolating a mutein capable of binding one or more such non-natural targets of wild-type ?1m polypeptide. These aspects are made possible due to, e.g, the structural elucidation of ?1m disclosed herein by the present inventors, an appreciation of ligand-binding sights thereof and, hence, an understanding of which amino acid positions are most suitable for mutagenesis for re-engineering specificity and affinity for any given target while maintaining the secondary and/or tertiary structure of a1m.

Abstract: The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 are the iodo-substituted or methyl-substituted amino acids D- and L-Tyr, iodo-substituted or methyl- substituted D- and L-homotyrosine, iodo-substituted or methyl-substituted D- and L-Phe, iodo-substituted or methyl-substituted D- and L-p-OH-phenylglycine, and iodo-substituted or methyl-substituted D- or L-Trp, Xaa2 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a radioactive or a detectable label; or ii) a radioactive or a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins an

Abstract: A method for manufacturing a three-dimensional object comprises making a material avail-able in a material volume and forming a three-dimensional object made of the material by means of selectively irradiating the material with ultrasound.

Abstract: The present disclosure presents a visuo-haptic sensor, which is based on a passive, deformable element whose deformation is observed by a camera. In particular, the improved simplified sensor may determine the force and/or torque applied to a point of the sensor in multiple spatial dimensions.

Abstract: A method for producing a component from a fiber composite. A number of layers of a dry fibrous material are stacked to form a pile, the pile is covered by a thermoplastic film in a gas-tight manner, the inner space occupied by the pile within the film is pumped dry and the layers are fixed to form a preform that is stable during transport, the preform is reshaped, a liquid thermosetting material is inserted into the inner space by infiltration of the fibrous material, and the preform is hardened with the infiltrated fibrous material to form the finished component, the film binding permanently as the surface. The invention also relates to a component produced in such a way, and to a corresponding preform. The production method provides a process-integrated surface finishing of the fiber composite. The surface properties are created by the bound thermoplastic film.

Abstract: The present invention relates to glypican-3-specific T-cell receptors. The present invention further relates to soluble TCR constructs, chimeric TCRs, bi-specific antibodies, nucleic acids, expression constructs and cells comprising said TCRs or TCR constructs. The present invention further relates to the use of the TCR or the soluble TCR constructs or chimeric TCRs or bi-specific antibodies as a medicament, preferably in the detection, diagnosis, prognosis, prevention and/or treatment of liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The present invention further relates to methods of detecting, diagnosing, prognosing, preventing and/or treating liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The present invention further relates to peptides comprising glypican-3 epitope(s) and respective nucleic acids encoding them, antibodies and compositions as well as their use as (peptide) vaccines.

Abstract: The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and polynucleotides for use in treating diseases or disorders of energy homeostasis. Said polypeptides, polynucleotides and pharmaceutical compositions may be administered locally, in particular locally into the visceral adipose tissue. Another aspect of the invention relates to a cosmetic product and the use of said cosmetic product for reducing body weight, in particular for reducing abdominal adipose tissue.

Abstract: The present disclosure relates to a collection of novel muteins derived from human ?1m (or a1m) polypeptide or a functional homolog thereof. The disclosure further refers to a ?1m mutein capable of specifically binding to one or more targets other than a target to which wild-type ?1m binds. The disclosure also relates to a method for producing such collection of muteins and a method for isolating a mutein capable of binding one or more such non-natural targets of wild-type ?1m polypeptide. These aspects are made possible due to, e.g, the structural elucidation of ?1m disclosed herein by the present inventors, an appreciation of ligand-binding sights thereof and, hence, an understanding of which amino acid positions are most suitable for mutagenesis for re-engineering specificity and affinity for any given target while maintaining the secondary and/or tertiary structure of a1m.

Abstract: A visuo-haptic sensor is presented which uses a deformable, passive material that is mounted in view of a camera. When objects interact with the sensor the deformable material is compressed, causing a change in the shape thereof. The change of shape is detected and evaluated by an image processor that is operatively connected to the camera. The camera may also observe the vicinity of the manipulator to measure ego-motion and motion of close-by objects. The visuo-haptic sensor may be attached to a mobile platform, a robotic manipulator or to any other machine which needs to acquire haptic information about the environment.

Abstract: A method and apparatus for modeling smoke turbulence is disclosed. The method of modeling smoke turbulence includes detecting a turbulent area comprising smoke turbulence in a low-resolution image, and searching for a high-resolution patch matching the turbulent area in a memory that comprises high-resolution patches representing smoke turbulence extracted from high-resolution images. The method also models the smoke turbulence by synthesizing the retrieved patch to the low-resolution image.

Abstract: The present inventors have solved the crystal structure of an Escherichia coli bacterial lipocalin polypeptide, which depicts a monomeric protein. Previous crystal structures have been reported, but these appear to he inaccurate, as they predicted, e.g., a dimeric protein. The crystal structure of a bacterial lipocalin provided by the present invention leads to numerous uses. For example, the present invention provides for the design, construction and use of recombinant libraries of diversified bacterial lipocalins resulting from a bacterial lipocalin polypeptide “backbone”.

Abstract: Device and method for dynamically adjusting an operating voltage for an electric motor (9), which voltage is provided by a voltage source (1) formed in a modular manner, wherein modules (2-i) of the voltage source (1) formed in a modular manner are switched in dependence upon a rotational speed (n) of the electric motor (9) such that the overall degree of efficiency of the electric drive train is improved in a low rotational speed range of the electric motor (9), wherein the modules (2-i) of the voltage source (1) are switched by means of a switching network (3) which is composed of controllable power switches (5) and can be actuated by control signals which are generated by a switching controller (4) in dependence upon the rotational speed (n) of the electric motor (9).

Abstract: A method is provided for demodulation of an analog receive signal carrying information, wherein a number of more than two analog signals is formed from the receive signal in separate channels such that the receive signal is multiplied in each case by a period function, the phase thereof respectively differing in the channels, and wherein the multiple signals are each low-pass filtered.

Abstract: A shaft power plant for generating electricity by energy conversion of an outflow between upper water and lower water in a river includes at least two power plant modules, each having a vertical shaft with an open top and a shaft crown forming an inflow plane. The inflow plane is substantially parallel with the river bed and extends below a water level of the upper water. Each of the power plant modules also has a turbine generator unit arranged in the shaft. The power plant also includes an ecological connecting channel formed as an outflow from the upper water into the lower water without generating electricity by energy conversion.

Abstract: The present invention relates to a method for compensation, for example, for temperature compensation of a fiber optic measurement system designed for determining a mechanical quantity. First and second fiber Bragg gratings have a respective Bragg wavelength, wherein the fiber Bragg gratings are irradiated with primary light. After applying a mechanical quantity to the first and second fiber Bragg gratings, the Bragg wavelengths of the fiber Bragg gratings are changed by the mechanical quantity.