Abstract: The present disclosure presents a visuo-haptic sensor, which is based on a passive, deformable element whose deformation is observed by a camera. In particular, the improved simplified sensor may determine the force and/or torque applied to a point of the sensor in multiple spatial dimensions.

Abstract: A core-shell nanowire laser structure comprises a substrate (12), an elongated support element (14) extending from the substrate, the support element having a first diameter, and an elongated body element (16) extending on and/or around the support element, the body element having a second diameter at least two times larger than the first diameter, wherein the body element is spaced apart from the substrate.

Abstract: The present invention relates to a novel method for the treatment and/or prophylaxis of a tau-mediated neurodegenerative disease and/or of a tau-mediated neurodegenerative pathological condition, especially of a neurodegenerative disease and/or of a neurodegenerative pathological condition associated with and/or accompanied by tau aggregation, and in particular for the treatment and/or prophylaxis of a tauopathy; compounds and/or agents and compositions for such treatment and/or prophylaxis, and the manufacture of the compounds and/or agents and compositions suitable for the said treatment and/or prophylaxis. In this regard, the present invention relates especially to the use of compounds acting as PERK activator, a prodrug thereof, a derivative thereof and/or a pharmaceutically acceptable salt of any thereof, as a medicament.

Abstract: The invention relates to a method of determining the dissociation rate constant (koff) of a receptor molecule R on a target cell using a combination of reversible and irreversible cell labeling. The invention further relates to a cell comprising such a receptor molecule R, wherein the cell has bound to it such a combination of cell labeling. The invention further relates to a kit and an apparatus useful in performing the methods of the invention. The invention further relates to a method of isolation a high-avidity T cell.

Abstract: Contacting apparatus for contacting an energy storage cell (1) comprising at least one printed circuit board (5) which is provided for discharging the electrical energy stored in the energy storage cell (1), wherein at least one electric pole of the energy storage cell (1) is pressed by a releasable mechanical connection (7) with a specific contact pressing force against an electrically conductive layer (5c) of the at least one printed circuit board (5) which is located on a front side of the at least one printed circuit board (5) facing the energy storage cell (1).

Abstract: The present invention provides compounds binding to neuropathological aggregates of peptides or proteins, including aggregates such as neurofibrillary tangles (NFTs), osynuclein aggregates and other amyloid aggregates. The compounds of the present invention are useful for the detection and/or diagnosis of disorders associated with such neuropathological aggregates. In further aspects, the invention provides diagnostic compositions comprising these compounds, and methods for the preparation of radiolabeled compound from non-radiolabeled precursors.

Abstract: A production device for layer-by-layer manufacture of a three-dimensional object, comprising a feeding device for feeding in of a starting material, and an application device for melting the starting material and for layer-by-layer shaping of the melted starting material into the object, wherein the feeding device comprises a drying device for drying of the starting material, or a drying device is connected upstream of the feeding device.

Abstract: A method and apparatus for modeling smoke turbulence is disclosed. The method of modeling smoke turbulence includes detecting a turbulent area comprising smoke turbulence in a low-resolution image, and searching for a high-resolution patch matching the turbulent area in a memory that comprises high-resolution patches representing smoke turbulence extracted from high-resolution images. The method also models the smoke turbulence by synthesizing the retrieved patch to the low-resolution image.

Abstract: A method for coating a cylinder wall of an internal combustion engine, in which the cylinder wall is roughened prior to coating, such that the cylinder wall is compressed prior to roughening by plastic deformation.

Abstract: A method for machining a wall of a cylinder of an internal combustion engine, in which recesses in the wall are introduced by mechanical machining. The invention is characterized in that the wall is radiated with a medium under high pressure after the mechanical machining in order to introduce micro-recesses.

Abstract: The disclosure refers to a synthesis filter bank, comprising: a transform module which is configured to receive a plurality of input signals, transform the plurality of input signals, and output a plurality of transformed signals, a plurality of filter modules, which are coupled to the transform module, and wherein each filter module of the plurality of filter modules is configured to receive two transformed signals from the transform module, process the two received transformed signals and output two processed signals, and a parallel-to-serial module which is coupled to the plurality of filter modules and which is configured to receive the processed signals from the plurality of filter modules, combine the received processed signals and output a combined signal. Furthermore, an analysis filter bank, a filter bank and methods for operating a synthesis filter bank and for operating an analysis filter bank are disclosed.

Abstract: The present invention relates to a nucleic acid molecule comprising a low repetitive nucleotide sequence encoding a proline/alanine-rich amino acid repeat sequence. The encoded polypeptide comprises a repetitive amino acid sequence that forms a random coil. The nucleic acid molecule comprising said low repetitive nucleotide sequences can further comprise a nucleotide sequence encoding a biologically or pharmacologically active protein. Further, the present invention provides for selection means and methods to identify said nucleic acid molecule comprising said low repetitive nucleotide sequence. The present invention also relates to a method for preparing said nucleic acid molecules. Also provided herein are methods for preparing the encoded polypeptide or drug conjugates with the encoded polypeptide using the herein provided nucleic acid molecules. The drug conjugate may comprise a biologically or pharmacologically active protein or a small molecule drug.

Abstract: A system and method for the evaluation of hearing implant signal processing is described. A cochlear implant signal processor converts a speech signal input into multi-channel stimulation pulse sequences for a cochlear implant electrode array. A temporal feature processing module extracts temporal feature information from the stimulation pulse sequences. A speech recognition engine evaluates the temporal information using automatic speech recognition to produce speech recognition outputs corresponding to the speech signal input.

Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.

Abstract: The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, wherein said biosynthetic random coil polypeptide, said biosynthetic random coil polypeptide segment or said biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. Said at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or said conjugates are described.

Abstract: The invention relates to a device (100; 200; 300; 400) for analyzing biological substances in a test solution, comprising a test substrate (101; 203; 303; 401) which is transparent at least in part, having a test region (107a, 108a, 109a, 110a; 211; 411) for receiving the test solution, a plurality of electrodes (111, 106; 201, 202; 301, 302; 402, 403) which are arranged on the test substrate (101; 203; 303; 401) and extend into the test region (107a, 108a, 109a, 110a; 211; 411), wherein in each case, at least one portion of the electrodes (111, 106; 201, 202; 301, 302; 402, 403) is made of a transparent material.

Abstract: The present invention relates to a hydrophobic cement-based material composition comprising a bacterial biofilm, or at least one hydrophobicity-conveying component of a bacterial biofilm, an additive for a cement-based material composition comprising a bacterial biofilm or at least one hydrophobicity-conveying component of a bacterial biofilm and the use of such biofilm or component therefore for decreasing the wettability of a cement-based material.

Abstract: The present invention relates to a prostate-specific membrane antigen (PSMA)-specific binding protein, wherein the PSMA-specific binding protein is a lipocalin 2 (Lcn2)-derived binding protein and binds to PSMA with a KD of 10 nM or lower. The present invention also relates to a nucleic acid molecule encoding the PSMA-specific binding protein of the invention, a vector comprising said nucleic acid molecule of the invention and a host cell transformed with the vector. Furthermore, the invention relates to a method of producing the PSMA-specific binding protein of the invention, the method comprising culturing the host cell of the invention under suitable conditions and isolating the PSMA-specific binding protein produced. The present invention further relates to a protein conjugate comprising the PSMA-specific binding protein of the invention, or the PSMA-specific binding protein produced by the method of the invention.

Abstract: The disclosure relates to a manually operable tactile input/output device for a data processing system, in particular a tactile computer mouse, which is configured with a housing and a plurality of actuators in operative connection with the housing and in which the actuators are arranged and jointly controlled in the housing to cause at least temporarily a tactile perception by a user in manual contact with the housing, by which simultaneously at least two and in particular all five tactile perception dimensions of microscopic roughness, macroscopic roughness, friction, hardness and heat are simulated. Furthermore, the disclosure relates to an operating method for a manually operable tactile input/output device and a data processing system.

Abstract: A method for fabricating a nanostructure comprises the steps of growing a first nanowire on a substrate, forming a dielectric layer on the substrate, the dielectric layer surrounding the first nanowire, wherein a thickness of the dielectric layer is smal- ler than a length of the first nanowire, and removing the first nanowire from the dielectric layer, thereby exposing an aperture in the dielectric layer.