Abstract: The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, wherein said biosynthetic random coil polypeptide, said biosynthetic random coil polypeptide segment or said biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. Said at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or said conjugates are described.

Abstract: The invention relates to a device (100; 200; 300; 400) for analyzing biological substances in a test solution, comprising a test substrate (101; 203; 303; 401) which is transparent at least in part, having a test region (107a, 108a, 109a, 110a; 211; 411) for receiving the test solution, a plurality of electrodes (111, 106; 201, 202; 301, 302; 402, 403) which are arranged on the test substrate (101; 203; 303; 401) and extend into the test region (107a, 108a, 109a, 110a; 211; 411), wherein in each case, at least one portion of the electrodes (111, 106; 201, 202; 301, 302; 402, 403) is made of a transparent material.

Abstract: The present invention relates to a hydrophobic cement-based material composition comprising a bacterial biofilm, or at least one hydrophobicity-conveying component of a bacterial biofilm, an additive for a cement-based material composition comprising a bacterial biofilm or at least one hydrophobicity-conveying component of a bacterial biofilm and the use of such biofilm or component therefore for decreasing the wettability of a cement-based material.

Abstract: The present invention relates to a prostate-specific membrane antigen (PSMA)-specific binding protein, wherein the PSMA-specific binding protein is a lipocalin 2 (Lcn2)-derived binding protein and binds to PSMA with a KD of 10 nM or lower. The present invention also relates to a nucleic acid molecule encoding the PSMA-specific binding protein of the invention, a vector comprising said nucleic acid molecule of the invention and a host cell transformed with the vector. Furthermore, the invention relates to a method of producing the PSMA-specific binding protein of the invention, the method comprising culturing the host cell of the invention under suitable conditions and isolating the PSMA-specific binding protein produced. The present invention further relates to a protein conjugate comprising the PSMA-specific binding protein of the invention, or the PSMA-specific binding protein produced by the method of the invention.

Abstract: The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, in which the biosynthetic random coil polypeptide, the biosynthetic random coil polypeptide segment, or the biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein the amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. The at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or conjugates are described.

Abstract: The disclosure relates to a manually operable tactile input/output device for a data processing system, in particular a tactile computer mouse, which is configured with a housing and a plurality of actuators in operative connection with the housing and in which the actuators are arranged and jointly controlled in the housing to cause at least temporarily a tactile perception by a user in manual contact with the housing, by which simultaneously at least two and in particular all five tactile perception dimensions of microscopic roughness, macroscopic roughness, friction, hardness and heat are simulated. Furthermore, the disclosure relates to an operating method for a manually operable tactile input/output device and a data processing system.

Abstract: A process for preparing a catalyst provided in the form of a metal oxide catalyst having at least one element selected from Mo, Te, Nb, V, Cr, Dy, Ga, Sb, Ni, Co, Pt and Ce. The catalyst is subjected to an aftertreatment to increase the proportion of the M1 phase, by contacting the catalyst with steam at a pressure below 100 bar or by contacting the catalyst with oxygen to obtain an aftertreated catalyst. The aftertreated catalyst may be used for oxidative dehydrogenation processes.

Abstract: The present invention is related to a method for detecting H. pylori infection in a subject, wherein the method comprises detecting in a sample from the subject an immune response against FliD, wherein the immune response comprises an anti-FliD antibody.

Abstract: A method and a device for discharging fertilizer for agricultural cultivated plants are disclosed. According to the invention, the required quantity of fertilizer is determined depending on the current nutrient uptake (nutrient status), optimum nutrient uptake (nutrient requirement) by the fertilizing deadline, and optimum nutrient uptake (nutrient requirement by the next fertilizing deadline, wherein other influencing factors are taken into consideration via a correction factor DIMA.

Abstract: There is provided a method of maintaining a hybrid OLTP and OLAP database, the method comprising: executing one or more OLTP transactions; creating a virtual memory snapshot; and executing one or more OLAP queries using the virtual memory snapshot. Preferably, the method further comprises replicating a virtual memory page on which a data object is stored in response to an update to the data object, whereby the updated data object is accessible for OLTP transactions, while the non-updated data object remains accessible for OLAP queries. Accordingly, the present invention provides a hybrid system that can handle both OLTP and OLAP simultaneously by using hardware-assisted replication mechanisms to maintain consistent snapshots of the transactional data.

Abstract: Device and method for generating brief strong current pulses in a coil for generating magnetic field pulses which according to the electromagnetic induction principle induce stimulation currents in the body tissue triggering an action potential of the nerve and/or muscle cells, where the coil is positionable close to the body tissue to be stimulated so that its magnetic field passes through the body tissue, and where the device comprises a power generating unit that can generate a freely selectable temporal course of the current through the coil during the current pulse.

Abstract: A static Fourier transform spectrometer is disclosed that includes a beam splitter, a mirror device, and a collection optic. The beam splitter divides an input light beam into a first arm and a second arm, wherein the first arm is reflected by the beam splitter and the second arm passes through the beam splitter, wherein the first arm extends to the converging optical unit without deflection after reflection at the mirror device, wherein the second arm extends to the converging optical unit without deflection after passing through the beam splitter, and wherein the collection optic merges the first arm and the second arm for interference.

Abstract: The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 are the iodo-substituted or methyl-substituted amino acids D- and L-Tyr, iodo-substituted or methyl- substituted D- and L-homotyrosine, iodo-substituted or methyl-substituted D- and L-Phe, iodo-substituted or methyl-substituted D- and L-p-OH-phenylglycine, and iodo-substituted or methyl-substituted D- or L-Trp, Xaa2 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a radioactive or a detectable label; or ii) a radioactive or a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins an

Abstract: A method for manufacturing a three-dimensional object comprises making a material avail-able in a material volume and forming a three-dimensional object made of the material by means of selectively irradiating the material with ultrasound.

Abstract: The present disclosure presents a visuo-haptic sensor, which is based on a passive, deformable element whose deformation is observed by a camera. In particular, the improved simplified sensor may determine the force and/or torque applied to a point of the sensor in multiple spatial dimensions.

Abstract: The present invention relates to nanocrystalline cellulose, an efficient way of its preparation and to uses of such nanocrystalline cellulose. The present invention also relates to porous metal oxides having a chiral nematic structure which are prepared using nanocrystalline cellulose.

Abstract: A method and system for scanning an object using an RGB-D sensor, the method includes: a plurality of elementary scans of the object using an RGB-D sensor and visual odometry, each elementary scan delivering a plurality of key frames associated with a pose of the sensor with respect to the object, and each elementary scan being associated with a position of the object; for each elementary scan, elaborating a three-dimensional model of the object using the plurality of key frames and poses of the scan; merging each three-dimensional model into a merged three-dimensional model of the object.

Abstract: A method for producing a component from a fiber composite. A number of layers of a dry fibrous material are stacked to form a pile, the pile is covered by a thermoplastic film in a gas-tight manner, the inner space occupied by the pile within the film is pumped dry and the layers are fixed to form a preform that is stable during transport, the preform is reshaped, a liquid thermosetting material is inserted into the inner space by infiltration of the fibrous material, and the preform is hardened with the infiltrated fibrous material to form the finished component, the film binding permanently as the surface. The invention also relates to a component produced in such a way, and to a corresponding preform. The production method provides a process-integrated surface finishing of the fiber composite. The surface properties are created by the bound thermoplastic film.

Abstract: The present invention relates to glypican-3-specific T-cell receptors. The present invention further relates to soluble TCR constructs, chimeric TCRs, bi-specific antibodies, nucleic acids, expression constructs and cells comprising said TCRs or TCR constructs. The present invention further relates to the use of the TCR or the soluble TCR constructs or chimeric TCRs or bi-specific antibodies as a medicament, preferably in the detection, diagnosis, prognosis, prevention and/or treatment of liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The present invention further relates to methods of detecting, diagnosing, prognosing, preventing and/or treating liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The present invention further relates to peptides comprising glypican-3 epitope(s) and respective nucleic acids encoding them, antibodies and compositions as well as their use as (peptide) vaccines.

Abstract: The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and polynucleotides for use in treating diseases or disorders of energy homeostasis. Said polypeptides, polynucleotides and pharmaceutical compositions may be administered locally, in particular locally into the visceral adipose tissue. Another aspect of the invention relates to a cosmetic product and the use of said cosmetic product for reducing body weight, in particular for reducing abdominal adipose tissue.