Abstract: The present invention provides a method for installing at least one sensor device within a rotor blade of a wind turbine. A first substantially planar light beam is emitted in the interior of the rotor blade. Finally, at least one second substantially planar light beam is emitted in the interior of the rotor blade, wherein the plane of the first planar light beam is oriented at a predetermined angle to the plane of the second planar light beam. Further, the planes of the first and second planar light beams are aligned on the blade flange of the rotor blade. At least one sensor device is subsequently aligned in reference to the planar light beams.

Abstract: The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a detectable label; or ii) a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins and combinations thereof, with the proviso that -L-Ar-D does not comprise a 18F-benzoyl residue.

Abstract: The present invention relates to the field of molecular imaging, i.e. nuclear and fluorescent imaging using metal ion radionuclides in combination with chelates highly functionalized with peptidic, nonpeptidic or protein ligands or additional signalling moieties.

Abstract: Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which consist essentially of Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention.

Abstract: In a first aspect, the present invention relates to the use of a TLR 9 agonist and/or a TLR 4 agonist in a prophylactic or therapeutic vaccine. According to the present vaccination strategy, the TLR 9 agonist and/or TLR 4 agonist is adapted or designed for use as a multiplying jump agent to enhance numbers and functionality of CD8 T cells in a prime-jump vaccination strategy for jump T cell expansion. In particular, the TLR 9 agonist and/or TLR 4 agonist is used as a component to be administered after priming of the individual to be vaccinated. The vaccination strategy is particularly useful against acute and chronic infections with intracellular pathogens or for anti-tumor vaccination. In another aspect, the present invention relates to a kit of part containing a prime agent and a multiplying jump agent according to the present invention.

Abstract: We discovered that a biosynthetic polypeptide, consisting of at least about 50 proline (Pro) and alanine (Ala) amino acid residues, forms a random coil, and increases the stability of other compounds to which it is conjugated, such as small molecules and polypeptides. We describe such biosynthetic polypeptides, constructs containing such polypeptides, ways of making them, and their use.

Abstract: The invention relates to a friction stir welding apparatus for joining workpieces 1, 2, having a welding pin 3, which is rotatable about its center axis 9 by means of a drive, and having at least one clamping apparatus for clamping the workpieces 1, 2 to be joined, characterized in that the clamping apparatus comprises at least two clamping elements 10, 11, which respectively have an undercut guideway 12, the guideways 12 being arranged parallel to one another and parallel to a joining region 8, in that between the clamping elements 10, 11 is arranged a sliding element 13, which is secured by the guideways 12 against the workpieces 1, 2 and is translatorily displaceable along the guideways 12, and in that the sliding element 12 is provided with an opening 14 for the lead-through of the welding pin 3, and further relates to a method for friction stir welding, using the above-stated apparatus.

Abstract: A shaft power plant for energy conversion of a discharge between a headwater and a tailwater, comprising a vertical shaft, the top of which forms an inflow plane which is parallel to the bed and extends below the headwater water level, wherein the shaft is open toward the top and is closed by a base at its bottom end, a unit composed of a turbine and an electrical machine, wherein the unit is arranged entirely under water in the shaft and wherein the turbine is arranged for water to pass through vertically, and an outflow, which is connected to the turbine, represents a closed flow channel and leads through a through-passage in the shaft to the tailwater, wherein, in a horizontal plane of a turbine runner of the turbine, a first cross-sectional area of the shaft is much larger than a second cross-sectional area taken up by the turbine runner.

Abstract: The invention relates to a friction stir welding apparatus for joining workpieces 1, 2, having a welding pin 3, which is rotatable about its center axis 9 by means of a drive, and having at least one clamping apparatus for clamping the workpieces 1, 2 to be joined, characterized in that the clamping apparatus comprises at least two clamping elements 10, 11, which respectively have an undercut guideway 12, the guideways 12 being arranged parallel to one another and parallel to a joining region 8, in that between the clamping elements 10, 11 is arranged a sliding element 13, which is secured by the guideways 12 against the workpieces 1, 2 and is translatorily displaceable along the guideways 12, and in that the sliding element 12 is provided with an opening 14 for the lead-through of the welding pin 3, and further relates to a method for friction stir welding, using the above-stated apparatus.

Abstract: An industrial truck is shown with a lifting frame, on which a load-receiving section is arranged so as to be movable vertically. The load-receiving section has at least one degree of movement freedom with respect to the lifting frame, which lies in a plane perpendicular to the main direction of travel of the industrial truck and has at least one horizontal component. In addition, a vibration control system is provided for damping or preventing vibrations in the relative position of load-receiving section and lifting frame.

Abstract: The invention relates to a nucleic acid construct comprising an adenoviral E2 late promoter or a fragment thereof and a nucleic acid. The nucleic acid is selected from the group of transgenes, genes and nucleic acids which are respectively different from adenoviral nucleic acid controlled by an E2 late promoter. The invention also relates to the uses of said nucleic acid construct.

Abstract: The present invention provides a method and apparatus for depth image acquisition of an object wherein at least two time-of-flight cameras are provided and the object is illuminated with a plurality of different light emission states by emitting light signals from each camera. Measurements of the light reflected by the object during each light emission state are obtained at all the cameras wherein the measurements may then be used to optimise the depth images at each of the cameras.

Abstract: A process for the production of a component (1) made of a fiber composite material, and also a component (1) produced in this way, are stated, where a foil composite (7) with a thermoplastic outer foil (6) and with a thermoplastic inner foil (5) is produced, where the modulus of elasticity (E) of the inner foil (5) within a temperature range is smaller than the modulus of elasticity (E) of the outer foil (6), the inner foil (5) of the foil composite (7) is bonded to a molding (4) comprising a fiber material (2) and comprising a thermoset (3), the molding (4) is hardened, and the foil composite (7) is subjected to a heat treatment in the temperature range within which the modulus of elasticity (E) of the inner foil (5) is smaller than the modulus of elasticity (E) of the outer foil (6), where the outer foil (6) undergoes stress relaxation.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which consist essentially of Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention.

Abstract: A shaft power plant for energy conversion of a discharge between a headwater and a tailwater, comprising a vertical shaft, the top of which forms an inflow plane which is parallel to the bed and extends below the headwater water level, wherein the shaft is open toward the top and is closed by a base at its bottom end, a unit composed of a turbine and an electrical machine, wherein the unit is arranged entirely under water in the shaft and wherein the turbine is arranged for water to pass through horizontally, and an outflow, which is connected to the turbine, represents a closed flow channel and leads through a through-passage in the shaft to the tailwater, wherein a horizontal first cross-sectional area of the shaft is much larger than a vertical second cross-sectional area taken up by the turbine runner.

Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.

Abstract: Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N?-methyl derivative of a basic amino acid.

Abstract: The present invention is directed to a cross-reactive antibody that specifically inhibits or blocks mammalian Toll-like receptor 2 (TLR2)-mediated immune cell activation. The invention is further directed to an isolated nucleic acid or vector coding for the variable regions of the heavy and/or light chain of such an antibody. Also provided is a pharmaceutical composition comprising such an antibody, or a nucleic acid or vector encoding it. Further provided are methods of use of such compositions in the prevention and/or treatment of inflammatory processes or any other process induced by bacterial infection, trauma, or chronic inflammation, or for the prevention and/or treatment of bacteriaemia or sepsis.