Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.

Abstract: The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

Abstract: The present invention describes a method for building models in layers, wherein a first material and subsequent thereto selectively a second material are applied in layers in a build space, and these two application steps are repeated until a desired model is obtained. The two materials form a solid object in a suitable mixing ratio, the first material including a particulate material and the second material being applied with the aid of a print head. The first material, the second material and/or the particulate material include one or more diamines and/or one or more dicarbonyl compounds as the binder.

Abstract: There is provided a visual localization method comprising: (a) transmitting data representative of one or more detected visual features from a mobile device to a server; (b) estimating the location of the mobile device at the server based on the visual features 5 received from the mobile device; (c) transmitting reference data associated with the estimated location from the server to the mobile device; and (d) the mobile device determining its location based on the reference data received from the server.

Abstract: Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which are Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention.

Abstract: The invention relates to lactocepins and/or a functionally active fragment thereof for use in the prophylaxis and/or the treatment of a disease and to one or more lactocepin(s) and/or one or more functionally active fragment(s) thereof for use in the prophylaxis and/or treatment of IP-10-mediated inflammatory diseases.

Abstract: The present invention relates to an in vitro produced, artificial cellulosome for enzymatic breakdown of resilient substrates. In particular, the present invention provides a complex having an increased activity on resilient substrates, such as crystalline cellulose. The in vitro formed complex comprises a backbone scaffold having at least four binding sites capable of binding the enzyme components, whereby at least two of the binding sites have essentially the same binding specificity; and at least three different enzyme components being randomly bound to the at least four binding sites. Method for preparing the complex and uses of the same for enzymatic breakdown of resilient substrates are also provided.

Abstract: A device for combined optical and nuclear image comprises a nuclear image acquisition module and a reference image acquisition module. The reference image acquisition module has: an optical image sensor and an optical imaging system for deflecting the optical radiation from a reference field of view to the image sensor, wherein the optical imaging system comprises a mirror for the optical radiation, which mirror is arranged between the reference field of view and the optical image sensor. On the image sensor, a respective image area is assigned to at least one of nuclear partial fields of view. The optical imaging system is arranged such that the optical radiation coming from the at least one nuclear partial field of view is deflected substantially exactly to the respectively assigned of the image areas.

Abstract: A method for producing a component from a fibre composite. A number of layers of a dry fibrous material are stacked to form a pile, the pile is covered by a thermoplastic film in a gas-tight manner, the inner space occupied by the pile within the film is pumped dry and the layers are fixed to form a preform that is stable during transport, the preform is reshaped, a liquid thermosetting material is inserted into the inner space by infiltration of the fibrous material, and the preform is hardened with the infiltrated fibrous material to form the finished component, the film binding permanently as the surface. The invention also relates to a component produced in such a way, and to a corresponding preform. The production method provides a process-integrated surface finishing of the fibre composite. The surface properties are created by the bound thermoplastic film.

Abstract: The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a detectable label; or ii) a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins and combinations thereof, with the proviso that -L-Ar-D does not comprise a 18F-benzoyl residue.

Abstract: There is provided a method of maintaining a hybrid OLTP and OLAP database, the method comprising: executing one or more OLTP transactions; creating a virtual memory snapshot; and executing one or more OLAP queries using the virtual memory snapshot. Preferably, the method further comprises replicating a virtual memory page on which a data object is stored in response to an update to the data object, whereby the updated data object is accessible for OLTP transactions, while the non-updated data object remains accessible for OLAP queries. Accordingly, the present invention provides a hybrid system that can handle both OLTP and OLAP simultaneously by using hardware-assisted replication mechanisms to maintain consistent snapshots of the transactional data.

Abstract: The present invention is directed to a animal feed for calves comprising calf-specific bacteria, optionally lipids, proteins, vitamins and/or mineral materials for conditioning of the intestinal flora in calves, and thus, for prophylaxis and/or treatment of diarrhea in calves.

Abstract: A shaft power plant (1) for generating electricity by energy conversion of a discharge between a headwater (2) and a tailwater (6), comprising a vertical shaft (7), the top (10) of which forms an inflow plane (11) which is parallel to the bed and extends below the water level (3) of the headwater, wherein the shaft (7) is open toward the top and is closed by a base (9) at its bottom end, a unit (15) composed of a turbine (16) and an electrical machine (17), wherein the unit (15) is arranged entirely under water in the shaft (7) and wherein the turbine (16) is arranged for water to pass through horizontally, and an outflow (24), which is connected to the turbine (16), represents a closed flow channel and leads through a through-passage (28) in the shaft (7) to the tailwater (6), wherein a horizontal first cross-sectional area of the shaft (7) is much larger than a vertical second cross-sectional area taken up by the turbine runner (19).

Abstract: Cavitation reactor for hydrodynamic generation of homogeneous, oscillating cavitation bubbles in a fluid, including, while forming a flow duct and arranged one behind the other in the direction of flow of the fluid, an acceleration section designed to increase a flow velocity, a diaphragm arranged transversely to the direction of flow with a plurality of micro-passages designed for generating cavitation bubbles, where at least 10 micro-passages per cm2 are provided over an entire flow cross-sectional surface defined on an oncoming flow side of the diaphragm, a stabilization section designed for stabilizing an oscillation of cavitation bubbles, and a collapse section with at least one widening of a flow cross-sectional surface of the flow duct in the direction of flow.

Abstract: A shaft power plant (1) for generating electricity by energy conversion of a discharge between a headwater (2) and a tailwater (6), comprising a vertical shaft (7), the top (10) of which forms an inflow plane (11) which is parallel to the bed and extends below the water level (3) of the headwater, wherein the shaft (7) is open toward the top and is closed by a base (9) at its bottom end, a unit (15) composed of a turbine (16) and an electrical machine (17), wherein the unit (15) is arranged entirely under water in the shaft (7) and wherein the turbine (16) is arranged for water to pass through vertically, and an outflow (24), which is connected to the turbine (16), represents a closed flow channel and leads through a through-passage (28) in the shaft (7) to the tailwater (6), wherein, in a horizontal plane of a turbine runner (19) of the turbine (16), a first cross-sectional area of the shaft (7) is much larger than a second cross-sectional area taken up by the turbine runner (19).

Abstract: A method for providing media contents for a plurality of addressable nodes in a data network, said media contents comprising at least one media file. For each media file to be provided, a decentralized structure managed via a first node is formed so the respective media file is divided into a plurality of sections and an identity value is allocated to the sections, the first node(s) respectively responsible for a sub-interval and for a sub-quantity of sections from the respective media file. In a respective first node, a number of second nodes and corresponding addresses are deposited, the second node(s) specified for providing said sections according to said sub-interval, for which the respective first node is responsible. A receiving node retrieves the addresses of second nodes having sections of said media file by a request to said first node, and downloads the sections from said retrieved addressed second nodes.

Abstract: The present invention relates to methods and compositions for preventing or treating diabetes. The invention in particular discloses compounds according to formula (I) for use in the prevention and treatment of type II or I diabetes.

Abstract: An industrial truck is shown with a lifting frame, on which a load-receiving section is arranged so as to be movable vertically. The load-receiving section has at least one degree of movement freedom with respect to the lifting frame, which lies in a plane perpendicular to the main direction of travel of the industrial truck and has at least one horizontal component. In addition, a vibration control system is provided for damping or preventing vibrations in the relative position of load-receiving section and lifting frame.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: A new and distinct cultivar of Prunus plant named ‘Weiroot 720’, characterized by its upright plant habit; weak vegetative growth and low vigor; good soil adaptation; and as a rootstock, weak vegetative growth imparts uniformity, higher yield and larger fruit size to the scion plant.