Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.
Type:
Application
Filed:
January 17, 2018
Publication date:
November 28, 2019
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Chang Zhi Adrian NG, Shen-Yi Ian CHEONG
Abstract: An improved system and method for digital image classification is provided. A host computer having a processor is coupled to a memory storing thereon reference feature data. A graphics processing unit (GPU) having a processor is coupled to the host computer and is configured to obtain, from the host computer, feature data corresponding to the digital image; to access, from the memory, the one or more reference feature data; and to determine a semi-metric distance based on a Poisson-Binomial distribution between the feature data and the one or more reference feature data. The host computer is configured to classify the digital image using the determined semi-metric distance.
Type:
Grant
Filed:
September 15, 2015
Date of Patent:
June 18, 2019
Assignee:
Temasek Life Sciences Laboratory Limited
Inventors:
Muthukaruppan Swaminathan, Tobias Sjoblom, Ian Cheong, Obdulio Piloto
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in fungal hosts selected from Rhodospordium and Rhodotorula genera.
Type:
Grant
Filed:
December 14, 2015
Date of Patent:
June 4, 2019
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of plant molecular biology. More particularly, the present invention relates to the isolation of nucleic acids encoding terpene synthases (TPSs), including a novel, multifunctional TPS identified herein as CoTPS2.
Type:
Grant
Filed:
October 19, 2015
Date of Patent:
April 23, 2019
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
Type:
Application
Filed:
November 14, 2018
Publication date:
March 21, 2019
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Lin CAI, Longhua SUN, Lin FU, Lianghui JI
Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
Type:
Application
Filed:
February 23, 2017
Publication date:
February 28, 2019
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Rongji SUM, Muthukaruppan SWAMINATHAN, Ian CHEONG
Abstract: An expression cassette, wherein said expression cassette comprises: (a) an ie 1 promoter from white spot syndrome virus or a variant thereof; (b) a nucleic acid sequence encoding an N-terminal gp64 signal peptide or variant thereof, a nucleic acid sequence encoding an antigenic peptide, a nucleic acid encoding a transmembrane region, and a nucleic acid encoding a gp64 cytoplasmic region or variant thereof; in which the promoter is operably linked to the nucleic acid sequence.
Type:
Grant
Filed:
February 8, 2012
Date of Patent:
February 12, 2019
Assignee:
Temasek Life Sciences Laboratory Limited
Inventors:
Premanand Balraj, Hwei-Sing Jimmy Kwang, Anbu Kumar Karuppannan
Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.
Type:
Application
Filed:
August 16, 2016
Publication date:
January 10, 2019
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
Type:
Grant
Filed:
December 4, 2009
Date of Patent:
January 1, 2019
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Lin Cai, Longhua Sun, Lin Fu, Lianghui Ji
Abstract: The present invention relates to the application of isolated promoters and synthetic constructs for efficient production of genetically modified cells in a species selected from the Pucciniomycotina and Ustilaginomycotina subphyla, in particular, species selected from the Rhodosporidium, Rhodotourla, Sporobolomyces or Pseudozyma genus.
Type:
Grant
Filed:
March 10, 2014
Date of Patent:
October 23, 2018
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of plant molecular biology, more particularly cotton WRINKLED 1-like (WREL) genes. More specifically, the present invention relates to cotton WRIL genes whose products act as transcription factors of genes involved in fatty acid biosynthesis. The present invention also relates to methods of increasing cotton fiber length in cotton. In one embodiment, the methods involve modulating the level of activity of an enzyme involved in a fatty acid biosynthesis in the host cotton cell and/or culturing the host cotton cell. In another embodiment, the methods involve the manipulation of transcription factors which can regulate an enzyme involved in fatty acid biosynthesis.
Type:
Grant
Filed:
April 19, 2012
Date of Patent:
October 16, 2018
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions.
Type:
Grant
Filed:
August 21, 2015
Date of Patent:
September 25, 2018
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of controlling pests, such as insects, using a virus to express pest genes in hosts. More specifically, the present invention relates to a method for rapidly screening for pest genes which can lead to mortality of the pest when the pest has ingested host tissues expressing virus-linked pest gene sequences. The present invention also relates to a method for controlling pests by viral expression of target pest sequences to modify endogenous expression of pest genes in cells or tissues of the pest.
Type:
Grant
Filed:
September 15, 2010
Date of Patent:
July 10, 2018
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Jian Ye, Nam-Hai Chua, Jing Qu, Shi-Qiang Gao
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to a strong inducible gene expression system in fungal species, such as a species of the Rhodosporidium genus or the Rhodotorula genus.
Type:
Application
Filed:
March 31, 2016
Publication date:
March 15, 2018
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Lianghui JI, Yanbin LIU, Chong Mei John KOH
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in fungal hosts selected from Rhodospordium and Rhodotorula genera.
Type:
Application
Filed:
December 14, 2015
Publication date:
December 21, 2017
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of plant molecular biology. More particularly, the present invention relates to the isolation of nucleic acids encoding terpene synthases (TPSs), including a novel, multifunctional TPS identified herein as CoTPS2.
Type:
Application
Filed:
October 19, 2015
Publication date:
September 7, 2017
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions.
Type:
Application
Filed:
August 21, 2015
Publication date:
July 13, 2017
Applicant:
Temasek Life Sciences Laboratory Limited
Abstract: The present invention relates in general to plant biotechnology. More particularly, the present invention relates to methods and media compositions for the efficient direct organogenesis and indirect organogenesis of Jathropha plants, such as Jatropha curcas.
Type:
Grant
Filed:
October 30, 2013
Date of Patent:
July 11, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Maria Shibu Thankaraj Salammal, Srinivasan Ramachandran
Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
Type:
Grant
Filed:
December 12, 2014
Date of Patent:
July 4, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Fang He, Hwei-Sing Jimmy Kwang, Prabakaran Mookkan
Abstract: The present invention relates to the field of plant molecular biology and gene silencing. More particularly, the present invention relates to gene silencing of Sugar-dependent 1 (JcSDP1) in Jatropha curcas. JcSDP1 encodes a patatin-domain triacylglyerol lipase. Silencing of JcSDP1 enhances seed oil accumulation in J. curcas.
Type:
Grant
Filed:
February 25, 2014
Date of Patent:
May 16, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Nam-Hai Chua, Mi Jung Kim, Seong Wook Yang