Abstract: The present invention provides nucleic acids and methods for conferring resistance to bacterial disease in plants. The present invention also provides promoters and promoter sequences useful for controlling expression in transgenic plants.
Type:
Grant
Filed:
September 6, 2010
Date of Patent:
May 16, 2017
Assignee:
Temasek Life Sciences Laboratory Limited
Inventors:
Zhong Chao Yin, Ke Yu Gu, Dong Sheng Tian
Abstract: The present invention relates to the murine monoclonal antibody (mAb) 11B9 and to mAb 62 each of which target major neutralizing epitopes of influenza A H7 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H7 influenza using murine mAb 11B9, mAb 62 or fragments thereof. The present invention further relates to methods and kits for determining, identifying and/or quantifying (a) influenza A hemagglutinin in a sample or vaccine or (b) an antibody against influenza A hemagglutinin.
Type:
Grant
Filed:
August 23, 2013
Date of Patent:
May 2, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORIES LIMITED
Inventors:
Hwei-Sing Jimmy Kwang, Fang He, Rajesh Kumar Subaschandrabose
Abstract: The present invention relates to the application of isolated promoters and synthetic dominant selection constructs and enhancers for gene targeting for efficient production of genetically modified cells in a species selected from the Pucciniomycotina and Ustilaginomycotina subphyla, in particular, species selected from the Rhodosporidium, Sporisorium, Sporobolomyces or Ustilago genera.
Type:
Grant
Filed:
May 10, 2012
Date of Patent:
April 25, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Liang Hui Ji, Yan Bin Liu, John Chong Mei Koh, Long Hua Sun
Abstract: The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant growth rate and seed productivity in agriculture through the application of a novel artificially manufactured formula containing a nitrogen-fixing bacterium that efficiently colonizes non-legume plants in aerial parts and the root system. The bacteria inocula and methods are particularly suitable for plants in the genera Jatropha, Sorghum, Gossypium, Elaeis, Ricinus, Oryza and Manihot.
Type:
Grant
Filed:
March 20, 2013
Date of Patent:
February 28, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of plant molecular biology, more particularly Jatropha microsomal co6 oleate desaturases. The present invention also relates to Jatropha plants or plants of other oil crops having seeds with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention relates to Jatropha plants or plants of other oil crops where the plants exhibit elevated levels of oleic acid.
Type:
Grant
Filed:
September 28, 2011
Date of Patent:
February 21, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to a universal H5N1 vaccine. More specifically, the present invention relates to the identification of three H5N1 strains which cover the entire variants in the neutralizing epitopes of hemagglutinin among most H5N1 lineages. The present invention further relates a universal H5N1 vaccine that comprises the three H5N1 strains or that comprises hemagglutinin peptides of each of these three strains.
Type:
Grant
Filed:
February 9, 2011
Date of Patent:
January 31, 2017
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Prabakaran Mookkan, Fang He, Hwei-Sing Jimmy Kwang
Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
Type:
Application
Filed:
December 12, 2014
Publication date:
January 5, 2017
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Fang HE, Hwei-Sing Jimmy KWANG, Prabakaran MOOKKAN
Abstract: The present invention relates to synthetic promoter and a synthetic gene which confers broad-spectrum disease resistance to Xanthomonands in plants. The present invention also relates to transgenic plants containing the synthetic gene and plants derived by crossing plants with such transgenic plants. More specifically, the synthetic promoter is a synthetic Xa10 promoter and the synthetic gene is a synthetic Xa10 gene which contains the synthetic Xa10 promoter. The resistance is resistance to bacterial blight and the plants are rice plants.
Type:
Grant
Filed:
November 1, 2012
Date of Patent:
December 27, 2016
Assignee:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Zhongchao Yin, Xuan Zeng, Dongsheng Tian
Abstract: The present invention relates to the murine monoclonal antibody (mAb) 11B9 and to mAb 62 each of which target major neutralizing epitopes of influenza A H7 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H7 influenza using murine mAb 11B9, mAb 62 or fragments thereof. The present invention further relates to methods and kits for determining, identifying and/or quantifying (a) influenza A hemagglutinin in a sample or vaccine or (b) an antibody against influenza A hemagglutinin.
Type:
Application
Filed:
August 23, 2013
Publication date:
September 8, 2016
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Hwei-Sing Jimmy KWANG, Fang HE, Rajesh Kumar SUBASCHANDRABOSE
Abstract: The present invention relates to the application of isolated promoters and synthetic constructs for efficient production of genetically modified cells in a species selected from the Pucciniomycotina and Ustilaginomycotina subphyla, in particular, species selected from the Rhodosporidium, Rhodotourla, Sporobolomyces or Pseudozyma genus.
Type:
Application
Filed:
March 10, 2014
Publication date:
February 4, 2016
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of plant molecular biology and gene silencing. More particularly, the present invention relates to gene silencing of Sugar-dependent 1 (JcSDP1) in Jatropha curcas. JcSDP1 encodes a patatin-domain triacylglyerol lipase. Silencing of JcSDP1 enhances seed oil accumulation in J. curcas.
Type:
Application
Filed:
February 25, 2014
Publication date:
January 14, 2016
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Nam-Hai CHUA, Mi Jung KIM, Seong Wook YANG
Abstract: The present invention relates to murine monoclonal antibodies C, F and H which target major neutralizing epitopes of influenza H5 hemagglutinin of clade 2.3 and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H5N1 influenza using murine monoclonal antibodies C, F or H or active fragments thereof. The present invention additionally relates to methods and compositions for providing universal protection against H5 influenza viruses using murine monoclonal antibodies C, F or H or fragments thereof together with complementary murine monoclonal antibody or active fragments thereof. The present invention further relates to methods and compositions for the characterization and quantification of H5 expression using these murine monoclonal antibody or fragments thereof.
Type:
Grant
Filed:
January 12, 2012
Date of Patent:
January 12, 2016
Assignee:
Temasek Life Sciences Laboratory Limited
Abstract: The present invention relates to synthetic promoter and a synthetic gene which confers broad-spectrum disease resistance to Xanthomonands in plants. The present invention also relates to transgenic plants containing the synthetic gene and plants derived by crossing plants with such transgenic plants. More specifically, the synthetic promoter is a synthetic Xa10 promoter and the synthetic gene is a synthetic Xa10 gene which contains the synthetic Xa10 promoter. The resistance is resistance to bacterial blight and the plants are rice plants.
Type:
Application
Filed:
November 1, 2012
Publication date:
October 15, 2015
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Zhongchao YIN, Xuan ZENG, Dongsheng TIAN
Abstract: Monoclonal antibodies and related binding proteins that are specific for conformational epitopes of avian influenza virus H5 subtype hemagglutinin glycoprotein are provided. The antibodies can be used for the detection and treatment of H5 subtype AIV in specimens.
Type:
Grant
Filed:
May 20, 2013
Date of Patent:
August 25, 2015
Assignees:
Temasek Life Sciences Laboratory Limited, National Institute of Health Research and Development (NIHRD)-Ministry of Health of the Republic of Indonesia
Abstract: The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant growth rate and seed productivity in agriculture through the application of a novel artificially manufactured formula containing a nitrogen-fixing bacterium that efficiently colonizes non-legume plants in aerial parts and the root system. The bacteria inocula and methods are particularly suitable for plants in the genera Jatropha, Sorghum, Gossypium, Elaeis, Ricinus, Oryza and Manihot.
Type:
Application
Filed:
March 20, 2013
Publication date:
April 16, 2015
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the murine monoclonal antibody 4C2 or to chimeric or humanized monoclonal antibodies specific to a major neutralizing epitope of influenza H5 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H5N1 influenza using such murine or chimeric or humanized monoclonal antibodies or fragments thereof.
Type:
Grant
Filed:
August 23, 2010
Date of Patent:
March 31, 2015
Assignee:
Temasek Life Sciences Laboratory Limited
Inventors:
Prabakaran Mookkan, Fang He, Hwei-Sing Jimmy Kwang
Abstract: The present invention relates to the field of plant molecular biology, more particularly cotton WRINKLED 1-like (WREL) genes. More specifically, the present invention relates to cotton WRIL genes whose products act as transcription factors of genes involved in fatty acid biosynthesis. The present invention also relates to methods of increasing cotton fiber length in cotton. In one embodiment, the methods involve modulating the level of activity of an enzyme involved in a fatty acid biosynthesis in the host cotton cell and/or culturing the host cotton cell. In another embodiment, the methods involve the manipulation of transcription factors which can regulate an enzyme involved in fatty acid biosynthesis.
Type:
Application
Filed:
April 19, 2012
Publication date:
March 12, 2015
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates to the field of modifying Jatropha branching, flowering time, fruiting and seed setting. More specifically, the present invention relates to a method for control and optimization of Jatropha curcas flowering time, fruiting and seed production by manipulating one gene from Jatropha. The present invention can be used in various Jatropha breeding efforts.
Type:
Application
Filed:
February 27, 2013
Publication date:
January 29, 2015
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventors:
Nam-Hai Chua, Jian Ye, Yun-Feng Geng, Bipei Zhang
Abstract: The present invention relates to murine monoclonal antibodies C, F and H which target major neutralizing epitopes of influenza H5 hemagglutinin of clade 2.3 and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H5N1 influenza using murine monoclonal antibodies C, F or H or active fragments thereof. The present invention additionally relates to methods and compositions for providing universal protection against H5 influenza viruses using murine monoclonal antibodies C, F or H or fragments thereof together with complementary murine monoclonal antibody or active fragments thereof. The present invention further relates to methods and compositions for the characterization and quantification of H5 expression using these murine monoclonal antibody or fragments thereof.
Type:
Application
Filed:
January 12, 2012
Publication date:
October 23, 2014
Applicant:
TEMASEK LIFE SCIENCES LABORATORY LIMITED
Abstract: The present invention relates generally to chemical-inducible system and to methods of use in transgenic animals. More specifically, the present invention relates to a chimeric transcription factor that binds to a ligand and functions in ligand-dependent manner to induce expression of genes of interest under the control of a synthetic operator-promoter sequence. The expression of genes of interest can be tightly controlled by adding or removing the ligand.
Type:
Grant
Filed:
July 2, 2008
Date of Patent:
October 7, 2014
Assignee:
Temasek Life Sciences Laboratory Limited
Inventors:
Alexander Emelyanov, Sergey Parinov, Nam-Hai Chua