Patents Assigned to Temasek Life Sciences Laboratory Limited
  • FRAGMENT SWITCH: A REVERSE GENETIC APPROACH
    Publication number: 20130053552
    Abstract: The present invention relates to the field of reverse genetics. More particularly, the present invention relates to a novel reverse genetic approach termed “fragment switch” which is used to generate an allelic series in genes of interest which are useful for functional analysis.
    Type: Application
    Filed: March 24, 2011
    Publication date: February 28, 2013
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Xie Tang, Mohan Balasubramanian
  • Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof
    Patent number: 8383121
    Abstract: Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: February 26, 2013
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Hong Liang Qian, Fang He, Hwei-Sing Kwang
  • N-terminal XA27 signal anchor and its use for localization of fusion proteins
    Patent number: 8367891
    Abstract: The present application is directed to a functional signal anchor that localizes a fusion protein to the apoplast of vascular elements in plants. The signal anchor is useful for engineering secretory proteins to the cell wall and or/apoplast of plant cells. The signal anchor is also useful for producing secretory proteins in transgenic plant cells in a bioreactor.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: February 5, 2013
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Zhongchao Yin, Lifang Wu
  • MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ AND NEURAMINIDASE FROM INFLUENZA VIRUS H5-SUBTYPE OR N1-SUBTYPE AND USES THEREOF
    Publication number: 20130004497
    Abstract: Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: Temasek Life Sciences Laboratory Limited
    Inventors: Hong Liang Qian, Fang He, Hwei-Sing Kwang
  • MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ AND NEURAMINIDASE FROM INFLUENZA VIRUS H5-SUBTYPE OR N1-SUBTYPE AND USES THEREOF
    Publication number: 20130004496
    Abstract: Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: Temasek Life Sciences Laboratory Limited
    Inventors: Hong Liang Qian, Fang He, Hwei-Sing Kwang
  • GENETIC TRANSFORMATION OF JATROPHA CURCAS
    Publication number: 20120272403
    Abstract: The present invention relates to methods for the regeneration and Agrobacterium-mediated transformation of plants in the genera of Jatropha, more specifically, in Jatropha curcas.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 25, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Hui Zhu MAO, Jian YE, Nam Hai CHUA
  • FISH CANCER MODEL
    Publication number: 20120270259
    Abstract: The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplasic transformation, or that modulate sensitivity to chemotherapy or radiation therapy Immortal tumor cells lines, methods of making immortal tumor cells lines and methods of their use are also provided.
    Type: Application
    Filed: June 26, 2012
    Publication date: October 25, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Sergey PARINOV, Alexander EMELYANOV
  • MEDIA COMPOSITIONS, SELECTION METHODS AND AGROBACTERIUM STRAINS FOR TRANSFORMATION OF PLANTS
    Publication number: 20120246759
    Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
    Type: Application
    Filed: December 4, 2009
    Publication date: September 27, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lin Cai, Longhua Sun, Lin Fu, Lianghui Ji
  • CONTROL OF PESTS IN PLANTS
    Publication number: 20120240288
    Abstract: The present invention relates to the field of controlling pests, such as insects, using a virus to express pest genes in hosts. More specifically, the present invention relates to a method for rapidly screening for pest genes which can lead to mortality of the pest when the pest has ingested host tissues expressing virus-linked pest gene sequences. The present invention also relates to a method for controlling pests by viral expression of target pest sequences to modify endogenous expression of pest genes in cells or tissues of the pest.
    Type: Application
    Filed: September 15, 2010
    Publication date: September 20, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Jian Ye, Nam-Hai Chua, Jing Qu, Shi-Qiang Gao
  • Fish cancer model
    Patent number: 8242326
    Abstract: The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplastic transformation, or that modulate sensitivity to chemotherapy or radiation therapy. Immortal tumor cells lines, methods of making immortal tumor cell lines and methods of their use are also provided.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: August 14, 2012
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Sergey Parinov, Alexander Emelyanov
  • TRANSPOSITION OF MAIZE AC/DS ELEMENTS IN VERTEBRATES
    Publication number: 20120174245
    Abstract: The present invention is directed to the use of the maize Ac/Ds transposable elements in vertebrates.
    Type: Application
    Filed: March 16, 2012
    Publication date: July 5, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Sergey PARINOV, Alexander EMELYANOV
  • VIRUS INDUCED GENE SILENCING (VIGS) FOR FUNCTIONAL ANALYSIS OF GENES IN COTTON
    Publication number: 20120096595
    Abstract: The invention relates to the functional analysis of genes in cotton by employing the Virus Induced Gene Silencing (VIGS) method. More specifically this method induces gene silencing in cotton with the help of the Tobacco Rattle Virus (TRV) vectors RNA1 and RNA2 and phenotypic effects on the cotton plant can be analysed Moreover this invention also provides transient expression vector TRV RNA2 in order to transiently express genes in cotton plants and plant tissue under the influence of a strong subgenomic promoter.
    Type: Application
    Filed: June 10, 2010
    Publication date: April 19, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Jian Ye, Nam Hai Chua, Jing Qu, Yun Feng Geng, Yun Ping Bu
  • JATROPHA CURCAS CURCIN GENES, TISSUE-SPECIFIC PROMOTERS AND GENERATION OF CURCIN-DEFICIENT TRANSGENIC JATROPHA PLANTS
    Publication number: 20120073018
    Abstract: The present invention relates to the isolation of Jatropha curcas curcin genes and tissue-specific promoters and to the production of curcin-deficient Jatropha plants. More specifically, the present invention relates to the isolation of Jatropha curcas Curcin 1, Curcin 2 and Curcin 2 A. The present invention further relates to of the Curcin 1, Curcin 2 A and Curcin 2 genes and more particularly to tissue specific promoters of the Curcin 1 and Curcin 2A genes. The present invention further relates to production of curcin-deficient transgenic jatropha plants by using RNAi technology to suppress curcin gene expression.
    Type: Application
    Filed: June 2, 2010
    Publication date: March 22, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Zhong Chao Yin, Li Fang Wu, Hui Zhu Mao, Cheng Xiang Qiu
  • Transposition of maize AC/DS elements in vertebrates
    Patent number: 8137974
    Abstract: The present invention is directed to the use of the maize Ac/Ds transposable elements in vertebrates.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: March 20, 2012
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Sergey Parinov, Alexander Emelyanov
  • Biomolecule Surface Display and Uses Thereof
    Publication number: 20120045473
    Abstract: A vaccine for the treatment or prevention of a disease in a subject, wherein said disease is associated with an avian influenza virus, and wherein said vaccine comprises an expression vector comprising a nucleic acid encoding a hemagglutinin peptide, such that in use said hemagglutinin peptide is expressed by said expression vector in said subject.
    Type: Application
    Filed: May 5, 2006
    Publication date: February 23, 2012
    Applicant: Temasek Life Sciences Laboratory Limited
    Inventor: Jimmy Kwang
  • DIGOXIN-LIKE FUNGAL GLYCOSIDE WITH CYTOTOXIC PROPERTIES: NOVEL ASSAY AND APPLICATIONS
    Publication number: 20120003261
    Abstract: The present invention provides methods of isolating cytotoxic metabolites from a fungus, and specific metabolites obtained from such methods. The present invention also provides methods of controlling fungal diseases in plants by treating the plants with cytotoxic metabolites as well as methods of treating cardiac arrhythmia in organisms in need of such treatment by administering the above-noted metabolites to such organisms.
    Type: Application
    Filed: June 18, 2009
    Publication date: January 5, 2012
    Applicant: Temasek Life Sciences Laboratory Limited
    Inventors: Rajesh Narhari Patkar, Naweed Isaak Naqvi
  • FUNCTIONAL ANALYSIS OF JATROPHA CURCAS GENES
    Publication number: 20110265223
    Abstract: The present invention relates to the field of functional analysis of Jatropha genes on a genomic scale. More specifically, the present invention relates to a method for high-throughtput functional analysis of Jatropha curcas genes on a genomic scale using virus-induced gene silencing. The method involves use of the tobacco rattle virus (TRV).
    Type: Application
    Filed: December 16, 2009
    Publication date: October 27, 2011
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Jian Ye, Nam Hai Chua, JIng Qu
  • Monoclonal Antibodies Specific to the Fusion Peptide From Hemagglutinin From Influenza A Viruses and Uses Thereof
    Publication number: 20110256141
    Abstract: This invention relates to methods and products for the diagnosis, surveillance, prevention, and treatment of influenza A virus infections in animals and humans. More particularly, the invention relates to antibodies and related binding proteins for the detection, prevention and treatment of influenza A viruses. The monoclonal antibodies and related binding proteins of the invention are useful for the treatment of the highly pathogenic H5 subtypes of avian influenza virus (AIV).
    Type: Application
    Filed: December 24, 2008
    Publication date: October 20, 2011
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Prabakaran Mookkan, Nayana Prabhu Padubidhri, Sumathy Velumani, Hwei-Sing Jimmy Kwang
  • GENETIC TRANSFORMATION OF JATROPHA CURCAS
    Publication number: 20110247099
    Abstract: The present invention relates to methods for the regeneration and Agrobacterium-mediated transformation of plants in the genera of Jatropha, more specifically, in Jatropha curcas.
    Type: Application
    Filed: December 15, 2009
    Publication date: October 6, 2011
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Hui Zhu Mao, Jian Ye, Nam Hai Chua
  • Fluorescent primer system for detection of nucleic acids (Q priming)
    Patent number: 7964716
    Abstract: The present invention is directed to a self-quenching primer comprising; a fluorophore that can be quenched by guanine; an oligonucleotide sequence that forms a hairpin; an oligonucleotide that is a target specific sequence and; use in amplification reactions, particularly in polymerase chain reactions, during which the fluorophore is released thereby emitting fluorescence.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: June 21, 2011
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Xiao Kun Liu, Yan Hong