Abstract: A method and kit for diagnosing Bloom's syndrome are provided relying on specific monoclonal antibodies, such as ATCC HB-9311, which recognize the base excision repair pathway enzyme uracil DNA glycosylase from normal healthy individuals and individuals afflicted with genetic syndromes, but fails to recognize uracil DNA glycosylase from individuals afflicted with Bloom's Syndrome.

Abstract: A method of and apparatus for measuring a stimulus, e.g. a force, applied to a piezoelectric transducer. The method comprises sampling the output of the transducer in response to the stimulus at intervals during application of the stimulus, resetting the output of the transducer to a predetermined value immediately following each sampling step, and summing the values of the sampled transducer output for each sampling step to provide a value indicative of the total applied stimulus. The apparatus of the invention comprises a sensor for sensing the transducer output in response to the stimulus a sampling circuit for sampling the sensed output at intervals during application of the force, a switch for resetting the output of transducer to a predetermined value immediately following each sampling operation, and circuitry for summing the values of the sampled transducer output for each sampling step and generating from them an output value indicative of the total applied stimulus.

Abstract: A pneumatic drive circuit for a pneumatically-driven artificial ventricle having a gas chamber and a blood chamber separated by a flexible diaphragm. The drive circuit comprises a source of pressurized gas at a preselected pressure. Valves operatively associated with the gas chamber of the ventricle admit gas to the gas chamber during systole and exhaust gas from the gas chamber during diastole. The drive circuit includes pneumatic logic circuitry for actuating the valves. The logic circuitry includes circuitry for causing the valves to admit gas to the gas chamber during systole at a pressure which increases gradually from zero pressure to a pressure less than the preselected pressure, and then increases rapidly to the preselected pressure.

Abstract: Two novel hybridoma cell lines, ATCC #HB-8397 and ATCC #HB-8398 produce monoclonal antibody monospecific to a single determinant shared by a set of three closely related cytoplasmic antigens of Candida albicans. The antigens have molecular weights of 120-135 Kd, 48-52 Kd, and 35-38 Kd. The hybridomas are formed by fusing splenocytes from immunized BALB/c mice with SP2/O-Ag 14 myeloma cells. Monoclonal and monospecific, polyclonal antibodies to these cytoplasmic antigens find application in the immunodiagnosis of Candida infections.A procedure is provided for preparing partially purified cytoplasmic antigen of pathogenic Candida species for administration to splenocyte-donating mice. Also provided is a method for the biochemical purification of cytoplasmic antigen of a pathogenic Candida species used for the preparation of monoclonal and monospecific, polyclonal antisera thereto.

Abstract: Sustained-released delivery forms comprising the reaction product of a Lewis acid salt with a Lewis base salt at the phase interface of their respective aqueous and non-aqueous solution to form an anisotropic high molecular weight salt of the acid and base and a neutral salt of the inorganic cation and anion in what is termed a "double decomposition" or "salt exchange" reaction.

Abstract: An integral blood pressure sensor for a cardiac prosthesis of the type having a fluid chamber and a blood chamber separated by a flexible diaphragm which is actuated by a drive fluid pulsatingly supplied to the fluid chamber for pumping blood from the blood chamber. The blood pressure sensor includes at least one transducer integral with a wall of the blood chamber and in pressure-sensing relation to the interior of the chamber. The invention also includes a method of manufacturing a cardiac prosthesis having an integral blood pressure sensor.

Abstract: A combination of drugs including a kappa opioid receptor agonist and a dopamine receptor blocker or dopamine receptor agonist provides a synergistic effect in inducing hypothermia and/or poikilothermia in humans and animals. Hypothermia as much as 10.degree. C. at an ambient temperature of 20.degree. C. is possible, with complete recovery and few, if any, side effects.

Abstract: Lewis acid-Lewis base high molecular weight salt microparticulate material of the type referred to in U.S. Pat. No. 3,959,457, which include biologically active peptides and proteins solubilized in a non-aqueous, non-denaturing manufacturing solvent.

Abstract: A method and apparatus for the permanent surgical reconstruction of the anterior cruciate ligament in the human knee, which will stabilize the tibia and femur relative to each other and restore a full range of motion to the knee, by precisely locating the ends and angular relationship of a replacement ligament within the knee joint, at bone attachment sites such that the degree of shortening and lengthening experienced by the replacement ligament over the range of joint motion is either as close to zero (isometric) as possible, or closely matches that of the natural uninjured ligament (physometric), whichever the surgeon feels is most desirable.

Abstract: A chromatographic column and process for isolating or purifying steroid hormone or cell membrane receptors using the column are provided in which the column contains at least three resin layers between the inlet and the outlet ends of the column, the layer closest the inlet being a strong cationic exchange resin, the middle layer being a matrix containing a triazine dye that will bind proteases and proteins with dinucleotide fold conformations, and the layer closest the outlet being a weak anionic exchange resin, the ratio of the volumes of the resin layers being 1:2:1.

Abstract: A method of predicting the occurrence of deep vein thrombosis after a surgical procedure comprises monitoring changes in the internal diameter of a blood vessel using a non-invasive ultrasound technique. The frequency and magnitude of changes in vessel diameter are used to predict whether deep vein thrombosis will occur.

Abstract: A device and method for converting ocean wave energy into electricity either on moored buoys or in small vessels. The device and method of the invention utilize a U-shaped tube in communication with a gas concentration cell. The U-shaped tube resides in a cradle or other support means, secured to the buoy or other base which imparts wave energy thereto. The U-shaped tube contains a combination of liquid and hydrogen gas. The rocking of the U-shaped tube creates varying gas pressure differentials, which deposits oppositely charged particles on parallel electrocatalytic electrodes located within the gas concentration thereby creating an electrical potential therebetween, according to the Nernst equation.

Abstract: The present invention is directed to an improved package for wrapping sterile disposable articles, such as surgical gowns. The package generally includes a generally rectangular wrapping material having corners. A strap is generally T-shaped and has three free ends. Each free end of the strap is affixed adjacent one corner of the material. A pull tab is affixed to the strap. The package is opened by pulling the tab away from the package. The sterile article is wrapped by folding the corners of the material over the article and tucking one corner under the other corners.

Abstract: An apparatus and method for utilizing energy, in which the apparatus may be used for generating electricity or as a heat pump. When used as an electrical generator, two gas concentration cells are connected in a closed gas circuit. The first gas concentration cell is heated and generates electricity. The second gas concentration cell repressurizes the gas which travels between the cells. The electrical energy which is generated by the first cell drives the second cell as well as an electrical load. When used as a heat pump, two gas concentration cells are connected in a closed gas circuit. The first cell is supplied with electrical energy from a direct current source and releases heat. The second cell absorbs heat. The apparatus has no moving parts and thus approximates a heat engine.

Abstract: Two novel hybridoma cell lines, ATCC #HB-8397 and ATCC #HB-8398 produce monoclonal antibody monospecific to a single determinant shared by a set of three closely related cytoplasmic antigens of Candida albicans. The antigens have molecular weights of 120-135 Kd, 48-52 Kd, and 35-38 Kd. The hybridomas are formed by fusing splenocytes from immunized BALB/c mice with SP2/O-Ag 14 myeloma cells. Monoclonal and monospecific, polyclonal antibodies to these cytoplasmic antigens find application in the immunodiagnosis of Candida infections.A procedure is provided for preparing partially purified cytoplasmic antigen of pathogenic Candida species for administration to splenocyte-donating mice. Also provided is a method for the biochemical purification of cytoplasmic antigen of a pathogenic Candida species used for the preparation of monoclonal and monospecific, polyclonal antisera thereto.

Abstract: An electro- and magneto-optic device which comprises a fluid suspension of anisotropic platelets in a dielectric media, and a means for imposing an electrical or magnetic field on the suspension. Orientation of such platelets in the media is accomplished by imposition of an electrical or magnetic field. The invention may be used to provide an information display or a field controlled shutter in window glass.

Abstract: A novel polycyanogen (MW at least 500) is made by electrochemical polymerization of cyanogen in solution. Fiber and pyrolyzed forms of this polymer and methods of making same are also described.

Abstract: Several novel hybridoma cell lines, ATCC #HB-8510, 8511, 8512, 8513, 8514, 8515, 8516, and 8517 produce monoclonal antibody to an antigen, peptidoglycan, which is a normal structural component of neREFERENCE TO GOVERNMENTThe invention described herein was supported by National Institutes of Health grants DE-03487 and DE-05160.

Abstract: A low viscosity, short pitch, cholesteric liquid crystal composition consisting of an alkali cromoglycate dissolved in water or water with a polar solvent, together with an optically active solute in sufficient concentration to render the cromoglycate cholesteric. Suitable compositions will reflect light in the visible spectrum and may be magnetically, electrically, or thermally addressed to produce optical effects therein.

Abstract: A strain of Neisseria gonorrhoeae ATCC 31953 is described which is abnormal in that it has characteristically poor growth on chocolate agar at a temperature range of about 30.degree. C. to about 37.degree. C. in a CO.sub.2 atmosphere suitable for growth of N. gonorrhoeae. This strain is resistant to nalidixic acid at the 5-10 mcg/ml level and resistant to streptomycin at the 1000 mcg/ml level or greater. N. gonorrhoeae ATCC 31953 is a test strain suitable for use in the method described for the laboratory diagnosis of gonorrhea.