Patents Assigned to The Board of Regents of the University of Oklahoma
  • Semiconductor interband lasers and method of forming
    Patent number: 9287683
    Abstract: A semiconductor interband laser that includes a first cladding layer formed using a first high-doped semiconductor material having a first refractive index/permittivity and a second cladding layer formed using a second high-doped semiconductor material having a second refractive index/permittivity. The laser also includes a waveguide core having a waveguide core refractive index/permittivity, the waveguide core is positioned between the first and the second cladding layers. The waveguide core including an active region adapted to generate light based on interband transitions. The light being generated defines the lasing wavelength or the lasing frequency. The first refractive index and the second refractive index are lower than the waveguide core refractive index. The first cladding layer and/or the second cladding layers can also be formed using a metal.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: March 15, 2016
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Rui Q. Yang, Tetsuya Mishima, Michael B. Santos, Zhaobing Tian, Matthew B. Johnson, Robert T. Hinkey
  • PEPTIDE COMPOUNDS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20160060315
    Abstract: Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptide compounds.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 3, 2016
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Heloise Anne Pereira, Ann KASUS-JACOBI, Gina L. GRIFFITH
  • Methods of producing protoporphyrin IX and bacterial mutants therefor
    Patent number: 9273334
    Abstract: The presently disclosed inventive concepts are directed in certain embodiments to a method of producing protoporphyrin IX by (1) cultivating a strain of Shewanella bacteria in a culture medium under conditions suitable for growth thereof, and (2) recovering the protoporphyrin IX from the culture medium. The strain of Shewanella bacteria comprises at least one mutant hemH gene which is incapable of normal expression, thereby causing an accumulation of protoporphyrin IX. In certain embodiments of the method, the strain of Shewanella bacteria is a strain of S. loihica, and more specifically may be S. loihica PV-4. In certain embodiments, the mutant hemH gene of the strain of Shewanella bacteria may be a mutant of shew_2229 and/or of shew_1140.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 1, 2016
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jizhong Zhou, Dongru Qiu, Zhili He, Ming Xie
  • SYSTEM AND METHOD FOR MEASURING SEPARATION RATE OF WATER FROM WATER-IN-CRUDE OIL EMULSIONS
    Publication number: 20160047792
    Abstract: System and method relates to measuring separation rate of water from water-in-crude oil emulsions at elevated temperature. The system includes an electrolytic interface (conductivity) cell comprising a plurality of capacitance/conductance probes disposed at different heights in a fluid stream disposed within the interface cell and an analyzer. Logic of the analyzer determines the separation rate based on signals received from the plurality of capacitance/conductance probes in the interface cell that are coupled to monitor the fluid stream. Methods for making and using the system are also disclosed.
    Type: Application
    Filed: July 17, 2015
    Publication date: February 18, 2016
    Applicants: Phillips 66 Company, Board of Regents of the University of Oklahoma
    Inventors: Moniraj GHOSH, Brian P. GRADY, Jeffrey H. HARWELL, James A. MILES
  • Optical cryptography systems and methods
    Patent number: 9246680
    Abstract: Systems and methods for encoding a message are disclosed. A message may be passed from a first node to a second node via a communication link using a multi-stage cryptography algorithm distributed between the first node and the second node and applied by circuitry within the first node and the second node in which the multi-stage cryptography algorithm includes instructions for transmitting at least two optical signal transmissions across the communication path and using a number of independent transformations of polarization state of the optical signal transmission by a combination of the first node and the second node at least equal to the number of optical signal transmissions across the communication link.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 26, 2016
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Pramode Verma, Mayssaa El Rifai, Nikhil Vishnu Punekar
  • TARGET PEPTIDES FOR OVARIAN CANCER THERAPY AND DIAGNOSTICS
    Publication number: 20160000893
    Abstract: A set of target peptides are presented by HLA A*0201 on the surface of ovarian cancer cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., ovarian cancer, (b) function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
    Type: Application
    Filed: December 13, 2013
    Publication date: January 7, 2016
    Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Donald F. Hunt, Jeffrey Shabanowitz, Jennifer G. Abelin, William H. Hildebrand
  • Mutants of cholesterol-dependent cytolysins and uses thereof
    Patent number: 9228001
    Abstract: Mutants of cholesterol-dependent cytolysins comprising at least one amino acid substitution in at least one of Loop 1, Loop 2, or Loop 3 of Domain 4, nucleic acids, vectors, and host cells encoding such polypeptide mutants, and compositions and vaccines comprising such polypeptide mutants.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: January 5, 2016
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rodney K. Tweten
  • CARDIAC NEUROMODULATION AND METHODS OF USING SAME
    Publication number: 20150374995
    Abstract: The present invention relates in general to methodologies for the treatment quenching preconditioning and communication between the intrinsic cardiac nervous system and an electrical stimulus. In particular, the present invention utilizes spinal cord stimulation to alter and/or affect the intrinsic cardiac nervous system and thereby protect the myocytes, stabilize myocardial electrical instability and/or alleviate or diminish cardiac pathologies.
    Type: Application
    Filed: July 6, 2015
    Publication date: December 31, 2015
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Robert D. Foreman, Jeffrey L. Ardell, John A. Armour, Michael J.L. DeJongste, Bengt G.S. Linderoth
  • Peptide Compounds and Methods of Production and Use Thereof
    Publication number: 20150374785
    Abstract: Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.
    Type: Application
    Filed: December 3, 2013
    Publication date: December 31, 2015
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Heloise Anne Pereira, Anne Kasus-Jacobi, Gina L. Griffith
  • Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
    Patent number: 9200024
    Abstract: A methodology for polymer grafting by a polysaccharide synthase allows the creation of a variety of glycosaminoglycan oligosaccharides that have a natural, chimeric, hybrid and/or unnatural sugar structure and/or a targeted size (i.e., substantially monodisperse in size).
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: December 1, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Alison Sismey-Ragatz
  • Anionic lipids and lipid nano-structures and methods of producing and using same
    Patent number: 9173839
    Abstract: Anionic non-phospholipids, as well as lipid nanostructures formed therefrom, are disclosed herein. Also disclosed are methods of producing and using same.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: November 3, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Vibhudutta Awasthi, Pallavi Lagisetty
  • Interband cascade (IC) photovoltaic (PV) architecture for PV devices
    Patent number: 9166084
    Abstract: A photovoltaic (PV) device, comprising a PV interband cascade (IC) stage, wherein the IC PV stage comprises an absorption region with a band gap, the absorption region configured to absorb photons, an intraband transport region configured to act as a hole barrier, and an interband tunneling region configured to act as an electron barrier. An IC PV architecture for a photovoltaic device, the IC PV architecture comprising an absorption region, an intraband transport region coupled to the absorption region, and an interband tunneling region coupled to the intraband transport region and to the adjacent absorption region, wherein the absorption region, the intraband transport region, and the interband tunneling region are positioned such that electrons will flow from the absorption region to the intraband transport region to the interband tunneling region.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: October 20, 2015
    Assignee: Board of Regents University of Oklahoma
    Inventors: Rui Q. Yang, Zhaobing Tian, Tetsuya D. Mishima, Michael B. Santos, Matthew B. Johnson, John F. Klem
  • Methods for obtaining clean energy from coal
    Patent number: 9139780
    Abstract: The present invention provides methods for stimulating or enhancing the conversion of coal to methane. The methods of the current invention subject coal to an oxidation step, for example ozonolysis, thereby converting at least a portion of the coal to partially-oxidized and water-soluble forms of organic matter. Subsequent contact of the oxidized coal components with a suitable inoculum containing a methanogenic microbial community produces methane.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: September 22, 2015
    Assignee: The Board of Regents of The University of Oklahoma
    Inventors: Joseph Suflita, Mark Nanny, Margarita Mendivelso Castro, Jan Sunner
  • Epitope testing using soluble HLA
    Patent number: 9110080
    Abstract: The present invention relates generally to a methodology for assaying the binding of a peptide to an individual, specific, soluble HLA molecule using fluorescence polarization. The peptides utilized in the method may be identified by indirect methods utilizing T lymphocytes, or by a direct method of epitope discovery described herein.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: August 18, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: William H. Hildebrand, Rico Buchli
  • Peptide compounds and methods of production and use thereof
    Patent number: 9096679
    Abstract: Peptide compounds based on the CAP37 (cationic antimicrobial protein of Mr 37 kDa) protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: August 4, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Heloise Anne Pereira
  • Cardiac neuromodulation and methods of using same
    Patent number: 9072901
    Abstract: The present invention relates in general to methodologies for the treatment quenching preconditioning and communication between the intrinsic cardiac nervous system and an electrical stimulus. In particular, the present invention utilizes spinal cord stimulation to alter and/or affect the intrinsic cardiac nervous system and thereby protect the myocytes, stabilize myocardial electrical instability and/or alleviate or diminish cardiac pathologies.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: July 7, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Robert D. Foreman, Jeffrey L. Ardell, John A. Armour, Michael J. L. DeJongste, Bengt G. S. Linderoth
  • SINGLET OXYGEN-LABILE LINKERS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20150165026
    Abstract: Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.
    Type: Application
    Filed: April 24, 2013
    Publication date: June 18, 2015
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Youngjae You, Moses Bio, Abugafar Hossion
  • Thermoelectric materials
    Patent number: 9059363
    Abstract: A thermoelectric material having a high ZT value is provided. In general, the thermoelectric material is a thin film thermoelectric material that includes a heterostructure formed of IV-VI semiconductor materials, where the heterostructure includes at least one potential barrier layer. In one embodiment, the heterostructure is formed of IV-VI semiconductor materials and includes a first matrix material layer, a potential barrier material layer adjacent to the first matrix material layer and formed of a wide bandgap material, and a second matrix material layer that is adjacent the potential barrier material layer opposite the first matrix material layer. A thickness of the potential barrier layer is approximately equal to a mean free path distance for charge carriers at a desired temperature.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: June 16, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Patrick John McCann
  • Genes of an otitis media isolate of nontypeable
    Patent number: 9034642
    Abstract: The invention relates to the polynucleotide sequence of a nontypeable strain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: May 19, 2015
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, THE BOARD OF REGENTS OF UNIVERSITY OF OKLAHOMA
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
  • ANTI-C.DIFFICILE TOXIN ANTIBODIES AND ASSOCIATED METHODS
    Publication number: 20150104454
    Abstract: Embodiments of the invention are directed to a composition comprising a recombinant protein in soluble form wherein said recombinant protein comprises a portion of the Clostridium difficile toxin B sequence that comprises an epitope for anti-toxin B antibody. Other embodiments of the invention are directed to the generation of antibodies using peptide fragments of C. difficile toxin B.
    Type: Application
    Filed: September 13, 2012
    Publication date: April 16, 2015
    Applicant: Board of Regents of the University of Oklahoma
    Inventors: Jimmy D. Ballard, Jordi M. Melton, Latisha Heinlen, Elaine E. Hamm