Abstract: The present invention provides sulfur- or selenium-containing compounds comprising hydrophobic moieties and ethoxylated ester or ethoxylated amide moieties such that the compounds have surfactant properties. Also provided are methods for using the disclosed compounds or mixtures thereof in a variety of applications.

Abstract: High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.

Abstract: A t-junction for use in a pipe manifold of a pumping system for supplying a fracturing fluid to well head.

Abstract: Peptide compounds based on the CAP37 (cationic antimicrobial protein of Mr 37 kDa) protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.

Abstract: Apparatus and methods for laser ablation sampling, electrophoretic extraction from the laser plume, electrophoretic transport to a container, and capture of macromolecules of interest. In certain embodiments, when macromolecules of interest are nucleic acid, the apparatus and methods further provides for nucleic acid amplification and detection in a rapid mobile platform for environmental and clinical identification of pathogens.

Abstract: Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.

Abstract: The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) in an individual. These include enzyme linked immunosorbent assays (ELISAs) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor D1, dopamine receptor D2, serotonin receptor 5HT2A, and serotonin receptor 5HT2C. Antibody titers against at least four of these neuronal antigens are required in the present methods; preferably antibody tiers against all of these neuronal antigens are measured. A final assay is used to quantify calcium/calmodulin-dependent protein kinase activity using a neuronal cell line.

Abstract: R-spondin variants comprising a ZNRF3 binding region of a first R-spondin and an LGR4 binding region of a second R-spondin are disclosed. Cell culture media and compositions containing the R-spondin variants, as well as methods of their use, are also disclosed.

Abstract: A method of collecting data using a polarimetric phased array antenna is described. The method includes directing electromagnetic signals to selected panels of an array of panels so as to transmit a dual H and V polarized electromagnetic beam (1) having the same beam width in all azimuth directions and (2) maintaining cross-polarization isolation via orthogonal dual-polarizations in all beam pointing directions. The panels include antennas having a horizontally (H) polarized array element and a vertically (V) polarized array element arranged to form two orthogonally polarized horizontal and vertical radiating fields which together form the dual H and V polarized electromagnetic beam. The array of panels is arranged so as to form a substantially cylindrical configuration on a support system. Reflection signals sensed by the selected panels formed by scattering of said dual H and V polarized electromagnetic beam are received and have a reflection frequency spectrum.

Abstract: Methods for treating various cardiovascular disorders include targeted delivery of calcium ions for permanently impairing a portion of the autonomic nervous system (ANS). Targeted delivery may be via magnetically-targetable nanoparticles.

Abstract: Systems and methods for sharing data between a first node and second node are disclosed. The methods may include sharing a first initialization vector between a first node and a second node using a multi-stage cryptography protocol. A first bit stream of first information may be passed from the first node to the second node using a single-stage cryptography protocol that encodes a message with the first initialization vector.

Abstract: In at least one embodiment, a semiconductor laser is constructed to have a waveguide core including an active region, a top cladding, and a bottom cladding. The top cladding is positioned above the waveguide core and comprises a dielectric layer and a metal layer and optionally a thin semiconductor contact layer. In at least one embodiment of the semiconductor laser, the top cladding is absent a semiconductor material which is able to contain at least 1% of an optical wave that is generated within the waveguide core.

Abstract: Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n.

Abstract: Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.

Abstract: The present invention includes compositions, methods, and systems for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.

Abstract: Disclosed herein are methods and mid-IR detection apparatus to measure analytes in gas or liquid phase. Solid state cooling of a crystalline lattice is effectively achieved with the controlled flow of charge carriers that absorb thermal energy from the semiconductor material which senses mid-IR photons. Reduction in temperature improves signal-to-noise ratios thus improving molecular sensitivity. In one embodiment the apparatus is used to detect a biomarker.

Abstract: Compositions for inhibition of RNA Polymerase I include peptides of Rpa43. Methods of production and use thereof are also disclosed.

Abstract: Monoclonal antibodies against DCLK1 and conjugates containing these monoclonal antibodies are disclosed. Methods of producing and using these monoclonal antibodies are also disclosed.

Abstract: Biomaterial compositions that include an isolated heparosan polymer are disclosed, as well as kits containing such biomaterial compositions and methods of producing and using such biomaterial compositions.

Abstract: Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptide compounds.