Patents Assigned to The Board of Regents of the University of Oklahoma
  • Identification of MHC class I phospho-peptide antigens from breast cancer utilizing SHLA technology and complementary enrichment strategies
    Patent number: 10640535
    Abstract: The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: May 5, 2020
    Assignees: AGENUS INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Donald F. Hunt, Andrew Norris, Ann Michelle English, Jeffrey Shabanowitz, William H. Hilderbrand, Oriana E. Hawkins
  • ALTERTOXIN II AS A SELECTIVE INHIBITOR OF EWING FAMILY OF TUMOR CELLS
    Publication number: 20200101038
    Abstract: Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 2, 2020
    Applicants: The Board of Regents of the University of Texas System, The Board of Regents of the University of Oklahoma System
    Inventors: Susan L MOOBERRY, Andrew J ROBLES, April L RISINGER, Robert H CICHEWICZ, Salkat HALDAR, Peter HOUGHTON
  • Surfactant microemulsions
    Patent number: 10584306
    Abstract: The present invention relates to microemulsions and methods of preparing and using the microemulsions.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: March 10, 2020
    Assignees: Board of Regents of the University of Oklahoma, Novus International, Inc.
    Inventors: Scott Long, Graciela Arhancet, Brian Grady, Jeff Harwell, Guangzhe Yu
  • Pneumolysin mutants and methods of use thereof
    Patent number: 10562941
    Abstract: The present disclosure provides, in various embodiments, immunogenic mutants of cholesterol-dependent cytolysins, such as pneumolysin, which have reduced hemolytic activity and reduced pore-forming activity in comparison to their wild type protein. The present disclosure also provides, in various embodiments, nucleic acids which encode such mutants, and methods of the use of such mutants.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 18, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rodney K. Tweten
  • Thermophotovoltaic materials, methods of deposition, and devices
    Patent number: 10546965
    Abstract: Novel materials, material deposition methods, and devices used to generate electrical power from thermal radiators based on thermophotovoltatic (TPV) operating principles using group IV-VI alloys and materials are disclosed. A semiconductor structure comprising (N) stacked junctions, each junction formed of a IV-VI semiconductor alloy and each of said N junctions having a bandgap, where N is an integer and N>1 is disclosed. The semiconductor structure is configured to capture electromagnetic radiation having wavelengths from about 1 ?m to about 7 ?m. TPV devices comprising the novel semiconductor structure and methods of making the novel structures and devices are also disclosed.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: January 28, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Patrick John McCann
  • Surgical cleaning tool, system, and method
    Patent number: 10537402
    Abstract: A surgical cleaning tool and method of cleaning a surgical tool. The surgical cleaning tool includes a shaft, a handle and an end portion. The shaft has a distal end and a proximal end. The handle is attached to the distal end of the shaft The end portion is connected to the proximal end of the shaft, wherein the end portion has an outer surface, an inner cavity, an inner surface, at least one cleaning element connected to at least a portion of the inner surface, and an opening in a wall portion of the end portion, wherein the opening allows access to the cleaning element in the inner cavity of the end portion.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: January 21, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Nilesh Vasan, Michael Petri, Andrew Stewart, Patrick Stevens, Rannyu Ngoran, Jonathan Schick, Derrick Jones
  • Dual-linear-polarized, highly-isolated, crossed-dipole antenna and antenna array
    Patent number: 10530068
    Abstract: A dual linear polarized dipole antenna (and arrays of such antennas) having high isolation between ports. The antenna may include a pair of crossed (collocated) bent (angled) dipole antenna elements which are excited by a unique dual-polarized feeding structure. The antenna elements may be printed. Stripline feeding along with substantially symmetrical and substantially identical radiative (e.g., “radiating”) elements results in high level of port isolation. Sub-ground planes may be positioned about the stripline on both sides of a balun block to limit or reduce parasitic stripline radiation, thereby improving polarization purity. Polarization purity may be additionally reinforced by a principal ground plane which isolates the radiative elements from the baluns. The antennas and antenna arrays may be used, for example, for weather observation and air surveillance.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: January 7, 2020
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Mirhamed Mirmozafari, Guifu Zhang
  • Inhibitors of retinaldehyde dehydrogenases and methods of use
    Patent number: 10519108
    Abstract: Compounds having inhibitory activity against retinaldehyde dehydrogenases (RALDHs). The compounds can be used, for example, to inhibit synthesis of retinoic acid for the treatment of refractive error disorders such as myopia, and as infertility treatments by inhibiting spermatogenesis.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 31, 2019
    Assignees: The Board of Regents of the University of Oklahoma, Oklahoma Medical Research Foundation
    Inventors: Jody A. Summers, Angelica R. Harper, Tim Mather, Anthony Burgett, Anh Thi Quynh Le
  • High isomerohydrolase activity mutants of human RPE65
    Patent number: 10494619
    Abstract: Mutant mammalian RPE65 proteins and portions thereof, and nucleic acids encoding the mutants, for use in treating a condition related to retinal degeneration in a subject, the mutant mammalian RPE65 proteins or portions thereof having isomerohydrolase activity. A gene therapy method of treating a condition related to retinal degeneration in a mammalian subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of a vector comprising a nucleic acid encoding a mutant mammalian RPE65 protein or a portion thereof. A method of treating a condition related to retinal degeneration in a subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of at least one of a mutant mammalian RPE65 protein or a portion thereof.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: December 3, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jian-Xing Ma, Yusuke Takahashi, Gennadiy Moiseyev
  • Variants of adrenomedullin and calcitonin gene-related peptide and methods of use
    Patent number: 10464983
    Abstract: Variant peptides of calcitonin gene-related peptide alpha (?CGRP), calcitonin gene-related peptide beta (?CGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high binding affinity and agonistic or antagonistic activity for at least one receptor complex of CLR:RAMP1, CLR:RAMP2, and CLR:RAMP3. Also disclosed are methods of use of the variant peptides in therapeutic treatments.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: November 5, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Augen A. Pioszak
  • Glutamate treatment of cardiovascular disorders
    Patent number: 10398668
    Abstract: Compositions and methods for treating various cardiovascular disorders include targeted delivery of glutamate for impairing a targeted portion of the autonomic nervous system (ANS). Targeted delivery may be via direct injection into the targeted portion of the ANS or via vascular injection of magnetically-targetable nanoparticles.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: September 3, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Sunny Po
  • High molecular weight heparosan polymers and methods of production and use thereof
    Patent number: 10392642
    Abstract: High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: August 27, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Phillip E. Pummill, Regina C. Visser
  • Stabilized carbon nanotube suspensions
    Patent number: 10377941
    Abstract: Stable CNT dispersions having a combination of polymeric dispersants, including at least one first dispersant and at least one second dispersant, wherein the second dispersant is stable under saline conditions, and methods of using the CNT dispersions in subterranean formations for enhancing oil recovery therefrom.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: August 13, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Mohannad J. Kadhum, Daniel E. Resasco, Jeffrey H. Harwell, Ben Shiau, Daniel P. Swatske
  • Methods of determining shale pore connectivity
    Patent number: 10359379
    Abstract: A method of using NMR to estimate pore connectivity in a shale formation by estimating organic pore connectivity in a first sample of the shale formation and inorganic pore connectivity in a second sample of the shale formation based on uptake of brine and hydrocarbon phases. Porosity partitioning of the shale formation may be estimated with a third sample of the shale formation.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 23, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Ali Ousseini Tinni, Carl Sondergeld, Chandra Rai
  • MICRORNA EXPRESSION SIGNATURES FOR DOUBLECORTIN-LIKE KINASE 1 (DCLK1) ACTIVITY
    Publication number: 20190218603
    Abstract: Primer and/or probe sets and arrays for determining microRNA (miRNA) expression signatures that are specific to doublecortin-like kinase 1 (DCLK1) activity, and methods of their use, are disclosed.
    Type: Application
    Filed: May 18, 2017
    Publication date: July 18, 2019
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Courtney W. HOUCHEN, Nathaniel WEYGANT, Dongfeng QU, Randal MAY, Parthasarathy CHANDRAKESAN
  • System and method for measuring separation rate of water from water-in-crude oil emulsions
    Patent number: 10330663
    Abstract: System and method relates to measuring separation rate of water from water-in-crude oil emulsions at elevated temperature. The system includes an electrolytic interface (conductivity) cell comprising a plurality of capacitance/conductance probes disposed at different heights in a fluid stream disposed within the interface cell and an analyzer. Logic of the analyzer determines the separation rate based on signals received from the plurality of capacitance/conductance probes in the interface cell that are coupled to monitor the fluid stream. Methods for making and using the system are also disclosed.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 25, 2019
    Assignees: PHILLIPS 66 COMPANY, BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Moniraj Ghosh, Brian P. Grady, Jeffrey H. Harwell, James A. Miles
  • Anionic surfactants
    Patent number: 10329518
    Abstract: Monomeric and oligomeric compounds of Formula (I) comprising hydrophobic alkyl or alkenyl ester moieties and hydrophilic carboxylate moieties: wherein R1 is C1-C6 alkyl, R2 is Cl0-C30 alkyl or C8-C30 alkenyl, Y is a cation, Z is a sulfur-containing moiety, and n and k are integers as defined herein. The compounds of Formula (I) have surfactant properties. Also provided are compositions comprising the compounds of Formula (I), and methods of using the compounds or compositions for cleaning purposes.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 25, 2019
    Assignees: Board of Regents of the University of Oklahoma, Novus International, Inc.
    Inventors: Graciela B. Arhancet, Scott A. Long, Brian Grady, Jeff Harwell, Guangzhe Yu
  • Cardiac neuromodulation and methods of using same
    Patent number: 10279180
    Abstract: A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the device to deliver electrical stimulation to the spinal cord.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: May 7, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Robert D. Foreman, Jeffrey L. Ardell, John A. Armour, Michael J. L. DeJongste, Bengt G. S. Linderoth
  • Interband cascade devices
    Patent number: 10283658
    Abstract: Photovoltaic (PV) and photodetector (PD) devices, comprising a plurality of interband cascade (IC) stages, wherein the IC stages comprise an absorption region with a type-I superlattice and/or a bulk semiconductor material having a band gap, the absorption region configured to absorb photons, an intraband transport region configured to act as a hole barrier, and an interband tunneling region configured to act as an electron barrier, wherein the absorption region, the intraband transport region, and the interband tunneling region are positioned such that electrons will flow from the absorption region to the intraband transport region to the interband tunneling region.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: May 7, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rui Q. Yang
  • Methods of producing testosteronan polymers using testosteronan synthase
    Patent number: 10273517
    Abstract: Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: April 30, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Nigel J. Otto