Abstract: The present invention is directed methods for identifying, in a sample, one or more target nucleotide sequences differing from other nucleotide sequences in the sample by one or more nucleotides, one or more copy numbers, one or more transcript sequences, and/or one or more methylated residues, using ligation detection reactions, polymerase mediated extension reactions, and/or cleavage reactions. The present invention is also directed to methods for identifying, in a sample, one or more nucleotides in a target nucleotide sequence.
Type:
Grant
Filed:
March 23, 2016
Date of Patent:
November 10, 2020
Assignees:
The University of North Carolina at Chapel Hill, Cornell University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Francis Barany, John William Efcavitch, Steven A. Soper, Sunggook Park
Abstract: The present invention is directed to methods comprising a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The nanotubes have a passage extending between an input end proximate to the bioreactor chamber and an output end distal to the bioreactor chamber, and comprises one or more nanopores within the passage with each nanopore having a reduced diameter relative to the passage.
Type:
Grant
Filed:
July 17, 2019
Date of Patent:
November 10, 2020
Assignees:
The University of North Carolina at Chapel Hill, Cornell University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Steven A. Soper, Francis Barany, Sunggook Park, Michael Murphy, Collin J. McKinney, John William Efcavitch, Mateusz Hupert
Abstract: The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.
Type:
Application
Filed:
February 7, 2020
Publication date:
November 5, 2020
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: An artificial turf system has polymeric turf fibers resembling grass, and infill particles interspersed among said turf fibers. At least some of the infill comprises synthetic composite particles containing a thermoplastic polymer and cellulosic fibers, in which thermoplastic polymer is a matrix that binds together the other components of each synthetic particle into a composite particle.
Type:
Grant
Filed:
June 10, 2016
Date of Patent:
November 3, 2020
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: This invention features compositions, methods, and kits for treating conditions associated with pathological ocular neovascularization, reducing scarring in the eye, treating dry eye, treating macular degeneration, and treating keratitis by administering a serotonin receptor agonist.
Type:
Application
Filed:
May 1, 2018
Publication date:
October 22, 2020
Applicant:
The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
Inventors:
Timothy Paul Foster, Charles David Nichols
Abstract: A method of preventing or reducing the occurrence and/or development of a hernia within a subject at risk of developing a hernia includes implanting a graft material in contact with an opening in an abdominal wall. The graft material promotes healing of the abdominal wall and includes placental or placental derived tissue.
Type:
Application
Filed:
March 27, 2020
Publication date:
October 22, 2020
Applicant:
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Frank Ho Pak Lau, Ian Hodgdon, Michael Cook
Abstract: The present disclosure provides compositions comprising a lyn kinase activator and TRPM8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, Syndrome X, obesity, prediabetes, type II diabetes, type I diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration.
Type:
Grant
Filed:
April 9, 2018
Date of Patent:
September 29, 2020
Assignees:
Melior Pharmaceuticals I, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Andrew G. Reaume, Weina Cong, Frank Greenway, Ann Coulter
Abstract: A method for one of altering and enhancing the stereospecificity of an enzyme comprising introducing a stereospecific editing domain into the enzyme.
Type:
Grant
Filed:
September 23, 2016
Date of Patent:
September 22, 2020
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
Inventors:
Eric Allen First, Charles Joseph Richardson
Abstract: The poor water solubility of high molecular weight chitosan has limited its use in areas such as food and beverage products, post-harvest treatments, cosmetic and pharmaceutical products, medical treatments, and environmental pollution treatments. Disclosed is a high-molecular-weight, solid-state chitosan powder that is completely water-soluble.
Type:
Application
Filed:
November 14, 2016
Publication date:
August 13, 2020
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a means for molecular scale healing is disclosed; the composition has the ability to resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer serves to bring surfaces of a structural defect into approximation, whereafter use of the means for molecular scale healing allowed for movement of the healing means into the defect and thus obtain molecular scale healing. The means for molecular scale healing can be a thermoplastic such as fibers, particles or spheres which are used by heating to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. Compositions of the invention have the ability to not only close macroscopic defects, but also to do so repeatedly even if another wound/damage occurs in a previously healed/repaired area.
Type:
Application
Filed:
April 17, 2020
Publication date:
August 6, 2020
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Mogrosides may be used as a flavor modifier in various foods, beverages, pharmaceutical compositions, and the like to block the perception of bitter and astringent flavors or other off flavors.
Type:
Application
Filed:
March 18, 2020
Publication date:
July 9, 2020
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
John W. Finley, Darryl Holliday, Joan M. King, Alfredo D. Prudente, JR.
Abstract: A method of treating a condition of in a human patient comprising pharmacologically activating a translocator protein of 18 kDa (TSPO), wherein the condition is one of a chronic methamphetamine addiction, a medical consequence of methamphetamine use; a behavioral consequence of methamphetamine use, an HIV associated cognitive motor disorder, an HIV-associated neurodegenerative disorder, and a neuroinflammatory response.
Type:
Grant
Filed:
June 4, 2018
Date of Patent:
July 7, 2020
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY and Agricultural and Mechanical College
Inventors:
Nicholas E. Goeders, Christopher Dalton Schmoutz
Abstract: A new variety of sweetpotato, identified as ‘LA17-120’, is disclosed having resistance to southern root-knot nematode; a purple flesh storage root and attractive 5-lobed green leaves with purple vines.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
July 14, 2020
Assignee:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Abstract: A new variety of sweetpotato, identified as ‘LA17-40’, is disclosed having resistance to southern root-knot nematode; an orange flesh and attractive 5 lobed dark green and purple leaves.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
July 14, 2020
Assignee:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Abstract: A new variety of sweetpotato, identified as ‘LA08-21P’, is disclosed having resistance to both Fusarium wilt and southern root knot nematode; a light purple-banded flesh and deep-purple skin, and moderately high yield characteristics.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
July 14, 2020
Assignee:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Inventors:
Don R. LaBonte, Arthur Q. Villordon, Christopher A. Clark
Abstract: A new variety of sweetpotato, identified as ‘LA17-54’, is disclosed having disease resistance to Fusarium wilt; an orange flesh, red-copper skin storage root and attractive purple, red-hued and green leaves with purple venation and purple vines.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
July 21, 2020
Assignee:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Abstract: A new variety of sweetpotato, identified as ‘LA17-31’ is disclosed having resistance to southern root-knot nematode and Fusarium wilt; an orange flesh, red-purple skin storage root and attractive zero to three or five lobed dark green leaves with purple venation and purple vines.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
July 28, 2020
Assignee:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Abstract: A new variety of sweetpotato, identified as ‘LA13-81’, is disclosed having disease resistance to both Fusarium wilt and Streptomyces soil rot; an orange flesh storage root and deep red-purple skin, and high yield characteristics.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
July 28, 2020
Assignee:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Inventors:
Don R. LaBonte, Arthur Q. Villordon, Tara P. Smith, Christopher A. Clark