Patents Assigned to The Board of Supervisors of Louisiana State University
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Publication number: 20220243040Abstract: Disclosed herein is a self-healing asphalt binder composition comprising i) an asphalt binder, ii) an oxetane substituted polysaccharide, and iii) a polyurethane, as well as asphalts comprising said self-healing asphalt binder and an asphalt mixture. Also disclosed are methods of making the self-healing asphalt binder.Type: ApplicationFiled: January 31, 2022Publication date: August 4, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Sharareh Shirzad, Marwa M. Hassan
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Publication number: 20220241401Abstract: The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.Type: ApplicationFiled: December 14, 2021Publication date: August 4, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Konstantin G. Kousoulas
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Publication number: 20220233743Abstract: A composition for wound healing, comprising an amount of a macrophage proresolving polarizer, wherein the amount is effective to promote wound healing. The composition includes wherein the macrophage proresolving polarizer is lipin-1. The composition includes wherein the composition includes one, two, or three of IL-4, apoptotic cells (ACs), and AC derived lipids. The composition includes wherein the macrophage proresolving polarizer is a lipin-1 transcriptional coregulatory activity promoter. The composition includes, wherein the lipin-1 transcriptional coregulatory activity promoter is an inhibitor of lipin-1 macrophage pro-inflammatory responses enzymatic activity. A method for promoting wound healing, comprising contacting a wound on a skin of a mammal with the composition. A kit comprising one or more containers including the composition in sterile packaging.Type: ApplicationFiled: December 14, 2020Publication date: July 28, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Matthew WOOLARD, Robert SCHILKE, Cassidy BLACKBURN
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Patent number: 11392734Abstract: Embodiments of the present invention include apparatuses and methods for performing remote experiments in real-time. The method includes sending requests to perform remote experiments for a desired configuration to a first and second facility. The desired configuration may include a first and second configuration. The method includes running a first remote experiment in real-time at the first facility to obtain a first output variable. The first facility may include the first configuration with a first input variable. The method includes simultaneously running a second remote experiment in real-time at a second facility to obtain a second output variable. The second facility may include the second configuration with a second input variable. The first output variable may be set as the second input variable to mimic the desired configuration. The method includes obtaining experimental results of the desired configuration via the first and second input and output variables.Type: GrantFiled: November 22, 2019Date of Patent: July 19, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventor: Paulo J. Waltrich
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Patent number: 11384019Abstract: High-strength concrete-like FG blends and methods for producing them are described. The blend includes FG, hydraulic cement, additional alkali material, and pozzolanic material. The blend further includes an admixture used in the formulation of concrete. The blend further includes an aggregate. The aggregate is a coarse aggregate or a fine aggregate.Type: GrantFiled: November 12, 2020Date of Patent: July 12, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Michele Barbato, Yasser Bigdeli, Maria Teresa Gutierrez-Wing, Charles Davis Lofton
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Patent number: 11376573Abstract: Methods of preparing an acidic catalyst are disclosed that include heating a metal halide to produce a vapor phase metal halide, contacting an initial support material with the vapor phase metal halide in a reaction vessel causing a first chemical reaction and producing an intermediate acidic catalyst, contacting the intermediate acidic catalyst with HBr causing a second chemical reaction and producing an acidic catalyst product which is both more acidic than the intermediate acidic catalyst and more acidic than the initial support material.Type: GrantFiled: February 14, 2020Date of Patent: July 5, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: James J. Spivey, Kunlun Ding, Swarom Kanitkar
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Patent number: 11371913Abstract: The present disclosure provides for sampling instruments and methods of collecting sample particles. The sampling instrument can include a high-pressure pulsed valve coupled to a gas flow system to displace a sample from a surface. Also included can be a voltage supply coupled to a voltage switch, a suction device, a sample collector, and a collection filter. To collect a sample, extractive particles can be deposited onto a sample present on a substrate. At least a portion of the sample becomes coupled to a portion of the extractive particles to form sample particles. High-pressure gas can be discharged at the sample, thereby aerosolizing a portion of the sample particles to disperse aerosolized sample particles. A portion of the aerosolized sample particles can be collected onto a collection filter to form a collected sample.Type: GrantFiled: September 16, 2019Date of Patent: June 28, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITYInventors: Kermit King Murray, Fabrizio Donnarumma, Jamira Stephenson
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Publication number: 20220193105Abstract: The presently disclosed invention relates to products and methods of treating cancer in a patient comprising administering to the patient a pharmaceutically therapeutic dose of a chemotherapeutic, or any pharmaceutically acceptable salt, solvate, or prodrug thereof, conjugated to a nanocarrier. According to a further embodiment, the chemotherapeutic has a primary (10) amine (—NH2) group in within a pharmaceutical structure of the chemotherapeutic structure. According to a further embodiment, the chemotherapeutic is one of a platinum-based pharmaceutical and an Anthracycline family pharmaceutical. According to a further embodiment, the chemotherapeutic is one of gemcitabine, methotrexate, cisplatin, oxaliplatin, doxorubicin, daunorubicine, idarubicine, and epirubicine. According to a further embodiment, the chemotherapeutic is either attached to the nanocarrier by means that includes covalent bonds or is attached by means that does not included covalent bonds.Type: ApplicationFiled: March 1, 2021Publication date: June 23, 2022Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Shenuarin BHUIYAN, Mohuddin QUADAIR
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Patent number: 11367904Abstract: An energy storage apparatus is described and claimed herein comprising, generally, a battery housing enclosing a negative electrode, a positive electrode, and an electrolyte, wherein the electrolyte comprises a salt dissolved in either an amide-based solvent. In various embodiments, the amide-based solvent is a tertiary amide. Moreover, the energy storage apparatus may be a lithium ion battery that comprises an electrolyte with a lithium salt dissolved in a tertiary amide.Type: GrantFiled: September 11, 2020Date of Patent: June 21, 2022Assignee: Board of Supervisors of Louisiana State UniversityInventors: Daniel Kuroda, Kristen Fulfer, Kaylee Theresa Woodard
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Patent number: 11358901Abstract: A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and methods for molecular scale healing are provided. The composition can resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer can provide molecular scale healing in a structural defect. The methods for molecular scale healing can include heating a composition including a thermoplastic such as fibers, particles or spheres to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. The compositions have the ability to close macroscopic defects repeatedly even if another wound/damage occurs in a previously healed/repaired area.Type: GrantFiled: April 17, 2020Date of Patent: June 14, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Guoqiang Li, Harper Meng
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Patent number: 11357191Abstract: The herbicide-tolerant rice cultivar designated “PVL01” and its hybrids and derivatives are disclosed. The present invention provides a method for producing rice, wherein said rice is tolerant to a quizalofop herbicide or tolerant to a tepraloxdyim herbicide; wherein said rice belongs to any of (a) variety “PVL01” or (b) a hybrid, derivative, or progeny of “PVL01”. Further provided are methods for producing a hybrid or a new variety by crossing the rice variety “PVL01” with another rice line, one or more times. In another embodiment, this invention allows for single-gene converted plants of “PVL01”. In another embodiment, this invention provides regenerable cells for use in tissue culture of rice plant “PVL01”.Type: GrantFiled: June 19, 2018Date of Patent: June 14, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Steven D. Linscombe
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Patent number: 11351628Abstract: A wedge for on-line inspection of a weld includes a wedge body defining a coolant channel and at least one couplant channel, and a coolant input port in fluid connection with a first end of the coolant channel. The wedge body has a surface for disposing a phased array ultrasonic transducer comprising an array of ultrasonic elements. The coolant channel is formed in proximity to the surface for disposing the phased array ultrasonic transducer such that coolant flowing through the coolant channel maintains the phased array ultrasonic transducer below a predetermined temperature without obstructing the array of ultrasonic elements.Type: GrantFiled: February 9, 2017Date of Patent: June 7, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Daniel J. Huggett, Mohammad W. Dewan, Muhammad A. Wahab, Thunshun W. Liao, Ayman M. Okeil
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Patent number: 11351273Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.Type: GrantFiled: June 21, 2017Date of Patent: June 7, 2022Assignees: Board Of Supervisors Of Louisiana State University & Agricultural & Mechanical College, University of Florida Research Foundation, IncorporatedInventors: David C. Bloom, Alfred S. Lewin, Donna M. Neumann, Zachary L. Watson, Sonal Sanjeev Tuli, Gregory Scott Schultz
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Patent number: 11357085Abstract: The absorbance or emission wavelength of composite materials comprising a transition metal doped shell disposed over a rare earth doped core and a functionalizable group on the surface of the transition metal doped shell can change upon subjection to a carboxylic acid. This method of changing the absorbance or emission wavelength of a composite material can be used to identify counterfeit currency using an ink comprising a composite material.Type: GrantFiled: September 25, 2018Date of Patent: June 7, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventor: James Anthony Dorman
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Publication number: 20220169508Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for treating or reducing pain, improving symptoms of a microvascular disease, and improving nerve conduction velocity.Type: ApplicationFiled: February 14, 2022Publication date: June 2, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Amol SOIN, Christopher KEVIL, Kyle CHAN, Anthony GIORDANO
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Publication number: 20220163541Abstract: The presently disclosed invention relates to a method of diagnosing Multiple Sclerosis (MS) in a patient comprising obtaining a sample from the patient, determining a level of one or more H2S generating enzymes in the sample from the patient, and diagnosing the patient with MS when the level of the one or more H2S generating enzymes is one of at least 15% higher or lower than a control level for the one or more H2S generating enzymes, and at least 10% higher or lower than a control level for the one or more H2S generating enzymes.Type: ApplicationFiled: November 26, 2021Publication date: May 26, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Johnathan Steven ALEXANDER, Christopher KEVIL, Elizabeth DISBROW, Karen Y. STOKES, J. Winny YUN, Pooja VEERAREDDY, Urska Cvek
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Patent number: 11331492Abstract: Methods and apparatus are disclosed relating to the stimulating of tissue including nerve tissue based on combinations of capacitors and resistors. Application and removal of voltage to an electrical circuit is taught as part of a method of creating voltage waveforms for nerve and other tissue with such waveforms creating neural signals. The electrical apparatus taught may, include a first electrical node grounded through a first resistor; a second electrical node grounded through a second resistor; a first capacitor connected to both the first electrical node and the second electrical node; a second capacitor separating the second electrical node from a biological grounding point and direct current sources connected to the two nodes.Type: GrantFiled: April 29, 2020Date of Patent: May 17, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jose A. Parodi Amaya, Edward F Austin, Jin-Woo Choi
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Patent number: 11332565Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.Type: GrantFiled: April 30, 2019Date of Patent: May 17, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Ang Li, Guoqiang Li
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Publication number: 20220117937Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.Type: ApplicationFiled: October 15, 2021Publication date: April 21, 2022Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, Oklahoma State UniversityInventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N.D. Punchi Hewage, Scott Lovell, Anabel Soldano
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Patent number: 11285191Abstract: Disclosed are compositions and methods for stimulating immune responses. More particularly, these compositions and methods involve the use of an inhibitor of IL-25 function and an immune stimulator that stimulates an immune response to a target antigen for stimulating protective or therapeutic immune responses to a target antigen. The compositions and methods of the present invention are particularly useful in the prevention and treatment of infections and cancers.Type: GrantFiled: July 26, 2017Date of Patent: March 29, 2022Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Ronald James Jackson, Charani Ranasinghe