Patents Assigned to The Curators of the University of Missouri
  • Patent number: 12005018
    Abstract: The present invention is an apparatus and method for use in a treatment for prevention of arthrofibrosis that includes a first and a second substantially L-shaped frames, each L-shaped frame having a first member and a second member extending from the first member in a substantially perpendicular direction and terminating in a first end, a fixed plate extending between the first members of the L-shaped frames, the fixed plate being parallel with the first members of the L-shaped frames, a movable plate pivotally coupled to the first ends of the first members of the L-shaped frames with, a pneumatic piston coupled to the movable plate and the fixed plate, a hand operated valve operatively coupled to the pneumatic piston and a goniometer coupled to the movable plate and one of the L-shaped frames, the goniometer adapted and configured to indicate the angle between the movable plate and the fixed plate.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: June 11, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: James L. Cook, Cory Crecelius, Trent Guess, Kylee Rucinski, Jonathan Williams
  • Patent number: 12006350
    Abstract: One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwitterion-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: June 11, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: Bret Ulery, Rui Zhang, Caitlin Leeper, Josiah Smith, Logan Morton
  • Patent number: 12002891
    Abstract: A method of producing a four-layer silicon diode, including selecting a first silicon wafer, wherein said first silicon wafer is CZ-grown B-doped with <100> orientation, a resistivity of less than 0.01 Ohm-cm, and an oxygen content of greater than 10 ppma, and then selecting a second silicon wafer, wherein said second silicon wafer is CZ-grown P-doped with <100> orientation, a resistivity of less than 0.005 Ohm-cm, and an oxygen content of greater than 10 ppma, followed by cleaning the respective first and second silicon wafers. The wafers are then HF treated to yield respective first and second cleaned wafers, the first cleaned wafer is positioned into a first furnace and the second cleaned wafer is positioned into a second furnace, wherein the first and second furnaces are not unitary.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: June 4, 2024
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Alex Usenko, Anthony Caruso, Steven Bellinger
  • Patent number: 12000037
    Abstract: A method of depositing a nanoscale-thin film onto a substrate is disclosed. The method generally comprises depositing a layer of a solid or gaseous state functionalizing molecule onto or adjacent to the first surface of the substrate and exposing the first surface to a source of ionizing radiation, thereby functionalizing the first surface of the substrate. Once the layer of functionalizing molecule is removed, a nanoscale-thin film is then deposited onto the functionalized first surface of the substrate.
    Type: Grant
    Filed: December 23, 2022
    Date of Patent: June 4, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: Matthew R. Maschmann, Matthias J. Young
  • Patent number: 11996129
    Abstract: A semiconductor device includes ferromagnetic, magnetostrictive layer that exhibits a biaxial magnetic anisotropy and an underlying structure exhibits a spin Hall effect to provide a conversion between electrical energy and magnetic energy with more than two distinctive magnetic states, wherein the underlying structure includes a piezoelectric material structure and a spin Hall metal layer.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: May 28, 2024
    Assignees: Cornell University, The Curators of the University of Missouri, The Regents of the University of Michigan, Oregon State University
    Inventors: Darrell Schlom, Mostafizur Rahman, Kelin Kuhn, John Heron
  • Patent number: 11993850
    Abstract: A method for manufacturing a component comprising bombarding nanoparticles in a dispersion with a laser to transform the ligand and cause the nanoparticles to drop out of the dispersion and deposit onto a substrate; and bombarding additional nanoparticles in the dispersion with the laser to transform the ligand and cause the nanoparticles to drop out of the dispersion and deposit onto the nanoparticles previously deposited out of the dispersion.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: May 28, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: Heng Pan, Chinmoy Podder, Wan Shou, Xiaowei Yu
  • Publication number: 20240165296
    Abstract: The current invention describes a method for developing bioactive borate glass (BBG)-hydrogel constructs based on 3D printing technology for healing of burn wounds and low-tomoderate exuding wounds. The hydrogels serve as a water reservoir and binder for BBG, to provide hydration of the BBG-hydrogel construct and to make the bioink printable, while 3D printing technology enables the layer-by-layer deposition of multiple materials including BG and hydrogels such as alginate, gelatin, GelMa, cellulose, chitosan and other like materials, as well as control of pore geometry to increase the available surface area for wound-dressing contact and more favorable cell-biomaterial interactions.
    Type: Application
    Filed: March 15, 2022
    Publication date: May 23, 2024
    Applicant: The Curators of the University of Missouri
    Inventors: Fateme FAYYAZBAKHSH, Ming C. LEU, Delbert E. DAY
  • Publication number: 20240156783
    Abstract: Provided herein are compositions suitable for treating chemically induced eye damage comprising (a) a nonsteroidal anti-inflammatory drug (NSAID), (b) a histone deacetylase (HDAC) inhibitor and (c) an angiotensin converting enzyme (ACE) inhibitor and, optionally, (d) a water-soluble vitamin. Methods of using provided compositions to treat ocular toxicity and corneal damage following exposure to chemical agents (e.g., mustard gas) are also provided.
    Type: Application
    Filed: December 20, 2023
    Publication date: May 16, 2024
    Applicants: The Curators of the University of Missouri, The United States Government as Represented by the Department of Veterans Affairs
    Inventor: Rajiv R. Mohan
  • Publication number: 20240161395
    Abstract: Methods and systems for generating 3D models of surfaces that accurately reconstruct both the global structure of an object and its local features are described. The methods and systems generally operated by fusing point features from the point cloud data with voxel features extracted from voxelization procedures. Furthermore, the methods and systems utilize voxelization at multiple spatial resolutions. The use of point-voxel fusion and multiple spatial resolutions may permit the extraction of both global and local geometric features, increasing the accuracy of 3D modeling of objects.
    Type: Application
    Filed: November 8, 2023
    Publication date: May 16, 2024
    Applicants: Nikon Corporation, The Curators of the University of Missouri
    Inventors: Chuanmao Fan, Ye Duan, Bausan Yuan
  • Patent number: 11978430
    Abstract: A programmable metasurface and method is described having a plurality of parallel slits in an elastic substrate plate defining a plurality of unit cells, each having an actuator beam and a sensing beam with a slit therebetween. Each sensing beam has a pair of sensors for sensing flexural waves in the substrate. The actuator beam has a piezoelectric actuator that is controlled by a control circuit where the control circuit generates an actuator signal and where the control circuit compares the preceding actuator signal to the difference between the sensors and an electrical transfer function to result in the metasurface being able to perform a desired function.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: May 7, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: Guoliang Huang, Yangyang Chen, Xiaopeng Li
  • Publication number: 20240140882
    Abstract: Novel methods of synthesizing amorphous carbon and graphitic carbon aerogels are provided. The carbon aerogels produced by these methods are highly porous, monolithic carbon aerogels and are extremely robust. Specifically, the amorphous carbon aerogels have high surface areas and large micropore volumes. Due to these extraordinary properties, these aerogels possess high carbon dioxide (CO2) sorption capacities and are highly selective towards CO2 versus other gases, such as H2 and N2. As a result, the amorphous carbon aerogels can be used to effectively capture or remove CO2 from the air and/or from flue gases. Furthermore, the graphitic carbon aerogels notably have high graphite content, crystallite size, and graphite quality, of which are comparable to those of commercial graphite.
    Type: Application
    Filed: April 5, 2022
    Publication date: May 2, 2024
    Applicant: The Curators of the University of Missouri
    Inventors: Chariklia Sotiriou-Leventis, Nicholas Leventis, Rushi Soni, Vaibhav Edlabadkar, Parwani Rewatkar, ABM Shaheen ud Doulah
  • Patent number: 11959087
    Abstract: The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by down-regulating the biotin/lipoyl attachment domain containing (BADC) genes through biotechnology or selective breeding approaches.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: April 16, 2024
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Jay Thelen, Matthew Salie
  • Patent number: 11952197
    Abstract: A thermal liquid container system comprising a main body, a phase change material (PCM) liner disposed within the main body having a PCM disposed therein, a liquid reservoir defined by PCM liner, a liquid dispensing partition disposed within the liquid reservoir such that the liquid reservoir is partitioned into a temperature conditioning channel and a liquid retention chamber, and a lid comprising a liquid ingress and a liquid dispensing opening, the temperature conditioning channel for placing a liquid passing therethrough in thermal contact with the PCM whereby thermal energy is exchanged between the liquid flowing through the temperature conditioning channel and the PCM such that the liquid is dispensed at a temperature that is within a desired temperature range determined by the selected PCM melting temperature.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: April 9, 2024
    Assignee: The Curators of the University of Missouri
    Inventor: Hongbin Ma
  • Patent number: 11937596
    Abstract: An improved ultra-fast cooling system is disclosed for cryopreservation of biomaterials. The ultra-fast cooling system is designed to uniformly vitrify or partially vitrify biomaterials, including but not limited to, human biomaterials, proteins, peptides, cells, stem cells, antibodies, neurons, human tissue, organs, cornea, skin, retina, eggs, sperm, embryos, body fluids, blood, serum, lymph fluid, animal tissue, plant biomaterials, plant tissue, germ plasma, pollen, plant sap, and bioengineered tissue, without cryoprotectants or with a low concentration of cryoprotectants. Cooling rates are sufficient to uniformly cryopreserve biomaterials, and can be used in diagnostic cytology and biological cryofixation applications. Other materials also can be cooled uniformly, such as inorganic materials for processing.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: March 26, 2024
    Assignees: THE CURATORS OF THE UNIVERSITY OF MISSOURI, CRYOCRATE LLC
    Inventors: Xu Han, Henry W. White, Peter Koulen
  • Patent number: 11925705
    Abstract: Nanogels and methods of synthesizing and using these nanogels are provided. The nanogels are formed by mixing a building block (e.g., polymer), crosslinker, preferably a target (e.g., biomedical compound or molecule), and a solvent in a multi-inlet vortex mixer, so as to cause the polymer and crosslinker to react and form a chemically crosslinked polymer network. In embodiments including a target, the target will be interspersed in and among that network and can be physically embedded and/or chemically bound therein.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: March 12, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: Hu Yang, Da Huang
  • Publication number: 20240076611
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Application
    Filed: July 24, 2023
    Publication date: March 7, 2024
    Applicant: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
  • Patent number: 11911436
    Abstract: The present disclosure provides amphiphilic peptide chaperones. Also provided are their incorporation into pharmaceutical compositions and methods of use for preventing or reducing a source of stress in cells and for the treatment of disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), cataract, age-related macular degeneration (AMD), glaucoma, and retinitis pigmentosa.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: February 27, 2024
    Assignee: The Curators of the University of Missouri
    Inventors: Santhoshkumar Puttur, Krishna Sharma, Sundararajan Mahalingam
  • Patent number: 11905518
    Abstract: Disclosed are modified plants and methods for producing modified plants having a modified 5?-untranslated region of small auxin upregulated protein flooding tolerance (SAUR_FT) gene. Modified plants disclosed herein have at least one of an increased root system architecture, an increased waterlogging tolerance, an increased drought tolerance, and combinations thereof.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: February 20, 2024
    Assignee: Curators of the University of Missouri
    Inventors: Henry T. Nguyen, Heng Ye, Babu Valliyodan
  • Publication number: 20240042259
    Abstract: Agents for decontaminating and/or neutralizing organophosphorus compounds (e.g., nerve agents, pesticides) and methods of using those agents are disclosed. Preferred agents comprise aminoguanidine imines, and these agents do not require a strongly alkaline environment to be effective. The aminoguanidine imines can hydrolytically decontaminate substantially all of the target organophosphorus compound(s) in a matter of minutes.
    Type: Application
    Filed: August 1, 2023
    Publication date: February 8, 2024
    Applicant: The Curators of the University of Missouri
    Inventors: V. Prakash Reddy, Puspa Aryal
  • Patent number: D1025206
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: April 30, 2024
    Assignee: The Curators of the University of Missouri
    Inventor: Damon Coyle