Patents Assigned to The Curators of the University of Missouri
  • Patent number: 10566638
    Abstract: A radiolytic electrochemical system that comprises a cathode, an anode that comprises a semiconductor, an aqueous electrolyte solution disposed between the cathode and anode, and ionizing radiation, wherein the ionizing radiation splits water molecules and forms solvated free radicals that migrate to the anode or cathode, depending upon a radical's charge, and participate in redox reactions at the anode and cathode thereby producing electrical current capable of performing work when the anode and cathode are electrically connected.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: February 18, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Jae Wan Kwon, Baek Hyun Kim
  • Patent number: 10556393
    Abstract: A method of manufacturing a tire is provided that includes curing the tire (10) in a curing press (12) and applying microwave energy at a given frequency band into the tire. The interaction between the microwave energy and the tire is monitored to obtain a complex reflection coefficient. A root-mean-squared error is calculated using the measured complex reflection coefficient and a reference reflection coefficient. The reference reflection coefficient is from a fully cured tire made from the same material as the tire. Continuous monitoring of the interaction takes place to obtain the complex reflection coefficient along with continuous calculation of the root-mean-squared error at different times during the curing of the tire in the curing press. The calculated root-mean-squared errors are used to determine whether to stop the curing of the tire in the curing press.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: February 11, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: David Judd, Frank Gramling, Reza Zoughi, Mohammad Tayeb Ghasr
  • Patent number: 10548989
    Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: February 4, 2020
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Feng Chen, Barney Yoo, Jason Lewis, Ulrich Wiesner, Kai Ma
  • Patent number: 10548319
    Abstract: The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: February 4, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: George W. Gokel, Mohit B. Patel
  • Patent number: 10548580
    Abstract: A surgical instrument can be introduced to the abdominal cavity through a current trocar puncture to place a suture in the deep facia and peritoneum of the anterior abdominal wall. The instrument is lightweight and easy to use, and can be operated quickly and efficiently to close the trocar puncture wound in a simple and economical manner. The instrument is used to suture the deep facia and peritoneum of the anterior abdominal wall on opposite sides of the trocar puncture wound inside the abdomen to close the trocar puncture wound.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: February 4, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Roger de la Torre, Jaya Ghosh, Ellie Koehly, Yaw Sarpong
  • Patent number: 10547044
    Abstract: A dry electrode manufacturing process employed for low cost battery through a dry mixing and formation process. A thermal activation renders the dry fabricated electrode comparable to conventional slurry casted electrodes. The dry electrode mixture results from a combination of a plurality of types of constituent particles, including at least an active charge material and a binder, and typically a conductive material such as carbon. The process heats the deposited mixture to a moderate temperature for activating the binder for adhering the mixture to the substrate; and compresses the deposited mixture to a thickness for achieving an electrical sufficiency of the compressed, deposited mixture as a charge material in a battery.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: January 28, 2020
    Assignees: Worcester Polytechnic Institute, The Curators of the University of Missouri
    Inventors: Yan Wang, Zhangfeng Zheng, Brandon Ludwig, Heng Pan
  • Patent number: 10542911
    Abstract: A system for elucidating physiological characteristics of laryngeal adductor reflex (LAR) responses in a human or animal subject's larynx's vocal folds (VFs) includes a pressure pulsing component to provide a stable and adjustable pulse of pressure to the larynx, a control system component in functional communication with the pressure pulsing component to control or regulate one or more aspects of the timing, magnitude and number of pulses of pressure delivered by the pressure pulsing component during respiratory cycles, and a respiratory sensor component to detect and/or determine physiological characteristics of the subject's LAR response. The method includes evoking a LAR response in the subject and determining one or more physiological measurements including duration, velocity, and angles of motion of the subject's VFs during the LAR response. The present disclosure provides for enhanced endoscopic field of view of the larynx and delivering stimuli over a wider range of controlled parameters.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: January 28, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Teresa Lever, Cameron Hinkel
  • Patent number: 10537089
    Abstract: A system and method for thermally exchanging heat between waste air being expelled from a poultry barn and fresh outside/outdoor ambient air being introduced into the poultry barn.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 21, 2020
    Assignees: The Curators of the University of Missouri, Heartland Farm Energy LLC
    Inventors: Tingsheng Xu, Yunsheng Xu
  • Publication number: 20200018544
    Abstract: In general, the present invention is directed to processes for separating a vapor comprising a first component and a second component using high-pressure density-driven separation. The present invention further relates to various processes for the capture of carbon dioxide. In particular, various processes of the present invention relate to the separation of carbon dioxide from flue gas of combustion processes. The invention also applies to upgrading fuel gases containing carbon dioxide. The invention also applies to separation of hydrogen from fuel gas vapor solutions.
    Type: Application
    Filed: February 14, 2018
    Publication date: January 16, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: William Jacoby, Reza Espanani
  • Publication number: 20200008623
    Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 9, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Hongbin Ma, Michael Merwin, Hao Bai, Robert Riegler, Christopher Vincent, Susan Liu
  • Patent number: 10526651
    Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER to Golgi trafficking. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: January 7, 2020
    Assignees: Whitehead Institute for Biomedical Research, The Curators of the University of Missouri
    Inventors: Susan L. Lindquist, Aaron D. Gitler, Anil Cashikar, Antony A. Cooper, Cole M. Haynes
  • Patent number: 10512394
    Abstract: The present invention discloses a new and improved endoscopic-enabled mouth gag for routine ENT procedures, such as adenoidectomy and nasopharyngeal biopsy. The invention modifies the existing mouth gag, provides a stable and adjustable placement for an endoscopic device potentially employed during an ENT procedure, and is to replace the outdated surgical method where the surgical field is visualized indirectly via a handheld mirror (with or without the preexisting mouth gag). The inventive endoscopic-enabled mouth gag not only provides enhanced visualization of the surgical field for a clinician, assistants, and trainees, but also enables a clinician to perform the procedure bimanually (with both hands).
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: December 24, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Eliav Gov-Ari, Alexander Madinger
  • Patent number: 10516170
    Abstract: A catalyst obtained by first preparing a cermet material with the general formula ABOx, wherein A is selected from the group consisting of Co, Cu, Ni, Ti, and combinations thereof, wherein B is selected from the group consisting of Mo, W, Ce, and combinations thereof, wherein A and B are different elements, and wherein x is a nonzero number ranging from 3 to 7 and represents the moles of O. Next, the cermet is activated in a reducing atmosphere to yield metal particles dispersed within and/or on the cermet.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: December 24, 2019
    Assignee: The Curators of the University of Missouri
    Inventor: Fatih Dogan
  • Patent number: 10490679
    Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: November 26, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Sangho Bok, Samiullah Pathan, Cherian Joseph Mathai, Sagnik Basuray, Keshab Gangopadhyay, Biyan Chen, Sheila Grant, Aaron Wood
  • Patent number: 10472630
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: November 12, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Christian Lorson, Erkan Osman
  • Publication number: 20190341836
    Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.
    Type: Application
    Filed: July 16, 2019
    Publication date: November 7, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: Nuh Sadi Yuksek, Mahmoud Almasri
  • Patent number: 10469076
    Abstract: Combining the functionality of sleep transistors with logic devices in power-gating circuits by utilizing fully depleted silicon-on-insulator (FDSOI) transistors. In an embodiment, a back gate of a FDSOI transistor controls the threshold voltage to eliminate the need for standalone sleep transistors.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: November 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Masud H. Chowdhury, Emesahw Ashenafi
  • Patent number: 10467400
    Abstract: Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among a plurality of decoy images. Gaze tracking can be used to determine which images the user has selected without allowing an observer to learn which images have been selected. Images for the visual story can be retrieved from the user's social networking profile, and corresponding text storied generated to indicate which images should be selected. Multiple security levels are possible by varying the number of story images and decoy images.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Chi-Ren Shyu, Hongfei Cao, Matthew Klaric, Jeffrey Uhlmann
  • Patent number: 10465258
    Abstract: A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: November 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Simon Lekakh, Von Richards, Ronald O'Malley, Jun Ge
  • Patent number: 10456198
    Abstract: Systems and methods for the controlled delivery of laser light to target tissue using an improved waveguide. A waveguide controls transmission of wave energy to a target based on direct contact with the target. The waveguide comprises a propagation medium, a cladding causing the electromagnetic wave to be internally reflected in the medium, and an interface formed in the cladding and configured for direct contact with the target. A portion of the laser light penetrates through the cladding at the interface and propagates into the target while a portion internally reflects within the propagation medium.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 29, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Paul James Douglas Whiteside, Benjamin Samuel Goldschmidt, John A. Viator, Randy D. Curry, Nicholas J. Golda